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  2. Apoptosis Protein Tyrosine Kinase/RTK
  3. Apoptosis Bcl-2 Family MDM-2/p53 VEGFR
  4. Poly-L-lysine (hydrobromide) (MW 30000-70000)

Poly-L-lysine hydrobromide (MW 30000-70000) 是一種水溶性合成多肽。Poly-L-lysine hydrobromide (MW 30000-70000) 下調(diào) Bcl-2，上調(diào) Bax 和 p53 蛋白。Poly-L-lysine hydrobromide (MW 30000-70000) 促進(jìn)凋亡 (Apoptosis) 和降低 VEGF 表達(dá)。Poly-L-lysine hydrobromide (MW 30000-70000) 對(duì)多種腫瘤顯示出抗癌活性。Poly-L-lysine hydrobromide (MW 30000-70000) 還可用作涂層材料。

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Poly-L-lysine (hydrobromide) (MW 30000-70000) Chemical Structure

Poly-L-lysine (hydrobromide) (MW 30000-70000) Chemical Structure

CAS No. : 25988-63-0

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Poly-L-lysine hydrobromide (MW 30000-70000) is a water-soluble synthetic polypeptide. Poly-L-lysine hydrobromide (MW 30000-70000) downregulates Bcl-2 and upregulates Bax and p53 proteins. Poly-L-lysine hydrobromide (MW 30000-70000) promotes Apoptosis and reduces VEGF expression. Poly-L-lysine hydrobromide (MW 30000-70000) shows anticancer activity against a variety of tumors. Poly-L-lysine hydrobromide (MW 30000-70000) can also be used as a coating material[1][2][3][4][5][6][7][8].

IC50 & Target[1][2][3][4][5][6][7][8]

Bax

 

Bcl-2

 

體外研究
(In Vitro)

Poly-L-lysine hydrobromide (MW 30000-70000) (0.1-25 μg/mL, 24 h) 對(duì)人類(lèi)癌細(xì)胞表現(xiàn)出抗增殖活性，對(duì) K562、A549、U937 和 B16F10 細(xì)胞的 IC50 值分別為 3.36 μM、8.23 μM、3.53 μM 和 6.04 μM[2]。
Poly-L-lysine hydrobromide (MW 30000-70000) (0.5-40 μg/mL, 48 h) 在 MCF-7 細(xì)胞中表現(xiàn)出抗增殖活性 (IC50 值為 4.22 μg/mL)[3]。
Poly-L-lysine hydrobromide (MW 30000-70000) (0.5-30.0 μg/mL，24-72 h) 可降低體外 HUVEC 和 DAL 細(xì)胞的細(xì)胞增殖，并改變 DAL 細(xì)胞的細(xì)胞形態(tài)[4]。
Poly-L-lysine hydrobromide (MW 30000-70000) (0-200 μg/mL) 可刺激用 [3H] 花生四烯酸生物合成標(biāo)記的 3T3 瑞士小鼠成纖維細(xì)胞培養(yǎng)物中花生四烯酸的釋放[5]。
Poly-L-lysine hydrobromide (MW 30000-70000) (在工作 pH 下，等電點(diǎn) ～10.5)/肝素多層涂層可防止血液蛋白吸附[6]。
Poly-L-lysine hydrobromide (MW 30000-70000) (1.0-40.0 μg/mL，48 h) 抑制 MDA-MB-231 和 B16F10 癌細(xì)胞的增殖[7]。
Poly-L-lysine hydrobromide (MW 30000-70000) (10-120 μg/mL，2-4 h) 劑量依賴(lài)性地降低 HeLa 細(xì)胞的活力[8]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: K562, A549, U937, and B16F10 cells
Concentration: 0.1, 0.5,1, 5, 10, 20, 25 μg/mL
Incubation Time: 24 h
Result: Showed anti-proliferative activities in cancers cells (K562, A549, U937, and B16F10).
Was the most potent in K562 cells.
體內(nèi)研究
(In Vivo)

Poly-L-lysine hydrobromide (MW 30000-70000) (20-40 mg/kg，腹腔注射，14 天) 可抑制小鼠艾氏腹水癌 (EAC)，導(dǎo)致 EAC 細(xì)胞凋亡[2]。
Poly-L-lysine hydrobromide (MW 30000-70000) (20-40 mg/kg，腹腔注射，21 天) 可抑制瑞士雌性白化小鼠的肉瘤-180 實(shí)體腫瘤[2]。
Poly-L-lysine hydrobromide (MW 30000-70000) (20-40 mg/kg，腹腔注射，腫瘤接種后 10 天開(kāi)始，持續(xù) 21 天) 可抑制 DAL 實(shí)體腫瘤的生長(zhǎng)小鼠[4]。
Poly-L-lysine hydrobromide (MW 30000-70000) (20-40 mg/kg，腹腔注射，腫瘤接種后 10 天開(kāi)始，持續(xù) 21 天) 可在 MDA-MB-231 和 B16F10 誘導(dǎo)小鼠模型的 2D 和 3D 腫瘤微環(huán)境中誘導(dǎo)細(xì)胞凋亡[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: EAC tumor bearing mouse (inoculated with 0.1 ml of tumor cell suspension, prepared in phosphate buffer solution containing 2×106 cells/mL)[2]
Dosage: 20, 40 mg/kg
Administration: Intraperitoneal injection (i.p.), 14 days
Result: Reduced the ascite fluid volume, packed cell volume and viable tumor cell count, whereas, increased non-viable tumor cell count in a dose dependent manner.
Increased the hemoglobin counts towards the normal levels.
Showed chromatin condensation, blebbing of plasma membrane, irregularity in cell morphology (EAC).
Inhibited peritoneal angiogenesis.
Showed apoptosis of EAC cells.
Animal Model: Sarcoma-180 solid tumor model (given subcutaneous inoculation (s.c.) of 0.1 ml sarcoma-180 cell suspension containing 2×106 cells/mL)[2]
Dosage: 20, 40 mg/kg
Administration: Intraperitoneal injection (i.p.), 21 days
Result: Inhibited tumor growth.
Could bring down the WBC level compare to Sarcoma-180 control group.
Enhanced the survival of sarcoma-180 bearing mice.
Showed less proliferation and muscle invasion in extents areas of coagulative necrosis.
Induced cell apoptosis by triggering the expression of p53 and Bcl-2.
分子量

30000-70000

Formula

C8H19BrN2O
CAS 號(hào)
性狀

固體

顏色

White to off-white

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

H2O 中的溶解度 : 100 mg/mL (超聲助溶)

  • 摩爾計(jì)算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱(chēng)：
Poly-L-lysine (hydrobromide) (MW 30000-70000)
目錄號(hào)：
HY-126437
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