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  2. Metabolic Enzyme/Protease Autophagy
  3. Oxidative Phosphorylation Endogenous Metabolite Autophagy
  4. Acetyl coenzyme A lithium

Acetyl coenzyme A lithium  (Synonyms: 乙酰輔酶A鋰鹽; Acetyl-CoA lithium)

目錄號: HY-113596A 純度: 97%
COA 產品使用指南 技術支持

Acetyl-coenzyme A (Acetyl-CoA) lithium 是一種膜非滲透性的中樞代謝中間體，參與 TCA 循環(huán)和氧化磷酸化代謝過程。Acetyl-coenzyme A lithium 通過向目標氨基酸殘基提供 (唯一供體) 乙酰基團，來完成蛋白質的翻譯后乙酰化反應，從而調節(jié)各種細胞機制。Acetyl Coenzyme A lithium 也是脂質合成的關鍵前體。

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Acetyl coenzyme A lithium Chemical Structure

Acetyl coenzyme A lithium Chemical Structure

CAS No. : 32140-51-5

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規(guī)格 價格 是否有貨 數量
1 mg ￥960
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5 mg ￥2560
In-stock
10 mg ￥4160
In-stock
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Customer Review

Other Forms of Acetyl coenzyme A lithium:

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Acetyl-coenzyme A (Acetyl-CoA) lithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A lithium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A lithium is also a key precursor of lipid synthesis[1][2][3][4].

IC50 & Target

Human Endogenous Metabolite

 

體外研究
(In Vitro)

Acetyl coenzyme A lithium increases cytoplasmic protein acetylation in starved U2OS cells while reducing starvation-induced autophagic fluxes. (U2OS cells stably expressing GFP-LC3 and are microinjected with Acetyl coenzyme A lithium; incubated in nutrient-free conditions in the presence of 100 nM BafA1 and fixed after 3 h)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內研究
(In Vivo)

Acetyl coenzyme A lithium blunts pressure overload-induced cardiomyopathy in a mice cardiac pressure overload model by Suppressing maladaptive autophagy[2][3]. Mice deprived of food (but with access to water ad libitum) for 24 h exhibit a significant reduction in total Acetyl coenzyme A lithium levels in several organs, including the heart and muscles, corresponding to a decrease in protein acetylation levels. However, the same experimental conditions have no major effects on Acetyl coenzyme A lithium concentrations in the brain and actually increase hepatic Acetyl coenzyme A lithium and protein acetylation levels[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

809.57

Formula

C23H38N7O17P3S
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

乙酰輔酶A鋰鹽
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

純度 & 產品資料

純度: 97%

參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Acetyl coenzyme A lithium
目錄號：
HY-113596A
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