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  2. Cell Cycle/DNA Damage Cytoskeleton
  3. Kinesin
  4. (S)-Monastrol

(S)-Monastrol ((+)-Monastrol) 是一種有絲分裂運(yùn)動(dòng)蛋白 Eg5 的變構(gòu)抑制劑，對(duì)多種癌細(xì)胞系具有抗增殖作用。(S)-Monastrol 抑制哺乳動(dòng)物單極紡錘體有絲分裂中的細(xì)胞。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

(S)-Monastrol Chemical Structure

(S)-Monastrol Chemical Structure

CAS No. : 254753-54-3

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥2450
1 - 2 周
5 mg   詢價(jià)  
10 mg   詢價(jià)  

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Customer Review

Other Forms of (S)-Monastrol:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

(S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles[1][2].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-431 IC50
53 μg/mL
Compound: Monastrol
Cytotoxicity against human A431 cells after 48 hrs by MTT assay
Cytotoxicity against human A431 cells after 48 hrs by MTT assay
[PMID: 21620531]
A549 IC50
> 10 μM
Compound: Monastrol
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
[PMID: 21856161]
A549 IC50
> 100 μM
Compound: 1
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
[PMID: 31673316]
A549 IC50
118 μg/mL
Compound: Monastrol
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 21620531]
AGS IC50
> 10 μM
Compound: Monastrol
Cytotoxicity against human AGS cells after 48 hrs by SRB assay
Cytotoxicity against human AGS cells after 48 hrs by SRB assay
[PMID: 21856161]
BXPC-3 EC50
> 100 nM
Compound: rac-monastrol
Antiproliferative activity against human BxPC3 cells after 72 hrs by Alamar blue assay
Antiproliferative activity against human BxPC3 cells after 72 hrs by Alamar blue assay
[PMID: 20597485]
C6 IC50
> 200 μM
Compound: 1
Antiproliferative activity against rat C6 cells after 24 hrs by MTS assay
Antiproliferative activity against rat C6 cells after 24 hrs by MTS assay
[PMID: 30108989]
C6 IC50
87.83 μM
Compound: Manastrol
Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 30151081]
COLO 205 IC50
164 μg/mL
Compound: Monastrol
Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay
Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay
[PMID: 21620531]
HCT-116 IC50
> 50 μM
Compound: Monastrol
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 20934346]
HCT-116 EC50
1.2 μM
Compound: monastrol
Effect on cell cycle progression in human HCT116 cells assessed as mitotic arrest measured by doubling DNA content by fluorescence microscopy
Effect on cell cycle progression in human HCT116 cells assessed as mitotic arrest measured by doubling DNA content by fluorescence microscopy
[PMID: 18793847]
HCT-116 EC50
1.5 μM
Compound: monastrol
Effect on cell cycle progression in human HCT116 cells assessed as increase in phospho-histone H3 by fluorescence microscopy
Effect on cell cycle progression in human HCT116 cells assessed as increase in phospho-histone H3 by fluorescence microscopy
[PMID: 18793847]
HCT-116 EC50
24155 nM
Compound: rac-monastrol
Antiproliferative activity against human HCT116 cells after 72 hrs by Alamar blue assay
Antiproliferative activity against human HCT116 cells after 72 hrs by Alamar blue assay
[PMID: 20597485]
HCT-116 IC50
9 μM
Compound: 1
Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay
[PMID: 31673316]
HeLa IC50
176.9 μM
Compound: Monastrol
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by MTT assay
[PMID: 29908443]
HeLa IC50
51.3 μM
Compound: 1, monastrol
Induction of monoastral spindles in HeLa cells after 7 hrs
Induction of monoastral spindles in HeLa cells after 7 hrs
[PMID: 17587586]
HeLa IC50
6.1 μM
Compound: 1, monastrol
Inhibition of Eg5 ATPase activity expressed in HeLa cells after 12 hrs
Inhibition of Eg5 ATPase activity expressed in HeLa cells after 12 hrs
[PMID: 17587586]
HL-60(TB) IC50
0.147 μM
Compound: Monastrol
Growth inhibition of human HL-60(TB) cells incubated for 24 hrs by MTT assay
Growth inhibition of human HL-60(TB) cells incubated for 24 hrs by MTT assay
[PMID: 28667871]
K562 EC50
> 100 nM
Compound: rac-monastrol
Antiproliferative activity against human K562 cells after 72 hrs by Alamar blue assay
Antiproliferative activity against human K562 cells after 72 hrs by Alamar blue assay
[PMID: 20597485]
KB 3-1 EC50
56494 nM
Compound: rac-monastrol
Antiproliferative activity against human KB3-1 cells after 72 hrs by Alamar blue assay in presence of zosuquidar
Antiproliferative activity against human KB3-1 cells after 72 hrs by Alamar blue assay in presence of zosuquidar
[PMID: 20597485]
KB 3-1 EC50
85114 nM
Compound: rac-monastrol
Antiproliferative activity against human KB3-1 cells after 72 hrs by Alamar blue assay
Antiproliferative activity against human KB3-1 cells after 72 hrs by Alamar blue assay
[PMID: 20597485]
KB-V1 EC50
45394 nM
Compound: rac-monastrol
Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay in presence of zosuquidar
Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay in presence of zosuquidar
[PMID: 20597485]
KB-V1 EC50
99083 nM
Compound: rac-monastrol
Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay
Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay
[PMID: 20597485]
MCF7 IC50
45 μg/mL
Compound: Monastrol
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 21620531]
MCF7 IC50
59.1 μM
Compound: Monastrol
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay
[PMID: 29908443]
MCF7 IC50
73 μM
Compound: 1
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
[PMID: 31673316]
MM1.S IC50
8.7 μM
Compound: 1
Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay
[PMID: 31673316]
MOLT-4 IC50
0.215 μM
Compound: Monastrol
Growth inhibition of human MOLT4 cells incubated for 24 hrs by MTT assay
Growth inhibition of human MOLT4 cells incubated for 24 hrs by MTT assay
[PMID: 28667871]
NCI-H1299 EC50
> 100 nM
Compound: rac-monastrol
Antiproliferative activity against human NCI-H1299 cells after 72 hrs by Alamar blue assay
Antiproliferative activity against human NCI-H1299 cells after 72 hrs by Alamar blue assay
[PMID: 20597485]
U138-MG IC50
> 200 μM
Compound: 1
Antiproliferative activity against human U138MG cells after 24 hrs by MTS assay
Antiproliferative activity against human U138MG cells after 24 hrs by MTS assay
[PMID: 30108989]
分子量

292.35

Formula

C14H16N2O3S
CAS 號(hào)
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
(S)-Monastrol
目錄號(hào)：
HY-101071
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