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Rotenone

別名: Barbasco, Dactinol, Paraderil, Rotenon, Rotocide 中文名稱：魚藤酮

Rotenone是一種植物殺蟲劑，是線粒體電子傳遞mitochondrial electron transport的抑制劑。Rotenone 可抑制 NADH/DB oxidoreductase 和 NADH oxidase，對應的IC50值分別為28.8 nM和5.1 nM。Rotenone 可通過增強線粒體活性氧的產(chǎn)生來誘導凋亡。Rotenone 可用于誘導帕金森病動物模型。

Rotenone Chemical Structure

Rotenone Chemical Structure

CAS: 83-79-4

規(guī)格 價格 庫存 購買數(shù)量
10mM (1mL in DMSO) 958.23 現(xiàn)貨
25mg 794.7 現(xiàn)貨
1g 3030.98 現(xiàn)貨
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Rotenone相關(guān)產(chǎn)品

細胞實驗數(shù)據(jù)示例

細胞系 實驗類型 給藥濃度 孵育時間 活性描述 文獻信息
MG63 Function assay 1 uM 1 hr Increase in lactate production in MG63 cells at 1 uM after 1 hr by ELISA 17088489
N548 Activation of AKT in 10 uM 6 hrs Activation of AKT in DNA-deficient rat striatal neuronal N548 mutant cells at 10 uM after 6 hrs by Western blotting 17726098
N548 Cell death rescue assay 10 uM 7 days Cell death rescue in rat striatal neuronal N548 mutant cells analysed every day for 7 days at 10 uM by trypan blue dye-exclusion assay 17726098
T47D Function assay 0.01 to 0.1 uM 72 hrs Reduction in ATP level in human T47D cells at 0.01 to 0.1 uM after 72 hrs by HPLC-UV analysis 21875114
T47D Function assay 0.1 to 1 uM 30 mins Inhibition of mTOR in human T47D cells assessed as eIF2alpha hyperphosphorylation on Ser 51 at 0.1 to 1 uM after 30 mins by Western blotting 21875114
T47D Function assay 0.1 to 1 uM 30 mins Inhibition of mTOR in human T47D cells assessed as eEF2 hyperphosphorylation on Ser 56 at 0.1 to 1 uM after 30 mins by Western blotting 21875114
MDA-MB-231 Function assay 0.1 to 1 uM 30 mins Inhibition of mTOR in human MDA-MB-231 cells assessed as eIF2alpha hyperphosphorylation on Ser 51 at 0.1 to 1 uM after 30 mins by Western blotting 21875114
MDA-MB-231 Function assay 0.1 to 1 uM 30 mins Inhibition of mTOR in human MDA-MB-231 cells assessed as eEF2 hyperphosphorylation on Ser 56 at 0.1 to 1 uM after 30 mins by Western blotting 21875114
MDA-MB-231 Function assay 0.01 to 0.1 uM 48 hrs Reduction in ATP level in human MDA-MB-231 cells at 0.01 to 0.1 uM after 48 hrs by HPLC-UV analysis 21875114
N548 Activation of ERK in 10 uM Activation of ERK in rat striatal neuronal N548 mutant cells at 10 uM by Western blotting 17726098
N548 Activation of AKT in 10 uM Activation of AKT in rat striatal neuronal N548 mutant cells at 10 uM by Western blotting 17726098
N548 Activation of ERK in 50 uM Activation of ERK in rat striatal neuronal N548 mutant cells at 50 uM by Western blotting 17726098
N548 Activation of AKT in 50 uM Activation of AKT in rat striatal neuronal N548 mutant cells at 50 uM by Western blotting 17726098
N548 Cell death rescue assay 10 uM Cell death rescue in DNA-deficient rat striatal neuronal N548 mutant cells at 10 uM 17726098
T47D Function assay 0.001 to 0.1 uM Inhibition of cellular respiration in human T47D cells assessed as rate of oxygen consumption at 0.001 to 0.1 uM 21875114
TA3/Ha Function assay 12 uM Induction of NAD(P)H oxidation in mouse TA3/Ha cells assessed as reduction of NAD(P)H/NAD(P)+ ratio at 12 uM by spectrofluorometer analysis 24568614
U937 Antiproliferative assay 72 hrs Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay, IC50=0.07μM 17158054
U937 Antiproliferative assay 48 hrs Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay, IC50=0.2μM 17158054
U937 Antiproliferative assay 24 hrs Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay, IC50=13μM 17158054
HepG2 Antitumor assay 24 hrs Antitumor activity against human HepG2 cells after 24 hrs by MTT assay, ED50=15μM 17482824
A549 Antitumor assay 24 hrs Antitumor activity against human A549 cells after 24 hrs by MTT assay, ED50=26μM 17482824
U373 MG Antiproliferative assay 72 hrs Antiproliferative activity against human U373 MG cells after 72 hrs 18513974
T47D Function assay 48 hrs Reduction in ATP level in human T47D cells after 48 hrs by HPLC-UV analysis 21875114
697 Cytotoxicity assay 72 hrs Cytotoxicity against human 697 cells after 72 hrs by MTS assay, IC50=0.3μM 23895019
697 Cytotoxicity assay 48 hrs Cytotoxicity against human 697 cells after 48 hrs by MTS assay, IC50=0.3μM 23895019
HT-29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay, IC50=0.3μM 23895019
Raji Cytotoxicity assay 72 hrs Cytotoxicity against human Raji cells after 72 hrs by MTS assay, IC50=1.1μM 23895019
Raji Cytotoxicity assay 48 hrs Cytotoxicity against human Raji cells after 48 hrs by MTS assay, IC50=4.2μM 23895019
HepG2 Cytotoxicity assay 24 hrs Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay, IC50=1.52μM 30613327
HEK293 Function assay Effect on cofilin1 expressed in HEK293 cells assessed as effect on cofilin1; Limk2 interaction complexes in presence of camptothecin by EYFP and/or YFP Venus fragment based reporter gene assay 16680159
HEK293 Function assay Inhibition of of c-Jun expressed in HEK293 cells assessed as induction of protein interaction in presence of camptothecin with Pin1 by EYFP based reporter gene assay 16680159
HEK293 Function assay Effect on p53 expressed in HEK293 cells assessed as effect on p53-p53 interaction complexes in presence of camptothecin by EYFP and/or YFP Venus fragment based reporter gene assay 16680159
HEK293 Function assay Effect on Cdc2 expressed in HEK293 cells assessed as effect on Cdc2:Cdc25A interaction complexes in presence of camptothecin by EYFP and/or YFP Venus fragment based reporter gene assay 16680159
HEK293 Function assay Effect on Cdc2 expressed in HEK293 cells assessed as effect on Cdc2:Cdc25C interaction complexes in presence of camptothecin by EYFP and/or YFP Venus fragment based reporter gene assay 16680159
HT1080 Function assay Inhibition of proMMP2 production in human HT1080 cells by gelatin zymography analysis 17158054
HT1080 Function assay Inhibition of proMMP9 production in human HT1080 cells by gelatin zymography analysis 17158054
neural precursor cells Function assay Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 17417631
N548 Cell death rescue assay Cell death rescue in rat striatal neuron N548 mutant cells, EC50=0.5μM 17726098
ASH neuronal cells Cell death rescue assay Cell death rescue of ASH neuronal cells in Caenorhabditis elegans Huntington's disease model, EC50=2μM 17726098
neuronal cells Cell death rescue assay Cell death rescue of neuronal cells in drosophila Huntington's disease model, EC50=10μM 17726098
N548 Toxicity assay Toxicity in rat striatal neuronal N548 mutant cells, TC50=40μM 17726098
N548 Cell death rescue assay Suppression of cell death in rat striatal neuronal N548 mutant cells assessed as suppression of caspase 7 activation by Western blotting 17726098
N548 Cell death rescue assay Cell death rescue in rat striatal neuronal N548 mutant cells by calcein acetoxymethyl ester assay 17726098
N548 Cell death rescue assay Suppression of cell death in rat striatal neuronal N548 mutant cells assessed as suppression of caspase 3 activation by Western blotting 17726098
Hepa-1c1c7 Cytotoxicity assay Cytotoxicity against mouse Hepa-1c1c7 cells, IC50=0.7μM 23895019
Hepa1c1c7 Function assay Induction of quinone reductase in mouse Hepa1c1c7 cells, CD=0.8μM 23895019
L5178Y Cytotoxicity assay Cytotoxicity against mouse L5178Y cells by MTT assay, IC50=0.3μM 28075580
TC32 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells 29435139
DAOY qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells 29435139
SJ-GBM2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells 29435139
A673 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells 29435139
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells 29435139
BT-37 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells 29435139
NB-EBc1 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells 29435139
Saos-2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells 29435139
LAN-5 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells 29435139
BT-12 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells 29435139
OHS-50 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells 29435139
Rh41 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells 29435139
A673 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells) 29435139
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells 29435139
BT-12 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells 29435139
LAN-5 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells 29435139
NB-EBc1 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells 29435139
BT-37 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells 29435139
TC32 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells 29435139
MG 63 (6-TG R) qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells 29435139
fibroblast cells qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for control Hh wild type fibroblast cells 29435139
OHS-50 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells 29435139
DLD1 Function assay Inhibition of mitochondrial oxidative phosphorylation in human DLD1 cells assessed as reduction in oxygen consumption rate by seahorse XFe96 analyser based assay 31774672
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生物活性

產(chǎn)品描述 Rotenone是一種植物殺蟲劑，是線粒體電子傳遞mitochondrial electron transport的抑制劑。Rotenone 可抑制 NADH/DB oxidoreductase 和 NADH oxidase，對應的IC50值分別為28.8 nM和5.1 nM。Rotenone 可通過增強線粒體活性氧的產(chǎn)生來誘導凋亡。Rotenone 可用于誘導帕金森病動物模型。

化學信息&溶解度

分子量 394.42 分子式

C23H22O6
CAS號 83-79-4 SDF Download Rotenone SDF
儲存條件(自收到貨起)

體外溶解度
批次：

DMSO : 40 mg/mL ( (101.41 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩爾濃度計算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑

 動物體內(nèi)配方計算器

實驗計算

摩爾濃度計算器

質(zhì)量 濃度 體積 分子量

動物體內(nèi)配方計算器（澄清溶液）

第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）

mg/kg g μL 只

第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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