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  2. Metabolic Enzyme/Protease Anti-infection
  3. Glutaminase Bacterial Influenza Virus Antibiotic
  4. 6-Diazo-5-oxo-L-nor-Leucine

6-Diazo-5-oxo-L-nor-Leucine  (Synonyms: 6-重氮-5-氧代-L-正亮氨酸; L-6-Diazo-5-oxonorleucine; DON)

目錄號(hào): HY-108357 純度: 99.98%
COA 產(chǎn)品使用指南

6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) 是一種谷氨酰胺拮抗劑，能不可逆地抑制谷氨酰胺的分解作用。6-Diazo-5-oxo-L-nor-Leucine 具有較好的抗癌活性 (尤其是胰腺癌)，能降低腫瘤細(xì)胞的自我更新潛力和轉(zhuǎn)移能力。6-Diazo-5-oxo-L-nor-Leucine 還具有抗菌和抗病毒活性。

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6-Diazo-5-oxo-L-nor-Leucine Chemical Structure

6-Diazo-5-oxo-L-nor-Leucine Chemical Structure

CAS No. : 157-03-9

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in Water ￥1713
In-stock
1 mg ￥910
In-stock
5 mg ￥3850
In-stock
10 mg ￥5968
In-stock
50 mg   詢(xún)價(jià)  
100 mg   詢(xún)價(jià)  

* Please select Quantity before adding items.

Customer Review

    6-Diazo-5-oxo-L-nor-Leucine purchased from MCE. Usage Cited in: Front Immunol. 2022 May 19;13:880262.  [Abstract]

    Splenocytes treated with 6-Diazo-5-oxo-L-nor-Leucine (DON; 2.5 μM; 24 h) has lower expressions of CD25 and CD69 in CD4(+) T cells.

    6-Diazo-5-oxo-L-nor-Leucine purchased from MCE. Usage Cited in: Front Immunol. 2022 May 19;13:880262.  [Abstract]

    6-Diazo-5-oxo-L-nor-Leucine (DON; 2.5 μM; 24 h) inhibits the the levels of phosphorylated mTOR and P70S6K (ConA-induced) in splenocytes.

    6-Diazo-5-oxo-L-nor-Leucine purchased from MCE. Usage Cited in: Front Immunol. 2022 May 19;13:880262.  [Abstract]

    Splenocytes treated with 6-Diazo-5-oxo-L-nor-Leucine (DON; 2.5 μM; 24 h) has lower expressions of CD25 and CD69 in CD8(+) T cells.

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity[1][2][3].

    IC50 & Target

    Bacterial[3].
    體外研究
    (In Vitro)

    6-Diazo-5-oxo-L-nor-Leucine (DON) (0.3 mM; 1 h) shows inhibition of glutamine catabolism in WI-L2 cells[1].
    6-Diazo-5-oxo-L-nor-Leucine (DON) decreases the selfrenewal potential and metastatic ability of tumor cell[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: WI-L2 cells
    Concentration: 0.3 mM
    Incubation Time: 1 h
    Result: Inhibited the rapid catabolism of glutamine by the cultured human lymphoblast line WI-L2 greater than 95%.
    體內(nèi)研究
    (In Vivo)

    6-Diazo-5-oxo-L-nor-Leucine sensitizes pancreatic tumors to anti-PD1 resulting in tumor regression and prolonged survival in vivo[2].
    6-Diazo-5-oxo-L-nor-Leucine decreases hyaluronan and collagen in the tumor microenvironment, leading to an extensive remodeling of the ECM (extensive extracellular matrix), and an increases infiltration CD8+ T-cells[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    171.15

    Formula

    C6H9N3O3
    CAS 號(hào)
    性狀

    固體

    顏色

    Off-white to light yellow

    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲(chǔ)存方式

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    H2O 中的溶解度 : 25 mg/mL (146.07 mM; 超聲助溶)

    配制儲(chǔ)備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 5.8428 mL 29.2141 mL 58.4283 mL
    5 mM 1.1686 mL 5.8428 mL 11.6857 mL
    查看完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    * 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動(dòng)物溶解方案計(jì)算器
    請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動(dòng)物的平均體重

    g

    每只動(dòng)物的給藥體積

    μL

    動(dòng)物數(shù)量

    只
    由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    該產(chǎn)品水溶性佳，請(qǐng)具體參考實(shí)測(cè) 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
    您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
    純度 & 產(chǎn)品資料

    純度: 99.98%

    參考文獻(xiàn)

    完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 5.8428 mL 29.2141 mL 58.4283 mL 146.0707 mL
    5 mM 1.1686 mL 5.8428 mL 11.6857 mL 29.2141 mL
    10 mM 0.5843 mL 2.9214 mL 5.8428 mL 14.6071 mL
    15 mM 0.3895 mL 1.9476 mL 3.8952 mL 9.7380 mL
    20 mM 0.2921 mL 1.4607 mL 2.9214 mL 7.3035 mL
    25 mM 0.2337 mL 1.1686 mL 2.3371 mL 5.8428 mL
    30 mM 0.1948 mL 0.9738 mL 1.9476 mL 4.8690 mL
    40 mM 0.1461 mL 0.7304 mL 1.4607 mL 3.6518 mL
    50 mM 0.1169 mL 0.5843 mL 1.1686 mL 2.9214 mL
    60 mM 0.0974 mL 0.4869 mL 0.9738 mL 2.4345 mL
    80 mM 0.0730 mL 0.3652 mL 0.7304 mL 1.8259 mL
    100 mM 0.0584 mL 0.2921 mL 0.5843 mL 1.4607 mL

    * 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Inquiry Information

    產(chǎn)品名稱(chēng)：
    6-Diazo-5-oxo-L-nor-Leucine
    目錄號(hào)：
    HY-108357
    需求量：