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  2. PI3K/Akt/mTOR
  3. PIKfyve
  4. MOMIPP

MOMIPP，一種巨胞飲作用的誘導劑，是一種 PIKfyve 抑制劑。MOMIPP 可穿過血腦屏障 (BBB)。

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MOMIPP Chemical Structure

MOMIPP Chemical Structure

CAS No. : 1363421-46-8

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規(guī)格 價格 是否有貨 數量
10 mM * 1 mL in DMSO ￥3672
In-stock
1 mg ￥1142
In-stock
5 mg ￥2000
In-stock
10 mg ￥3200
In-stock
25 mg ￥5800
In-stock
50 mg 現貨 詢價
100 mg   詢價  
200 mg   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of MOMIPP:

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB)[1][2].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 IC50
5.02 μM
Compound: 1; MOMIPP
Antiproliferative activity against human A375 cells after 48 hrs by MTS assay
Antiproliferative activity against human A375 cells after 48 hrs by MTS assay
[PMID: 29878764]
A549 IC50
> 10 μM
Compound: 1; MOMIPP
Antiproliferative activity against human A549 cells after 48 hrs by MTS assay
Antiproliferative activity against human A549 cells after 48 hrs by MTS assay
[PMID: 29878764]
BGC-823 IC50
> 10 μM
Compound: 1; MOMIPP
Antiproliferative activity against human BGC823 cells after 48 hrs by MTS assay
Antiproliferative activity against human BGC823 cells after 48 hrs by MTS assay
[PMID: 29878764]
HCT-116 IC50
> 10 μM
Compound: 1; MOMIPP
Antiproliferative activity against human HCT116 cells after 48 hrs by MTS assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTS assay
[PMID: 29878764]
HepG2 IC50
> 10 μM
Compound: 1; MOMIPP
Antiproliferative activity against human HepG2 cells after 48 hrs by MTS assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTS assay
[PMID: 29878764]
MCF-10A IC50
> 10 μM
Compound: 1; MOMIPP
Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 29878764]
MCF7 IC50
> 10 μM
Compound: 1; MOMIPP
Antiproliferative activity against human MCF7 cells after 48 hrs by MTS assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTS assay
[PMID: 29878764]
MDA-MB-231 IC50
> 10 μM
Compound: 1; MOMIPP
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTS assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTS assay
[PMID: 29878764]
MDA-MB-435S IC50
> 10 μM
Compound: 1; MOMIPP
Antiproliferative activity against human MDA-MB-435S cells after 48 hrs by MTS assay
Antiproliferative activity against human MDA-MB-435S cells after 48 hrs by MTS assay
[PMID: 29878764]
SK-MEL-28 IC50
8.156 μM
Compound: 1; MOMIPP
Antiproliferative activity against human SK-MEL-28 cells after 48 hrs by MTS assay
Antiproliferative activity against human SK-MEL-28 cells after 48 hrs by MTS assay
[PMID: 29878764]
SK-MEL-30 IC50
> 10 μM
Compound: 1; MOMIPP
Antiproliferative activity against human SK-MEL-30 cells after 48 hrs by MTS assay
Antiproliferative activity against human SK-MEL-30 cells after 48 hrs by MTS assay
[PMID: 29878764]
U-251 IC50
1.9 μM
Compound: 19, MOMIPP
Cytotoxicity against human U251 cells after 24 hrs by MTT assay
Cytotoxicity against human U251 cells after 24 hrs by MTT assay
[PMID: 22335538]
U-251 GI50
2.1 μM
Compound: 1, MOMIPP
Growth inhibition of human U251 cells preincubated for 24 hrs followed by compound-washout measured at 48 hrs by sulforhodamine assay
Growth inhibition of human U251 cells preincubated for 24 hrs followed by compound-washout measured at 48 hrs by sulforhodamine assay
[PMID: 24527179]
U-251 GI50
2.3 μM
Compound: 1a
Induction of methuosis in human U251 cells after 4 to 48 hrs by phase contrast microscopic analysis
Induction of methuosis in human U251 cells after 4 to 48 hrs by phase contrast microscopic analysis
[PMID: 27343855]
U-251 GI50
2.32 μM
Compound: 1a
Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B colorimetric assay
Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B colorimetric assay
[PMID: 27343855]
U-251 GI50
2.32 μM
Compound: 1a, MOMIPP
Growth inhibition of human U251 cells after 24 hrs sulphorhodomine B colorimetric assay
Growth inhibition of human U251 cells after 24 hrs sulphorhodomine B colorimetric assay
[PMID: 25654321]
體外研究
(In Vitro)

MOMIPP 可誘導強烈的巨胞飲作用，導致培養(yǎng)的膠質母細胞瘤細胞在低微摩爾濃度下發(fā)生細胞分裂[1]。
在 U373 和 Hs683 細胞系中，3 μM MOMIPP 誘導細胞空泡化[1]。
MOMIPP (10 μM) 導致葡萄糖攝取和糖酵解代謝的早期中斷。MOMIPP 選擇性激活 JNK1/2 應激激酶通路，導致 c-Jun、Bcl-2 和 Bcl-xL 磷酸化[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: U251 cells
Concentration: 10?μM
Incubation Time: 4?h or 24?h
Result: Activated the JNK stress kinase pathway.
體內研究
(In Vivo)

MOMIPP (80 mg/kg；腹腔注射；每天一次；連續(xù) 15 天) 在抑制腦內膠質母細胞瘤異種移植物的進展方面表現出適度的有效性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic CrTac:NCR-Foxn1 mice (female, 7-8?weeks)[2]
Dosage: 80?mg/kg
Administration: i.p.; once daily; for 15 consecutive days
Result: Suppressed progression of intracerebral glioblastoma xenografts.
分子量

292.33

Formula

C18H16N2O2
CAS 號
性狀

固體

顏色

Yellow to orange

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數據
細胞實驗： 

DMSO 中的溶解度 : 31.25 mg/mL (106.90 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 3.4208 mL 17.1040 mL 34.2079 mL
5 mM 0.6842 mL 3.4208 mL 6.8416 mL
查看完整儲備液配制表

* 請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料

純度: 99.37%

參考文獻

完整儲備液配制表

* 請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4208 mL 17.1040 mL 34.2079 mL 85.5198 mL
5 mM 0.6842 mL 3.4208 mL 6.8416 mL 17.1040 mL
10 mM 0.3421 mL 1.7104 mL 3.4208 mL 8.5520 mL
15 mM 0.2281 mL 1.1403 mL 2.2805 mL 5.7013 mL
20 mM 0.1710 mL 0.8552 mL 1.7104 mL 4.2760 mL
25 mM 0.1368 mL 0.6842 mL 1.3683 mL 3.4208 mL
30 mM 0.1140 mL 0.5701 mL 1.1403 mL 2.8507 mL
40 mM 0.0855 mL 0.4276 mL 0.8552 mL 2.1380 mL
50 mM 0.0684 mL 0.3421 mL 0.6842 mL 1.7104 mL
60 mM 0.0570 mL 0.2851 mL 0.5701 mL 1.4253 mL
80 mM 0.0428 mL 0.2138 mL 0.4276 mL 1.0690 mL
100 mM 0.0342 mL 0.1710 mL 0.3421 mL 0.8552 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

產品名稱：
MOMIPP
目錄號：
HY-119624
需求量：