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  2. Anti-infection Apoptosis
  3. Antibiotic Fungal Apoptosis
  4. Pyoluteorin

Pyoluteorin  (Synonyms: 藤黃綠菌素；藤黃綠膿菌素；黃綠膿菌素)

目錄號: HY-114979 純度: 99.90%
COA 產(chǎn)品使用指南 技術(shù)支持

Pyoluteorin 是一種抗生素 (antibiotic)，可抑制 Oomycete fungi，包括植物病原體 Oomycete fungi，并抑制由該真菌引起的植物病害。 Pyoluteorin 在體外誘導(dǎo)人三陰性乳腺癌 MDA-MB-231 細(xì)胞凋亡 (apoptosis)。 Pyoluteorin 可用于人類三陰性乳腺癌的研究。

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Pyoluteorin Chemical Structure

Pyoluteorin Chemical Structure

CAS No. : 25683-07-2

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5 mg ￥4363
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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus[1]. Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. Pyoluteorin can be used for the research of human triple-negative breast cancer[2].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
MDCK IC50
4.8 μM
Compound: Pyoluteorin
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 30793902]
體外研究
(In Vitro)

Pyoluteorin is an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, were identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5[1].
Pyoluteorin has significant cytotoxicity towards MCF-7 (IC50=1.84 μM). Pyoluteorin also displays significantly selective cytotoxicity against BT474, HCC1954, MAD-MB-468, MDA-MB-231, and MCF-10A cells with IC50s of 9.75±0.16, 0.94±0.01, 3.89±0.08, 0.97±0.01, and 57.01±0.76 μM, respectively[2].
Pyoluteorin (0.1-10 μM; for 24 hours) induces change of apoptosis-related protein expressions. Pyoluteorin-induced cell apoptosis in MDA-MB-231 is related to Bcl-2 family proteins and caspase cascade[2].
Pyoluteorin (0.1-10 μM; for 24 h) induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human triple-negative breast cancer cell MDA-MB-231
Concentration: 0, 0.032, 0.16, 0.8, 4, 20, 100 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibited cells proliferation in a dose- and time-dependent manner.

Western Blot Analysis[2]

Cell Line: MDA-MB-231 cells
Concentration: 0.1, 0.3, 1, 3, 10 μM
Incubation Time: 24 hours
Result: The levels of the anti-apoptotic proteins Bcl-2, Bcl-XL and PARP were obviously decreased while the pro-apoptotic proteins BAX and caspase 3 were increased in a dose-dependent manner.
分子量

272.08

Formula

C11H7Cl2NO3
CAS 號
性狀

固體

顏色

Off-white to yellow

中文名稱

藤黃綠菌素；藤黃綠膿菌素；黃綠膿菌素
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗： 

DMSO 中的溶解度 : 125 mg/mL (459.42 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.6754 mL 18.3769 mL 36.7539 mL
5 mM 0.7351 mL 3.6754 mL 7.3508 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實(shí)驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實(shí)驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.90%

參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6754 mL 18.3769 mL 36.7539 mL 91.8847 mL
5 mM 0.7351 mL 3.6754 mL 7.3508 mL 18.3769 mL
10 mM 0.3675 mL 1.8377 mL 3.6754 mL 9.1885 mL
15 mM 0.2450 mL 1.2251 mL 2.4503 mL 6.1256 mL
20 mM 0.1838 mL 0.9188 mL 1.8377 mL 4.5942 mL
25 mM 0.1470 mL 0.7351 mL 1.4702 mL 3.6754 mL
30 mM 0.1225 mL 0.6126 mL 1.2251 mL 3.0628 mL
40 mM 0.0919 mL 0.4594 mL 0.9188 mL 2.2971 mL
50 mM 0.0735 mL 0.3675 mL 0.7351 mL 1.8377 mL
60 mM 0.0613 mL 0.3063 mL 0.6126 mL 1.5314 mL
80 mM 0.0459 mL 0.2297 mL 0.4594 mL 1.1486 mL
100 mM 0.0368 mL 0.1838 mL 0.3675 mL 0.9188 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Pyoluteorin
目錄號：
HY-114979
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