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AZD7762

AZD7762是一種有效的，選擇性Chk1抑制劑，無細(xì)胞試驗中IC50為5 nM，作用于Chk2也同樣有效，對CAM， Yes， Fyn， Lyn， Hck和Lck作用效果稍弱。Phase 1。

AZD7762 Chemical Structure

AZD7762 Chemical Structure

CAS: 860352-01-8

規(guī)格 價格 庫存 購買數(shù)量
10mM (1mL in DMSO) 1562.52 現(xiàn)貨
2mg 576.88 現(xiàn)貨
5mg 974.33 現(xiàn)貨
25mg 3040.33 現(xiàn)貨
1g 24488.1 現(xiàn)貨
更大包裝 有超大折扣

400-668-6834

info@selleck.cn
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AZD7762相關(guān)產(chǎn)品

相關(guān)信號通路圖

Chk Signaling Pathways

Chk信號通路圖

細(xì)胞實驗數(shù)據(jù)示例

細(xì)胞系 實驗類型 給藥濃度 孵育時間 活性描述 文獻(xiàn)信息
EW-16 Growth Inhibition Assay IC50=0.53774 μM SANGER
NB13 Growth Inhibition Assay IC50=0.53657 μM SANGER
SNU-423 Growth Inhibition Assay IC50=0.53466 μM SANGER
SK-N-DZ Growth Inhibition Assay IC50=0.53078 μM SANGER
CHL-1 Growth Inhibition Assay IC50=0.52551 μM SANGER
HC-1 Growth Inhibition Assay IC50=0.52114 μM SANGER
RKO Growth Inhibition Assay IC50=0.52019 μM SANGER
CAL-51 Growth Inhibition Assay IC50=0.51437 μM SANGER
SBC-5 Growth Inhibition Assay IC50=0.51344 μM SANGER
SW626 Growth Inhibition Assay IC50=0.50633 μM SANGER
A375 Growth Inhibition Assay IC50=0.49922 μM SANGER
RT-112 Growth Inhibition Assay IC50=0.49921 μM SANGER
HT-1080 Growth Inhibition Assay IC50=0.4927 μM SANGER
HGC-27 Growth Inhibition Assay IC50=0.49115 μM SANGER
HT-3 Growth Inhibition Assay IC50=0.4903 μM SANGER
HSC-3 Growth Inhibition Assay IC50=0.48626 μM SANGER
U031 Growth Inhibition Assay IC50=0.48234 μM SANGER
NCI-H1563 Growth Inhibition Assay IC50=0.47035 μM SANGER
HuP-T4 Growth Inhibition Assay IC50=0.46868 μM SANGER
KS-1 Growth Inhibition Assay IC50=0.46603 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=0.46419 μM SANGER
MOLT-13 Growth Inhibition Assay IC50=0.46294 μM SANGER
D-392MG Growth Inhibition Assay IC50=0.45612 μM SANGER
GI-ME-N Growth Inhibition Assay IC50=0.4546 μM SANGER
TE-11 Growth Inhibition Assay IC50=0.45293 μM SANGER
Hs-578-T Growth Inhibition Assay IC50=0.45278 μM SANGER
A2058 Growth Inhibition Assay IC50=0.45136 μM SANGER
Daoy Growth Inhibition Assay IC50=0.45103 μM SANGER
SK-MES-1 Growth Inhibition Assay IC50=0.44293 μM SANGER
HCE-T Growth Inhibition Assay IC50=0.44187 μM SANGER
ES6 Growth Inhibition Assay IC50=0.44185 μM SANGER
CAL-12T Growth Inhibition Assay IC50=0.43288 μM SANGER
A2780 Growth Inhibition Assay IC50=0.43162 μM SANGER
EFO-27 Growth Inhibition Assay IC50=0.43049 μM SANGER
LOXIMVI Growth Inhibition Assay IC50=0.42885 μM SANGER
D-336MG Growth Inhibition Assay IC50=0.42138 μM SANGER
SJSA-1 Growth Inhibition Assay IC50=0.41714 μM SANGER
PC-14 Growth Inhibition Assay IC50=0.41661 μM SANGER
GP5d Growth Inhibition Assay IC50=0.41225 μM SANGER
FADU Growth Inhibition Assay IC50=0.41172 μM SANGER
PFSK-1 Growth Inhibition Assay IC50=0.41092 μM SANGER
COR-L23 Growth Inhibition Assay IC50=0.40286 μM SANGER
NCI-H720 Growth Inhibition Assay IC50=0.40191 μM SANGER
KYSE-180 Growth Inhibition Assay IC50=0.40151 μM SANGER
SW954 Growth Inhibition Assay IC50=0.40131 μM SANGER
OE33 Growth Inhibition Assay IC50=0.39118 μM SANGER
MHH-NB-11 Growth Inhibition Assay IC50=0.3897 μM SANGER
786-0 Growth Inhibition Assay IC50=0.38823 μM SANGER
Ca-Ski Growth Inhibition Assay IC50=0.38792 μM SANGER
G-361 Growth Inhibition Assay IC50=0.38712 μM SANGER
GAMG Growth Inhibition Assay IC50=0.38567 μM SANGER
SW1990 Growth Inhibition Assay IC50=0.38353 μM SANGER
TK10 Growth Inhibition Assay IC50=0.37948 μM SANGER
LS-411N Growth Inhibition Assay IC50=0.37606 μM SANGER
MIA-PaCa-2 Growth Inhibition Assay IC50=0.37497 μM SANGER
T-24 Growth Inhibition Assay IC50=0.36985 μM SANGER
COR-L88 Growth Inhibition Assay IC50=0.36482 μM SANGER
NH-12 Growth Inhibition Assay IC50=0.35696 μM SANGER
OVCAR-8 Growth Inhibition Assay IC50=0.35584 μM SANGER
8505C Growth Inhibition Assay IC50=0.35002 μM SANGER
MKN1 Growth Inhibition Assay IC50=0.35002 μM SANGER
KP-N-YN Growth Inhibition Assay IC50=0.34887 μM SANGER
DU-4475 Growth Inhibition Assay IC50=0.34875 μM SANGER
C32 Growth Inhibition Assay IC50=0.34682 μM SANGER
MZ7-mel Growth Inhibition Assay IC50=0.34677 μM SANGER
BV-173 Growth Inhibition Assay IC50=0.34596 μM SANGER
MEG-01 Growth Inhibition Assay IC50=0.34584 μM SANGER
HT-144 Growth Inhibition Assay IC50=0.3381 μM SANGER
Detroit562 Growth Inhibition Assay IC50=0.33343 μM SANGER
D-423MG Growth Inhibition Assay IC50=0.33142 μM SANGER
KALS-1 Growth Inhibition Assay IC50=0.32594 μM SANGER
ChaGo-K-1 Growth Inhibition Assay IC50=0.32489 μM SANGER
NCI-H209 Growth Inhibition Assay IC50=0.32353 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=0.32021 μM SANGER
NBsusSR Growth Inhibition Assay IC50=0.31819 μM SANGER
HCC2998 Growth Inhibition Assay IC50=0.3165 μM SANGER
LCLC-97TM1 Growth Inhibition Assay IC50=0.31566 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=0.31525 μM SANGER
HCC70 Growth Inhibition Assay IC50=0.30665 μM SANGER
Mewo Growth Inhibition Assay IC50=0.30431 μM SANGER
FTC-133 Growth Inhibition Assay IC50=0.30265 μM SANGER
MDA-MB-361 Growth Inhibition Assay IC50=0.29896 μM SANGER
MSTO-211H Growth Inhibition Assay IC50=0.29855 μM SANGER
COLO-829 Growth Inhibition Assay IC50=0.29845 μM SANGER
SF295 Growth Inhibition Assay IC50=0.29802 μM SANGER
HuO9 Growth Inhibition Assay IC50=0.29793 μM SANGER
NCI-H28 Growth Inhibition Assay IC50=0.29704 μM SANGER
COLO-684 Growth Inhibition Assay IC50=0.29406 μM SANGER
HOP-92 Growth Inhibition Assay IC50=0.29279 μM SANGER
CCRF-CEM Growth Inhibition Assay IC50=0.29154 μM SANGER
RXF393 Growth Inhibition Assay IC50=0.29008 μM SANGER
EW-24 Growth Inhibition Assay IC50=0.2891 μM SANGER
CAKI-1 Growth Inhibition Assay IC50=0.2868 μM SANGER
H-EMC-SS Growth Inhibition Assay IC50=0.28354 μM SANGER
SNU-C2B Growth Inhibition Assay IC50=0.28134 μM SANGER
TYK-nu Growth Inhibition Assay IC50=0.2806 μM SANGER
MKN45 Growth Inhibition Assay IC50=0.2798 μM SANGER
OVCAR-3 Growth Inhibition Assay IC50=0.27385 μM SANGER
NCI-H1755 Growth Inhibition Assay IC50=0.27304 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=0.27097 μM SANGER
HCC1395 Growth Inhibition Assay IC50=0.27089 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=0.27059 μM SANGER
J-RT3-T3-5 Growth Inhibition Assay IC50=0.26678 μM SANGER
ABC-1 Growth Inhibition Assay IC50=0.26064 μM SANGER
8-MG-BA Growth Inhibition Assay IC50=0.25768 μM SANGER
MC116 Growth Inhibition Assay IC50=0.25654 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=0.24761 μM SANGER
KOSC-2 Growth Inhibition Assay IC50=0.24671 μM SANGER
NCI-H510A Growth Inhibition Assay IC50=0.24626 μM SANGER
T98G Growth Inhibition Assay IC50=0.24568 μM SANGER
MPP-89 Growth Inhibition Assay IC50=0.24451 μM SANGER
IGROV-1 Growth Inhibition Assay IC50=0.24401 μM SANGER
SNU-387 Growth Inhibition Assay IC50=0.24339 μM SANGER
ALL-PO Growth Inhibition Assay IC50=0.24243 μM SANGER
MOLT-4 Growth Inhibition Assay IC50=0.2385 μM SANGER
JAR Growth Inhibition Assay IC50=0.23238 μM SANGER
RPMI-7951 Growth Inhibition Assay IC50=0.23056 μM SANGER
JVM-3 Growth Inhibition Assay IC50=0.23036 μM SANGER
RH-1 Growth Inhibition Assay IC50=0.22666 μM SANGER
KYSE-270 Growth Inhibition Assay IC50=0.22633 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50=0.2257 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=0.22557 μM SANGER
HEL Growth Inhibition Assay IC50=0.22454 μM SANGER
769-P Growth Inhibition Assay IC50=0.22298 μM SANGER
COR-L105 Growth Inhibition Assay IC50=0.22235 μM SANGER
EPLC-272H Growth Inhibition Assay IC50=0.22068 μM SANGER
H4 Growth Inhibition Assay IC50=0.22062 μM SANGER
KY821 Growth Inhibition Assay IC50=0.21429 μM SANGER
HAL-01 Growth Inhibition Assay IC50=0.2097 μM SANGER
TI-73 Growth Inhibition Assay IC50=0.20873 μM SANGER
RS4-11 Growth Inhibition Assay IC50=0.20318 μM SANGER
BE-13 Growth Inhibition Assay IC50=0.20117 μM SANGER
A427 Growth Inhibition Assay IC50=0.19832 μM SANGER
CHP-212 Growth Inhibition Assay IC50=0.19782 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=0.19761 μM SANGER
GI-1 Growth Inhibition Assay IC50=0.19561 μM SANGER
5637 Growth Inhibition Assay IC50=0.19278 μM SANGER
EW-1 Growth Inhibition Assay IC50=0.18905 μM SANGER
SK-N-AS Growth Inhibition Assay IC50=0.18815 μM SANGER
SK-UT-1 Growth Inhibition Assay IC50=0.18599 μM SANGER
GR-ST Growth Inhibition Assay IC50=0.17827 μM SANGER
RPMI-8226 Growth Inhibition Assay IC50=0.17464 μM SANGER
ACN Growth Inhibition Assay IC50=0.17171 μM SANGER
KARPAS-45 Growth Inhibition Assay IC50=0.16847 μM SANGER
KU812 Growth Inhibition Assay IC50=0.1683 μM SANGER
TGBC24TKB Growth Inhibition Assay IC50=0.16535 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=0.16503 μM SANGER
ESS-1 Growth Inhibition Assay IC50=0.16413 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50=0.16311 μM SANGER
LoVo Growth Inhibition Assay IC50=0.16166 μM SANGER
ES7 Growth Inhibition Assay IC50=0.16011 μM SANGER
U-2-OS Growth Inhibition Assay IC50=0.15847 μM SANGER
NB17 Growth Inhibition Assay IC50=0.15786 μM SANGER
YH-13 Growth Inhibition Assay IC50=0.15674 μM SANGER
NOS-1 Growth Inhibition Assay IC50=0.14967 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=0.14842 μM SANGER
D-566MG Growth Inhibition Assay IC50=0.1469 μM SANGER
M14 Growth Inhibition Assay IC50=0.14463 μM SANGER
PANC-03-27 Growth Inhibition Assay IC50=0.14288 μM SANGER
RPMI-8866 Growth Inhibition Assay IC50=0.13925 μM SANGER
OVCAR-5 Growth Inhibition Assay IC50=0.13894 μM SANGER
D-283MED Growth Inhibition Assay IC50=0.13687 μM SANGER
SF539 Growth Inhibition Assay IC50=0.1368 μM SANGER
ES5 Growth Inhibition Assay IC50=0.13476 μM SANGER
ACHN Growth Inhibition Assay IC50=0.13369 μM SANGER
CTB-1 Growth Inhibition Assay IC50=0.13325 μM SANGER
P30-OHK Growth Inhibition Assay IC50=0.1316 μM SANGER
MEL-JUSO Growth Inhibition Assay IC50=0.13128 μM SANGER
DOHH-2 Growth Inhibition Assay IC50=0.13064 μM SANGER
KYSE-140 Growth Inhibition Assay IC50=0.13041 μM SANGER
MC-IXC Growth Inhibition Assay IC50=0.12843 μM SANGER
ML-2 Growth Inhibition Assay IC50=0.12484 μM SANGER
NCI-H2122 Growth Inhibition Assay IC50=0.1225 μM SANGER
H9 Growth Inhibition Assay IC50=0.12165 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50=0.1186 μM SANGER
TGBC11TKB Growth Inhibition Assay IC50=0.11093 μM SANGER
697 Growth Inhibition Assay IC50=0.11063 μM SANGER
HSC-4 Growth Inhibition Assay IC50=0.10554 μM SANGER
ES3 Growth Inhibition Assay IC50=0.102 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=0.10033 μM SANGER
ES8 Growth Inhibition Assay IC50=0.09918 μM SANGER
EM-2 Growth Inhibition Assay IC50=0.09903 μM SANGER
COLO-679 Growth Inhibition Assay IC50=0.09091 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=0.08807 μM SANGER
A3-KAW Growth Inhibition Assay IC50=0.08806 μM SANGER
HuP-T3 Growth Inhibition Assay IC50=0.0871 μM SANGER
MDA-MB-157 Growth Inhibition Assay IC50=0.08659 μM SANGER
SK-LU-1 Growth Inhibition Assay IC50=0.08421 μM SANGER
OC-314 Growth Inhibition Assay IC50=0.07807 μM SANGER
A4-Fuk Growth Inhibition Assay IC50=0.07486 μM SANGER
L-363 Growth Inhibition Assay IC50=0.0739 μM SANGER
ES1 Growth Inhibition Assay IC50=0.07146 μM SANGER
G-402 Growth Inhibition Assay IC50=0.0646 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50=0.06255 μM SANGER
ONS-76 Growth Inhibition Assay IC50=0.06196 μM SANGER
NB14 Growth Inhibition Assay IC50=0.06136 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=0.06115 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=0.06102 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50=0.06025 μM SANGER
KM12 Growth Inhibition Assay IC50=0.05158 μM SANGER
DEL Growth Inhibition Assay IC50=0.04592 μM SANGER
P12-ICHIKAWA Growth Inhibition Assay IC50=0.04316 μM SANGER
NEC8 Growth Inhibition Assay IC50=0.04203 μM SANGER
HCC1806 Growth Inhibition Assay IC50=0.04022 μM SANGER
CTV-1 Growth Inhibition Assay IC50=0.03896 μM SANGER
SW756 Growth Inhibition Assay IC50=0.03579 μM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=0.03442 μM SANGER
ATN-1 Growth Inhibition Assay IC50=0.03417 μM SANGER
ES4 Growth Inhibition Assay IC50=0.03251 μM SANGER
KE-37 Growth Inhibition Assay IC50=0.03142 μM SANGER
GOTO Growth Inhibition Assay IC50=0.0312 μM SANGER
MLMA Growth Inhibition Assay IC50=0.02849 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50=0.0142 μM SANGER
A204 Growth Inhibition Assay IC50=0.00856 μM SANGER
NCI-H1703 Growth Inhibition Assay IC50=0.00643 μM SANGER
MV-4-11 Growth Inhibition Assay IC50=0.000425 μM SANGER
NKM-1 Growth Inhibition Assay IC50=0.000415 μM SANGER
KASUMI-1 Growth Inhibition Assay IC50=0.000234 μM SANGER
A704 Growth Inhibition Assay IC50=0.53881 μM SANGER
Ca9-22 Growth Inhibition Assay IC50=0.54077 μM SANGER
NCI-H1299 Growth Inhibition Assay IC50=0.5558 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=0.55933 μM SANGER
EW-11 Growth Inhibition Assay IC50=0.56326 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=0.56522 μM SANGER
KNS-62 Growth Inhibition Assay IC50=0.56553 μM SANGER
CAL-62 Growth Inhibition Assay IC50=0.57121 μM SANGER
SF126 Growth Inhibition Assay IC50=0.57421 μM SANGER
OMC-1 Growth Inhibition Assay IC50=0.57497 μM SANGER
AGS Growth Inhibition Assay IC50=0.58162 μM SANGER
EW-22 Growth Inhibition Assay IC50=0.58375 μM SANGER
KP-N-YS Growth Inhibition Assay IC50=0.58382 μM SANGER
BFTC-909 Growth Inhibition Assay IC50=0.58833 μM SANGER
PSN1 Growth Inhibition Assay IC50=0.59118 μM SANGER
NB10 Growth Inhibition Assay IC50=0.59129 μM SANGER
COLO-800 Growth Inhibition Assay IC50=0.60328 μM SANGER
647-V Growth Inhibition Assay IC50=0.61787 μM SANGER
VM-CUB-1 Growth Inhibition Assay IC50=0.61861 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50=0.6201 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=0.62788 μM SANGER
NCI-H661 Growth Inhibition Assay IC50=0.63712 μM SANGER
ETK-1 Growth Inhibition Assay IC50=0.63721 μM SANGER
SW1710 Growth Inhibition Assay IC50=0.64023 μM SANGER
GCT Growth Inhibition Assay IC50=0.64935 μM SANGER
SKG-IIIa Growth Inhibition Assay IC50=0.65036 μM SANGER
LU-134-A Growth Inhibition Assay IC50=0.6565 μM SANGER
Becker Growth Inhibition Assay IC50=0.65805 μM SANGER
PANC-08-13 Growth Inhibition Assay IC50=0.66068 μM SANGER
SW620 Growth Inhibition Assay IC50=0.66223 μM SANGER
AsPC-1 Growth Inhibition Assay IC50=0.66361 μM SANGER
LXF-289 Growth Inhibition Assay IC50=0.67625 μM SANGER
RERF-LC-MS Growth Inhibition Assay IC50=0.67671 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50=0.67852 μM SANGER
23132-87 Growth Inhibition Assay IC50=0.68306 μM SANGER
BHY Growth Inhibition Assay IC50=0.68804 μM SANGER
C2BBe1 Growth Inhibition Assay IC50=0.68928 μM SANGER
A172 Growth Inhibition Assay IC50=0.69217 μM SANGER
NCI-H727 Growth Inhibition Assay IC50=0.69812 μM SANGER
NB69 Growth Inhibition Assay IC50=0.70549 μM SANGER
HCC1937 Growth Inhibition Assay IC50=0.70631 μM SANGER
HuCCT1 Growth Inhibition Assay IC50=0.70765 μM SANGER
HH Growth Inhibition Assay IC50=0.70781 μM SANGER
MN-60 Growth Inhibition Assay IC50=0.72124 μM SANGER
CFPAC-1 Growth Inhibition Assay IC50=0.72257 μM SANGER
HOP-62 Growth Inhibition Assay IC50=0.7262 μM SANGER
EW-3 Growth Inhibition Assay IC50=0.73552 μM SANGER
SW1417 Growth Inhibition Assay IC50=0.73593 μM SANGER
NCI-H1155 Growth Inhibition Assay IC50=0.73864 μM SANGER
CAL-54 Growth Inhibition Assay IC50=0.7403 μM SANGER
Saos-2 Growth Inhibition Assay IC50=0.74584 μM SANGER
NCI-H446 Growth Inhibition Assay IC50=0.74806 μM SANGER
LS-513 Growth Inhibition Assay IC50=0.74908 μM SANGER
PA-1 Growth Inhibition Assay IC50=0.74968 μM SANGER
HCC38 Growth Inhibition Assay IC50=0.74984 μM SANGER
DMS-273 Growth Inhibition Assay IC50=0.75456 μM SANGER
U-266 Growth Inhibition Assay IC50=0.76262 μM SANGER
HL-60 Growth Inhibition Assay IC50=0.77355 μM SANGER
UACC-62 Growth Inhibition Assay IC50=0.77553 μM SANGER
DoTc2-4510 Growth Inhibition Assay IC50=0.78211 μM SANGER
SW982 Growth Inhibition Assay IC50=0.78432 μM SANGER
8305C Growth Inhibition Assay IC50=0.78939 μM SANGER
SW48 Growth Inhibition Assay IC50=0.7924 μM SANGER
NB5 Growth Inhibition Assay IC50=0.79651 μM SANGER
J82 Growth Inhibition Assay IC50=0.80487 μM SANGER
HDLM-2 Growth Inhibition Assay IC50=0.81349 μM SANGER
HEC-1 Growth Inhibition Assay IC50=0.81371 μM SANGER
AU565 Growth Inhibition Assay IC50=0.8244 μM SANGER
KYSE-520 Growth Inhibition Assay IC50=0.82636 μM SANGER
HTC-C3 Growth Inhibition Assay IC50=0.83474 μM SANGER
AN3-CA Growth Inhibition Assay IC50=0.83711 μM SANGER
KG-1 Growth Inhibition Assay IC50=0.84484 μM SANGER
NCI-N87 Growth Inhibition Assay IC50=0.84556 μM SANGER
HN Growth Inhibition Assay IC50=0.84591 μM SANGER
SiHa Growth Inhibition Assay IC50=0.85882 μM SANGER
C-33-A Growth Inhibition Assay IC50=0.86185 μM SANGER
A673 Growth Inhibition Assay IC50=0.86536 μM SANGER
HSC-2 Growth Inhibition Assay IC50=0.87334 μM SANGER
LN-405 Growth Inhibition Assay IC50=0.87731 μM SANGER
HOS Growth Inhibition Assay IC50=0.87995 μM SANGER
SF268 Growth Inhibition Assay IC50=0.88097 μM SANGER
DJM-1 Growth Inhibition Assay IC50=0.88602 μM SANGER
HT-29 Growth Inhibition Assay IC50=0.89417 μM SANGER
NCI-H292 Growth Inhibition Assay IC50=0.89777 μM SANGER
UM-UC-3 Growth Inhibition Assay IC50=0.90316 μM SANGER
VMRC-RCZ Growth Inhibition Assay IC50=0.90578 μM SANGER
D-263MG Growth Inhibition Assay IC50=0.90943 μM SANGER
TE-10 Growth Inhibition Assay IC50=0.90984 μM SANGER
SW1088 Growth Inhibition Assay IC50=0.91552 μM SANGER
NCI-H1048 Growth Inhibition Assay IC50=0.91852 μM SANGER
A431 Growth Inhibition Assay IC50=0.92452 μM SANGER
SW1783 Growth Inhibition Assay IC50=0.93251 μM SANGER
NCI-H2452 Growth Inhibition Assay IC50=0.93557 μM SANGER
OAW-42 Growth Inhibition Assay IC50=0.93665 μM SANGER
HuO-3N1 Growth Inhibition Assay IC50=0.94092 μM SANGER
K5 Growth Inhibition Assay IC50=0.94127 μM SANGER
SW1573 Growth Inhibition Assay IC50=0.94227 μM SANGER
NCI-H1792 Growth Inhibition Assay IC50=0.94237 μM SANGER
HCC1187 Growth Inhibition Assay IC50=0.96749 μM SANGER
HCE-4 Growth Inhibition Assay IC50=0.9696 μM SANGER
HPAF-II Growth Inhibition Assay IC50=0.97028 μM SANGER
MEL-HO Growth Inhibition Assay IC50=0.97945 μM SANGER
LCLC-103H Growth Inhibition Assay IC50=0.98027 μM SANGER
CAL-33 Growth Inhibition Assay IC50=0.98378 μM SANGER
NB6 Growth Inhibition Assay IC50=0.98462 μM SANGER
BFTC-905 Growth Inhibition Assay IC50=0.98473 μM SANGER
NMC-G1 Growth Inhibition Assay IC50=0.98592 μM SANGER
RCM-1 Growth Inhibition Assay IC50=0.99258 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=1.00412 μM SANGER
NCI-H2030 Growth Inhibition Assay IC50=1.01813 μM SANGER
SCC-4 Growth Inhibition Assay IC50=1.01859 μM SANGER
KYSE-410 Growth Inhibition Assay IC50=1.0352 μM SANGER
NCI-H1650 Growth Inhibition Assay IC50=1.03971 μM SANGER
S-117 Growth Inhibition Assay IC50=1.04 μM SANGER
GAK Growth Inhibition Assay IC50=1.05075 μM SANGER
KYSE-450 Growth Inhibition Assay IC50=1.05336 μM SANGER
M059J Growth Inhibition Assay IC50=1.06828 μM SANGER
LAN-6 Growth Inhibition Assay IC50=1.07773 μM SANGER
NCI-H1651 Growth Inhibition Assay IC50=1.09352 μM SANGER
KMOE-2 Growth Inhibition Assay IC50=1.10973 μM SANGER
SN12C Growth Inhibition Assay IC50=1.11785 μM SANGER
SW900 Growth Inhibition Assay IC50=1.12251 μM SANGER
TE-8 Growth Inhibition Assay IC50=1.12291 μM SANGER
HO-1-N-1 Growth Inhibition Assay IC50=1.14353 μM SANGER
BHT-101 Growth Inhibition Assay IC50=1.14714 μM SANGER
639-V Growth Inhibition Assay IC50=1.1667 μM SANGER
RVH-421 Growth Inhibition Assay IC50=1.19347 μM SANGER
SW780 Growth Inhibition Assay IC50=1.19515 μM SANGER
SNB75 Growth Inhibition Assay IC50=1.19819 μM SANGER
U-87-MG Growth Inhibition Assay IC50=1.21334 μM SANGER
TE-1 Growth Inhibition Assay IC50=1.21367 μM SANGER
CAS-1 Growth Inhibition Assay IC50=1.21418 μM SANGER
MKN7 Growth Inhibition Assay IC50=1.21478 μM SANGER
KM-H2 Growth Inhibition Assay IC50=1.21773 μM SANGER
NCI-H1693 Growth Inhibition Assay IC50=1.22758 μM SANGER
KGN Growth Inhibition Assay IC50=1.23359 μM SANGER
NCI-H2347 Growth Inhibition Assay IC50=1.23525 μM SANGER
MFM-223 Growth Inhibition Assay IC50=1.24343 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=1.26666 μM SANGER
SAS Growth Inhibition Assay IC50=1.26672 μM SANGER
BT-549 Growth Inhibition Assay IC50=1.26782 μM SANGER
NCI-H2228 Growth Inhibition Assay IC50=1.2864 μM SANGER
BxPC-3 Growth Inhibition Assay IC50=1.30672 μM SANGER
SCH Growth Inhibition Assay IC50=1.32503 μM SANGER
GMS-10 Growth Inhibition Assay IC50=1.34551 μM SANGER
GB-1 Growth Inhibition Assay IC50=1.37564 μM SANGER
NCI-H520 Growth Inhibition Assay IC50=1.38168 μM SANGER
GCIY Growth Inhibition Assay IC50=1.39051 μM SANGER
HuH-7 Growth Inhibition Assay IC50=1.39501 μM SANGER
IA-LM Growth Inhibition Assay IC50=1.39986 μM SANGER
BB49-HNC Growth Inhibition Assay IC50=1.40231 μM SANGER
Calu-6 Growth Inhibition Assay IC50=1.41187 μM SANGER
NCI-H650 Growth Inhibition Assay IC50=1.41795 μM SANGER
TE-5 Growth Inhibition Assay IC50=1.41954 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=1.42018 μM SANGER
HCT-116 Growth Inhibition Assay IC50=1.42176 μM SANGER
NCI-H1573 Growth Inhibition Assay IC50=1.42257 μM SANGER
NCI-H358 Growth Inhibition Assay IC50=1.43128 μM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50=1.44319 μM SANGER
KP-4 Growth Inhibition Assay IC50=1.46151 μM SANGER
LK-2 Growth Inhibition Assay IC50=1.46382 μM SANGER
EFM-19 Growth Inhibition Assay IC50=1.48104 μM SANGER
GT3TKB Growth Inhibition Assay IC50=1.48613 μM SANGER
A549 Growth Inhibition Assay IC50=1.48833 μM SANGER
no-11 Growth Inhibition Assay IC50=1.49026 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=1.4938 μM SANGER
NCI-H2170 Growth Inhibition Assay IC50=1.52313 μM SANGER
NCI-H460 Growth Inhibition Assay IC50=1.52961 μM SANGER
NCI-H526 Growth Inhibition Assay IC50=1.53706 μM SANGER
KYSE-510 Growth Inhibition Assay IC50=1.5825 μM SANGER
YKG-1 Growth Inhibition Assay IC50=1.58328 μM SANGER
EW-18 Growth Inhibition Assay IC50=1.60227 μM SANGER
MDA-MB-231 Growth Inhibition Assay IC50=1.6038 μM SANGER
HT55 Growth Inhibition Assay IC50=1.60591 μM SANGER
NCI-H1793 Growth Inhibition Assay IC50=1.61345 μM SANGER
TE-9 Growth Inhibition Assay IC50=1.63456 μM SANGER
DSH1 Growth Inhibition Assay IC50=1.69256 μM SANGER
A101D Growth Inhibition Assay IC50=1.69983 μM SANGER
DB Growth Inhibition Assay IC50=1.70067 μM SANGER
ME-180 Growth Inhibition Assay IC50=1.71785 μM SANGER
BT-20 Growth Inhibition Assay IC50=1.72407 μM SANGER
A498 Growth Inhibition Assay IC50=1.72963 μM SANGER
UMC-11 Growth Inhibition Assay IC50=1.76749 μM SANGER
EC-GI-10 Growth Inhibition Assay IC50=1.77556 μM SANGER
NCI-H630 Growth Inhibition Assay IC50=1.78642 μM SANGER
EGI-1 Growth Inhibition Assay IC50=1.80267 μM SANGER
22RV1 Growth Inhibition Assay IC50=1.80853 μM SANGER
LS-123 Growth Inhibition Assay IC50=1.81214 μM SANGER
OAW-28 Growth Inhibition Assay IC50=1.84746 μM SANGER
CaR-1 Growth Inhibition Assay IC50=1.8707 μM SANGER
HT Growth Inhibition Assay IC50=1.87342 μM SANGER
BCPAP Growth Inhibition Assay IC50=1.88676 μM SANGER
RMG-I Growth Inhibition Assay IC50=1.90787 μM SANGER
C8166 Growth Inhibition Assay IC50=1.90932 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=1.92035 μM SANGER
SCC-9 Growth Inhibition Assay IC50=1.99105 μM SANGER
EKVX Growth Inhibition Assay IC50=2.00154 μM SANGER
KU-19-19 Growth Inhibition Assay IC50=2.00372 μM SANGER
K-562 Growth Inhibition Assay IC50=2.00898 μM SANGER
SW962 Growth Inhibition Assay IC50=2.04059 μM SANGER
MDA-MB-453 Growth Inhibition Assay IC50=2.05442 μM SANGER
BPH-1 Growth Inhibition Assay IC50=2.07098 μM SANGER
DK-MG Growth Inhibition Assay IC50=2.08603 μM SANGER
Capan-2 Growth Inhibition Assay IC50=2.10041 μM SANGER
SCC-15 Growth Inhibition Assay IC50=2.12541 μM SANGER
DOK Growth Inhibition Assay IC50=2.13147 μM SANGER
YAPC Growth Inhibition Assay IC50=2.15307 μM SANGER
AM-38 Growth Inhibition Assay IC50=2.17015 μM SANGER
EFO-21 Growth Inhibition Assay IC50=2.17788 μM SANGER
A388 Growth Inhibition Assay IC50=2.19271 μM SANGER
RH-18 Growth Inhibition Assay IC50=2.19369 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=2.19596 μM SANGER
COLO-668 Growth Inhibition Assay IC50=2.29973 μM SANGER
RPMI-2650 Growth Inhibition Assay IC50=2.32659 μM SANGER
HMV-II Growth Inhibition Assay IC50=2.33868 μM SANGER
NCI-H2342 Growth Inhibition Assay IC50=2.34603 μM SANGER
SH-4 Growth Inhibition Assay IC50=2.38204 μM SANGER
L-428 Growth Inhibition Assay IC50=2.38794 μM SANGER
U-118-MG Growth Inhibition Assay IC50=2.39805 μM SANGER
RO82-W-1 Growth Inhibition Assay IC50=2.43727 μM SANGER
NCI-H2291 Growth Inhibition Assay IC50=2.46994 μM SANGER
SK-OV-3 Growth Inhibition Assay IC50=2.50249 μM SANGER
NCI-H441 Growth Inhibition Assay IC50=2.50305 μM SANGER
NCI-H2009 Growth Inhibition Assay IC50=2.52934 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50=2.53747 μM SANGER
PANC-10-05 Growth Inhibition Assay IC50=2.61116 μM SANGER
CAL-85-1 Growth Inhibition Assay IC50=2.66161 μM SANGER
PC-3 Growth Inhibition Assay IC50=2.66611 μM SANGER
COLO-824 Growth Inhibition Assay IC50=2.67374 μM SANGER
D-502MG Growth Inhibition Assay IC50=2.70406 μM SANGER
SBC-1 Growth Inhibition Assay IC50=2.71627 μM SANGER
CAPAN-1 Growth Inhibition Assay IC50=2.71949 μM SANGER
D-247MG Growth Inhibition Assay IC50=2.73756 μM SANGER
CAL-39 Growth Inhibition Assay IC50=2.86389 μM SANGER
NCI-H2087 Growth Inhibition Assay IC50=2.88431 μM SANGER
NB7 Growth Inhibition Assay IC50=2.92139 μM SANGER
NCI-H1437 Growth Inhibition Assay IC50=2.92257 μM SANGER
RD Growth Inhibition Assay IC50=2.99939 μM SANGER
TCCSUP Growth Inhibition Assay IC50=3.02636 μM SANGER
MKN28 Growth Inhibition Assay IC50=3.03463 μM SANGER
NCI-H596 Growth Inhibition Assay IC50=3.0671 μM SANGER
SW948 Growth Inhibition Assay IC50=3.09693 μM SANGER
WM-115 Growth Inhibition Assay IC50=3.11827 μM SANGER
HCC1954 Growth Inhibition Assay IC50=3.12141 μM SANGER
MS-1 Growth Inhibition Assay IC50=3.18474 μM SANGER
SW13 Growth Inhibition Assay IC50=3.2326 μM SANGER
OE19 Growth Inhibition Assay IC50=3.28489 μM SANGER
HT-1197 Growth Inhibition Assay IC50=3.29179 μM SANGER
HLE Growth Inhibition Assay IC50=3.3281 μM SANGER
NUGC-3 Growth Inhibition Assay IC50=3.44761 μM SANGER
UACC-257 Growth Inhibition Assay IC50=3.52417 μM SANGER
SK-MEL-3 Growth Inhibition Assay IC50=3.53214 μM SANGER
KNS-81-FD Growth Inhibition Assay IC50=3.562 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=3.57986 μM SANGER
KLE Growth Inhibition Assay IC50=3.59867 μM SANGER
NCI-H2052 Growth Inhibition Assay IC50=3.60009 μM SANGER
NCI-H1838 Growth Inhibition Assay IC50=3.81119 μM SANGER
NCI-H1623 Growth Inhibition Assay IC50=4.01396 μM SANGER
SCC-25 Growth Inhibition Assay IC50=4.23597 μM SANGER
CP66-MEL Growth Inhibition Assay IC50=4.25191 μM SANGER
TE-12 Growth Inhibition Assay IC50=4.29271 μM SANGER
LU-99A Growth Inhibition Assay IC50=4.31345 μM SANGER
CAMA-1 Growth Inhibition Assay IC50=4.352 μM SANGER
SK-MEL-30 Growth Inhibition Assay IC50=4.41913 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50=4.45528 μM SANGER
BEN Growth Inhibition Assay IC50=4.52362 μM SANGER
NCI-H226 Growth Inhibition Assay IC50=4.54871 μM SANGER
CAL-27 Growth Inhibition Assay IC50=4.71694 μM SANGER
G-401 Growth Inhibition Assay IC50=4.83841 μM SANGER
CAL-120 Growth Inhibition Assay IC50=4.84991 μM SANGER
DMS-114 Growth Inhibition Assay IC50=5.14506 μM SANGER
KYSE-70 Growth Inhibition Assay IC50=5.14859 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50=5.29782 μM SANGER
MDA-MB-175-VII Growth Inhibition Assay IC50=5.44014 μM SANGER
NCI-H2029 Growth Inhibition Assay IC50=5.48022 μM SANGER
LS-1034 Growth Inhibition Assay IC50=5.66889 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=5.70345 μM SANGER
MDA-MB-415 Growth Inhibition Assay IC50=5.7081 μM SANGER
TE-6 Growth Inhibition Assay IC50=5.74182 μM SANGER
SK-MEL-24 Growth Inhibition Assay IC50=5.74564 μM SANGER
HUTU-80 Growth Inhibition Assay IC50=5.75333 μM SANGER
OCUB-M Growth Inhibition Assay IC50=5.77563 μM SANGER
IGR-1 Growth Inhibition Assay IC50=5.86894 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=6.24585 μM SANGER
COLO-680N Growth Inhibition Assay IC50=6.39403 μM SANGER
NB12 Growth Inhibition Assay IC50=6.79722 μM SANGER
SNU-449 Growth Inhibition Assay IC50=6.99591 μM SANGER
D-542MG Growth Inhibition Assay IC50=7.12299 μM SANGER
COLO-792 Growth Inhibition Assay IC50=7.87127 μM SANGER
NCI-H810 Growth Inhibition Assay IC50=8.02984 μM SANGER
T47D Growth Inhibition Assay IC50=8.16024 μM SANGER
Calu-3 Growth Inhibition Assay IC50=8.28886 μM SANGER
COLO-741 Growth Inhibition Assay IC50=8.93093 μM SANGER
LU-135 Growth Inhibition Assay IC50=9.03452 μM SANGER
COLO-678 Growth Inhibition Assay IC50=9.28844 μM SANGER
NCI-H2126 Growth Inhibition Assay IC50=9.33919 μM SANGER
SK-MEL-28 Growth Inhibition Assay IC50=9.53596 μM SANGER
MFE-280 Growth Inhibition Assay IC50=10.0229 μM SANGER
DBTRG-05MG Growth Inhibition Assay IC50=10.4369 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=10.5255 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=10.6852 μM SANGER
C3A Growth Inhibition Assay IC50=12.3172 μM SANGER
MHH-ES-1 Growth Inhibition Assay IC50=12.5284 μM SANGER
LU-139 Growth Inhibition Assay IC50=12.6333 μM SANGER
KNS-42 Growth Inhibition Assay IC50=12.8771 μM SANGER
MCF7 Growth Inhibition Assay IC50=13.2365 μM SANGER
SW872 Growth Inhibition Assay IC50=14.5461 μM SANGER
HT-1376 Growth Inhibition Assay IC50=14.8582 μM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50=15.1741 μM SANGER
NCI-H2405 Growth Inhibition Assay IC50=15.4474 μM SANGER
KYSE-150 Growth Inhibition Assay IC50=15.7611 μM SANGER
SW837 Growth Inhibition Assay IC50=16.0124 μM SANGER
LU-65 Growth Inhibition Assay IC50=19.726 μM SANGER
JEG-3 Growth Inhibition Assay IC50=20.3577 μM SANGER
SK-MEL-1 Growth Inhibition Assay IC50=20.7836 μM SANGER
SK-HEP-1 Growth Inhibition Assay IC50=21.5541 μM SANGER
NCI-H1770 Growth Inhibition Assay IC50=23.4086 μM SANGER
MG-63 Growth Inhibition Assay IC50=23.7673 μM SANGER
ECC10 Growth Inhibition Assay IC50=25.571 μM SANGER
SW1463 Growth Inhibition Assay IC50=27.8316 μM SANGER
JVM-2 Growth Inhibition Assay IC50=28.3248 μM SANGER
HCT-15 Growth Inhibition Assay IC50=28.4192 μM SANGER
CAL-72 Growth Inhibition Assay IC50=31.4912 μM SANGER
HCC2218 Growth Inhibition Assay IC50=32.8858 μM SANGER
BT-474 Growth Inhibition Assay IC50=33.0843 μM SANGER
NCI-H1092 Growth Inhibition Assay IC50=33.5145 μM SANGER
Mo-T Growth Inhibition Assay IC50=37.3585 μM SANGER
DU-145 Growth Inhibition Assay IC50=40.6295 μM SANGER
NCI-H1666 Growth Inhibition Assay IC50=42.4488 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=46.4196 μM SANGER
SW1116 Growth Inhibition Assay IC50=48.1756 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50=48.5026 μM SANGER
點擊查看更多細(xì)胞系數(shù)據(jù)

生物活性

產(chǎn)品描述 AZD7762是一種有效的，選擇性Chk1抑制劑，無細(xì)胞試驗中IC50為5 nM，作用于Chk2也同樣有效，對CAM， Yes， Fyn， Lyn， Hck和Lck作用效果稍弱。Phase 1。
靶點
Chk1 [1]
(Cell-free assay)		 Chk2 [1]
(Cell-free assay)
5 nM <10 nM
體外研究(In Vitro)
體外研究活性

AZD7762是Chk1選擇性抑制劑, 通過與Chk1的ATP結(jié)合位點可逆結(jié)合而抑制cdc25C肽段的Chk1磷酸化，IC50 為5 nM，Ki為 3.6 nM。AZD7762誘導(dǎo)細(xì)胞周期停滯，EC50為0.620 μM, 且通過阻斷cdc25A依賴chk1的降解 和Cyclin A的激活，顯著廢除Camptothecin誘導(dǎo)的G2期停滯，EC50為10 nM。300 nM AZD7762增強作用于SW620的抗癌活性，也增強作用于MDA-MB-231 的抗癌活性，通過降低 GI50 值，分別從24.1 nM和2.25 μM 降到1.08 nM 和0.15 μM。[1] AZD7762 作用于多種攜帶p53野生型，p53突變型，MDM2增添，或p14 缺失的神經(jīng)母細(xì)胞瘤細(xì)胞系，IC50為82.6 nM 到505.9 nM。[2]
激酶實驗 Chk1激酶實驗
使用桿狀病毒載體，融合在昆蟲細(xì)胞中，重組人類Chk1表達(dá)作為谷胱甘肽S轉(zhuǎn)移酶，通過胱甘肽親和層析純化。合成的肽底物 (N-biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR)用于Chk1 合成。實驗中，肽和ATP(完全和40 nCi [33P]ATP) 的終濃度分別為0.8和1 μM。不同濃度AZD7762, 含肽和chk1激酶和ATP的buffer相繼加到384孔板中。然后溫育2小時,加入含EDTA和鄰近閃爍分析(SPA)圓球微粒的buffer終止反應(yīng), 然后使用TopCount計數(shù)器讀數(shù)。進(jìn)行數(shù)據(jù)分析，測定IC50值。
細(xì)胞實驗 細(xì)胞系 HT29,SW620和MDA-MB-231細(xì)胞
濃度 溶于DMSO, 終濃度為12.5 μM 左右
孵育時間 20或48小時
方法

檢測點廢除實驗中, 用Camptothecin(拓?fù)洚悩?gòu)酶I 抑制劑;0.07 μg/mL)處理HT29細(xì)胞2小時，誘導(dǎo)產(chǎn)生G2期檢測點。然后用AZD7762(12.5 μM 到6 nM)12點滴定法和Nocodazole處理細(xì)胞20分鐘。細(xì)胞和3.7%甲醛混合1小時，用含0.05% Triton X的PBS滲透處理, 然后與anti-phH3抗體溫育1小時，然后用Hoechst染料染色1小時。使用ArrayScan測定有絲分裂指數(shù)，作為進(jìn)行有絲分裂細(xì)胞的百分?jǐn)?shù)。增強實驗中,用9點滴定（0.01到 100 nM）和固定劑量AZD7762(300 nM)處理SW620或MDA-MB-231細(xì)胞24小時。24小時后, 移除培養(yǎng)基，單獨加入AZD7762，再處理24小時。細(xì)胞在無AZD7762培養(yǎng)基中再溫育72小時，通過MTT測定細(xì)胞增殖。
實驗圖片 檢測方法 檢測指標(biāo) 實驗圖片 PMID
Western blot pChk1 / Chk1 / Wee1 / p21 / p53 29963769
Growth inhibition assay Cell viability 23715154
體內(nèi)研究(In Vivo)
體內(nèi)研究活性

AZD7762 按25 mg/kg劑量單獨作用于攜帶H460-DNp53移植瘤的小鼠和攜帶SW620移植瘤的小鼠，顯示很弱的抗癌活性,但是聯(lián)用處理這兩種攜帶移植瘤的小鼠，則具有強抗癌活性。AZD7762聯(lián)用作用于攜帶H460-DNp53移植瘤大鼠，抑制腫瘤體積，這種作用存在劑量依賴性。AZD7762 (25 mg/kg) 聯(lián)用作用于攜帶SW620移植瘤的小鼠，引起全部腫瘤衰退。[1]
動物實驗 Animal Models 皮下注射H460-DNp53細(xì)胞或SW620細(xì)胞的雄性NCr小鼠, 或皮下注射H460-DNp53細(xì)胞的雄性rnu大鼠
Dosages ~25 mg/kg
Administration 靜脈注射
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00937664 Terminated
Cancer|Solid Tumors|Advanced Solid Malignancies
AstraZeneca
 July 2009 Phase 1
NCT00473616 Terminated
Advanced Solid Tumors|Cancer|Advanced Solid Malignancies
AstraZeneca
 May 2007 Phase 1
NCT00413686 Completed
Solid Tumors
AstraZeneca
 December 2006 Phase 1

化學(xué)信息&溶解度

分子量 362.42 分子式

C17H19FN4O2S
CAS號 860352-01-8 SDF Download AZD7762 SDF
Smiles C1CC(CNC1)NC(=O)C2=C(C=C(S2)C3=CC(=CC=C3)F)NC(=O)N
儲存條件(自收到貨起)

體外溶解度
批次：

DMSO : 73 mg/mL ( (201.42 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Ethanol : 3 mg/mL (8.27 mM)

Water : Insoluble

摩爾濃度計算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑

 動物體內(nèi)配方計算器

實驗計算

摩爾濃度計算器

質(zhì)量 濃度 體積 分子量

動物體內(nèi)配方計算器（澄清溶液）

第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）

mg/kg g μL 只

第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

技術(shù)支持

在訂購、運輸、儲存和使用我們的產(chǎn)品的任何階段，您遇到的任何問題，均可以通過撥打我們的熱線電話400-668-6834，或者技術(shù)支持郵箱tech@selleck.cn，直接聯(lián)系到我們。我們會在24小時內(nèi)盡快聯(lián)系您。

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常見問題及建議解決方法

問題 1:
If I want to use the inhibitor for i.p. injection, can I use DMSO to dissolve it?

回答：
Since DMSO has low toxicity with i.p. injection, hydroxyproplyl-β-cyclodextrin is consider a safer co-solvent in compound formulation. In a previous literature report, 11.3% hydroxyproplyl-β-cyclodextrin was used to formulate this compound for i.v. injection.

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