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  2. 天然產(chǎn)物
  3. 疾病研究領(lǐng)域 海洋天然產(chǎn)物 動物 其他類
  4. 癌癥 其他海洋生物
  5. Didemnin B

Didemnin B 是從海洋被囊動物三苯胺藍藻中提取的一種 depsipeptide。Didemnin B 可以用于癌癥的研究。

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Didemnin B Chemical Structure

Didemnin B Chemical Structure

CAS No. : 77327-05-0

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥11624
In-stock
1 mg ￥2900
In-stock
5 mg 現(xiàn)貨 詢價
10 mg 現(xiàn)貨 詢價
50 mg   詢價  
100 mg   詢價  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer[1].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
2 nM
Compound: 27
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 3 days
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 3 days
[PMID: 33592144]
HT-29 IC50
2 nM
Compound: 27
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 3 days
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 3 days
[PMID: 33592144]
P388 IC50
> 1 μM
Compound: 27
Inhibition of RNA synthesis in mouse P388 cells measured after 72 hrs
Inhibition of RNA synthesis in mouse P388 cells measured after 72 hrs
[PMID: 33592144]
P388 IC50
0.1 μM
Compound: 27
Inhibition of protein synthesis in mouse P388 cells measured after 72 hrs
Inhibition of protein synthesis in mouse P388 cells measured after 72 hrs
[PMID: 33592144]
P388 IC50
0.4 μM
Compound: 27
Inhibition of DNA synthesis in mouse P388 cells measured after 72 hrs
Inhibition of DNA synthesis in mouse P388 cells measured after 72 hrs
[PMID: 33592144]
P388 IC50
2 nM
Compound: 27
Antiproliferative activity against mouse P388 cells assessed as cell growth inhibition incubated for 3 days
Antiproliferative activity against mouse P388 cells assessed as cell growth inhibition incubated for 3 days
[PMID: 33592144]
SK-MEL-28 IC50
2 nM
Compound: 27
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 3 days
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 3 days
[PMID: 33592144]
體外研究
(In Vitro)

Didemnin B has activity against miirine B16 melanoma, P388 leukemia, and M5076 sarcoma[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Didemnin B is a potent inhibitor of L1210 growth[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1112.35

Formula

C57H89N7O15
CAS 號
性狀

固體

顏色

White to off-white

結(jié)構(gòu)分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 100 mg/mL (89.90 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 0.8990 mL 4.4950 mL 8.9900 mL
5 mM 0.1798 mL 0.8990 mL 1.7980 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8990 mL 4.4950 mL 8.9900 mL 22.4749 mL
5 mM 0.1798 mL 0.8990 mL 1.7980 mL 4.4950 mL
10 mM 0.0899 mL 0.4495 mL 0.8990 mL 2.2475 mL
15 mM 0.0599 mL 0.2997 mL 0.5993 mL 1.4983 mL
20 mM 0.0449 mL 0.2247 mL 0.4495 mL 1.1237 mL
25 mM 0.0360 mL 0.1798 mL 0.3596 mL 0.8990 mL
30 mM 0.0300 mL 0.1498 mL 0.2997 mL 0.7492 mL
40 mM 0.0225 mL 0.1124 mL 0.2247 mL 0.5619 mL
50 mM 0.0180 mL 0.0899 mL 0.1798 mL 0.4495 mL
60 mM 0.0150 mL 0.0749 mL 0.1498 mL 0.3746 mL
80 mM 0.0112 mL 0.0562 mL 0.1124 mL 0.2809 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Didemnin B
目錄號：
HY-105055
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