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  2. TGF-beta/Smad Stem Cell/Wnt
  3. Organoid TGF-β Receptor
  4. LDN-193189 dihydrochloride

LDN-193189 dihydrochloride  (Synonyms: DM-3189 dihydrochloride)

目錄號: HY-12071B 純度: 99.75%
COA 產(chǎn)品使用指南 技術(shù)支持

LDN-193189 (dihydrochloride) 是一種有效的選擇性 BMP I 型受體抑制劑。LDN-193189 有效抑制 BMP I 型受體 ALK2 和 ALK3 的轉(zhuǎn)錄活性，IC50 值分別為 5 nM 和 30 nM。LDN-193189 可用于骨形態(tài)發(fā)生蛋白信號傳導(dǎo)的研究，例如進(jìn)行性骨化纖維發(fā)育不良。

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LDN-193189 dihydrochloride Chemical Structure

LDN-193189 dihydrochloride Chemical Structure

CAS No. : 1435934-00-1

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥1002
In-stock
5 mg ￥950
In-stock
10 mg ￥1600
In-stock
50 mg ￥4800
In-stock
100 mg   詢價(jià)  
200 mg   詢價(jià)  

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Customer Review

Other Forms of LDN-193189 dihydrochloride:

MCE 顧客使用本產(chǎn)品發(fā)表的 64 篇科研文獻(xiàn)

IHC
WB

    LDN-193189 dihydrochloride purchased from MCE. Usage Cited in: Oxid Med Cell Longev. 2020 Jun 8;2020:4175613.  [Abstract]

    Western blot and grey analysis of CYP11a1, CYP19a1, BCL2, CALR, CHOP, caspase3, caspase12, PERK, and GRP78. qRT-PCR analyzed ATF4, caspase3, and GRP78 mRNAs. The relieving function of BMP4 on ER stress is diminished after blockade of BMP receptor I (BMPRI) with DM-3189.

    LDN-193189 dihydrochloride purchased from MCE. Usage Cited in: Cardiovasc Toxicol. 2019 Jun;19(3):264-275.  [Abstract]

    H9c2 cells are treated as following: control, DOX, DOX + rhBMP (Bmpr1a agonist) and DOX + LDN193189 (Bmpr1a inhibitor). Cells with red fluorescence indicate favorable MMP while green fluorescence indicates damage.

    查看 TGF-β Receptor 亞型特異性產(chǎn)品:

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    LDN-193189 (dihydrochloride) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva[1][2][3].

    體外研究
    (In Vitro)

    LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively[1].
    LDN-193189 has weake effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7 with IC50 values of ≥ 500 nM[1].
    LDN-193189 binds ActRIIA with Kd value of 14 nM[2].
    LDN-193189 (0.5 μM; 30 min) targets GDF8 induced Smad2/3 signaling and repression of myogenic transcription factors[2].
    LDN-193189 (0.05, 0.5, 5 μM) efficiently inhibits GDF8 induced Smad3/4 reporter gene activity[2].
    LDN-193189 (0-5 μM) rescues myogenesis in myoblasts treated with GDF8[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    LDN-193189 (i.p.; 3 mg/kg; daily; for 35 days) might affect the interaction between breast cancer cells and the bone environment[3].
    LDN-193189 (i.p.; 3 mg/kg; single) shows a reduction in ectopic ossification and functional impairment[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    479.40

    Formula

    C25H24Cl2N6
    CAS 號
    性狀

    固體

    顏色

    Orange to red

    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    H2O 中的溶解度 : 11.11 mg/mL (23.17 mM; 超聲助溶)

    DMSO 中的溶解度 : 10 mg/mL (20.86 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 2.0859 mL 10.4297 mL 20.8594 mL
    5 mM 0.4172 mL 2.0859 mL 4.1719 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用，-20°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用。

    * 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物溶解方案計(jì)算器
    請輸入動物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實(shí)驗(yàn)過程有損耗，建議您多配一只動物的量
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    純度 & 產(chǎn)品資料
    參考文獻(xiàn)

    LDN-193189 dihydrochloride 相關(guān)分類

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用，-20°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 2.0859 mL 10.4297 mL 20.8594 mL 52.1485 mL
    5 mM 0.4172 mL 2.0859 mL 4.1719 mL 10.4297 mL
    10 mM 0.2086 mL 1.0430 mL 2.0859 mL 5.2149 mL
    15 mM 0.1391 mL 0.6953 mL 1.3906 mL 3.4766 mL
    20 mM 0.1043 mL 0.5215 mL 1.0430 mL 2.6074 mL

    * 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    產(chǎn)品名稱：
    LDN-193189 dihydrochloride
    目錄號：
    HY-12071B
    需求量：