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  2. Membrane Transporter/Ion Channel
  3. EAAT
  4. cis-α-(Carboxycyclopropyl)glycine

cis-α-(Carboxycyclopropyl)glycine  (Synonyms: L-CCG III)

目錄號: HY-100838
產品使用指南 技術支持

cis-α-(Carboxycyclopropyl)glycine (L-CCG III) 是一種有效的、競爭性谷氨酸攝取 (glutamate uptake) 抑制劑。cis-α-(Carboxycyclopropyl)glycine 是 glutamate transporters (GluT) 的底物 (EC50: EAAT 1 和 EAAT 2 分別為 13 μM、2 μM)。cis-α-(Carboxycyclopropyl)glycine 抑制膠質質膜囊泡 (GPV) 和突觸體 (synaptosomes) 中 Na+-依賴性的高親和力 L-谷氨酸攝取。

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Custom Peptide Synthesis

cis-α-(Carboxycyclopropyl)glycine Chemical Structure

cis-α-(Carboxycyclopropyl)glycine Chemical Structure

CAS No. : 117857-95-1

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥1266
3 - 4 周
5 mg   詢價  
10 mg   詢價  

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Customer Review

查看 EAAT 亞型特異性產品:

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC50: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na+-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes[1][2].

IC50 & Target

EAAT1

 

EAAT2

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
Oocyte EC50
0.036 μM
Compound: 4a, (S)-CCG-IV
Agonist activity at rat recombinant wild type GluN1/GluN2D receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique
Agonist activity at rat recombinant wild type GluN1/GluN2D receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique
[PMID: 23614571]
Oocyte EC50
0.083 μM
Compound: 4a, (S)-CCG-IV
Agonist activity at rat recombinant wild type GluN1/GluN2B receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique
Agonist activity at rat recombinant wild type GluN1/GluN2B receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique
[PMID: 23614571]
Oocyte EC50
0.11 μM
Compound: 4a, (S)-CCG-IV
Agonist activity at rat recombinant wild type GluN1/GluN2C receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique
Agonist activity at rat recombinant wild type GluN1/GluN2C receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique
[PMID: 23614571]
Oocyte EC50
0.262 μM
Compound: 4a, (S)-CCG-IV
Agonist activity at rat recombinant wild type GluN1/GluN2A receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique
Agonist activity at rat recombinant wild type GluN1/GluN2A receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp technique
[PMID: 23614571]
分子量

159.14

Formula

C6H9NO4
CAS 號
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產品資料
參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   體積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
cis-α-(Carboxycyclopropyl)glycine
目錄號：
HY-100838
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