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  2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. 3-Hydroxy Midostaurin

3-Hydroxy Midostaurin  (Synonyms: CGP52421)

目錄號(hào): HY-108263 純度: 97.02%
COA 產(chǎn)品使用指南 技術(shù)支持

3-Hydroxy Midostaurin (CGP 52421) 是 PKC412 的代謝產(chǎn)物，可有效抑制 FMS 樣酪氨酸激酶 3 (FLT3) 自磷酸化，在培養(yǎng)基和血漿中的 IC50 分別為 132 nM 和 9.8 μM。與 PKC412 相比，3-Hydroxy Midostaurin 的選擇性較低，但細(xì)胞毒性更高。

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3-Hydroxy Midostaurin Chemical Structure

3-Hydroxy Midostaurin Chemical Structure

CAS No. : 179237-49-1

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥4680
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Other Forms of 3-Hydroxy Midostaurin:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].

IC50 & Target

IC50: 132 nM (FLT3 in culture medium) and 9.8 μM (FLT3 in plasma)[1]
體外研究
(In Vitro)

CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

586.64

Formula

C35H30N4O5
CAS 號(hào)
性狀

固體

顏色

Light yellow to yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料
參考文獻(xiàn)

3-Hydroxy Midostaurin 相關(guān)分類

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
3-Hydroxy Midostaurin
目錄號(hào)：
HY-108263
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