Terameprocol (Synonyms: EM-1421)

目錄號(hào): HY-10447 純度: 99.76%: FAQs
Data Sheet SDS COA 產(chǎn)品使用指南技術(shù)支持

Terameprocol 是 Nordihydroguaiaretic acid 的合成衍生物，是一種非選擇性的脂氧合酶抑制劑。

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Terameprocol Chemical Structure

CAS No. : 24150-24-1

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規(guī)格	價(jià)格	是否有貨
10 mM * 1 mL in DMSO	￥610	In-stock
5 mg	￥343	In-stock
10 mg	￥550	In-stock
25 mg	￥1000	In-stock
50 mg	￥1600	In-stock
100 mg	￥2600	In-stock
200 mg		詢價(jià)
500 mg		詢價(jià)

or 大包裝詢價(jià)

* Please select Quantity before adding items.

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Terameprocol 相關(guān)產(chǎn)品

•相關(guān)化合物庫(kù):

•同靶點(diǎn)產(chǎn)品:

•同靶點(diǎn)蛋白產(chǎn)品:

查看 Lipoxygenase 亞型特異性產(chǎn)品:

查看所有亞型

5-LOX 12-LOX 15-LOX

生物活性
純度 & 產(chǎn)品資料
參考文獻(xiàn)

生物活性

Terameprocol is a synthetic derivative of Nordihydroguaiaretic acid and a non-selective lipoxygenase inhibitor. Terameprocol has antiviral and antitumor effects^[1]^[2]^[3].

細(xì)胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
786-0	GI₅₀	4.54 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human 786-0 cells after 72 hrs by MTT assay Cytotoxicity against human 786-0 cells after 72 hrs by MTT assay	[PMID: 24080463]
A-375	IC₅₀	16.6 μM Compound: 1a, M4N	Cytotoxicity against human A375 cells after 5 days by MTT assay Cytotoxicity against human A375 cells after 5 days by MTT assay	[PMID: 19615898]
BXPC-3	GI₅₀	17.1 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human BxPC3 cells after 72 hrs by MTT assay Cytotoxicity against human BxPC3 cells after 72 hrs by MTT assay	[PMID: 24080463]
C8166	CC₅₀	28.8 μM Compound: 21	Cytotoxicity against human C8166 cells by MTT assay Cytotoxicity against human C8166 cells by MTT assay	[PMID: 19413342]
HeLa	GI₅₀	> 50 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 24080463]
Hep 3B2	IC₅₀	≤ 10 μM Compound: 3, M4N	Cytotoxicity against human Hep3B cells after 3 days by MTT assay Cytotoxicity against human Hep3B cells after 3 days by MTT assay	[PMID: 21123067]
HepG2	IC₅₀	44.5 μM Compound: 1a, M4N	Cytotoxicity against human HepG2 cells after 5 days by MTT assay Cytotoxicity against human HepG2 cells after 5 days by MTT assay	[PMID: 19615898]
HT-29	IC₅₀	≤ 10 μM Compound: 3, M4N	Cytotoxicity against human HT-29 cells after 3 days by MTT assay Cytotoxicity against human HT-29 cells after 3 days by MTT assay	[PMID: 21123067]
HT-29	IC₅₀	61.5 μM Compound: 1a, M4N	Cytotoxicity against human HT-29 cells after 5 days by MTT assay Cytotoxicity against human HT-29 cells after 5 days by MTT assay	[PMID: 19615898]
K562	IC₅₀	5.87 mg/L Compound: 2, EM-1421, M4N, Terameprocol	Inhibition of growth metabolism of human K562 cells at 37 degC by TAM air microcalorimetry Inhibition of growth metabolism of human K562 cells at 37 degC by TAM air microcalorimetry	[PMID: 23434529]
LNCaP	IC₅₀	≤ 10 μM Compound: 3, M4N	Cytotoxicity against human LNCAP cells after 3 days by MTT assay Cytotoxicity against human LNCAP cells after 3 days by MTT assay	[PMID: 21123067]
MCF7	IC₅₀	≤ 10 μM Compound: 3, M4N	Cytotoxicity against human MCF7 cells after 3 days by MTT assay Cytotoxicity against human MCF7 cells after 3 days by MTT assay	[PMID: 21123067]
MCF7	IC₅₀	42.4 μM Compound: 1a, M4N	Cytotoxicity against human MCF7 cells after 5 days by MTT assay Cytotoxicity against human MCF7 cells after 5 days by MTT assay	[PMID: 19615898]
NCI/ADR-RES	IC₅₀	≤ 10 μM Compound: 3, M4N	Cytotoxicity against human NCI/ADR-RES cells after 3 days by MTT assay Cytotoxicity against human NCI/ADR-RES cells after 3 days by MTT assay	[PMID: 21123067]
T47D	GI₅₀	5.36 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human T47D cells after 72 hrs by MTT assay Cytotoxicity against human T47D cells after 72 hrs by MTT assay	[PMID: 24080463]
T98G	GI₅₀	> 50 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human T98G cells after 72 hrs by MTT assay Cytotoxicity against human T98G cells after 72 hrs by MTT assay	[PMID: 24080463]
U-87MG ATCC	GI₅₀	> 50 μM Compound: Terameprocol, M4N, EM-1421	Cytotoxicity against human U87 cells after 72 hrs by MTT assay Cytotoxicity against human U87 cells after 72 hrs by MTT assay	[PMID: 24080463]

Clinical Trial

分子量

358.47

Formula

C₂₂H₃₀O₄

CAS 號(hào)

24150-24-1

性狀

固體

顏色

White to off-white

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性數(shù)據(jù)

細(xì)胞實(shí)驗(yàn)：

DMSO 中的溶解度 : 100 mg/mL (278.96 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

配制儲(chǔ)備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	2.7896 mL	13.9482 mL	27.8963 mL
5 mM	0.5579 mL	2.7896 mL	5.5793 mL
10 mM	0.2790 mL	1.3948 mL	2.7896 mL

查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

摩爾計(jì)算器
稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動(dòng)物溶解方案計(jì)算器

請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只

由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量

計(jì)算結(jié)果

工作液所需濃度 : mg/mL

純度 & 產(chǎn)品資料

純度: 99.76%

選擇批次：

Data Sheet (584 KB) SDS (398 KB)

COA (261 KB) HNMR (239 KB) LCMS (87 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻(xiàn)

[1]. Hwu JR, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation. J Med Chem. 1998 Jul 30;41(16):2994-3000. [Content Brief]

[2]. Chen H, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA. J Med Chem. 1998 Jul 30;41(16):3001-7. [Content Brief]

[3]. Park R, et al. Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors. Clin Cancer Res. 2005 Jun 15;11(12):4601-9. [Content Brief]

Terameprocol 相關(guān)分類

完整儲(chǔ)備液配制表

可選溶劑	濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7896 mL	13.9482 mL	27.8963 mL	69.7408 mL
	5 mM	0.5579 mL	2.7896 mL	5.5793 mL	13.9482 mL
	10 mM	0.2790 mL	1.3948 mL	2.7896 mL	6.9741 mL
	15 mM	0.1860 mL	0.9299 mL	1.8598 mL	4.6494 mL
	20 mM	0.1395 mL	0.6974 mL	1.3948 mL	3.4870 mL
	25 mM	0.1116 mL	0.5579 mL	1.1159 mL	2.7896 mL
	30 mM	0.0930 mL	0.4649 mL	0.9299 mL	2.3247 mL
	40 mM	0.0697 mL	0.3487 mL	0.6974 mL	1.7435 mL
	50 mM	0.0558 mL	0.2790 mL	0.5579 mL	1.3948 mL
	60 mM	0.0465 mL	0.2325 mL	0.4649 mL	1.1623 mL
	80 mM	0.0349 mL	0.1744 mL	0.3487 mL	0.8718 mL
	100 mM	0.0279 mL	0.1395 mL	0.2790 mL	0.6974 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Terameprocol24150-24-1EM-1421EM1421EM 1421LipoxygenaseLOXInhibitorinhibitorinhibit

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滬公網(wǎng)安備31011502019417

滬(浦)應(yīng)急管危經(jīng)許[2021]201709(QFYS)

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Terameprocol (Synonyms: EM-1421)

Customer Review