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  2. GPCR/G Protein
  3. TSH Receptor
  4. Org41841

ORG41841 是促黃體激素/絨毛膜促性腺激素受體 (LHCGR) 和促甲狀腺激素受體 (TSHR) 的部分激動劑，其 EC50 值分別為 0.2 和 7.7 μM。

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Org41841 Chemical Structure

Org41841 Chemical Structure

CAS No. : 301847-37-0

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥2310
In-stock
5 mg ￥2100
In-stock
10 mg ￥3600
In-stock
25 mg 現(xiàn)貨 詢價
50 mg   詢價  
100 mg   詢價  

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Customer Review

  • 生物活性

  • 實(shí)驗參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively.

IC50 & Target

EC50: 0.2 μM (LHCGR), 7.7 μM (TSHR)[1]
細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
0.3 μM
Compound: 3,Org 41841
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
[PMID: 16789744]
HEK293 EC50
6.5 μM
Compound: 3,Org 41841
Agonist activity at TSHR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
Agonist activity at TSHR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
[PMID: 16789744]
體外研究
(In Vitro)

Functional assays demonstrate that Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively. Treatment of L570F with Org41841 reveals an improved EC50 of 800 nM. M9 responds to Org41841 with an improved EC50 of 2700 nM and a greatly improved efficacy for signaling to 99% of the maximal value observed for thyroid-stimulating hormone (TSH) stimulation of thyroid-stimulating hormone receptor (TSHR)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

402.53

Formula

C19H22N4O2S2
CAS 號
性狀

固體

顏色

White to yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗： 

DMSO 中的溶解度 : 100 mg/mL (248.43 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.4843 mL 12.4214 mL 24.8429 mL
5 mM 0.4969 mL 2.4843 mL 4.9686 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實(shí)驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實(shí)驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)
Kinase Assay
[1]

Transfected cells are cultured for 48 h before incubation for 1 h in serum-free Dulbecco's modified Eagle's medium containing 1 mM 3-isobutyl-1-methylxanthine and bovine thyroid-stimulating hormone (TSH) (0 to 1.8 μM) or human LH (0.1 to 1000 ng) or Org41841 (0 to100 μM) in a humidified 5% CO2 incubator. Following aspiration of the medium, cells are lysed using lysis buffer 1 of the cAMP Biotrak Enzymeimmunoassay System. The cAMP content of the cell lysate is determined and data are analyzed[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

Org41841 相關(guān)分類

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4843 mL 12.4214 mL 24.8429 mL 62.1072 mL
5 mM 0.4969 mL 2.4843 mL 4.9686 mL 12.4214 mL
10 mM 0.2484 mL 1.2421 mL 2.4843 mL 6.2107 mL
15 mM 0.1656 mL 0.8281 mL 1.6562 mL 4.1405 mL
20 mM 0.1242 mL 0.6211 mL 1.2421 mL 3.1054 mL
25 mM 0.0994 mL 0.4969 mL 0.9937 mL 2.4843 mL
30 mM 0.0828 mL 0.4140 mL 0.8281 mL 2.0702 mL
40 mM 0.0621 mL 0.3105 mL 0.6211 mL 1.5527 mL
50 mM 0.0497 mL 0.2484 mL 0.4969 mL 1.2421 mL
60 mM 0.0414 mL 0.2070 mL 0.4140 mL 1.0351 mL
80 mM 0.0311 mL 0.1553 mL 0.3105 mL 0.7763 mL
100 mM 0.0248 mL 0.1242 mL 0.2484 mL 0.6211 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Org41841
目錄號：
HY-100271
需求量：