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Isoliquiritigenin
中文名稱：異甘草素
Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一種類黃酮，能抑制醛糖還原酶，IC50為320 nM。具有抗腫瘤活性。
Isoliquiritigenin Chemical Structure
CAS: 961-29-5
產(chǎn)品質(zhì)控
批次：
純度：
99.26%
99.26
Isoliquiritigenin相關(guān)產(chǎn)品
| 相關(guān)產(chǎn)品 | Epalrestat Alrestatin | 點擊展開 |
|---|---|---|
| 相關(guān)化合物庫 | 代謝化合物庫 抗癌代謝化合物庫 谷氨酰胺代謝化合物庫 糖代謝化合物庫 脂代謝化合物庫 | 點擊展開 |
細(xì)胞實驗數(shù)據(jù)示例
| 細(xì)胞系 | 實驗類型 | 給藥濃度 | 孵育時間 | 活性描述 | 文獻(xiàn)信息 |
|---|---|---|---|---|---|
| MCF7 cells | Cytotoxicity assay | 25-150 μM | 72 h | Cytotoxicity against human MCF7 cells at 25 to 150 uM after 72 hrs by MTT assay | 18603336 |
| U937 cells | Function assay | 5 ug/ml | 24 h | Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced CCL5 secretion at 5 ug/ml after 24 hrs by ELISA relative to control | 21866899 |
| dog MDCK cells | Function assay | 20 ug/mL | 1 h | Antiviral activity against Influenza virus A/Puerto Rico/8/34 H1N1 infected in dog MDCK cells assessed as inhibition of viral replication at 20 ug/mL incubated at 1 hr post-infection measured after 24 hrs by hemagglutininating unit assay relative to control | 22743086 |
| U937 cells | Function assay | 5 ug/ml | Inhibition of LPS-induced AP-1 activation in human U937 cells at 5 ug/ml after 1 hr relative to control | 21866899 | |
| J774.1 cells | Function assay | 24 h | Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay, IC50=29.3 μM | 15974608 | |
| colon 26-L5 cells | Cytotoxicity assay | 72 h | Cytotoxicity against mouse colon 26-L5 cells after 72 hrs by MTT assay, IC50=21.8 μM | 18440233 | |
| human T47D cells | Function assay | 96 h | Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay | 19928832 | |
| MCF7 cells | Function assay | 96 h | Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay | 19928832 | |
| mouse NIH3T3 cells | Function assay | 8 h | Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay, IC50=4.8 μM | 21112783 | |
| OE21 cells | Cytotoxicity assay | 72 h | Cytotoxicity against human OE21 cells after 72 hrs by MTT assay, IC50=48 μM | 21696954 | |
| dog MDCK cells | Function assay | 8 h | Inhibition of PKC/p38MAPK-mediated nuclear-cytoplasmic viral ribonucleoprotein export in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 8 hrs post-infection by inmmunofluorescence | 22743086 | |
| HUVEC | Cytotoxicity assay | 48 h | Toxicity against HUVEC incubated for 48 hrs by MTT assay, IC50=41.17 μM | 25590864 | |
| K562 cells | Cytotoxicity assay | 48 h | Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay, IC50=29.27 μM | 25590864 | |
| KB cells | Growth inhibition assay | Compound concentration required to reduce the exponential growth of KB cells by 50%, CC50=12 μM | 9767632 | ||
| MT-4 cells | Growth inhibition assay | Compound concentration required to reduce the exponential growth of MT-4 cells by 50%, CC50=7.4 μM | 9767632 | ||
| Hepa lclc7 cells | Cytotoxicity assay | Cytotoxicity against mouse Hepa lclc7 cells, IC50=39 μM | 18076142 | ||
| CHO cells | Cytotoxicity assay | Cytotoxicity against CHO cells by MTT assay, IC50=45.9 μM | 19572738 | ||
| MCF7 cells | Function assay | Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by luciferase reporter gene assay | 19928832 | ||
| NCI-H292 cells | Function assay | Inhibition of PKC-mediated PKD phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis | 22743086 | ||
| NCI-H292 cells | Function assay | Inhibition of PKC-mediated p38MAPK phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis | 22743086 | ||
| NCI-H292 cells | Function assay | Inhibition of PKC-mediated JNK phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis | 22743086 | ||
| dog MDCK cells | Function assay | Restoration of GSH level in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 24 hrs post-infection by DTNB-based colometric assay | 22743086 | ||
| RBL-1 cells | Function assay | In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined, IC50=35 μM | 8254620 | ||
| PC3 cells | Cytotoxicity assay | Cytotoxicity against human PC3 cells, IC50=46.4 μM | 16441066 | ||
| Hepa-1c1c7 cells | Function assay | Induction of quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double enzyme activity | 12762787 | ||
| Hepa lclc7 cells | Function assay | Induction of mouse quinone reductase in mouse Hepa lclc7 cells assessed as concentration required to double enzyme activity | 18076142 | ||
| 點擊查看更多細(xì)胞系數(shù)據(jù) | |||||
生物活性
| 產(chǎn)品描述 | Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一種類黃酮，能抑制醛糖還原酶，IC50為320 nM。具有抗腫瘤活性。 | ||
|---|---|---|---|
| 靶點 |
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| 體外研究(In Vitro) | ||||
| 體外研究活性 | Isoliquiritigenin通過抑制大鼠晶狀體醛糖還原酶可能能夠有效預(yù)防糖尿病并發(fā)癥，IC50為320 nM，并且能夠預(yù)防山梨糖醇在人類紅細(xì)胞中的積累，IC50為2.0 μM。[1] Isoliquiritigenin通過抑制單酚酪氨酸酶和二酚酪氨酸酶的活性可以用作美白劑，IC50為8.1 μM。[2] 在DU145和LNCaP 細(xì)胞系中，Isoliquiritigenin誘導(dǎo)細(xì)胞周期停滯并抑制細(xì)胞生長。[3]在人類胃癌MGC-803細(xì)胞中， Isoliquiritigenin通過增加細(xì)胞內(nèi)游離鈣離子濃度，并降低線粒體膜電位(Deltapsi(m))而誘導(dǎo)細(xì)胞凋亡。[4] | |||
|---|---|---|---|---|
| 體內(nèi)研究(In Vivo) | ||
| 體內(nèi)研究活性 | LD50: 小鼠>6克/千克(灌胃) [5] | |
|---|---|---|
化學(xué)信息&溶解度
| 分子量 | 256.25 | 分子式 | C15H12O4 |
| CAS號 | 961-29-5 | SDF | Download Isoliquiritigenin SDF |
| Smiles | C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O | ||
| 儲存條件(自收到貨起) | |||
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體外溶解度 |
Ethanol : 26 mg/mL (101.46 mM) DMSO : 12 mg/mL ( (46.82 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO) Water : Insoluble |
摩爾濃度計算器 |
|
體內(nèi)溶解度 現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑 |
動物體內(nèi)配方計算器 | ||||
實驗計算
動物體內(nèi)配方計算器（澄清溶液）
第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）
mg/kg
g
μL
只
第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
計算結(jié)果：
工作液濃度： mg/ml；
DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；
體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。
體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。
注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。
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