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  2. Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor
  3. Insulin Receptor PPAR
  4. Azemiglitazone potassium

Azemiglitazone potassium  (Synonyms: MSDC-0602K)

目錄號: HY-108022A 純度: 99.53%
COA 產(chǎn)品使用指南 技術(shù)支持

Azemiglitazone potassium (MSDC-0602K) 是一種噻唑烷二酮類化合物，與 PPARγ 結(jié)合，IC50 為 18.25 μM。Azemiglitazone potassium 調(diào)節(jié)線粒體丙酮酸載體 (MPC)。Azemiglitazone potassium 可用于脂肪肝的研究，包括功能失調(diào)的脂質(zhì)代謝、炎癥和胰島素抵抗。Azemiglitazone potassium 是一種胰島素 (insulin) 增敏劑，單獨(dú)或與 Liraglutide 聯(lián)合使用可改善小鼠的胰島素血癥和脂肪肝疾病。

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Azemiglitazone potassium Chemical Structure

Azemiglitazone potassium Chemical Structure

CAS No. : 1314533-27-1

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥560
In-stock
5 mg ￥1200
In-stock
10 mg ￥1900
In-stock
25 mg ￥3800
In-stock
50 mg ￥5650
In-stock
100 mg 現(xiàn)貨 詢價
200 mg   詢價  
500 mg   詢價  

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Customer Review

Other Forms of Azemiglitazone potassium:

查看 PPAR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Azemiglitazone potassium (MSDC-0602K), a PPARγ-sparing thiazolidinedione (Ps-TZD), binds to PPARγ with the IC50 of 18.25 μM[1]. Azemiglitazone potassium modulates the mitochondrial pyruvate carrier (MPC). Azemiglitazone potassium can be used for the research of fatty liver including dysfunctional lipid metabolism, inflammation, and insulin resistance[2]. Azemiglitazone potassium, an insulin sensitizer, improves insulinemia and fatty liver disease in mice, alone and in combination with Liraglutide[3].

IC50 & Target[1]

PPAR-γ

18.25 μM (IC50)

體內(nèi)研究
(In Vivo)

Diabetic db/db and MS-NASH mice are treated with Azemiglitazone potassium by oral gavage, Liraglutide by s.c. injection, or combination Azemiglitazone potassium + Liraglutide. This combination treatment may be an effective therapeutic strategy for diabetes and non-alcoholic steatohepatitis (NASH).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old male db/db mice on C57BL/6J background and age/sex-matched db/+ control mice[1]
Dosage: 30 mg/kg MSDC-0602K; 0.2 mg/kg Liraglutide (obtained from MedChemExpress; HY-P0014)
Administration: MSDC-0602K gavage daily, Liraglutide s.c. injection every other day, or combined MSDC-0602K+ Liraglutide
Result: MSDC-0602K corrected glycemia and reduced insulinemia when given alone, or in combination with Liraglutide. However, MSDC-0602K + Liraglutide combination more significantly improved glucose tolerance and liver histology.
Clinical Trial
分子量

409.50

Formula

C19H16KNO5S
CAS 號
性狀

固體

顏色

White to off-white

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗： 

DMSO 中的溶解度 : 250 mg/mL (610.50 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.4420 mL 12.2100 mL 24.4200 mL
5 mM 0.4884 mL 2.4420 mL 4.8840 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實(shí)驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實(shí)驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4420 mL 12.2100 mL 24.4200 mL 61.0501 mL
5 mM 0.4884 mL 2.4420 mL 4.8840 mL 12.2100 mL
10 mM 0.2442 mL 1.2210 mL 2.4420 mL 6.1050 mL
15 mM 0.1628 mL 0.8140 mL 1.6280 mL 4.0700 mL
20 mM 0.1221 mL 0.6105 mL 1.2210 mL 3.0525 mL
25 mM 0.0977 mL 0.4884 mL 0.9768 mL 2.4420 mL
30 mM 0.0814 mL 0.4070 mL 0.8140 mL 2.0350 mL
40 mM 0.0611 mL 0.3053 mL 0.6105 mL 1.5263 mL
50 mM 0.0488 mL 0.2442 mL 0.4884 mL 1.2210 mL
60 mM 0.0407 mL 0.2035 mL 0.4070 mL 1.0175 mL
80 mM 0.0305 mL 0.1526 mL 0.3053 mL 0.7631 mL
100 mM 0.0244 mL 0.1221 mL 0.2442 mL 0.6105 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Azemiglitazone potassium
目錄號：
HY-108022A
需求量：