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  2. Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease
  3. SHP2 Phosphatase
  4. Bis(maltolato)oxovanadium(IV)

Bis(maltolato)oxovanadium(IV)  (Synonyms: BMOV)

目錄號(hào): HY-118567 純度: 99.34%
COA 產(chǎn)品使用指南 技術(shù)支持

Bis(maltolato)oxovanadium(IV) (BMOV) 是一種有效，可逆，競(jìng)爭(zhēng)性和具有口服活性的光譜 蛋白酪氨酸磷酸酶 (PTP) 抑制劑。Bis(maltolato)oxovanadium(IV) 抑制 HCPTPA，PTP1B，HPTPβ 和 SHP2 的 IC50 分別為 126 nM，109 nM，26 nM 和 201 nM。Bis(maltolato)oxovanadium(IV) 是一種有效的胰島素增敏劑。

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Bis(maltolato)oxovanadium(IV) Chemical Structure

Bis(maltolato)oxovanadium(IV) Chemical Structure

CAS No. : 38213-69-3

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥440
In-stock
5 mg ￥400
In-stock
10 mg ￥600
In-stock
25 mg ￥1200
In-stock
50 mg ￥1920
In-stock
100 mg ￥2913
In-stock
200 mg ￥4350
In-stock
500 mg   詢價(jià)  
1 g   詢價(jià)  

* Please select Quantity before adding items.

Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis(maltolato)oxovanadium(IV) inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectively. Bis(maltolato)oxovanadium(IV) is a potent insulin sensitizer[1][2].

IC50 & Target

IC50: 126 nM (HCPTPA), 109 nM (PTP1B), 26 nM (HPTPβ) and 201 nM (SHP2)[2]
體外研究
(In Vitro)

Bis(maltolato)oxovanadium(IV) treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. Bis(maltolato)oxovanadium(IV) (BMOV; 50 μM) treatment also resultes in an increased glucose uptake in C2C12 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Bis(maltolato)oxovanadium(IV) (BMOV; 0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; C57BL/6J mice) treatment ameliorates the metabolic phenotype. Liver, skeletal muscle, and adipose tissue revealed a significantly reduced PTP activity in all analysed tissues compared to HFD mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (4-6 weeks) fed with high-fat diet (HFD)[1]
Dosage: 0.75-3.0 mmol
Administration: Intraperitoneal injection; twice weekly; for 6 weeks
Result: Ameliorated the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.
分子量

317.15

Formula

C12H10O7V
CAS 號(hào)
性狀

固體

顏色

Brown to black

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 25 mg/mL (78.83 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.1531 mL 15.7654 mL 31.5308 mL
5 mM 0.6306 mL 3.1531 mL 6.3062 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.34%

參考文獻(xiàn)

Bis(maltolato)oxovanadium(IV) 相關(guān)分類

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1531 mL 15.7654 mL 31.5308 mL 78.8271 mL
5 mM 0.6306 mL 3.1531 mL 6.3062 mL 15.7654 mL
10 mM 0.3153 mL 1.5765 mL 3.1531 mL 7.8827 mL
15 mM 0.2102 mL 1.0510 mL 2.1021 mL 5.2551 mL
20 mM 0.1577 mL 0.7883 mL 1.5765 mL 3.9414 mL
25 mM 0.1261 mL 0.6306 mL 1.2612 mL 3.1531 mL
30 mM 0.1051 mL 0.5255 mL 1.0510 mL 2.6276 mL
40 mM 0.0788 mL 0.3941 mL 0.7883 mL 1.9707 mL
50 mM 0.0631 mL 0.3153 mL 0.6306 mL 1.5765 mL
60 mM 0.0526 mL 0.2628 mL 0.5255 mL 1.3138 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Bis(maltolato)oxovanadium(IV)
目錄號(hào)：
HY-118567
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