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  2. Metabolic Enzyme/Protease MAPK/ERK Pathway
  3. Endogenous Metabolite p38 MAPK
  4. 7-Ketocholesterol

7-Ketocholesterol 

目錄號: HY-113342 純度: 99.87%
COA 產品使用指南

7-Ketocholesterol 是膽固醇氧化產物，廣泛存在于動脈粥樣硬化斑塊中，比膽固醇具有更強的致動脈粥樣硬化作用。7-Ketocholesterol 能夠抑制膽汁酸和膽固醇的合成限速酶，如膽固醇 7α-羥化酶和 HMG-CoA 還原酶。7-Ketocholesterol 在體內外具有促炎作用，可誘導細胞凋亡 (apoptosis)。

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7-Ketocholesterol Chemical Structure

7-Ketocholesterol Chemical Structure

CAS No. : 566-28-9

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥304
In-stock
5 mg ￥800
In-stock
10 mg ￥1300
In-stock
25 mg ￥2600
In-stock
50 mg   詢價  
100 mg   詢價  

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Customer Review

Other Forms of 7-Ketocholesterol:

MCE 顧客使用本產品發(fā)表的 1 篇科研文獻

查看 p38 MAPK 亞型特異性產品:

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis)[1].

IC50 & Target

Human Endogenous Metabolite

 

體外研究
(In Vitro)

7-Ketocholesterol (50 μM，2.5-2 小時) 可通過 p38 MAPK 通路增強白細胞與內皮細胞的粘附[4]。
7-Ketocholesterol (2.5-40 μg/mL，24 小時) 以劑量依賴性方式激活人微血管內皮細胞中的 caspase-3/7、-8 和 -12，從而誘導細胞凋亡[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[4]

Cell Line: Human umbilical vein endothelial cells (HUVECs)
Concentration: 50 μM
Incubation Time: 0.5-2 h
Result: Stimulated the phosphorylation of p38 MAPK, reaching a peak within 30-120 minutes, with no significant effect on JNK.
Enhanced the adhesion of THP-1 cells to HUVECs and upregulated the expression of E-selectin.
Promoted the expression of E-selectin by activating the transcription factor ATF-2.

Cell Viability Assay[5]

Cell Line: Human umbilical vein endothelial cells (HUVECs)
Concentration: 2.5, 5, 10, 15, 20, 40 μg/mL
Incubation Time: 24 h
Result: The average cell viability of HMVEC cells treated with 7-Ketocholesterol at concentrations of 40, 20, 10, 5, and 2.5 μg/ml for 24 hours was 45.33%, 72.83% (p < 0.001), 82.7% (p < 0.05), 88.47%, and 88.5% (p > 0.05), respectively, while the untreated control was 88.83%.
體內研究
(In Vivo)

7-Ketocholesterol (5-20 mg/mL，通過生物降解晶片植入大鼠眼前房，單次給藥) 在棕色挪威大鼠體內具有促血管生成和促炎作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Brown Norway rats (150-200 g)[3]
Dosage: 5, 10, 15, 20 mg/mL
Administration: Implanting biodegradable wafers containing 7-Ketocholesterol into the anterior chamber of rats' eyes, single dose
Result: Significantly increased angiogenesis, with a large infiltration of macrophages detected by immunohistochemistry.
Promoted the growth of new blood vessels originating from the limbus and extending through the cornea, peaking between days 7 and 10 after implantation.
Led to a marked increase in vascular endothelial growth factor (VEGF), IL-1b, and GRO/KC in the aqueous humor.
分子量

400.64

Formula

C27H44O2
CAS 號
性狀

固體

顏色

White to off-white

結構分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 6.25 mg/mL (15.60 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 2.4960 mL 12.4800 mL 24.9601 mL
5 mM 0.4992 mL 2.4960 mL 4.9920 mL
查看完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料

純度: 99.87%

參考文獻

完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4960 mL 12.4800 mL 24.9601 mL 62.4002 mL
5 mM 0.4992 mL 2.4960 mL 4.9920 mL 12.4800 mL
10 mM 0.2496 mL 1.2480 mL 2.4960 mL 6.2400 mL
15 mM 0.1664 mL 0.8320 mL 1.6640 mL 4.1600 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
7-Ketocholesterol
目錄號：
HY-113342
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