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  2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. DIPPA hydrochloride

DIPPA (hydrochloride) 是一種不可逆、長效、選擇性和高親和力的 κ-opioid receptor 拮抗劑。DIPPA (hydrochloride)可用于焦慮和抗抑郁活性分子的研究。

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DIPPA hydrochloride Chemical Structure

DIPPA hydrochloride Chemical Structure

CAS No. : 155512-52-0

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規(guī)格 價格 是否有貨 數(shù)量
5 mg ￥2846
In-stock
10 mg ￥4558
In-stock
50 mg   詢價  
100 mg   詢價  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

DIPPA (hydrochloride) is an irreversible, long-lasting, selective and high affinity κ-opioid receptor antagonist. DIPPA (hydrochloride) can be used for the research of anxiety and antidepressant[1][2][3][4].

IC50 & Target

κ Opioid Receptor/KOR

 

體內(nèi)研究
(In Vivo)

DIPPA (2.5 and 5 mg/kg; s.c.) hydrochloride decreases the latency to feed in Wistar Kyoto rats, but treatment did not alter approach latencies in SD rats[2].
DIPPA (1 and 5 mg/kg; s.c.) hydrochloride high dose increases immobility in SD rats compared to the saline-treated strain control group[2].
DIPPA (5 mg/kg) hydrochloride decreases consumption in SD rats compared to the 5 mg/kg group of Wistar Kyoto rats. DIPPA hydrochloride significantly decreases burying time in both strains. DIPPA (5 mg/kg) hydrochloride decreases burying in both strains compared to the within strain control groups. DIPPA hydrochloride tends to decrease consumption in SD rats in the home cage but significantly increases feeding in the novel cage where potential anxiolytic-like effects of DIPPA hydrochloride may oppose the hypophagic effects of the compound[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar Kyoto rats and SD rats (250–300 g)[2]
Dosage: 2.5 and 5 mg/kg
Administration: S.c.
Result: Decreased the latency to feed in Wistar Kyoto rats, but treatment did not alter approach latencies in SD rats.
Animal Model: Wistar Kyoto rats and SD rats (250–300 g)[2]
Dosage: 1 and 5 mg/kg
Administration: S.c.
Result: High dose increased immobility in SD rats compared to the saline-treated strain control group.
分子量

484.87

Formula

C22H24Cl3N3OS
CAS 號
性狀

固體

顏色

Off-white to light yellow

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 24 mg/mL (49.50 mM; 超聲加熱助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.0624 mL 10.3120 mL 20.6241 mL
5 mM 0.4125 mL 2.0624 mL 4.1248 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.7%

參考文獻

DIPPA hydrochloride 相關(guān)分類

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0624 mL 10.3120 mL 20.6241 mL 51.5602 mL
5 mM 0.4125 mL 2.0624 mL 4.1248 mL 10.3120 mL
10 mM 0.2062 mL 1.0312 mL 2.0624 mL 5.1560 mL
15 mM 0.1375 mL 0.6875 mL 1.3749 mL 3.4373 mL
20 mM 0.1031 mL 0.5156 mL 1.0312 mL 2.5780 mL
25 mM 0.0825 mL 0.4125 mL 0.8250 mL 2.0624 mL
30 mM 0.0687 mL 0.3437 mL 0.6875 mL 1.7187 mL
40 mM 0.0516 mL 0.2578 mL 0.5156 mL 1.2890 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
DIPPA hydrochloride
目錄號：
HY-101223
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