成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

  2. Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
  4. Alpha-Naphthoflavone

Alpha-Naphthoflavone  (Synonyms: α-萘黃酮)

目錄號(hào): HY-125833 純度: 98.54%
COA 產(chǎn)品使用指南 技術(shù)支持

Alpha-Naphthoflavone 是一種具有口服活性的黃酮類化合物，為有效、競(jìng)爭(zhēng)性的芳香酶 aromatase 抑制劑，IC50 和 Ki 值分別為 0.5 和 0.2 μM。Alpha-Naphthoflavone 可抑制細(xì)胞增殖，誘導(dǎo)細(xì)胞凋亡。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Alpha-Naphthoflavone Chemical Structure

Alpha-Naphthoflavone Chemical Structure

CAS No. : 604-59-1

1.  客戶無(wú)需承擔(dān)相應(yīng)的運(yùn)輸費(fèi)用。

2.  同一機(jī)構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機(jī)構(gòu)（單位）一年內(nèi)

     可免費(fèi)申領(lǐng)三個(gè)不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥550
In-stock
5 mg ￥500
In-stock
10 mg ￥800
In-stock
20 mg ￥1400
In-stock
50 mg ￥2100
In-stock
100 mg ￥3200
In-stock
200 mg   詢價(jià)  
500 mg   詢價(jià)  

* Please select Quantity before adding items.

Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis[1][2][3][4].

IC50 & Target

Aromatase

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
2008 IC50
11.3 μM
Compound: 14
Inhibition of MRP1 (unknown origin) expressed in human 2008 cells assessed as calcein-AM accumulation preincubated for 30 mins before calcein-AM addition measured up to 90 mins by fluorescence assay
Inhibition of MRP1 (unknown origin) expressed in human 2008 cells assessed as calcein-AM accumulation preincubated for 30 mins before calcein-AM addition measured up to 90 mins by fluorescence assay
[PMID: 23851114]
A2780 ADR IC50
24.6 μM
Compound: 14
Inhibition of p-glycoprotein (unknown origin) expressed in human A2780Adr cells assessed as calcein-AM accumulation preincubated for 30 mins before calcein-AM addition measured up to 90 mins by fluorescence assay
Inhibition of p-glycoprotein (unknown origin) expressed in human A2780Adr cells assessed as calcein-AM accumulation preincubated for 30 mins before calcein-AM addition measured up to 90 mins by fluorescence assay
[PMID: 23851114]
HEK293 IC50
> 10 μM
Compound: ANF
Inhibition of human CYP1A1 expressed in HEK293 cells using fluorogenic substrate 7-ethoxyresorufin as substrate preincubated for 30 mins followed by substrate addition measured for 60 mins by fluorescence assay
Inhibition of human CYP1A1 expressed in HEK293 cells using fluorogenic substrate 7-ethoxyresorufin as substrate preincubated for 30 mins followed by substrate addition measured for 60 mins by fluorescence assay
[PMID: 28711350]
HEK293 IC50
> 10 μM
Compound: ANF
Inhibition of human CYP1B1 expressed in HEK293 cells using fluorogenic 7-ethoxyresorufin as substrate preincubated for 30 mins followed by substrate addition measured for 60 mins by fluorescence assay
Inhibition of human CYP1B1 expressed in HEK293 cells using fluorogenic 7-ethoxyresorufin as substrate preincubated for 30 mins followed by substrate addition measured for 60 mins by fluorescence assay
[PMID: 28711350]
HEK293 IC50
> 10000 nM
Compound: 3; ANF
Inhibition of recombinant human liver CYP1A1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substrate addition measured for 60 mins by EROD assay
Inhibition of recombinant human liver CYP1A1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substrate addition measured for 60 mins by EROD assay
[PMID: 28259840]
HEK293 IC50
> 10000 nM
Compound: 3; ANF
Inhibition of recombinant human liver CYP1B1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substrate addition measured for 60 mins by EROD assay
Inhibition of recombinant human liver CYP1B1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substrate addition measured for 60 mins by EROD assay
[PMID: 28259840]
HEK293 IC50
> 50 μM
Compound: 4; ANF
Inhibition of human liver CYP1B1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluorescence assay
Inhibition of human liver CYP1B1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluorescence assay
[PMID: 28222316]
HEK293 IC50
> 50 μM
Compound: 4; ANF
Inhibition of human liver CYP1B1 expressed in HEK293 cells using CEC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluorescence assay
Inhibition of human liver CYP1B1 expressed in HEK293 cells using CEC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluorescence assay
[PMID: 28222316]
HEK293 EC50
40 μM
Compound: 4; ANF
Inhibition of human CYP1B1 expressed in HEK293 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin EC50 at 0.016 uM by MTT assay (Rvb = 61 +/- 8 uM)
Inhibition of human CYP1B1 expressed in HEK293 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin EC50 at 0.016 uM by MTT assay (Rvb = 61 +/- 8 uM)
[PMID: 28222316]
HepG2 IC50
0.32 μM
Compound: alpha-naphthoflavone
Inhibition of TCDD-induced EROD activity in human HepG2 cells after 24 hrs
Inhibition of TCDD-induced EROD activity in human HepG2 cells after 24 hrs
[PMID: 15787451]
MCF7 IC50
> 100 μM
Compound: ANF
Cytotoxicity against drug-resistant TCCD-induced human MCF7 cells overexpressing CYP1B1 assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against drug-resistant TCCD-induced human MCF7 cells overexpressing CYP1B1 assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31803401]
MCF7 IC50
110.6 μM
Compound: ANF
Inhibition of CYP1B1 in TCDD-stimulated human MCF7 cells assessed as inhibition of anticancer drug resistance by measuring docetaxel cytotoxic IC50 at 5 uM after 48 hrs by MTT assay (Rvb = 139.8 +/- 11.5 microM)
Inhibition of CYP1B1 in TCDD-stimulated human MCF7 cells assessed as inhibition of anticancer drug resistance by measuring docetaxel cytotoxic IC50 at 5 uM after 48 hrs by MTT assay (Rvb = 139.8 +/- 11.5 microM)
[PMID: 25799264]
MCF7 IC50
80.7 μM
Compound: ANF
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31803401]
MCF7 IC50
98.2 μM
Compound: ANF
Inhibition of CYP1B1 in TCDD-stimulated human MCF7 cells assessed as inhibition of anticancer drug resistance by measuring docetaxel cytotoxic IC50 at 10 uM after 48 hrs by MTT assay (Rvb = 139.8 +/- 11.5 microM)
Inhibition of CYP1B1 in TCDD-stimulated human MCF7 cells assessed as inhibition of anticancer drug resistance by measuring docetaxel cytotoxic IC50 at 10 uM after 48 hrs by MTT assay (Rvb = 139.8 +/- 11.5 microM)
[PMID: 25799264]
MDA-MB-231 IC50
> 100 μM
Compound: ANF
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31803401]
MDCK-II IC50
1.31 μM
Compound: 14
Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of Hoechst 33342 preincubated for 30 mins before Hoechst 33342 addition measured after 120 mins by fluorescence assay
Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of Hoechst 33342 preincubated for 30 mins before Hoechst 33342 addition measured after 120 mins by fluorescence assay
[PMID: 23851114]
MDCK-II IC50
1.4 μM
Compound: 14
Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of pheophorbide-A preincubated for 30 mins before pheophorbide-A addition measured after 120 mins by flow cytometry
Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of pheophorbide-A preincubated for 30 mins before pheophorbide-A addition measured after 120 mins by flow cytometry
[PMID: 23851114]
體外研究
(In Vitro)

Alpha-Naphthoflavone (0.01-100 μM, 5 min) 通過(guò)誘導(dǎo)內(nèi)皮細(xì)胞外鈣內(nèi)流和 NO 形成誘導(dǎo)血管松弛[2]。
Alpha-Naphthoflavone (0.01-100 μM, 48 h) 可抑制 HeLa 細(xì)胞增殖，阻滯細(xì)胞 G1/S 期，增加 p53水平和細(xì)胞凋亡[3]。
Alpha-Naphthoflavone (5, 10, 20, 40 μM, 24 h) 對(duì)油酸 (OA) 處理的 HepG2 肝細(xì)胞具有保護(hù)作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: HeLa
Concentration: 0.01, 1, 10, 100 μM
Incubation Time: 6 days
Result: Decreased cell proliferation in a dose-dependent manner with IC50 value of 36.81 μM.

Apoptosis Analysis[3]

Cell Line: HeLa
Concentration: 50 μM
Incubation Time: 12, 24, 36 h
Result: Induced a mild but significant apoptosis rate.

Western Blot Analysis[3]

Cell Line: HeLa
Concentration: 50 μM
Incubation Time: 12, 24, 36 h
Result: Increased the level of p53 at 12 h.
體內(nèi)研究
(In Vivo)

Alpha-Naphthoflavone (80, 160 mg/kg/day, 灌胃, 4 周) 對(duì)高脂飲食 (HFD) 誘導(dǎo)的NAFLD 小鼠具有保護(hù)作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD-induced mice model[4]
Dosage: 80, 160 mg/kg
Administration: i.g.
Result: Decreased the levels of AST, TG and TC.
分子量

272.30

Formula

C19H12O2
CAS 號(hào)
性狀

固體

顏色

White to light yellow

中文名稱

α-萘黃酮
結(jié)構(gòu)分類
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 25 mg/mL (91.81 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.6724 mL 18.3621 mL 36.7242 mL
5 mM 0.7345 mL 3.6724 mL 7.3448 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 98.54%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6724 mL 18.3621 mL 36.7242 mL 91.8105 mL
5 mM 0.7345 mL 3.6724 mL 7.3448 mL 18.3621 mL
10 mM 0.3672 mL 1.8362 mL 3.6724 mL 9.1811 mL
15 mM 0.2448 mL 1.2241 mL 2.4483 mL 6.1207 mL
20 mM 0.1836 mL 0.9181 mL 1.8362 mL 4.5905 mL
25 mM 0.1469 mL 0.7345 mL 1.4690 mL 3.6724 mL
30 mM 0.1224 mL 0.6121 mL 1.2241 mL 3.0604 mL
40 mM 0.0918 mL 0.4591 mL 0.9181 mL 2.2953 mL
50 mM 0.0734 mL 0.3672 mL 0.7345 mL 1.8362 mL
60 mM 0.0612 mL 0.3060 mL 0.6121 mL 1.5302 mL
80 mM 0.0459 mL 0.2295 mL 0.4591 mL 1.1476 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的產(chǎn)品:

Your information is safe with us. * Required Fields.

   產(chǎn)品名稱：

  

* 需求量：

* 客戶姓名：

 

* Email：

* 電話：

 

* 公司或機(jī)構(gòu)名稱：

   留言給我們：

Bulk Inquiry

Inquiry Information

產(chǎn)品名稱：
Alpha-Naphthoflavone
目錄號(hào)：
HY-125833
需求量：