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  2. Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease
  3. Sirtuin Endogenous Metabolite
  4. Nicotinamide riboside malate

Nicotinamide riboside malate  (Synonyms: 煙酰胺核糖蘋果酸鹽)

目錄號: HY-123033C
產(chǎn)品使用指南 技術(shù)支持

Nicotinamide riboside malate 是具有口服活性的 NAD+ 的前體，增加 NAD+ 水平并激活 SIRT1 和 SIRT3。Nicotinamide riboside malate 是維生素 B3 (煙酸) 的來源，可以增強(qiáng)氧化代謝并防止高脂肪飲食誘導(dǎo)的代謝異常。Nicotinamide riboside malate 可以減少阿爾茨海默氏病轉(zhuǎn)基因小鼠模型中的認(rèn)知退化。

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Nicotinamide riboside malate Chemical Structure

Nicotinamide riboside malate Chemical Structure

CAS No. : 2415659-01-5

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規(guī)格 價(jià)格 是否有貨
100 mg ￥500
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Nicotinamide riboside malate 的其他形式現(xiàn)貨產(chǎn)品:

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  • 生物活性

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  • 參考文獻(xiàn)

生物活性

Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].

IC50 & Target[1]

SIRT1

 

SIRT3

 

Human Endogenous Metabolite

 

體外研究
(In Vitro)

Nicotinamide riboside malate (0.5 mM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1].
Nicotinamide riboside malate increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM[1].
Nicotinamide riboside malate boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 0.5 mM
Incubation Time: 24 hours
Result: Reduced the acetylation status of Ndufa9 and SOD2.
體內(nèi)研究
(In Vivo)

Chronic Nicotinamide riboside malate (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 10-week-old C57Bl/6J mice[1]
Dosage: 400 mg/kg
Administration: PO; daily; for 16 weeks
Result: Increased plasma and intracellular NAD+ content in a tissue-specific manner.
Clinical Trial
分子量

388.33

Formula

C15H20N2O10
CAS 號
中文名稱

煙酰胺核糖蘋果酸鹽
結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Nicotinamide riboside malate
目錄號：
HY-123033C
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