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  2. Anti-infection
  3. Fungal
  4. Swinholide A

Swinholide A 是結(jié)合肌動(dòng)蛋白的一種海洋聚酮化合物，可將肌動(dòng)蛋白二聚化，Kd 約為 50 nM。 Swinholide A 是一種破壞海洋毒素的微絲，可穩(wěn)定肌動(dòng)蛋白二聚體并切斷肌動(dòng)蛋白絲。Swinholide A 破壞細(xì)胞的肌動(dòng)蛋白細(xì)胞骨架。具有抗真菌 (antifungal)活性。

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Swinholide A Chemical Structure

Swinholide A Chemical Structure

CAS No. : 95927-67-6

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 μg 詢價(jià)
10 μg ￥2439
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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Swinholide A is the actin-binding marine polyketide and dimerizes actin with the Kd of ~ 50 nM[1]. Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity[2].

體外研究
(In Vitro)

Swinholide A, first isolated from the Okinawan marine sponge Theonella swinhoei, dimerizes actin[1].
Swinholide A, isolated from the marien sponge Theonella swinhoei, is highly cytotoxic to a variety of cancer cell lines[2].
Swinholide A disrupts the actin cytoskeleton of cells grown in culture, sequesters actin dimers in vitro in both polymerizing and non-polymerizing buffers with a binding stoichiometry of one swinholide A molecule per actin dimer, and rapidly severs F-actin in vitro with high cooperativity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Balb/c 3T3 and Swiss 3T3 cells
Concentration: 5-100 nM
Incubation Time: 1-24 h
Result: Exponentially growing cells exposed to 10 nM for 24 h became arborized with diffuse cytoplasmic staining and fluorescent punctate structures.
Partial cell retraction or arborization and diminution of microfilament bundles began after 2-4 h, with complete loss of stress fibers by 5-7 h at concentrations of 10-50 nM.
Caused rounding of cultured mouse embryo 3T3 fibroblast cells within 1 h at concentration of 80 nM.
分子量

1389.87

Formula

C78H132O20
CAS 號(hào)
性狀

液體（密度：1.15±0.1 g/cm3）

顏色

Colorless to light yellow

結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料

純度: 98.3%

參考文獻(xiàn)

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產(chǎn)品名稱：
Swinholide A
目錄號(hào)：
HY-111009
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