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  2. Autophagy
  3. Mitophagy
  4. Sulfosuccinimidyl oleate

Sulfosuccinimidyl oleate  (Synonyms: Sulfo-N-succinimidyl oleate)

目錄號: HY-112847
產(chǎn)品使用指南

Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) 是一種長鏈脂肪酸，抑制脂肪酸向細(xì)胞轉(zhuǎn)運(yùn)。Sulfosuccinimidyl oleate 是一種有效且不可逆的線粒體呼吸鏈抑制劑。Sulfosuccinimidyl oleate 結(jié)合小膠質(zhì)細(xì)胞表面上的 CD36 受體。具有抗炎作用。

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Sulfosuccinimidyl oleate Chemical Structure

Sulfosuccinimidyl oleate Chemical Structure

CAS No. : 135661-44-8

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規(guī)格 價格 是否有貨 數(shù)量
5 mg ￥3192
1 - 2 周
10 mg ￥5107
1 - 2 周
25 mg 現(xiàn)貨 1 - 2 周
50 mg   詢價  
100 mg   詢價  

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Customer Review

Other Forms of Sulfosuccinimidyl oleate:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1][2].

體外研究
(In Vitro)

Sulfosuccinimidyl oleate (20 μM and 50 μM, 24 hours) alone does not alter the cellular viability. Exposure to 100 ng/ml LPS+5 ng/mL IFNγ modestly, yet significantly reduces the viability of the BV2 cells. Co-treatment with Sulfosuccinimidyl oleate prevents the LPS+IFNγ-induced reduction in the cell viability[1].
Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: BV2 cells
Concentration: 20 μM and 50 μM
Incubation Time: 24 hours
Result: Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100 ng/mL LPS and 5 ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it.

Western Blot Analysis[1]

Cell Line: BV2 cells
Concentration: 50 μM
Incubation Time: 24 hours
Result: Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38.
體內(nèi)研究
(In Vivo)

Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls in male BALB/cABom mice with pMCAo model. In addition, Sulfosuccinimidyl oleate at 50 mg/kg is suitable to see a beneficial effect after stroke[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-month-old male BALB/cABom mice with pMCAo model[1]
Dosage: 50 mg/kg
Administration: Administered once by single oral gavage
Result: Reduced brain damage following ischemia. Attenuated infarct size.
分子量

459.60

Formula

C22H37NO7S
CAS 號
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

Sulfosuccinimidyl oleate 相關(guān)分類

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Sulfosuccinimidyl oleate
目錄號：
HY-112847
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