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  2. Apoptosis
  3. Bcl-2 Family
  4. BM-1197

BM-1197 (UBX1967) 是一種有效的和選擇性的 Bcl-2/Bcl-xL 的雙重抑制劑，抑制 Bcl-2 和 Bcl-xL 的 IC50 值分別為 3.5 nM 和 5.2 nM。BM-1197 在體外和體內(nèi)均表現(xiàn)出抗腫瘤作用。

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BM-1197 Chemical Structure

BM-1197 Chemical Structure

CAS No. : 1391107-89-3

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥83412
In-stock
1 mg ￥6700
In-stock
5 mg   詢價  
10 mg   詢價  

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查看 Bcl-2 Family 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

BM-1197 (UBX1967) is a potent and selective inhibitor of dual Bcl-2/Bcl-xL, with IC50s of 3.5 nM and 5.2 nM for Bcl-2 and Bcl-xL, respectively. BM-1197 exhibits antitumor effects both in vitro and in vivo[1][2].

IC50 & Target[1]

Bcl-2

3.5 nM (IC50)

Bcl-xL

5.2 nM (IC50)

體外研究
(In Vitro)

BM-1197 (2-2000 nM; 3 d) has marginal cytotoxicity against wild-type mouse embryonic fibroblast (MEF) cells but exerts potent growth-inhibitory activity in the MCL1?/? cells[1].
BM-1197 shows potent growth-inhibitory activities in 7 small cell lung cancer (SCLC) cell lines with IC50s <100 nM, moderate activity in 3 SCLC cell lines with IC50s of ～600 nM and weak activity in 2 SCLC cell lines with IC50s >2000 nM[1].
BM-1197 (100 nM; 16 h) potently induces apoptosis in H146 cells[1].
BM-1197 (100 nM; 2 h) disrupts the association between Bcl-xl and Puma or Bim in H146 cells[1].
BM-1197 (100 nM; 0.5-2 h) induces Bax translocation, and it (3-30 nM; 2 h) induces cytochrome c release in H146 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MEF/MCL1?/? cells
Concentration: 2, 20, 200, 2000 nM
Incubation Time: 3 days
Result: Inhibited MCL1?/? cells proliferation.

Apoptosis Analysis[1]

Cell Line: H146 cells
Concentration: 100 nM
Incubation Time: 16 hours
Result: Induced apoptosis in a strictly Bax/Bak-dependent manner.

Western Blot Analysis[1]

Cell Line: H146 cells
Concentration: 100 nM
Incubation Time: 2 hours
Result: Attenuated the associations between Bcl-xL and BimEL or Puma.
體內(nèi)研究
(In Vivo)

BM-1197 (10 mg/kg; i.v. daily 5 days per week for 2 weeks) results in rapid and complete tumor regression in all 8 mice in H146 and H1963 tumor model[1].
BM-1197 (15 mg/kg; i.v.) causes thrombocytopenia in mice but the effect is reversible even at highly efficacious doses[1].
BM-1197 (10 mg/kg; i.v. qd) exerts a strong anti-tumor effect and is well tolerated in OCI-Ly8 xenograft models[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice bearing H146 cells[1]
Dosage: 10 mg/kg
Administration: I.v. daily 5 days per week for 2 weeks
Result: Remained tumor free for at least 32 days after the end of the treatment.
分子量

1131.78

Formula

C53H59ClF4N6O7S4
CAS 號
性狀

固體

顏色

White to light yellow

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 250 mg/mL (220.89 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 0.8836 mL 4.4178 mL 8.8356 mL
5 mM 0.1767 mL 0.8836 mL 1.7671 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.48%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8836 mL 4.4178 mL 8.8356 mL 22.0891 mL
5 mM 0.1767 mL 0.8836 mL 1.7671 mL 4.4178 mL
10 mM 0.0884 mL 0.4418 mL 0.8836 mL 2.2089 mL
15 mM 0.0589 mL 0.2945 mL 0.5890 mL 1.4726 mL
20 mM 0.0442 mL 0.2209 mL 0.4418 mL 1.1045 mL
25 mM 0.0353 mL 0.1767 mL 0.3534 mL 0.8836 mL
30 mM 0.0295 mL 0.1473 mL 0.2945 mL 0.7363 mL
40 mM 0.0221 mL 0.1104 mL 0.2209 mL 0.5522 mL
50 mM 0.0177 mL 0.0884 mL 0.1767 mL 0.4418 mL
60 mM 0.0147 mL 0.0736 mL 0.1473 mL 0.3682 mL
80 mM 0.0110 mL 0.0552 mL 0.1104 mL 0.2761 mL
100 mM 0.0088 mL 0.0442 mL 0.0884 mL 0.2209 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
BM-1197
目錄號：
HY-120882
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