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  2. Metabolic Enzyme/Protease
  3. Acyltransferase
  4. Melinamide

Melinamide  (Synonyms: 甲亞油酰胺; AC 223; DL-N-(α-Methylbenzyl)linoleamide)

目錄號(hào): HY-101722 純度: 99.94%
COA 產(chǎn)品使用指南 技術(shù)支持

Melinamide是不飽和長(zhǎng)鏈脂肪酸的酰胺衍生物。它是膽固醇吸收的抑制劑，IC50值為20.9 μM。

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Melinamide Chemical Structure

Melinamide Chemical Structure

CAS No. : 14417-88-0

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥2200
In-stock
1 mg ￥909
In-stock
5 mg ￥2000
In-stock
10 mg ￥3500
In-stock
25 mg ￥6000
In-stock
50 mg 現(xiàn)貨 詢價(jià)
100 mg   詢價(jià)  
200 mg   詢價(jià)  

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查看 Acyltransferase 亞型特異性產(chǎn)品:

  • 生物活性

  • 實(shí)驗(yàn)參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Melinamide, an amide derivative of an unsaturated long-chain fatty acid, is an inhibitor of cholesterol absorption with an IC50 of 20.9 μM.

IC50 & Target

IC50: 20.9 μM (cholesterol)[1]
細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
THP-1 IC50
5.2 μM
Compound: 2b
Inhibition of LPS-induced TNFalpha production in human THP-1 cells incubated for 2 hrs followed by LPS stimulation and measured after 12 hrs by ELISA
Inhibition of LPS-induced TNFalpha production in human THP-1 cells incubated for 2 hrs followed by LPS stimulation and measured after 12 hrs by ELISA
[PMID: 33479624]
THP-1 CC50
95.8 μM
Compound: 2b
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33479624]
體外研究
(In Vitro)

DL-Melinamide inhibits acyl CoA:cholesterol acyltransferase activity (ACAT) in the mucosal microsomes, with 50% inhibition occurring at approximately 0.5 μM. Kinetic studies indicate that DL-Melinamide is an uncompetitive inhibitor of acyl CoA:cholesterol acyltransferase. D-Melinamide is found to be a more effective inhibitor than L-Melinamide[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Melinamide is a new hypocholesterolaemic drug. Melinamide causes a substantial decrease of the enhanced intestinal ACAT activity in diabetic rats, but does not affect intestinal cholesterol esterase activity. Furthermore, marked improvement of hypercholesterolaemia in cholesterol-fed diabetic rats occurrs concomitantly with the drug treatment[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

383.61

Formula

C26H41NO
CAS 號(hào)
性狀

油狀物

顏色

Colorless to light yellow

中文名稱

甲亞油酰胺；甲亞油脂酰胺
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 200 mg/mL (521.36 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.6068 mL 13.0341 mL 26.0681 mL
5 mM 0.5214 mL 2.6068 mL 5.2136 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)
Animal Administration
[3]

Rats: 10 diabetic rats are divided into two groups: a cholesterol-fed diabetic group and a melinamide-treated cholesterol-fed diabetic group. Five control rats are injected with citrate buffer only. The rats are fed each diet for 3 weeks after injection. The chol-fed DM group receives a diet (20 g/day) containing 1% cholesterol, 0.5% cholic acid and 5% lard. The melinamide-treated group receives the same diet but supplemented with 0.1% melinamide. Control rats are fed a standard chow (20 g/day). Following a 24-h fast the animals are killed. Blood is collected by aortic puncture and samples of small intestine are retained[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

Melinamide 相關(guān)分類(lèi)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6068 mL 13.0341 mL 26.0681 mL 65.1704 mL
5 mM 0.5214 mL 2.6068 mL 5.2136 mL 13.0341 mL
10 mM 0.2607 mL 1.3034 mL 2.6068 mL 6.5170 mL
15 mM 0.1738 mL 0.8689 mL 1.7379 mL 4.3447 mL
20 mM 0.1303 mL 0.6517 mL 1.3034 mL 3.2585 mL
25 mM 0.1043 mL 0.5214 mL 1.0427 mL 2.6068 mL
30 mM 0.0869 mL 0.4345 mL 0.8689 mL 2.1723 mL
40 mM 0.0652 mL 0.3259 mL 0.6517 mL 1.6293 mL
50 mM 0.0521 mL 0.2607 mL 0.5214 mL 1.3034 mL
60 mM 0.0434 mL 0.2172 mL 0.4345 mL 1.0862 mL
80 mM 0.0326 mL 0.1629 mL 0.3259 mL 0.8146 mL
100 mM 0.0261 mL 0.1303 mL 0.2607 mL 0.6517 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Melinamide
目錄號(hào)：
HY-101722
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