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  2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. Olvanil

Olvanil  (Synonyms: NE-19550; N-Vanillyloleamide)

目錄號(hào): HY-101323 純度: ≥98.0%
COA 產(chǎn)品使用指南 技術(shù)支持

Olvanil (NE-19550) 是一種瞬時(shí)受體電位香草素受體亞型1 (TRPV1) 通道激動(dòng)劑，EC50 為 0.7 nM，可用作緩解疼痛。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Olvanil Chemical Structure

Olvanil Chemical Structure

CAS No. : 58493-49-5

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規(guī)格 價(jià)格 是否有貨 數(shù)量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥605
In-stock
5 mg ￥550
In-stock
10 mg ￥900
In-stock
25 mg ￥1900
In-stock
50 mg ￥3200
In-stock
100 mg ￥5200
In-stock
200 mg   詢價(jià)  
500 mg   詢價(jià)  

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Customer Review

查看 TRP Channel 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC50 of 0.7 nM[1].

IC50 & Target[1]

TRPV1

0.7 nM (EC50)

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
DMS-114 IC50
> 50 μM
Compound: 5
Antiproliferative activity in human DMS-114 cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human DMS-114 cells assessed as cell growth inhibition by MTT assay
[PMID: 33508189]
EFM-19 IC50
0.7 μM
Compound: 5
Antiproliferative activity in human EFM-19 cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human EFM-19 cells assessed as cell growth inhibition by MTT assay
[PMID: 33508189]
MCF7 IC50
1 μM
Compound: 5
Antiproliferative activity in human MCF7 cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human MCF7 cells assessed as cell growth inhibition by MTT assay
[PMID: 33508189]
T47D IC50
0.75 μM
Compound: 5
Antiproliferative activity in human T47D cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human T47D cells assessed as cell growth inhibition by MTT assay
[PMID: 33508189]
體外研究
(In Vitro)

Olvanil 影響 C6 膠質(zhì)瘤細(xì)胞增殖 (IC50值為 5.5 μM)[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Olvanil 是一種辣椒素類似物，可作為香草素受體的激動(dòng)劑。Olvanil 可能會(huì)引起類似焦慮的作用。0、0.2、1.0 和 5.0 mg/kg 的 Olvanil 劑量分別在 5 分鐘時(shí)產(chǎn)生了 25±10.1、19.3±7.1、14.9±5.9 和 0±0[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats weighing approximately 200 g[3]
Dosage: 0, 0.2, 1.0 and 5.0 mg/kg
Administration: Injected intraperitoneally 30 min before the behavioral tests
Result: The percent open arm times at 5 min were 12.9±8.1 for the 0 mg/kg dose, 8.9±4.2 for the 0.2 mg/kg dose, 15.2±7.9 for the 1 mg/kg dose and 0±0 for the 5 mg/kg dose.
The mean number of entries into the closed arm at 5 min were 1.7±0.3, 3.3±0.8, 2.7±0.3 and 0.25±0.1 for doses of 0, 0.2, 1 and 5 mg/kg, respectively.?
Clinical Trial
分子量

417.62

Formula

C26H43NO3
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

奧伐尼
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 100 mg/mL (239.45 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.3945 mL 11.9726 mL 23.9452 mL
5 mM 0.4789 mL 2.3945 mL 4.7890 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: ≥99.0%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3945 mL 11.9726 mL 23.9452 mL 59.8630 mL
5 mM 0.4789 mL 2.3945 mL 4.7890 mL 11.9726 mL
10 mM 0.2395 mL 1.1973 mL 2.3945 mL 5.9863 mL
15 mM 0.1596 mL 0.7982 mL 1.5963 mL 3.9909 mL
20 mM 0.1197 mL 0.5986 mL 1.1973 mL 2.9932 mL
25 mM 0.0958 mL 0.4789 mL 0.9578 mL 2.3945 mL
30 mM 0.0798 mL 0.3991 mL 0.7982 mL 1.9954 mL
40 mM 0.0599 mL 0.2993 mL 0.5986 mL 1.4966 mL
50 mM 0.0479 mL 0.2395 mL 0.4789 mL 1.1973 mL
60 mM 0.0399 mL 0.1995 mL 0.3991 mL 0.9977 mL
80 mM 0.0299 mL 0.1497 mL 0.2993 mL 0.7483 mL
100 mM 0.0239 mL 0.1197 mL 0.2395 mL 0.5986 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Olvanil
目錄號(hào)：
HY-101323
需求量：