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  2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Cimaterol

Cimaterol  (Synonyms: 西馬特羅; CL 263780; (±)-2-Amino-5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]benzonitrile)

目錄號: HY-100935 純度: 99.13%
COA 產品使用指南 技術支持

Cimaterol (CL 263780) 是一種 β-腎上腺素能 (β-adrenergic) 激動劑。Cimaterol 與 L6 β-受體結合的 Kd 為 26 nM，與其用于刺激蛋白質合成的 EC50 (約 5 nM) 相容。

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Cimaterol Chemical Structure

Cimaterol Chemical Structure

CAS No. : 54239-37-1

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥700
In-stock
5 mg ￥1380
In-stock
10 mg ￥2200
In-stock
50 mg   詢價  
100 mg   詢價  

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Customer Review

Other Forms of Cimaterol:

查看 Adrenergic Receptor 亞型特異性產品:

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Cimaterol (CL 263780) is a β-adrenergic agonist on energy metabolism in ob/ob mice[1]. The Kd for Cimaterol binding to the L6 β-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM)[2].

IC50 & Target[1]

β-adrenoceptor

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO-K1 EC50
10 μM
Compound: Cimaterol
Agonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
Agonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
[PMID: 23614528]
CHO-K1 EC50
10 μM
Compound: Cimaterol
Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
[PMID: 23614528]
體外研究
(In Vitro)

Increases in protein synthesis of 12% are found with two myogenic cell lines (L6 and G8-1) on treatment for 6 hr with the beta-adrenergic agonist Cimaterol. The Kd for Cimaterol binding to the L6 beta-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM)[2].
Cimaterol induces accumulation of intracellular cAMP and increases the viability of muscle cells during proliferation stage of C2C12 cells. Cimaterol (1 μM) shows a significant increase of cAMP concentration subsequent drug exposure[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: Mouse C2C12 myoblast cells
Concentration: 0.1 and 1 μM
Incubation Time: 8 days
Result: Fast proliferation with an increase of absorbance was noticed in treated cells compared to untreated cells at days 1, 2, and 3. From day 5 to day 8, the trend was reversed with absorbance in control cells significantly greater than that of treated cells.
體內研究
(In Vivo)

Cimaterol stimulates skeletal muscle gain in ob/ob mice[1].
Feeding Cimaterol to finishing pigs results in a slight improvement in daily gain at the 0.25 mg/kg dietary level[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: One hundred fifty crossbred pigs (55 kg)[4]
Dosage: Corn-soybean meal-based diets (.65% lysine) with 0, 0.25 and 0.5 mg/kg
Administration:
Result: Pigs fed 0.25 mg/kg with a 1-d drug withdrawal had 6.8, 7.7 and 13.5% less 10th rib fat depth and 11.1, 6.1 and 13.3% less P2 fat depth than those subjected to either a 3- or 5-d drug withdrawal or those fed the 0 mg/kg cimaterol diet (control), respectively.
Resulted in higher Warner-Bratzler shear force values and altered the proportion of saturation in some long-chain fatty acids at 0.5 mg/kg.
分子量

219.28

Formula

C12H17N3O
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

西馬特羅；喜馬特羅；喜馬特羅/塞曼特羅
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 125 mg/mL (570.05 mM; 超聲助溶; 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 4.5604 mL 22.8019 mL 45.6038 mL
5 mM 0.9121 mL 4.5604 mL 9.1208 mL
查看完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料

純度: 99.13%

參考文獻

完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5604 mL 22.8019 mL 45.6038 mL 114.0095 mL
5 mM 0.9121 mL 4.5604 mL 9.1208 mL 22.8019 mL
10 mM 0.4560 mL 2.2802 mL 4.5604 mL 11.4009 mL
15 mM 0.3040 mL 1.5201 mL 3.0403 mL 7.6006 mL
20 mM 0.2280 mL 1.1401 mL 2.2802 mL 5.7005 mL
25 mM 0.1824 mL 0.9121 mL 1.8242 mL 4.5604 mL
30 mM 0.1520 mL 0.7601 mL 1.5201 mL 3.8003 mL
40 mM 0.1140 mL 0.5700 mL 1.1401 mL 2.8502 mL
50 mM 0.0912 mL 0.4560 mL 0.9121 mL 2.2802 mL
60 mM 0.0760 mL 0.3800 mL 0.7601 mL 1.9002 mL
80 mM 0.0570 mL 0.2850 mL 0.5700 mL 1.4251 mL
100 mM 0.0456 mL 0.2280 mL 0.4560 mL 1.1401 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Cimaterol
目錄號：
HY-100935
需求量：