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  2. PI3K/Akt/mTOR Stem Cell/Wnt Autophagy
  3. GSK-3 Wnt β-catenin Autophagy
  4. Laduviglusib

Laduviglusib  (Synonyms: CHIR-99021; CT99021)

目錄號(hào): HY-10182G
產(chǎn)品使用指南

Laduviglusib (CHIR-99021) (GMP) 是 GMP 級(jí)別的 Laduviglusib (HY-10182)。GMP 級(jí)別的小分子可用做細(xì)胞療法中的輔助試劑。Laduviglusib 是一種有效的，選擇性的，具有口服活性的 GSK-3α/β 抑制劑。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Laduviglusib Chemical Structure

Laduviglusib Chemical Structure

CAS No. : 252917-06-9

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mg ￥10600
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50 mg ￥31500
In-stock
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200 mg   詢價(jià)  

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查看 GSK-3 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

IC50 & Target[1]

GSK-3β

6.7 nM (IC50)

GSK-3α

10 nM (IC50)

CDC2

8800 nM (IC50)

體外研究
(In Vitro)

Laduviglusib (GMP) (20 μM, 21 days) transdifferentiates mouse fibroblasts to neurons (determined by increased number of TAUEGFP-/TUJ1-positive neuronal cells)[1].
Laduviglusib (GMP) (3-5?μM, 2 days) induces somatic cells differentiation of pluripotent stem (PS) cells (the detailed method refers to the reference)[2].
Laduviglusib (GMP) (12?μM, 5 days) converts human fibroblasts (HFF) into functional cardiomyocytes[3].
Laduviglusib (GMP) (3 μM, 4 days, hESCs) activates the canonical WNT signaling pathway, confirmed by β-catenin translocation into the nucleus[4].
Laduviglusib (GMP) (in MEFs expressing MyoD) enhances the marked increase in the number of proliferative cells led by RepSox (GMP) (HY-13012G) together with Forskolin (HY-15371)[5].
Laduviglusib (GMP) (5 μM, 1 day) can be used to generate islets (hCiPSC-islets) from human chemically induced pluripotent stem cells (hCiPSC)[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

465.34

Formula

C22H18Cl2N8
CAS 號(hào)
性狀

固體

顏色

White to off-white

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Laduviglusib
目錄號(hào)：
HY-10182G
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