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  2. Anti-infection Autophagy NF-κB
  3. Bacterial HIV Autophagy Parasite IKK Influenza Virus
  4. Tizoxanide

Tizoxanide  (Synonyms: 替唑尼特; TIZ)

目錄號: HY-12687 純度: 99.09%
COA 產品使用指南 技術支持

Tizoxanide (TIZ) 是 Nitazoxanidede 的活性代謝物，也是一種噻唑胺類抗 感染 化合物，對厭氧菌、原生動物和一系列病毒產生作用。Tizoxanide (TIZ) 具有抗 HIV-1 活性，對 HBV 和 HCV 的復制有較強的抑制作用，EC50 分別為 0.46 μM 和 0.15 μM。Tizoxanide (TIZ) 還通過抑制 LPS 處理的巨噬細胞中促炎細胞因子的產生和 NF-κB 以及 MAPK 信號通路的激活發(fā)揮抗炎作用。

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Tizoxanide Chemical Structure

Tizoxanide Chemical Structure

CAS No. : 173903-47-4

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥595
In-stock
1 mg ￥204
In-stock
5 mg ￥437
In-stock
10 mg ￥700
In-stock
25 mg ￥1313
In-stock
50 mg ￥2025
In-stock
100 mg ￥3025
In-stock
200 mg   詢價  
500 mg   詢價  

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Customer Review

Other Forms of Tizoxanide:

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC50 of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells[1][3][4][5].

IC50 & Target

HIV-1

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
29.8 μM
Compound: TIZ
Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
[PMID: 34055214]
HepG2 2.2.15 CC50
> 100 μM
Compound: 2
Cytotoxicity against human HepG2(2.2.15) cells after 24 hrs by neutral red dye uptake assay
Cytotoxicity against human HepG2(2.2.15) cells after 24 hrs by neutral red dye uptake assay
[PMID: 21553812]
Huh-7 CC50
14 μM
Compound: 2
Cytotoxicity against human Huh7.5 cells after 3 days by neutral red dye assay
Cytotoxicity against human Huh7.5 cells after 3 days by neutral red dye assay
[PMID: 22059983]
Vero CC50
388 μM
Compound: Tizoxanide
Cytotoxicity against African green monkey Vero cells after 48 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells after 48 hrs by MTT assay
[PMID: 25801157]
Vero CC50
388 μM
Compound: TIZ
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
[PMID: 21397502]
體外研究
(In Vitro)

Tizoxanide (TIZ) induces mild mitochondrial uncoupling and activate AMPK in hepatocytes[1].
Tizoxanide (TIZ) inhibits hepatitis C virus (HCV) replication in HCV replicon systems[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 1-25 μmol/L
Incubation Time: 24 h
Result: Induced mitochondrial uncoupling and AMPK activation not due to the non-specific cytotoxicity in HepG2 cells at concentrations less than 25 μmol/L.

Immunofluorescence[1]

Cell Line: HepG2 cells
Concentration: 10 μmol/L
Incubation Time: 24 h
Result: Promoted the nuclear translocation of TFEB by activating AMPK in HepG2 cells.

RT-PCR[1]

Cell Line: HepG2 cells
Concentration: 1-25 μmol/L
Incubation Time: 24 h
Result: Induced the increase transcription of SQSTM1/P62 in HepG2 cells.

Western Blot Analysis[1]

Cell Line: HepG2 cells
Concentration: 1-25 μmol/L
Incubation Time: 24 h
Result: Activated AMPK and increased phosphorylation of ACC in HepG2 cells.

Cell Cytotoxicity Assay[3]

Cell Line: RP7 cells, NTZ-11 and TIZ-9 cell lines
Concentration: The initial drug concentration was 0.02 μM, followed by 0.05, 0.1, 0.5, and 1 μM, and subsequent weekly increases of 1 μM until a final concentration of 11 μM.
Incubation Time: 3 days
Result: Againsted HCV replication in RP7 cells (IC50: 0.16), NTZ-11 (IC50:1.2) and TIZ-9 cell lines (IC50: 1.5)
體內研究
(In Vivo)

Tizoxanide (TIZ) (10 mg/kg; i.v.) can pass the BBB and distribute to the brain tissue. Tizoxanide retains in brain is obviously longer than that in plasma[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley rats[2]
Dosage: 10 mg/kg
Administration: Tizoxanide (10 mg/kg; i.v.)
Result: Could pass the BBB and distribute to the brain tissue.
分子量

265.25

Formula

C10H7N3O4S
CAS 號
性狀

固體

顏色

White to yellow

中文名稱

替唑尼特
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 25 mg/mL (94.25 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

Ethanol 中的溶解度 : < 1 mg/mL (insoluble)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 3.7700 mL 18.8501 mL 37.7003 mL
5 mM 0.7540 mL 3.7700 mL 7.5401 mL
查看完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內使用， -20°C儲存時，請在1年內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實驗：

以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

  • 方案 一

    請依序添加每種溶劑： 15% Cremophor EL    85% Saline

    Solubility: 5 mg/mL (18.85 mM); 懸濁液; 超聲助溶 (<60°C)

  • 方案 二

    請依序添加每種溶劑： 17% Solutol HS-15 in Saline

    Solubility: 5 mg/mL (18.85 mM); 懸濁液; 超聲助溶 (<60°C)

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料

純度: 99.09%

參考文獻

完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內使用， -20°C儲存時，請在1年內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7700 mL 18.8501 mL 37.7003 mL 94.2507 mL
5 mM 0.7540 mL 3.7700 mL 7.5401 mL 18.8501 mL
10 mM 0.3770 mL 1.8850 mL 3.7700 mL 9.4251 mL
15 mM 0.2513 mL 1.2567 mL 2.5134 mL 6.2834 mL
20 mM 0.1885 mL 0.9425 mL 1.8850 mL 4.7125 mL
25 mM 0.1508 mL 0.7540 mL 1.5080 mL 3.7700 mL
30 mM 0.1257 mL 0.6283 mL 1.2567 mL 3.1417 mL
40 mM 0.0943 mL 0.4713 mL 0.9425 mL 2.3563 mL
50 mM 0.0754 mL 0.3770 mL 0.7540 mL 1.8850 mL
60 mM 0.0628 mL 0.3142 mL 0.6283 mL 1.5708 mL
80 mM 0.0471 mL 0.2356 mL 0.4713 mL 1.1781 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Tizoxanide
目錄號：
HY-12687
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