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  2. Cell Cycle/DNA Damage
  3. CDK
  4. BML-259

BML-259 是一種有效的細胞周期蛋白依賴性激酶 5 (Cdk5)抑制劑，對 Cdk5 和 Cdk2 的 IC50 分別為 64 和 98 nM。

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BML-259 Chemical Structure

BML-259 Chemical Structure

CAS No. : 267654-00-2

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規(guī)格 價格 是否有貨 數量
10 mM * 1 mL in DMSO ￥825
In-stock
5 mg ￥750
In-stock
10 mg ￥1310
In-stock
25 mg ￥2750
In-stock
50 mg ￥4680
In-stock
100 mg 現貨 詢價
200 mg   詢價  
500 mg   詢價  

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Customer Review

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

BML-259 is a potent cyclin-dependent kinase 5 (Cdk5) inhibitor, with IC50s of 64 and 98 nM for Cdk5 and Cdk2, respectively[1].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
Sf9 IC50
0.195 μM
Compound: BML259
Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
Sf9 IC50
0.458 μM
Compound: BML259
Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
Sf9 IC50
0.637 μM
Compound: BML259
Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
Sf9 IC50
1.7 μM
Compound: BML259
Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
Sf9 IC50
20.4 μM
Compound: BML259
Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
Sf9 IC50
3.4 μM
Compound: BML259
Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
體外研究
(In Vitro)

BML-259 (10 μM) 保護大量細胞免受阿爾茨海默病淀粉樣蛋白 (NAC) 的非 Aβ 成分誘發(fā)的細胞死亡[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

260.35

Formula

C14H16N2OS
CAS 號
性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數據
細胞實驗： 

DMSO 中的溶解度 : 125 mg/mL (480.12 mM; 超聲助溶; 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 3.8410 mL 19.2049 mL 38.4098 mL
5 mM 0.7682 mL 3.8410 mL 7.6820 mL
查看完整儲備液配制表

* 請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料
參考文獻

完整儲備液配制表

* 請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8410 mL 19.2049 mL 38.4098 mL 96.0246 mL
5 mM 0.7682 mL 3.8410 mL 7.6820 mL 19.2049 mL
10 mM 0.3841 mL 1.9205 mL 3.8410 mL 9.6025 mL
15 mM 0.2561 mL 1.2803 mL 2.5607 mL 6.4016 mL
20 mM 0.1920 mL 0.9602 mL 1.9205 mL 4.8012 mL
25 mM 0.1536 mL 0.7682 mL 1.5364 mL 3.8410 mL
30 mM 0.1280 mL 0.6402 mL 1.2803 mL 3.2008 mL
40 mM 0.0960 mL 0.4801 mL 0.9602 mL 2.4006 mL
50 mM 0.0768 mL 0.3841 mL 0.7682 mL 1.9205 mL
60 mM 0.0640 mL 0.3201 mL 0.6402 mL 1.6004 mL
80 mM 0.0480 mL 0.2401 mL 0.4801 mL 1.2003 mL
100 mM 0.0384 mL 0.1920 mL 0.3841 mL 0.9602 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
BML-259
目錄號：
HY-108348
需求量：