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  2. Apoptosis PROTAC
  3. Bcl-2 Family Molecular Glues
  4. CCT369260

CCT369260 (compound 1) 是具有口服活性的、B 細胞淋巴瘤 6 (BCL6) 抑制劑，具有抗腫瘤活性，其 IC50 值為 520 nM。

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CCT369260 Chemical Structure

CCT369260 Chemical Structure

CAS No. : 2647503-57-7

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥5040
In-stock
1 mg ￥2045
In-stock
5 mg ￥4500
In-stock
10 mg 現(xiàn)貨 詢價
50 mg   詢價  
100 mg   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of CCT369260:

查看 Bcl-2 Family 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

CCT369260 (compound 1) is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC50 of 520 nM[1].

IC50 & Target

IC50: 520 nM (BCL6)[1].
細胞效力
(Cellular Effect)
Cell Line Type Value Description References
OCI-Ly1 GI50
0.035 μM
Compound: 1; CCT369260
Antiproliferative activity agianst human OCI-LY1 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
Antiproliferative activity agianst human OCI-LY1 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
[PMID: 32275432]
OCI-Ly3 GI50
1.6 μM
Compound: 1; CCT369260
Antiproliferative activity agianst human OCI-LY3 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
Antiproliferative activity agianst human OCI-LY3 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
[PMID: 32275432]
SUD4 GI50
0.092 μM
Compound: 1; CCT369260
Antiproliferative activity agianst human SUDHL4 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
Antiproliferative activity agianst human SUDHL4 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
[PMID: 32275432]
體內(nèi)研究
(In Vivo)

CCT369260 (compound 1, 15 mg/kg, po, single dose) significantly inhibits BCL6 in OCI-Ly1 DLBCL xenograft model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: OCI-Ly1 DLBCL xenograft model (female SCID mice)[1].
Dosage: 15 mg/kg.
Administration: PO, single dose.
Result: Decreased the levels of BCL6 in the tumor observed up to 10 h after administration.
Animal Model: Female Balb/C mice[1].
Dosage: 1 mg/kg iv and 5 mg/kg po (Pharmacokinetic Analysis).
Administration: IV and PO
Result: Demonstrated moderate clearance (CL 20 mL min?1 kg?1) with mean oral bioavailability of 54%.
分子量

508.99

Formula

C24H31ClF2N6O2
CAS 號
性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 300 mg/mL (589.40 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.9647 mL 9.8234 mL 19.6468 mL
5 mM 0.3929 mL 1.9647 mL 3.9294 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9647 mL 9.8234 mL 19.6468 mL 49.1169 mL
5 mM 0.3929 mL 1.9647 mL 3.9294 mL 9.8234 mL
10 mM 0.1965 mL 0.9823 mL 1.9647 mL 4.9117 mL
15 mM 0.1310 mL 0.6549 mL 1.3098 mL 3.2745 mL
20 mM 0.0982 mL 0.4912 mL 0.9823 mL 2.4558 mL
25 mM 0.0786 mL 0.3929 mL 0.7859 mL 1.9647 mL
30 mM 0.0655 mL 0.3274 mL 0.6549 mL 1.6372 mL
40 mM 0.0491 mL 0.2456 mL 0.4912 mL 1.2279 mL
50 mM 0.0393 mL 0.1965 mL 0.3929 mL 0.9823 mL
60 mM 0.0327 mL 0.1637 mL 0.3274 mL 0.8186 mL
80 mM 0.0246 mL 0.1228 mL 0.2456 mL 0.6140 mL
100 mM 0.0196 mL 0.0982 mL 0.1965 mL 0.4912 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
CCT369260
目錄號：
HY-129188
需求量：