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  2. Protein Tyrosine Kinase/RTK
  3. Tie VEGFR
  4. TIE-2/VEGFR-2 kinase-IN-2

TIE-2/VEGFR-2 kinase-IN-2 是一種有效的 VEGFR2 和 Tie-2 雙抑制劑，pIC50 值分別為 8.61 和 8.56。TIE-2/VEGFR-2 kinase-IN-2 是一種抗血管生成劑，可用于癌癥研究?。

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TIE-2/VEGFR-2 kinase-IN-2 Chemical Structure

TIE-2/VEGFR-2 kinase-IN-2 Chemical Structure

CAS No. : 501693-48-7

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥1870
In-stock
1 mg ￥772
In-stock
5 mg ￥1700
In-stock
10 mg ￥2800
In-stock
25 mg ￥5700
In-stock
50 mg 現(xiàn)貨 詢價(jià)
100 mg   詢價(jià)  
200 mg   詢價(jià)  

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

TIE-2/VEGFR-2 kinase-IN-2 is a potent dual VEGFR2 and Tie-2 inhibitor with pIC50 values of 8.61 and 8.56, respectively[1]. TIE-2/VEGFR-2 kinase-IN-2 is an anti-angiogenic agent and can be used for cancer research[2].

IC50 & Target[1]

Tie2

8.56 nM (pIC50)

VEGFR-2

 

Tie-2

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HFF IC50
2506 nM
Compound: 8a
Cytotoxicity against human HFF cells after 3 days
Cytotoxicity against human HFF cells after 3 days
[PMID: 17276055]
HT-29 IC50
300 nM
Compound: 3
Induction of necroptosis in human HT-29 cells assessed as increase in TNFalpha/AT-406/zVAD-FMK-induced LDH release preincubated with cells followed by TNFalpha/AT-406/zVAD-FMK addition measured after 16 to 20 hrs by CytoTox 96 nonradioactive cytotoxicity
Induction of necroptosis in human HT-29 cells assessed as increase in TNFalpha/AT-406/zVAD-FMK-induced LDH release preincubated with cells followed by TNFalpha/AT-406/zVAD-FMK addition measured after 16 to 20 hrs by CytoTox 96 nonradioactive cytotoxicity
[PMID: 29485864]
HT-29 IC50
5084 nM
Compound: 8a
Cytotoxicity against human HT29 cells after 3 days
Cytotoxicity against human HT29 cells after 3 days
[PMID: 17276055]
Sf9 IC50
0.013 μM
Compound: 27
Inhibition of human N-terminal His-GST-TEV-fused RIP1 kinase domain (1 to 375) autophosphorylation expressed in baculovirus infected insect Sf9 cells after 4 hrs by ADP-Glo luminescence assay
Inhibition of human N-terminal His-GST-TEV-fused RIP1 kinase domain (1 to 375) autophosphorylation expressed in baculovirus infected insect Sf9 cells after 4 hrs by ADP-Glo luminescence assay
[PMID: 24900635]
Sf9 IC50
0.063 μM
Compound: 27
Displacement of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)-16,16,18,18-tetramethyl-6,7,7a,8a,9,10,16,18-octahydrobenzo[2'',3'']indolizino[8'',7'':5',6']pyrano[3',2':
Displacement of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)-16,16,18,18-tetramethyl-6,7,7a,8a,9,10,16,18-octahydrobenzo[2'',3'']indolizino[8'',7'':5',6']pyrano[3',2':
[PMID: 24900635]
U-937 IC50
0.25 μM
Compound: 27
Inhibition of RIP1 in human U937 cells assessed as prevention of TNFalpha/zVAD.fmk-induced necrotic cell death preincubated for 30 to 60 mins followed by TNF-alpha induction measured after overnight incubation by Cell Titer-Glo luminescence assay
Inhibition of RIP1 in human U937 cells assessed as prevention of TNFalpha/zVAD.fmk-induced necrotic cell death preincubated for 30 to 60 mins followed by TNF-alpha induction measured after overnight incubation by Cell Titer-Glo luminescence assay
[PMID: 24900635]
分子量

431.34

Formula

C20H13F4N5O2
CAS 號(hào)
性狀

固體

顏色

White to off-white

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 50 mg/mL (115.92 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.3184 mL 11.5918 mL 23.1836 mL
5 mM 0.4637 mL 2.3184 mL 4.6367 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)

TIE-2/VEGFR-2 kinase-IN-2 相關(guān)分類

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3184 mL 11.5918 mL 23.1836 mL 57.9589 mL
5 mM 0.4637 mL 2.3184 mL 4.6367 mL 11.5918 mL
10 mM 0.2318 mL 1.1592 mL 2.3184 mL 5.7959 mL
15 mM 0.1546 mL 0.7728 mL 1.5456 mL 3.8639 mL
20 mM 0.1159 mL 0.5796 mL 1.1592 mL 2.8979 mL
25 mM 0.0927 mL 0.4637 mL 0.9273 mL 2.3184 mL
30 mM 0.0773 mL 0.3864 mL 0.7728 mL 1.9320 mL
40 mM 0.0580 mL 0.2898 mL 0.5796 mL 1.4490 mL
50 mM 0.0464 mL 0.2318 mL 0.4637 mL 1.1592 mL
60 mM 0.0386 mL 0.1932 mL 0.3864 mL 0.9660 mL
80 mM 0.0290 mL 0.1449 mL 0.2898 mL 0.7245 mL
100 mM 0.0232 mL 0.1159 mL 0.2318 mL 0.5796 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
TIE-2/VEGFR-2 kinase-IN-2
目錄號(hào)：
HY-12572
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