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  2. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR
  3. Insulin Receptor Akt
  4. Insulin glargine

Insulin glargine  (Synonyms: 甘精胰島素)

目錄號: HY-108719 純度: ≥95.0%
COA 產(chǎn)品使用指南 技術支持

Insulin glargine 是一種長效胰島素類似物。Insulin glargine 具有降血糖的作用，可用于糖尿病的研究。此外，高劑量的 Insulin glargine 可促進膀胱癌細胞增殖。

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Custom Peptide Synthesis

Insulin glargine Chemical Structure

Insulin glargine Chemical Structure

CAS No. : 160337-95-1

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Other Forms of Insulin glargine:

查看 Akt 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Insulin glargine is a long-acting insulin analog. Insulin glargine has the effect of lowering blood sugar and can be used in the research of diabetes. In addition, high doses of Insulin glargine can promote the proliferation of bladder cancer cells[1][2][3][4].

體外研究
(In Vitro)

Insulin glargine (10-100 IU/L; 0-72 小時) 以 PI3K 非依賴性的方式激活 Akt，進而促進膀胱癌細胞增殖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: T24 bladder cancer cell
Concentration: 0.1, 1, 10 and 100 IU/L
Incubation Time: 72 h
Result: Promoted T24 cell proliferation at concentrations of 10 IU/L and 100 IU/L.
Did not affect cell proliferation at 0.1 IU/L and 1 IU/L.
體內(nèi)研究
(In Vivo)

Insulin glargine (2-12.5 IU/kg; 皮下注射; 3-12 個月) 在嚙齒動物中，未呈現(xiàn)出致癌風險[2]。
Insulin glargine (450 mg/kg; 皮下注射; 6 個月) 在糖尿病小鼠模型中具有改善作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Seven-week-old male db/db mice[3]
Dosage: 450 mg/kg
Administration: Subcutaneous injection (s.c.); 6 months
Result: Significantly improved glucose tolerance.
Upregulated pancreatic β-cell functional genes, such as INS1, Pdx1, Pax4 and Pax6.
Clinical Trial
分子量

6062.89

Formula

C267H404N72O78S6
CAS 號
性狀

液體

顏色

Colorless to light yellow

Sequence

A-chain: Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Gly; B-chain: Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Thr-Arg-Arg (Disulfide bridge: CysA6-CysA11, CysA7-CysB7, CysA20-CysB19)
Sequence Shortening

A-chain: GIVEQCCTSICSLYQLENYCG; B-chain: FVNQHLCGSHLVEALYLVCGERGFFYTPKTRR (Disulfide bridge: CysA6-CysA11, CysA7-CysB7, CysA20-CysB19)
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Store at 4°C, do not freeze
純度 & 產(chǎn)品資料

純度: 95.00%

參考文獻

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Insulin glargine
目錄號：
HY-108719
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