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  2. GPCR/G Protein
  3. Bradykinin Receptor
  4. Lys-[Des-Arg9]Bradykinin

Lys-[Des-Arg9]Bradykinin 是一種天然存在的激肽，是一種有效且高度選擇性的緩激肽 B1 受體激動劑，對人，小鼠和兔子的 B1 受體的 Ki 值為 0.12 nM，1.7 nM 和 0.23 nM。Lys-[Des-Arg9]Bradykinin 對 B2 受體的抑制活性較低。

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Custom Peptide Synthesis

Lys-[Des-Arg9]Bradykinin Chemical Structure

Lys-[Des-Arg9]Bradykinin Chemical Structure

CAS No. : 71800-36-7

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥3067
3 - 4 周
5 mg   詢價  
10 mg   詢價  

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Customer Review

Other Forms of Lys-[Des-Arg9]Bradykinin:

查看 Bradykinin Receptor 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Lys-[Des-Arg9]Bradykinin, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a Ki of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin has low inhibitory activity on B2 receptors[1][2].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
IMR-90 IC50
0.87 nM
Compound: (Des-Arg10)-Kallidin
Displacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 mins
Displacement of [3H](Des-Arg10)-Kallidin from bradykinin B1 receptor in human IMR90 cells after 60 mins
[PMID: 23403082]
體外研究
(In Vitro)

Lys-[Des-Arg9]Bradykinin 由緩激肽的蛋白水解裂解形成，通過緩激肽 B1 受體 (B1R) 發(fā)揮作用[1]。
Lys-[Des-Arg9]Bradykinin (Lda-BK; 10 μM) 增強 IL-12p70 的分泌并抑制成熟 hMo-DC 的 IL-12p40 分泌。用 Lys-[Des-Arg9]Bradykinin 預(yù)處理可減少成熟 hMo-DC 單獨向培養(yǎng)基的遷移，表明 Lys-[Des-Arg9]Bradykinin 可抑制成熟 hMo-DC 的趨化作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Lys-[Des-Arg9]Bradykinin (1 μg；鼻腔注射；新西蘭大白兔) 處理可降低脂多糖誘導(dǎo)家兔外周血管阻力，但效果短暫(T1/2=118-195 s)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1032.20

Formula

C50H73N13O11
CAS 號
Sequence

Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe
Sequence Shortening

KRPPGFSPF
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
細胞實驗： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
純度 & 產(chǎn)品資料
參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Lys-[Des-Arg9]Bradykinin
目錄號：
HY-103295
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