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  2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. DL-AP5

DL-AP5  (Synonyms: 2-APV; DL-2-Amino-5-phosphonovaleric acid)

目錄號(hào): HY-100714 純度: ≥98.0%
COA 產(chǎn)品使用指南

DL-AP5 (2-APV) 是一種競(jìng)爭(zhēng)性的 NMDA (N-methyl-D-aspartate) 受體拮抗劑。DL-AP5 表現(xiàn)出明顯的鎮(zhèn)痛活性。DL-AP5 可特異性阻斷兔視網(wǎng)膜的通道。

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DL-AP5 Chemical Structure

DL-AP5 Chemical Structure

CAS No. : 76326-31-3

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in Water ￥957
In-stock
5 mg ￥870
In-stock
10 mg ￥1400
In-stock
25 mg ￥3000
In-stock
50 mg ￥5000
In-stock
100 mg   詢價(jià)  
200 mg   詢價(jià)  

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Customer Review

Other Forms of DL-AP5:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

查看 iGluR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina[1][2][3].

IC50 & Target

NMDA Receptor

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
Pyramidal neuron IC50
0.31 μM
Compound: L-AP5
sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4,L-AP5 and L-AP6 after exposure to quisqualic acid
sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4,L-AP5 and L-AP6 after exposure to quisqualic acid
[PMID: 7966155]
Pyramidal neuron IC50
2.2 μM
Compound: L-AP5
sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 after reversal with L-alpha-AA
sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 after reversal with L-alpha-AA
[PMID: 7966155]
Pyramidal neuron IC50
2.3 μM
Compound: L-AP5
sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 before exposure to quisqualic acid
sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 before exposure to quisqualic acid
[PMID: 7966155]
體外研究
(In Vitro)

DL-AP5 (100 μM) partially prevents glutamate-induced increase in Arc/Arg3.1 protein levels[5].
DL-AP5 decreases the NMDA-induced Arc/Arg3.1 upregulation[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

DL-AP5 (0-10 μg/rat, Intra-CA1) significantly decreases the effect of NMDA[3].
DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption[4].
DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (180-230 g)[3]
Dosage: 1, 3.2 and 10 μg/rat
Administration: Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once
Result: Significantly decreased the effect of NMDA (10-2 μg/rat, intra-CA1) with significant interaction.
Animal Model: Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4]
Dosage: 0, 2.5, 5, and 10 nmol; in a volume of 10 μL
Administration: Intracerebroventricular injection
Result: Caused a dose-dependent increase in food consumption which was significant for 5 and 10 nmol doses.
Animal Model: Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4]
Dosage: 5 nmol
Administration: Intracerebroventricular injection, followed by ghrelin (0.6 nmol)
Result: Attenuated the decreased food consumption induced by the intracerebroventricular injection of ghrelin.
分子量

197.13

Formula

C5H12NO5P
CAS 號(hào)
性狀

固體

顏色

White to off-white

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

H2O 中的溶解度 : 33.33 mg/mL (169.08 mM; 超聲助溶 (<60°C))

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 5.0728 mL 25.3640 mL 50.7279 mL
5 mM 1.0146 mL 5.0728 mL 10.1456 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物實(shí)驗(yàn)：

以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶。

  • 方案 一

    請(qǐng)依序添加每種溶劑： PBS

    Solubility: 50 mg/mL (253.64 mM); 澄清溶液; 超聲助溶

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請(qǐng)具體參考實(shí)測(cè) 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.0728 mL 25.3640 mL 50.7279 mL 126.8199 mL
5 mM 1.0146 mL 5.0728 mL 10.1456 mL 25.3640 mL
10 mM 0.5073 mL 2.5364 mL 5.0728 mL 12.6820 mL
15 mM 0.3382 mL 1.6909 mL 3.3819 mL 8.4547 mL
20 mM 0.2536 mL 1.2682 mL 2.5364 mL 6.3410 mL
25 mM 0.2029 mL 1.0146 mL 2.0291 mL 5.0728 mL
30 mM 0.1691 mL 0.8455 mL 1.6909 mL 4.2273 mL
40 mM 0.1268 mL 0.6341 mL 1.2682 mL 3.1705 mL
50 mM 0.1015 mL 0.5073 mL 1.0146 mL 2.5364 mL
60 mM 0.0845 mL 0.4227 mL 0.8455 mL 2.1137 mL
80 mM 0.0634 mL 0.3170 mL 0.6341 mL 1.5852 mL
100 mM 0.0507 mL 0.2536 mL 0.5073 mL 1.2682 mL

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
DL-AP5
目錄號(hào)：
HY-100714
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