Sphingosine-1-phosphate (Synonyms: S1P)

目錄號(hào): HY-108496 純度: ≥99.0%: Data Sheet SDS COA 產(chǎn)品使用指南技術(shù)支持

溶解度

動(dòng)物溶解方案

Sphingosine-1-phosphate (S1P) 是 S1P_1-5 受體 (S1P_1-5 receptors) 的激動(dòng)劑和 GPR3、GPR6、GPR12 的配體。Sphingosine-1-phosphate 是細(xì)胞內(nèi)的第二信使，動(dòng)員 Ca²⁺ 作為 G 蛋白偶聯(lián)受體的細(xì)胞外配體。Sphingosine-1-phosphate 是由鞘磷脂 (HY-113498) 或其他膜磷脂生成的重要脂質(zhì)介質(zhì)。Sphingosine-1-phosphate 可以促進(jìn) DNA 合成，細(xì)胞的增殖和遷移。

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Sphingosine-1-phosphate Chemical Structure

CAS No. : 26993-30-6

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Other Forms of Sphingosine-1-phosphate:

Sphingosine-1-phosphate-d₇ In-stock
Sphingosine-1-phosphate (GMP) 詢價(jià)

MCE 顧客使用本產(chǎn)品發(fā)表的 9 篇科研文獻(xiàn)

•Genome Biol. 2023 Aug 31;24(1):199. [Abstract]
•J Neuroinflammation. 2024 Dec 23;21(1):327. [Abstract]
•Cell Commun Signal. 2024 Aug 7;22(1):391. [Abstract]
•Cell Prolif. 2024 Jun 26:e13700. [Abstract]
•Eur J Pharmacol. 2024 Jul 31:176848. [Abstract]
•FASEB J. 2024 Jan 31;38(2):e23417. [Abstract]
•Metabolites. 2023 Nov 4, 13(11), 1132.
•Chem Biol Interact. 2023 May 9;110541. [Abstract]
•Stem Cell Reports. 2022 Jan 28;S2213-6711(22)00051-0. [Abstract]

Sphingosine-1-phosphate 相關(guān)產(chǎn)品

•相關(guān)化合物庫(kù):

查看 LPL Receptor 亞型特異性產(chǎn)品:

查看所有亞型

LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

生物活性
純度 & 產(chǎn)品資料
參考文獻(xiàn)

生物活性

Sphingosine-1-phosphate (S1P) is an agonist of S1P_1-5 receptors and a ligand of GPR3, GPR6 and GPR12.?Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca²⁺ as an extracellular ligand for G protein-coupled receptors^[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids^[2]. Sphingosine-1-phosphate stimulates the DNA synthesis, cell proliferation and migration^[4].

IC₅₀ & Target

Human Endogenous Metabolite

細(xì)胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.2 nM Compound: S1P	Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation counting Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation counting	[PMID: 20446681]
CHO	EC₅₀	0.55 nM Compound: sphingosine-P	Activity at human recombinant S1P1 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay Activity at human recombinant S1P1 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay	[PMID: 17070046]
CHO	EC₅₀	0.91 nM Compound: sphingosine-P	Activity at human recombinant S1P5 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay Activity at human recombinant S1P5 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay	[PMID: 17070046]
CHO	EC₅₀	1.6 nM Compound: sphingosine-P	Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay	[PMID: 17070046]
CHO	EC₅₀	121 nM Compound: S1P	Agonist activity at human recombinant S1P5 receptor expressed in CHO cells by GTPgammaS binding assay Agonist activity at human recombinant S1P5 receptor expressed in CHO cells by GTPgammaS binding assay	[PMID: 20446681]
CHO	EC₅₀	164 nM Compound: S1P	Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay	[PMID: 20446681]
CHO	IC₅₀	2.9 nM Compound: S1P	Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting	[PMID: 20446681]
CHO	EC₅₀	7.9 nM Compound: sphingosine-P	Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay	[PMID: 17070046]
HEK293	EC₅₀	0.1 nM Compound: S1P	Displacement of [33P]S1P from human recombinant S1P1 receptor expressed in HEK cells by scintillation counting Displacement of [33P]S1P from human recombinant S1P1 receptor expressed in HEK cells by scintillation counting	[PMID: 20446681]
HEK293	EC₅₀	0.2 nM Compound: S1P	Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation counting Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation counting	[PMID: 20446681]
HEK293	EC₅₀	0.7 nM Compound: S1P	Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation counting Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation counting	[PMID: 20446681]
HEK293	EC₅₀	0.7 nM Compound: S1P	Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assay Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assay	[PMID: 20446681]
HEK293	EC₅₀	25.3 nM Compound: S1P	Agonist activity at human recombinant S1P1 receptor expressed in HEK cells by GTPgammaS binding assay Agonist activity at human recombinant S1P1 receptor expressed in HEK cells by GTPgammaS binding assay	[PMID: 20446681]
HEK293	EC₅₀	43.9 nM Compound: S1P	Agonist activity at human recombinant S1P2 receptor expressed in HEK cells by GTPgammaS binding assay Agonist activity at human recombinant S1P2 receptor expressed in HEK cells by GTPgammaS binding assay	[PMID: 20446681]
HEK-293T	IC₅₀	0.78 nM Compound: S1P	Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptor expressed in HEK293T cells after 60 mins by scintillation counting Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptor expressed in HEK293T cells after 60 mins by scintillation counting	[PMID: 20304639]
HEK-293T	EC₅₀	0.9 nM Compound: S1P	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 1 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1) In vitro binding affinity towards human Sphingosine 1-phosphate receptor 1 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)	[PMID: 14505636]
HEK-293T	IC₅₀	0.92 nM Compound: S1P	Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor expressed in HEK293T cells after 60 mins by scintillation counting Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor expressed in HEK293T cells after 60 mins by scintillation counting	[PMID: 20304639]
HEK-293T	IC₅₀	1.04 nM Compound: S1P	Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting	[PMID: 20304639]
HEK-293T	EC₅₀	1.1 nM Compound: S1P	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1) In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)	[PMID: 14505636]
HEK-293T	EC₅₀	1.2 nM Compound: S1P	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand	[PMID: 15341948]
HEK-293T	EC₅₀	1.3 nM Compound: S1P	Agonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting Agonist activity at human S1P2R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting	[PMID: 24900589]
HEK-293T	EC₅₀	1.7 nM Compound: S1P	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand	[PMID: 15341948]
HEK-293T	EC₅₀	1.8 nM Compound: S1P	Agonist activity at human S1P5R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting Agonist activity at human S1P5R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting	[PMID: 24900589]
HEK-293T	EC₅₀	13 nM Compound: S1P	Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting	[PMID: 24900589]
HEK-293T	IC₅₀	2 nM Compound: S1P	Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptor expressed in HEK293T cells after 60 mins by scintillation counting Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptor expressed in HEK293T cells after 60 mins by scintillation counting	[PMID: 20304639]
HEK-293T	EC₅₀	2.2 nM Compound: S1P	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand	[PMID: 15341948]
HEK-293T	EC₅₀	2.4 nM Compound: S1P	Antagonist activity at human S1P3 receptor expressed in HEK293T cells assessed as inhibition of sphingosine-1-phosphate-induced gamma-[35S]GTP binding after 30 mins by scintillation counting Antagonist activity at human S1P3 receptor expressed in HEK293T cells assessed as inhibition of sphingosine-1-phosphate-induced gamma-[35S]GTP binding after 30 mins by scintillation counting	[PMID: 20304639]
HEK-293T	EC₅₀	2.9 nM Compound: S1P	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1) In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)	[PMID: 14505636]
HEK-293T	EC₅₀	20 nM Compound: S1P	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 1 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand In vitro binding affinity towards human Sphingosine 1-phosphate receptor 1 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand	[PMID: 15341948]
HEK-293T	EC₅₀	270 nM Compound: S1P	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2) In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)	[PMID: 14505636]
HEK-293T	EC₅₀	3.94 nM Compound: S1P	Agonist activity at human S1P3R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting Agonist activity at human S1P3R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting	[PMID: 24900589]
HEK-293T	EC₅₀	37 nM Compound: S1P	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand	[PMID: 15341948]
HEK-293T	EC₅₀	4.25 nM Compound: S1P	Agonist activity at human S1P1R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting Agonist activity at human S1P1R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting	[PMID: 24900589]
HEK-293T	EC₅₀	4.5 nM Compound: S1P	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 1 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand. (Experiment 2) In vitro binding affinity towards human Sphingosine 1-phosphate receptor 1 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand. (Experiment 2)	[PMID: 14505636]
HEK-293T	EC₅₀	43.9 nM Compound: S1P	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1) In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1)	[PMID: 14505636]
HEK-293T	EC₅₀	5.6 nM Compound: S1P	Antagonist activity at human S1P1 receptor expressed in HEK293T cells assessed as inhibition of sphingosine-1-phosphate-induced gamma-[35S]GTP binding after 30 mins by scintillation counting Antagonist activity at human S1P1 receptor expressed in HEK293T cells assessed as inhibition of sphingosine-1-phosphate-induced gamma-[35S]GTP binding after 30 mins by scintillation counting	[PMID: 20304639]
HEK-293T	EC₅₀	8.3 nM Compound: S1P	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2) In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)	[PMID: 14505636]
HEK-293T	EC₅₀	8.7 nM Compound: S1P	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2) In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)	[PMID: 14505636]
HEK-293T	EC₅₀	9.2 nM Compound: S1P	In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2) In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)	[PMID: 14505636]
U2OS	EC₅₀	0.018 μM Compound: 1, S1P	Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Hoechst dye staining Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Hoechst dye staining	[PMID: 22104144]
U2OS	EC₅₀	2.8 nM Compound: S1P	Agonist activity at human S1P1 receptor expressed in EDG1-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin recruitment assay Agonist activity at human S1P1 receptor expressed in EDG1-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin recruitment assay	[PMID: 26687487]
U2OS	EC₅₀	79 nM Compound: S1P	Agonist activity at human S1P3 receptor expressed in EDG3-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin recruitment assay Agonist activity at human S1P3 receptor expressed in EDG3-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin recruitment assay	[PMID: 26687487]

體外研究
(In Vitro)

在血清饑餓條件下 (1% FCS)^[1]，S1P (1 μM) 在 HEK293 細(xì)胞中誘導(dǎo)顯著的 Ca²⁺ 釋放。
在功能性 Ca²⁺ 測(cè)定，Suramin (HY-B0879) 單獨(dú)對(duì)通過 gpr3、gpr6 或 gpr12 釋放細(xì)胞內(nèi) Ca²⁺ 沒有任何影響。相反，S1P (1 μM) 在不同濃度的蘇拉明 (HY-B0879) 存在下，在轉(zhuǎn)染的 HEK293 細(xì)胞中誘導(dǎo) gpr3、gpr6 和 gpr12 的 Ca²⁺ 釋放^[2]。
在功能性 Ca²⁺ 測(cè)定中，S1P (3-3000 nM) 在 Suramin (300 μM) 存在下表現(xiàn)出納摩爾 EC₅₀ 值對(duì)于 gpr3 (EC₅₀=29 nM)，gpr6 (EC₅₀=15 nM) 和 gpr12 (EC₅₀=24 nM)，大鼠gpr3 (EC₅₀=68 nM)，分別作用于HEK293細(xì)胞^[2]。
S1P增加表達(dá)S1P1和G_qi5，當(dāng)以 200 nM 的濃度使用時(shí)，它允許 G_i 蛋白刺激磷脂酶 C，以及表達(dá) S1P2 和 S1P3 受體的 TAg-Jurkat 細(xì)胞 (EC ₅₀s=8 和 11 nM)^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

379.47

Formula

C₁₈H₃₈NO₅P

CAS 號(hào)

26993-30-6

性狀

固體

顏色

White to yellow

結(jié)構(gòu)分類

Ketones, Aldehydes, Acids

初始來源

內(nèi)源性代謝物

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)

細(xì)胞實(shí)驗(yàn)：

1 M NaOH 中的溶解度 : 33.33 mg/mL (87.83 mM; 超聲助溶)

Methanol 中的溶解度 : 3.85 mg/mL (10.15 mM; ultrasonic and warming and adjust pH to 3 with 1M HCl and heat to 60°C)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制儲(chǔ)備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	2.6353 mL	13.1763 mL	26.3525 mL
5 mM	0.5271 mL	2.6353 mL	5.2705 mL
10 mM	0.2635 mL	1.3176 mL	2.6353 mL

查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

摩爾計(jì)算器
稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動(dòng)物實(shí)驗(yàn)：

以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

方案一

請(qǐng)依序添加每種溶劑： 0.1% BSA in Saline
Solubility: 0.5 mg/mL (1.32 mM); 懸濁液; 超聲助溶 (<60°C)

掃碼獲得
動(dòng)物溶解方案

動(dòng)物溶解方案計(jì)算器

請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只

由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量

純度 & 產(chǎn)品資料

純度: ≥99.0%

選擇批次：

Data Sheet (630 KB) SDS (393 KB)

COA (277 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻(xiàn)

[1]. Teresa Sanchez, et al. Structural and Functional Characteristics of S1P Receptors. J Cell Biochem. 2004 Aug 1;92(5):913-22. [Content Brief]

[2]. Kirsten Uhlenbrock, et al. Sphingosine 1-phosphate Is a Ligand of the Human gpr3, gpr6 and gpr12 Family of Constitutively Active G Protein-Coupled Receptors. Cell Signal.?2002 Nov;14(11):941-53. [Content Brief]

[3]. S An, et al. Transduction of Intracellular Calcium Signals Through G Protein-Mediated Activation of Phospholipase C by Recombinant Sphingosine 1-phosphate Receptors. Mol Pharmacol. 1999 May;55(5):787-94 [Content Brief]

[4]. Calise S, et al., Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: role of S1P receptors. Biochim Biophys Acta. 2012 Feb;1823(2):439-50. [Content Brief]

Sphingosine-1-phosphate 相關(guān)分類

完整儲(chǔ)備液配制表

可選溶劑	濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg	25 mg

Methanol / 1 M NaOH	1 mM	2.6353 mL	13.1763 mL	26.3525 mL	65.8814 mL
	5 mM	0.5271 mL	2.6353 mL	5.2705 mL	13.1763 mL
	10 mM	0.2635 mL	1.3176 mL	2.6353 mL	6.5881 mL
1 M NaOH	15 mM	0.1757 mL	0.8784 mL	1.7568 mL	4.3921 mL
	20 mM	0.1318 mL	0.6588 mL	1.3176 mL	3.2941 mL
	25 mM	0.1054 mL	0.5271 mL	1.0541 mL	2.6353 mL
	30 mM	0.0878 mL	0.4392 mL	0.8784 mL	2.1960 mL
	40 mM	0.0659 mL	0.3294 mL	0.6588 mL	1.6470 mL
	50 mM	0.0527 mL	0.2635 mL	0.5271 mL	1.3176 mL
	60 mM	0.0439 mL	0.2196 mL	0.4392 mL	1.0980 mL
	80 mM	0.0329 mL	0.1647 mL	0.3294 mL	0.8235 mL

Keywords:

Sphingosine-1-phosphate26993-30-6S1PEndogenous MetaboliteLPL ReceptorLysophospholipid Receptorneuroprotectivesphingolipidlipid mediatorphospholipidintracellularsecond messengermobilizationca2+Inhibitorinhibitorinhibit

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