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  1. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  2. COX Reactive Oxygen Species MMP
  3. Feprazone

Feprazone  (Synonyms: DA2370; Prenazone; Zepelin)

目錄號: HY-114911 純度: 99.88%
COA 產(chǎn)品使用指南 技術(shù)支持

Feprazone (DA2370; Prenazone) 是保泰松 Phenylbutazone (HY-B0230) 的類似物,是一種非甾體抗炎劑,具有鎮(zhèn)痛和退熱活性。Feprazone 通過抑制環(huán)加氧酶 COX-2 的活性來發(fā)揮作用。Feprazone 可通過減少線粒體活性氧 (ROS) 的產(chǎn)生來緩解游離脂肪酸 (FFA) 誘導(dǎo)的氧化應(yīng)激。Feprazone 能降低 MMP-2MMP-9 的表達。此外,F(xiàn)eprazone 還能在分化的3 T3-L1 細胞中抑制脂肪形成和增加脂肪分解。Feprazone 也可用于動脈粥樣硬化和抗肥胖的研究。

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Feprazone Chemical Structure

Feprazone Chemical Structure

CAS No. : 30748-29-9

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ¥173
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5 mg ¥360
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10 mg ¥522
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25 mg ¥1035
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Customer Review

Other Forms of Feprazone:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Feprazone (DA2370; Prenazone), an analogue of Phenylbutazone (HY-B0230), is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic activities. Feprazone acts by inhibiting the activity of cyclooxygenase (COX)-2. Feprazone ameliorates free fatty acid (FFA)-induced oxidative stress by reducing the production of mitochondrial reactive oxygen species (ROS). Feprazone can decrease the expression of MMP-2 and MMP-9. Besides, Feprazone can suppress adipogenesis and increase lipolysis in differentiating 3 T3-L1 cells. Feprazone also can be used to research atherosclerosis and obesity[1][2][3].

IC50 & Target

COX, Reactive oxygen species, MMP[1]

體外研究
(In Vitro)

Feprazone (2.5-10 μM; 48 h) rescues cell viability of FFAs-stimulated human aortic endothelial cells (HAECs)[1].
Feprazone (5, 10 μM; 24 h) reduces ROS production in HAECs to only 2.4- and 1.6-fold at 5 and 10 μM, respectively, while 300 μM FFA increases ROS production by 3.4-fold; also decreases the mRNA expression and secretion of cytokines CCL5, IL-6, and IL-8, as well as MMP-2 and MMP-9[1].
Feprazone (5, 10 μM; 6 h) decreases TLR4 and MyD88 activities, as well as reduces the phosphorylation of p65 and subsequent activation of NF-κB[1].
Feprazone (30 and 60 μM; 7 days) suppresses the adipogenesis in differentiating 3 T3-L1 cells; reduced the triglyceride content and increased lipolysis during 3 T3-L1 adipogenesis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HAECs (stimulated with 300 μM FFAs)
Concentration: 2.5, 5 and 10 μM
Incubation Time: 48 h
Result: Rescued cell viability to 81 and 93% of baseline at 5 and 10 μM, while FFAs reduced the cell viability to 63% of baseline.

RT-PCR[1]

Cell Line: HAECs (stimulated with 300 μM FFAs)
Concentration: 5 and 10 μM
Incubation Time: 24 h
Result: Decreased the mRNA expression and secretion of cytokines CCL5, IL-6, and IL-8 in a dose-dependent manner.
Dose-dependently mitigated the VCAM-1 and ICAM-1 expression to only 1.7- and 1.8-fold, respectively, while FFA increased to 2.8- and 3.4-fold, respectively.

Western Blot Analysis[1]

Cell Line: HAECs (stimulated with 300 μM FFAs)
Concentration: 5 and 10 μM
Incubation Time: 6 h
Result: Decreased TLR4 and MyD88 expression, as well as reduced the phosphorylation of p65 and subsequent activation of NF-κB.
體內(nèi)研究
(In Vivo)

Significantly inhibited the adipocyte size, the visceral adipocyte tissue weights and the average bodyweights in HFD mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 N mice [high-fat diet (HFD) induced obesity model][3]
Dosage: 75 mg/kg
Administration: (no described in the research)
Result: The visceral adipocyte tissue weights of mice in the control, HFD, and HFD + Feprazone groups were 0.38, 3.51, and 2.37 g, respectively.
The average bodyweights of mice in the control, HFD, and HFD + Feprazone groups were 29.6, 41.3, and 34.1 g, respectively.
分子量

320.39

Formula

C20H20N2O2

CAS 號
性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細胞實驗: 

DMSO 中的溶解度 : 12.5 mg/mL (39.01 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響,請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.1212 mL 15.6060 mL 31.2120 mL
5 mM 0.6242 mL 3.1212 mL 6.2424 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液;一旦配成溶液,請分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效
儲備液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時,請在6個月內(nèi)使用,-20°C儲存時,請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

掃碼獲得
動物溶解方案

動物溶解方案計算器
請輸入動物實驗的基本信息:

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

由于實驗過程有損耗,建議您多配一只動物的量
純度 & 產(chǎn)品資料
參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液;一旦配成溶液,請分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效
儲備液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時,請在6個月內(nèi)使用,-20°C儲存時,請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1212 mL 15.6060 mL 31.2120 mL 78.0299 mL
5 mM 0.6242 mL 3.1212 mL 6.2424 mL 15.6060 mL
10 mM 0.3121 mL 1.5606 mL 3.1212 mL 7.8030 mL
15 mM 0.2081 mL 1.0404 mL 2.0808 mL 5.2020 mL
20 mM 0.1561 mL 0.7803 mL 1.5606 mL 3.9015 mL
25 mM 0.1248 mL 0.6242 mL 1.2485 mL 3.1212 mL
30 mM 0.1040 mL 0.5202 mL 1.0404 mL 2.6010 mL

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產(chǎn)品名稱:
Feprazone
目錄號:
HY-114911
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