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  2. Epigenetics Metabolic Enzyme/Protease
  3. Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite
  4. L-2-Hydroxyglutaric acid

L-2-Hydroxyglutaric acid  (Synonyms: (S)-2-Hydroxyglutaric acid)

目錄號(hào): HY-113039 純度: ≥95.0%
COA 產(chǎn)品使用指南 技術(shù)支持

L-2-Hydroxyglutaric acid ((S)-2-Hydroxyglutaric acid) 是一種表觀遺傳修飾因子，可用于腎癌研究。L-2-Hydroxyglutaric acid 可抑制組蛋白去甲基化酶 (histone demethylases)，從而促進(jìn)組蛋白甲基化。

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L-2-Hydroxyglutaric acid Chemical Structure

L-2-Hydroxyglutaric acid Chemical Structure

CAS No. : 13095-48-2

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規(guī)格 價(jià)格 是否有貨 數(shù)量
5 mg (67.52 mM * 0.5 mL in Ethanol) ￥2000
In-stock
10 mg (67.52 mM * 1 mL in Ethanol) ￥3190
In-stock

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Customer Review

Other Forms of L-2-Hydroxyglutaric acid:

查看 Histone Demethylase 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].

IC50 & Target

Human Endogenous Metabolite

 

體外研究
(In Vitro)

L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

148.11

Formula

C5H8O5
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

中文名稱

L-2-羥基戊二酸
結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Solution, -20°C, 2 years
純度 & 產(chǎn)品資料

純度: ≥95.0%

參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
L-2-Hydroxyglutaric acid
目錄號(hào)：
HY-113039
需求量：