3 | 2123483-49-6 | Ser/Thr Protease | Serine proteases | Serine endopeptidases | Threonine proteases | orally | active | selective | potent | effective | cardiovascular | homeostasis | Inhibitor | inhibitor | inhibit"/>

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

  2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. WNK-IN-11-d3

WNK-IN-11-d3 是一種具有口服活性、選擇性和強(qiáng)效的 With-No-Lysine (WNK) 激酶抑制劑。WNK-IN-11-d3 有效調(diào)節(jié)心血管穩(wěn)態(tài)。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

我們將采用定制合成服務(wù)的方式為您快速提供所需產(chǎn)品和技術(shù)服務(wù)

WNK-IN-11-d<sub>3</sub> Chemical Structure

WNK-IN-11-d3 Chemical Structure

CAS No. : 2123483-49-6

1.  客戶無需承擔(dān)相應(yīng)的運(yùn)輸費(fèi)用。

2.  同一機(jī)構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機(jī)構(gòu)（單位）一年內(nèi)

     可免費(fèi)申領(lǐng)三個(gè)不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥1200
In-stock
5 mg ￥3200
In-stock
10 mg ￥5200
In-stock
50 mg   詢價(jià)  
100 mg   詢價(jià)  

* Please select Quantity before adding items.

Customer Review

Other Forms of WNK-IN-11-d3:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

WNK-IN-11-d3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11-d3 is effective at regulating cardiovascular homeostasis[1].

IC50 & Target

WNK[1]
體內(nèi)研究
(In Vivo)

WNK-IN-11 D3 (1.5 mg/kg; p.o.) shows an improved rat PK profile, including lower clearance, improvement in absolute oral exposure, and a 2-fold improvement in oral bioavailability[1].
WNK-IN-11 D3 (30 mg/kg; p.o.) shows significant reductions in systolic blood pressure (SBP) vs untreated mice[1].
WNK-IN-11 D3 (0~100 mg/kg; p.o.) induces dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg[1].
WNK-IN-11 D3 shows trends toward reduction of blood pressure, stroke volume, and total peripheral resistance, while increasing heart rate. WNK-IN-11 D3 shows efficacy in rodent models of hypertension and volume overload[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague?Dawley rats[1]
Dosage: 1.5 mg/kg
Administration: P.o.
Result: Showed an improved rat PK profile, including lower clearance, improvement in absolute oral exposure, and a 2-fold improvement in oral bioavailability.
Animal Model: FVB mice[1]
Dosage: 30 mg/kg
Administration: P.o.
Result: Showed significant reductions in systolic blood pressure (SBP) vs untreated mice.
Animal Model: FVB mice[1]
Dosage: 0~100 mg/kg
Administration: P.o.
Result: Induced dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg.
分子量

465.41

Formula

C21H18D3Cl2N5OS
CAS 號
非標(biāo)記 CAS
性狀

固體

顏色

Off-white to light yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : ≥ 100 mg/mL (214.86 mM; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.1486 mL 10.7432 mL 21.4864 mL
5 mM 0.4297 mL 2.1486 mL 4.2973 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用，-20°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計(jì)算器
請輸入動物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.84%

參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用，-20°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1486 mL 10.7432 mL 21.4864 mL 53.7161 mL
5 mM 0.4297 mL 2.1486 mL 4.2973 mL 10.7432 mL
10 mM 0.2149 mL 1.0743 mL 2.1486 mL 5.3716 mL
15 mM 0.1432 mL 0.7162 mL 1.4324 mL 3.5811 mL
20 mM 0.1074 mL 0.5372 mL 1.0743 mL 2.6858 mL
25 mM 0.0859 mL 0.4297 mL 0.8595 mL 2.1486 mL
30 mM 0.0716 mL 0.3581 mL 0.7162 mL 1.7905 mL
40 mM 0.0537 mL 0.2686 mL 0.5372 mL 1.3429 mL
50 mM 0.0430 mL 0.2149 mL 0.4297 mL 1.0743 mL
60 mM 0.0358 mL 0.1791 mL 0.3581 mL 0.8953 mL
80 mM 0.0269 mL 0.1343 mL 0.2686 mL 0.6715 mL
100 mM 0.0215 mL 0.1074 mL 0.2149 mL 0.5372 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的產(chǎn)品:

Your information is safe with us. * Required Fields.

   產(chǎn)品名稱：

  

* 需求量：

* 客戶姓名：

 

* Email：

* 電話：

 

* 公司或機(jī)構(gòu)名稱：

   留言給我們：

Bulk Inquiry

Inquiry Information

產(chǎn)品名稱：
WNK-IN-11-d3
目錄號：
HY-112094S
需求量：