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  2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. PGE synthase Lipoxygenase
  4. YS121

YS121 是一種微粒體前列腺素 E2 合酶-1 (mPGES-1; IC50=3.4 μM) 和 5-脂氧合酶 (5-LOX; IC50=6.5 μM) 的雙重抑制劑。在 IL-1β 刺激的 A549 細(xì)胞中，YS121劑量依賴性地減少 PGE2 的產(chǎn)生，EC50 為 12 μM。

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YS121 Chemical Structure

YS121 Chemical Structure

CAS No. : 916482-17-2

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5 mg ￥4990
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Customer Review

查看 Lipoxygenase 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50=3.4 μM) and 5-lipoxygenase (5-LOX; IC50=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC50=12 μM in IL-1β-stimulated A549 cells[1].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
12 μM
Compound: 2d
Inhibition of mPGES1 in human A549 cells assessed as inhibition of IL-1-beta-induced PGE2 formation by cell-intact assay
Inhibition of mPGES1 in human A549 cells assessed as inhibition of IL-1-beta-induced PGE2 formation by cell-intact assay
[PMID: 19053751]
A549 IC50
3.9 μM
Compound: 2d
Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation by cell-free assay
Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation by cell-free assay
[PMID: 19053751]
COS-7 EC50
1 μM
Compound: 3
Agonist activity at wild-type human PPARalpha LBD expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay
Agonist activity at wild-type human PPARalpha LBD expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay
[PMID: 25022880]
COS-7 IC50
1 μM
Compound: 2
Activation of human PPARalpha ligand binding domain expressed in COS7 cells by luciferase reporter gene assay
Activation of human PPARalpha ligand binding domain expressed in COS7 cells by luciferase reporter gene assay
[PMID: 25037914]
COS-7 EC50
3.6 μM
Compound: 3
Agonist activity at human PPARgamma LBD expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay
Agonist activity at human PPARgamma LBD expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay
[PMID: 25022880]
COS-7 EC50
3.6 μM
Compound: 2
Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Luciferase reporter gene assay
Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Luciferase reporter gene assay
[PMID: 20307981]
COS-7 IC50
3.6 μM
Compound: 2
Activation of human PPARgamma ligand binding domain expressed in COS7 cells by luciferase reporter gene assay
Activation of human PPARgamma ligand binding domain expressed in COS7 cells by luciferase reporter gene assay
[PMID: 25037914]
分子量

407.96

Formula

C20H26ClN3O2S
CAS 號(hào)
性狀

固體

顏色

White to off-white

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 125 mg/mL (306.40 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.4512 mL 12.2561 mL 24.5122 mL
5 mM 0.4902 mL 2.4512 mL 4.9024 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4512 mL 12.2561 mL 24.5122 mL 61.2805 mL
5 mM 0.4902 mL 2.4512 mL 4.9024 mL 12.2561 mL
10 mM 0.2451 mL 1.2256 mL 2.4512 mL 6.1281 mL
15 mM 0.1634 mL 0.8171 mL 1.6341 mL 4.0854 mL
20 mM 0.1226 mL 0.6128 mL 1.2256 mL 3.0640 mL
25 mM 0.0980 mL 0.4902 mL 0.9805 mL 2.4512 mL
30 mM 0.0817 mL 0.4085 mL 0.8171 mL 2.0427 mL
40 mM 0.0613 mL 0.3064 mL 0.6128 mL 1.5320 mL
50 mM 0.0490 mL 0.2451 mL 0.4902 mL 1.2256 mL
60 mM 0.0409 mL 0.2043 mL 0.4085 mL 1.0213 mL
80 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.7660 mL
100 mM 0.0245 mL 0.1226 mL 0.2451 mL 0.6128 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

產(chǎn)品名稱：
YS121
目錄號(hào)：
HY-111140
需求量：