Neocarzinostatin, a potent DNA-damaging, anti-tumor antibiotic, recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin induces apoptosis. Neocarzinostatin has potential for EpCAM-positive cancers treatment ^[1][2].

EpCAM 適體偶聯(lián)的 eocarzinostatin (NCS) 顯示出對(duì) EpCAM 陽(yáng)性細(xì)胞的特異性。綴合物對(duì)癌細(xì)胞的影響令人印象深刻，因?yàn)榫Y合物會(huì)阻止細(xì)胞周期并促進(jìn)細(xì)胞凋亡和壞死。高水平的 PARP 表達(dá)證實(shí)了 DNA 在綴合物處理后斷裂。與 EpCAM 結(jié)合的 NCS 可以靶向癌細(xì)胞而保留正常細(xì)胞^[3]。
Neocarzinostatin (72 小時(shí)) 對(duì) C6 細(xì)胞和 U87MG 的 IC₅₀ 值細(xì)胞分別為493.64 nM、462.96 nM^[4]。
在不同組織來(lái)源的人腫瘤細(xì)胞系中對(duì) Neocarzinostatin 的敏感性與Bcl-2相對(duì)含量的乘積成正比和 caspase-3^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

9014-02-2

液體

Colorless to light yellow

Room temperature in continental US; may vary elsewhere.

• [1]. Athyala PK, et al. Probing the biophysical interaction between Neocarzinostatin toxin and EpCAM RNA aptamer. Biochem Biophys Res Commun. 2016 Jan 8;469(2):257-62.  [Content Brief]

  [2]. Allen Taylor, et al. Ubiquitination capabilities in response to neocarzinostatin and H2O2 stress in cell lines from patients with ataxia-telangiectasia. Oncogene (2002) 21, 4363- 4373.

  [3]. Athyala PK, et al. Neocarzinostatin, Aptamer Conjugates for Targeting EpCAM-positive Tumor Cells. Anticancer Res. 2017 Jul;37(7):3615-3629.  [Content Brief]

  [4]. Tianqin G, et al. Synergistic Anti-glioma Effects in Vitro and in Vivo of Enediyne Antibiotic Neocarzinostatin and Paclitaxel via Enhanced Growth Delay and Apoptosis-Induction. Biol Pharm Bull. 2016 Oct 1;39(10):1623-1630.  [Content Brief]

  [5]. Rogers D, et al. Molecular predictors of human nervous system cancer responsiveness to enediyne chemotherapy.  [Content Brief]