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  2. Apoptosis TGF-beta/Smad Epigenetics Autophagy
  3. Apoptosis PKC Autophagy
  4. C8-Ceramide

C8-Ceramide  (Synonyms: N-辛?；?D-神經(jīng)鞘氨醇; N-Octanoyl-D-erythro-sphingosine)

目錄號: HY-108391 純度: ≥98.0%
COA 產(chǎn)品使用指南

C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) 是一種細胞滲透性的內(nèi)源性神經(jīng)酰胺類似物。C8-Ceramide 具有具有抗增殖特性，能作為化療試劑。C8-Ceramide 能刺激樹突狀細胞促進 T 細胞對病毒感染的反應(yīng)。C8-Ceramide 在體外能輕微地誘導 PKC 活化。

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C8-Ceramide Chemical Structure

C8-Ceramide Chemical Structure

CAS No. : 74713-59-0

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥1045
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5 mg ￥950
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10 mg ￥1650
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25 mg ￥3600
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50 mg 現(xiàn)貨 詢價
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200 mg   詢價  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro[1][2][3][4].

IC50 & Target[2][4][5]

PKC

 

apoptosis

 

autophagy

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
1.2 μM
Compound: C8-cer
Antiproliferative activity against tumor necrosis factor-resistant human MCF7 cells after 24 hrs by MTT assay
Antiproliferative activity against tumor necrosis factor-resistant human MCF7 cells after 24 hrs by MTT assay
[PMID: 19694470]
MCF7 IC50
4.2 μM
Compound: C8-cer
Inhibition of clonogenic survival of human MCF7 cells after 10 days by microscopy
Inhibition of clonogenic survival of human MCF7 cells after 10 days by microscopy
[PMID: 19694470]
MCF7 IC50
4.5 μM
Compound: C8-cer
Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
[PMID: 19694470]
MCF7 IC50
8.6 μM
Compound: C8-cer
Inhibition of clonogenic survival of tumor necrosis factor-resistant human MCF7 cells after 10 days by microscopy
Inhibition of clonogenic survival of tumor necrosis factor-resistant human MCF7 cells after 10 days by microscopy
[PMID: 19694470]
MDA-MB-231 IC50
1.8 μM
Compound: C8-cer
Antiproliferative activity against endocrine-resistant human MDA-MB-231 cells after 24 hrs by MTT assay
Antiproliferative activity against endocrine-resistant human MDA-MB-231 cells after 24 hrs by MTT assay
[PMID: 19694470]
MDA-MB-231 IC50
3 μM
Compound: C8-cer
Inhibition of clonogenic survival of endocrine-resistant human MDA-MB-231 cells after 10 days by microscopy
Inhibition of clonogenic survival of endocrine-resistant human MDA-MB-231 cells after 10 days by microscopy
[PMID: 19694470]
體外研究
(In Vitro)

C8-ceramide (3 μM; 48 hours) irreversibly reduces tumor-cell proliferation and induces morphological changes[1].
C8-ceramide can induce necrosis-like cell death, but does not induce caspase-dependent cleavage of PARP (biochemical marker of apoptosis) in human cervical tumor cells[1].
C8-ceramide may increase the endogenous ROS level (10-30 μM; 24 hours) by regulating the switch of SOD1 and SOD2, causing the anti-proliferation (10-50 μM; 24 hours), and consequently triggering the apoptosis (10-50 μM; 48 hours) of NSCLC H1299 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: CALO cells, INBL cells, HeLa cells
Concentration: 3 μM
Incubation Time: 48 hours
Result: Markedly reduced the tumor cell number.

Cell Proliferation Assay[2]

Cell Line: H1299 cells
Concentration: 10 μM, 20 μM, 30 μM, 40 μM, 50 μM
Incubation Time: 24 hours
Result: Decreased the rate of cellular proliferation in a dose-dependent manner, with an IC50 of 22.9 μM.

Cell Cycle Analysis[2]

Cell Line: H1299 cells
Concentration: 10 μM, 20 μM, 30 μM, 40 μM, 50 μM
Incubation Time: 24 hours
Result: Caused the G1 arrest.

Apoptosis Analysis[2]

Cell Line: H1299 cells
Concentration: 10 μM, 20 μM, 30 μM
Incubation Time: 24 hours, 48 hours
Result: Increased the level of cleaved caspase-3.
體內(nèi)研究
(In Vivo)

C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8+ and CD4+ T cell responses to viral infections in virus infected mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice, with lymphocytic choriomeningitis virus infected[3]
Dosage: 0.1 mg/kg
Administration: Intranasal administration
Result: Increased the CD8+ T cell response to influenza in the lungs.
分子量

425.69

Formula

C26H51NO3
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

N-辛?；?D-神經(jīng)鞘氨醇
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : ≥ 100 mg/mL (234.91 mM; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.3491 mL 11.7456 mL 23.4913 mL
5 mM 0.4698 mL 2.3491 mL 4.6983 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3491 mL 11.7456 mL 23.4913 mL 58.7282 mL
5 mM 0.4698 mL 2.3491 mL 4.6983 mL 11.7456 mL
10 mM 0.2349 mL 1.1746 mL 2.3491 mL 5.8728 mL
15 mM 0.1566 mL 0.7830 mL 1.5661 mL 3.9152 mL
20 mM 0.1175 mL 0.5873 mL 1.1746 mL 2.9364 mL
25 mM 0.0940 mL 0.4698 mL 0.9397 mL 2.3491 mL
30 mM 0.0783 mL 0.3915 mL 0.7830 mL 1.9576 mL
40 mM 0.0587 mL 0.2936 mL 0.5873 mL 1.4682 mL
50 mM 0.0470 mL 0.2349 mL 0.4698 mL 1.1746 mL
60 mM 0.0392 mL 0.1958 mL 0.3915 mL 0.9788 mL
80 mM 0.0294 mL 0.1468 mL 0.2936 mL 0.7341 mL
100 mM 0.0235 mL 0.1175 mL 0.2349 mL 0.5873 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
C8-Ceramide
目錄號：
HY-108391
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