K-Ras(G12C) inhibitor 9

目錄號: HY-12446: FAQs
Data Sheet SDS COA 產(chǎn)品使用指南技術支持

K-Ras (G12C) inhibitor 9 是 K-Ras (G12C) 的變構抑制劑。

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K-Ras(G12C) inhibitor 9 Chemical Structure

CAS No. : 1469337-91-4

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規(guī)格	價格	是否有貨
2 mg	￥1142	1 - 2 周
5 mg		詢價
10 mg		詢價

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K-Ras(G12C) inhibitor 9 相關產(chǎn)品

•同靶點產(chǎn)品:

•同靶點蛋白產(chǎn)品:

查看 Ras 亞型特異性產(chǎn)品:

查看所有亞型

K-Ras H-Ras N-Ras Ras

生物活性
純度 & 產(chǎn)品資料
參考文獻

生物活性

K-Ras (G12C) inhibitor 9 is an allosteric inhibitor of the K-Ras (G12C)^[1].

細胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	5.2 μM Compound: SH-9	Antiproliferative activity against human A549 cells harboring KRAS G12S mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells harboring KRAS G12S mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36228411]
MRC5	IC₅₀	10.3 μM Compound: SH-9	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36228411]
NCI-H2228	IC₅₀	7.2 μM Compound: SH-9	Antiproliferative activity against human NCI-H2228 cells harboring wild type KRAS assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H2228 cells harboring wild type KRAS assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36228411]
NCI-H23	IC₅₀	3 μM Compound: SH-9	Antiproliferative activity against human NCI-H23 cells harboring KRAS G12C mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H23 cells harboring KRAS G12C mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36228411]
NCI-H358	IC₅₀	4.4 μM Compound: SH-9	Antiproliferative activity against human NCI-H358 cells harboring KRAS G12C mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H358 cells harboring KRAS G12C mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36228411]
NCI-H441	IC₅₀	21.5 μM Compound: SH-9	Antiproliferative activity against human NCI-H441 cells harboring KRAS G12V mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H441 cells harboring KRAS G12V mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36228411]
SK-LU-1	IC₅₀	22.8 μM Compound: SH-9	Antiproliferative activity against human SK-LU-1 cells harboring KRAS G12D mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human SK-LU-1 cells harboring KRAS G12D mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36228411]

分子量

513.78

Formula

C₁₆H₂₁ClIN₃O₄S

CAS 號

1469337-91-4

性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

純度 & 產(chǎn)品資料

純度: ≥98.0%

選擇批次：

Data Sheet (506 KB) SDS (393 KB)

COA (191 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻

[1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51. [Content Brief]

K-Ras(G12C) inhibitor 9 相關分類

摩爾計算器
稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		體積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)	×	體積 _(start)	=	濃度 _(final)	×	體積 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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滬公網(wǎng)安備31011502019417

滬(浦)應急管危經(jīng)許[2021]201709(QFYS)

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K-Ras(G12C) inhibitor 9

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生物活性

純度 & 產(chǎn)品資料

參考文獻

K-Ras(G12C) inhibitor 9 相關分類

摩爾計算器

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The molarity calculator equation

The dilution calculator equation

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K-Ras(G12C) inhibitor 9

K-Ras(G12C) inhibitor 9 相關抗體

K-Ras(G12C) inhibitor 9 相關產(chǎn)品

•同靶點產(chǎn)品:

•同靶點蛋白產(chǎn)品:

查看 Ras 亞型特異性產(chǎn)品:

生物活性

純度 & 產(chǎn)品資料

參考文獻

K-Ras(G12C) inhibitor 9 相關分類

摩爾計算器

稀釋計算器

The molarity calculator equation

The dilution calculator equation

Keywords:

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