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  2. Membrane Transporter/Ion Channel
  3. CRAC Channel
  4. 5J-4

5J-4 是一種有效的 CRAC 抑制劑。5J-4 減少了浸潤到 CNS 中的單核細(xì)胞的數(shù)量，并顯著減少浸潤的 CD4+ 細(xì)胞。5J-4 可減輕炎癥小鼠模型中 EAE (實驗性自身免疫性腦脊髓炎) 的癥狀并延緩其發(fā)作。

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5J-4 Chemical Structure

5J-4 Chemical Structure

CAS No. : 827001-82-1

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥1590
In-stock
5 mg ￥3500
詢價
10 mg ￥5600
詢價
50 mg   詢價  
100 mg   詢價  

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation[1].

體內(nèi)研究
(In Vivo)

5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt[1].
5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (MOG35-55 peptide-immunized mice)[1]
Dosage: 2 m/kg
Administration: I.p., every alternate day for 30 days
Result: Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population.
分子量

312.34

Formula

C16H12N2O3S
CAS 號
性狀

粉末

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料
參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
5J-4
目錄號：
HY-110216
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