成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

  2. PI3K/Akt/mTOR Stem Cell/Wnt Cell Cycle/DNA Damage Anti-infection Membrane Transporter/Ion Channel Autophagy
  3. GSK-3 CDK Parasite Proton Pump HSV Autophagy
  4. Manzamine A

Manzamine A 是一種口服活性 β-carboline 生物堿，抑制 GSK-3β 和 CDK-5 的 IC50 值為 10.2 μM 和 1.5 μM。Manzamine A 靶向胰腺癌細胞的 vacuolar ATPases 并抑制自噬 (autophagy)。Manzamine A 具有抗瘧和抗癌活性。Manzamine A 對 HSV-1 具有較強的活性。

MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務

Manzamine A Chemical Structure

Manzamine A Chemical Structure

CAS No. : 104196-68-1

1.  客戶無需承擔相應的運輸費用。

2.  同一機構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機構(gòu)（單位）一年內(nèi)

     可免費申領(lǐng)三個不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥5220
3 - 4 周
5 mg   詢價  
10 mg   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of Manzamine A:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻

Cell Viability Assay
Proliferation Assay

    Manzamine A purchased from MCE. Usage Cited in: Mar Drugs. 2023, 21(3), 151.

    Manzamine A (MA) shows a long-term ability to inhibit both MCF-7 and MDA-MB-231 cells growth. The MA (0, 2, 4 μM; 24 h)-treated cells are seeded in 6-well plates and then cultured for 2 weeks.

    Manzamine A purchased from MCE. Usage Cited in: Mar Drugs. 2023, 21(3), 151.

    Manzamine A (MA; 0, 0.5, 1, 2, 4, 8 μM; 24 h) shows cytotoxic effects on MDA-MB-231 and MCF-7 cells but is non-toxic to normal breast epithelial MCF-10A cells in a dose-dependent manner.

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻

    生物活性

    Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1[1][2][3][4].

    IC50 & Target[1][2][3]

    Plasmodium

     

    GSK-3β

    10.2 μM (IC50)

    CDK5

    1.5 μM (IC50)

    vacuolar ATPases

     

    Malaria

     

    HSV-1

     

    細胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    A549 IC50
    1.3 μg/mL
    Compound: manzamine A
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 8350092]
    A549 IC50
    2.3 μM
    Compound: 3
    Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by Alamar blue assay
    Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by Alamar blue assay
    		[PMID: 27650927]
    A549 IC50
    5.8 μM
    Compound: Manzamine A
    Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    		[PMID: 34536668]
    C-33-A IC50
    1.6 μM
    Compound: 1
    Antiproliferative activity against human C33A cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
    Antiproliferative activity against human C33A cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
    		[PMID: 32022559]
    C-33-A IC50
    2.1 μM
    Compound: 1
    Antiproliferative activity against human C33A cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay
    Antiproliferative activity against human C33A cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay
    		[PMID: 32022559]
    C-33-A IC50
    5.2 μM
    Compound: 1
    Antiproliferative activity against human C33A cells assessed as reduction in cell viability after 24 hrs by CellTiter-Glo assay
    Antiproliferative activity against human C33A cells assessed as reduction in cell viability after 24 hrs by CellTiter-Glo assay
    		[PMID: 32022559]
    Ca-Ski IC50
    19.9 μM
    Compound: 1
    Antiproliferative activity against human CaSki cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay
    Antiproliferative activity against human CaSki cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay
    		[PMID: 32022559]
    Ca-Ski IC50
    33.6 μM
    Compound: 1
    Antiproliferative activity against human CaSki cells assessed as reduction in cell viability after 24 hrs by CellTiter-Glo assay
    Antiproliferative activity against human CaSki cells assessed as reduction in cell viability after 24 hrs by CellTiter-Glo assay
    		[PMID: 32022559]
    Ca-Ski IC50
    9.4 μM
    Compound: 1
    Antiproliferative activity against human CaSki cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
    Antiproliferative activity against human CaSki cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
    		[PMID: 32022559]
    CHO IC50
    4.8 μM
    Compound: 1
    Non-competitive inhibition of human microsomal ACAT2 overexpressed in CHO cells using [14C]oleoyl-CoA as substrate assessed as formation of cholesteryl [14C]-oleate after 24 hrs
    Non-competitive inhibition of human microsomal ACAT2 overexpressed in CHO cells using [14C]oleoyl-CoA as substrate assessed as formation of cholesteryl [14C]-oleate after 24 hrs
    		[PMID: 23665143]
    CHO IC50
    6.2 μM
    Compound: 1
    Non-competitive inhibition of human microsomal ACAT1 overexpressed in CHO cells using [14C]oleoyl-CoA as substrate assessed as formation of cholesteryl [14C]-oleate after 24 hrs
    Non-competitive inhibition of human microsomal ACAT1 overexpressed in CHO cells using [14C]oleoyl-CoA as substrate assessed as formation of cholesteryl [14C]-oleate after 24 hrs
    		[PMID: 23665143]
    HeLa IC50
    11.8 μM
    Compound: 1
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 24 hrs by CellTiter-Glo assay
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 24 hrs by CellTiter-Glo assay
    		[PMID: 32022559]
    HeLa IC50
    13 μM
    Compound: 1
    Cytotoxicity against human HeLa cells after 3 days by MTT assay
    Cytotoxicity against human HeLa cells after 3 days by MTT assay
    		[PMID: 24902064]
    HeLa IC50
    4 μM
    Compound: 1
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay
    		[PMID: 32022559]
    HeLa IC50
    5.3 μM
    Compound: 1
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
    		[PMID: 32022559]
    HT-29 IC50
    0.8 μg/mL
    Compound: manzamine A
    Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
    Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
    		[PMID: 8350092]
    IMR-90 IC50
    6.8 μM
    Compound: 3
    Cytotoxicity against human IMR90 cells assessed as decrease in cell viability after 48 hrs by Alamar blue assay
    Cytotoxicity against human IMR90 cells assessed as decrease in cell viability after 48 hrs by Alamar blue assay
    		[PMID: 27650927]
    K562 IC50
    5.2 μM
    Compound: Manzamine A
    Cytotoxicity against human K562 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    Cytotoxicity against human K562 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    		[PMID: 34536668]
    L5178Y ED50
    1.8 μg/mL
    Compound: 7
    Cytotoxicity against mouse L5178Y cells after 72 hrs by MTT assay
    Cytotoxicity against mouse L5178Y cells after 72 hrs by MTT assay
    		[PMID: 8946747]
    Microglia IC50
    < 0.1 μM
    Compound: 1
    Antineuroinflammatory activity in LPS-stimulated rat neonatal microglia assessed as inhibition of PMA-induced TXB2 production preincubated 15 mins prior to PMA challenge measured after 70 mins
    Antineuroinflammatory activity in LPS-stimulated rat neonatal microglia assessed as inhibition of PMA-induced TXB2 production preincubated 15 mins prior to PMA challenge measured after 70 mins
    		[PMID: 20017491]
    Microglia IC50
    0.1 μM
    Compound: 1
    Antineuroinflammatory activity in LPS-stimulated rat neonatal microglia assessed as inhibition of PMA-induced superoxide anion production preincubated 15 mins prior to PMA challenge measured after 70 mins
    Antineuroinflammatory activity in LPS-stimulated rat neonatal microglia assessed as inhibition of PMA-induced superoxide anion production preincubated 15 mins prior to PMA challenge measured after 70 mins
    		[PMID: 20017491]
    NCI-H1299 IC50
    1.5 μM
    Compound: 3
    Cytotoxicity against human NCI-H1299 cells assessed as decrease in cell viability after 48 hrs by Alamar blue assay
    Cytotoxicity against human NCI-H1299 cells assessed as decrease in cell viability after 48 hrs by Alamar blue assay
    		[PMID: 27650927]
    NCI-H1373 IC50
    2.1 μM
    Compound: 3
    Cytotoxicity against human NCI-H1373 cells assessed as decrease in cell viability after 48 hrs by Alamar blue assay
    Cytotoxicity against human NCI-H1373 cells assessed as decrease in cell viability after 48 hrs by Alamar blue assay
    		[PMID: 27650927]
    NCI-H1993 IC50
    3.9 μM
    Compound: 3
    Cytotoxicity against human NCI-H1993 cells assessed as decrease in cell viability after 48 hrs by Alamar blue assay
    Cytotoxicity against human NCI-H1993 cells assessed as decrease in cell viability after 48 hrs by Alamar blue assay
    		[PMID: 27650927]
    NCI-H2009 IC50
    1.6 μM
    Compound: 3
    Cytotoxicity against human NCI-H2009 cells assessed as decrease in cell viability after 48 hrs by Alamar blue assay
    Cytotoxicity against human NCI-H2009 cells assessed as decrease in cell viability after 48 hrs by Alamar blue assay
    		[PMID: 27650927]
    NCI-H441 IC50
    1.1 μM
    Compound: 3
    Cytotoxicity against human NCI-H441 cells assessed as decrease in cell viability after 48 hrs by Alamar blue assay
    Cytotoxicity against human NCI-H441 cells assessed as decrease in cell viability after 48 hrs by Alamar blue assay
    		[PMID: 27650927]
    P388 IC50
    2.4 μg/mL
    Compound: manzamine A
    Cytotoxicity against mouse P388 cells after 48 hrs by MTT assay
    Cytotoxicity against mouse P388 cells after 48 hrs by MTT assay
    		[PMID: 8350092]
    Peritoneal macrophage cell IC50
    6.2 μM
    Compound: 1
    Antihyperlipidemic activity in apoE-deficient mouse peritoneal macrophages assessed as inhibition of acetylated LDL-induced [3H]-cholesterol ester accumulation after 24 hrs by radioscanner analysis in presence of [3H]-oleate-conjugated BSA
    Antihyperlipidemic activity in apoE-deficient mouse peritoneal macrophages assessed as inhibition of acetylated LDL-induced [3H]-cholesterol ester accumulation after 24 hrs by radioscanner analysis in presence of [3H]-oleate-conjugated BSA
    		[PMID: 23665143]
    SiHa IC50
    19.9 μM
    Compound: 1
    Antiproliferative activity against human SiHa cells assessed as reduction in cell viability after 24 hrs by CellTiter-Glo assay
    Antiproliferative activity against human SiHa cells assessed as reduction in cell viability after 24 hrs by CellTiter-Glo assay
    		[PMID: 32022559]
    SiHa IC50
    4.1 μM
    Compound: 1
    Antiproliferative activity against human SiHa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
    Antiproliferative activity against human SiHa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
    		[PMID: 32022559]
    SiHa IC50
    9.9 μM
    Compound: 1
    Antiproliferative activity against human SiHa cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay
    Antiproliferative activity against human SiHa cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay
    		[PMID: 32022559]
    Vero IC50
    0.2 μg/mL
    Compound: 1
    Cytotoxicity against african green monkey Vero cells after 48 hrs by neutral red assay
    Cytotoxicity against african green monkey Vero cells after 48 hrs by neutral red assay
    		[PMID: 20017491]
    Vero IC50
    0.501 μM
    Compound: 1
    Cytotoxicity against african green monkey Vero cells after 48 hrs by neutral red assay
    Cytotoxicity against african green monkey Vero cells after 48 hrs by neutral red assay
    		[PMID: 18595720]
    Vero IC50
    1.2 μg/mL
    Compound: 1
    Cytotoxicity against african green monkey Vero cells by neutral red assay
    Cytotoxicity against african green monkey Vero cells by neutral red assay
    		[PMID: 16872140]
    Vero IC50
    11 nM
    Compound: 1
    Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs
    Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs
    		[PMID: 19833520]
    Vero IC50
    8 nM
    Compound: 1
    Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs
    Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs
    		[PMID: 19833520]
    體外研究
    (In Vitro)

    Manzamine A (5-50 μM, 18 h) decreases tau phosphorylation, measured with ELISA[1].
    Manzamine A (10 μM) inhibits yeast S. cerevisiae growth by 30%[2].
    Manzamine A displays a few enlarged vacuoles in yeast[2].
    Manzamine A (2.5-10 μM, 24 h) increases acidity in pancreatic cancer cells and non-malignant Vero cells[2].
    Manzamine A (1 μM, 24 h) inhibits HSV-1 infection in SIRC cells[4].
    Manzamine A shows antimalarial activity with an IC50 of 8.0 nM (D6 clone) and 11 nM (W2 clone)[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[4]

    Cell Line: SIRC cell
    Concentration: 0.1, 0.5, 1, 2, 3, 5, and 10 μM
    Incubation Time: 72 h
    Result: Inhibited SIRC cell viability with an IC50 of 5.6 μM.
    體內(nèi)研究
    (In Vivo)

    Manzamine A (50 and 100 mol/kg, p.o. or i.p.) inhibits the growth of the rodent malaria parasite Plasmodium berghei in infected mice[6].
    Manzamine A (8 mg/kg, i.p., daily for 8 consecutive days) prolongs the survival of SW mice to 20 days[7].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Plasmodium berghei in infected mice[6]
    Dosage: 50 or 100 mol/kg
    Administration: Intraperitoneal injection (i.p.) or oral administration (p.o.)
    Result: Inhibited the growth of the rodent malaria parasite Plasmodium berghei.
    Prolonged the survival of highly parasitaemic mice.
    分子量

    548.76

    Formula

    C36H44N4O
    CAS 號
    結(jié)構(gòu)分類
    初始來源

    Okinawan marine sponge
    運輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    溶解性數(shù)據(jù)
    細胞實驗： 

    DMSO 中的溶解度 : 10 mg/mL (18.22 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 1.8223 mL 9.1115 mL 18.2229 mL
    5 mM 0.3645 mL 1.8223 mL 3.6446 mL
    查看完整儲備液配制表

    • 摩爾計算器

    • 稀釋計算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物溶解方案計算器
    請輸入動物實驗的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實驗過程有損耗，建議您多配一只動物的量
    計算結(jié)果
    工作液所需濃度 : mg/mL
    純度 & 產(chǎn)品資料
    參考文獻

    完整儲備液配制表

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.8223 mL 9.1115 mL 18.2229 mL 45.5573 mL
    5 mM 0.3645 mL 1.8223 mL 3.6446 mL 9.1115 mL
    10 mM 0.1822 mL 0.9111 mL 1.8223 mL 4.5557 mL
    15 mM 0.1215 mL 0.6074 mL 1.2149 mL 3.0372 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    您最近查看的產(chǎn)品:

    Your information is safe with us. * Required Fields.

       產(chǎn)品名稱：

    		  

    * 需求量：

    * 客戶姓名：

    		 

    * Email：

    * 電話：

    		 

    * 公司或機構(gòu)名稱：

       留言給我們：

    Bulk Inquiry

    Inquiry Information

    產(chǎn)品名稱：
    Manzamine A
    目錄號：
    HY-117025
    需求量：