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  2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. DBCO-NHCO-PEG4-NH-Boc

DBCO-NHCO-PEG4-NH-Boc 是一種 PROTAC 連接橋，屬于 PEG 類和 Alkyl/ether 類。DBCO-NHCO-PEG4-NH-Boc 可用于合成一系列 PROTAC 分子。DBCO-NHCO-PEG4-NH-Boc 是一種可降解 (cleavable) 的 ADC 連接橋，用于抗體活性分子結(jié)合物 (ADCs) 的合成。DBCO-NHCO-PEG4-NH-Boc 是一種點(diǎn)擊化學(xué)試劑。它含有 DBCO 基團(tuán)，可以和含有 Azide 基團(tuán)的分子發(fā)生環(huán)張力 (strain) 促進(jìn)的炔-疊氮環(huán)加成反應(yīng) (SPAAC)。

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DBCO-NHCO-PEG4-NH-Boc Chemical Structure

DBCO-NHCO-PEG4-NH-Boc Chemical Structure

CAS No. : 1255942-12-1

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規(guī)格 價(jià)格 是否有貨
25 mg ￥435
詢問價(jià)格 & 貨期
50 mg ￥697
詢問價(jià)格 & 貨期
100 mg ￥1381
詢問價(jià)格 & 貨期
250 mg ￥3360
詢問價(jià)格 & 貨期

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

DBCO-NHCO-PEG4-NH-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-NH-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-NHCO-PEG4-NH-Boc is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target[1]

Cleavable Linker

 

PEGs

 

Alkyl/ether

 

體外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

623.74

Formula

C34H45N3O8
CAS 號(hào)
性狀

粘稠液體

顏色

Colorless to yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料
參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
DBCO-NHCO-PEG4-NH-Boc
目錄號(hào)：
HY-126884
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