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  2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. PGE synthase Lipoxygenase
  4. YS121

YS121 是一種微粒體前列腺素 E2 合酶-1 (mPGES-1; IC50=3.4 μM) 和 5-脂氧合酶 (5-LOX; IC50=6.5 μM) 的雙重抑制劑。在 IL-1β 刺激的 A549 細胞中，YS121劑量依賴性地減少 PGE2 的產(chǎn)生，EC50 為 12 μM。

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YS121 Chemical Structure

YS121 Chemical Structure

CAS No. : 916482-17-2

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規(guī)格 價格 是否有貨 數(shù)量
5 mg ￥4990
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查看 Lipoxygenase 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50=3.4 μM) and 5-lipoxygenase (5-LOX; IC50=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC50=12 μM in IL-1β-stimulated A549 cells[1].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
12 μM
Compound: 2d
Inhibition of mPGES1 in human A549 cells assessed as inhibition of IL-1-beta-induced PGE2 formation by cell-intact assay
Inhibition of mPGES1 in human A549 cells assessed as inhibition of IL-1-beta-induced PGE2 formation by cell-intact assay
[PMID: 19053751]
A549 IC50
3.9 μM
Compound: 2d
Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation by cell-free assay
Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation by cell-free assay
[PMID: 19053751]
COS-7 EC50
1 μM
Compound: 3
Agonist activity at wild-type human PPARalpha LBD expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay
Agonist activity at wild-type human PPARalpha LBD expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay
[PMID: 25022880]
COS-7 IC50
1 μM
Compound: 2
Activation of human PPARalpha ligand binding domain expressed in COS7 cells by luciferase reporter gene assay
Activation of human PPARalpha ligand binding domain expressed in COS7 cells by luciferase reporter gene assay
[PMID: 25037914]
COS-7 EC50
3.6 μM
Compound: 3
Agonist activity at human PPARgamma LBD expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay
Agonist activity at human PPARgamma LBD expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay
[PMID: 25022880]
COS-7 EC50
3.6 μM
Compound: 2
Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Luciferase reporter gene assay
Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Luciferase reporter gene assay
[PMID: 20307981]
COS-7 IC50
3.6 μM
Compound: 2
Activation of human PPARgamma ligand binding domain expressed in COS7 cells by luciferase reporter gene assay
Activation of human PPARgamma ligand binding domain expressed in COS7 cells by luciferase reporter gene assay
[PMID: 25037914]
分子量

407.96

Formula

C20H26ClN3O2S
CAS 號
性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 125 mg/mL (306.40 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.4512 mL 12.2561 mL 24.5122 mL
5 mM 0.4902 mL 2.4512 mL 4.9024 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4512 mL 12.2561 mL 24.5122 mL 61.2805 mL
5 mM 0.4902 mL 2.4512 mL 4.9024 mL 12.2561 mL
10 mM 0.2451 mL 1.2256 mL 2.4512 mL 6.1281 mL
15 mM 0.1634 mL 0.8171 mL 1.6341 mL 4.0854 mL
20 mM 0.1226 mL 0.6128 mL 1.2256 mL 3.0640 mL
25 mM 0.0980 mL 0.4902 mL 0.9805 mL 2.4512 mL
30 mM 0.0817 mL 0.4085 mL 0.8171 mL 2.0427 mL
40 mM 0.0613 mL 0.3064 mL 0.6128 mL 1.5320 mL
50 mM 0.0490 mL 0.2451 mL 0.4902 mL 1.2256 mL
60 mM 0.0409 mL 0.2043 mL 0.4085 mL 1.0213 mL
80 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.7660 mL
100 mM 0.0245 mL 0.1226 mL 0.2451 mL 0.6128 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
YS121
目錄號：
HY-111140
需求量：