Camptothecin (CPT)

別名: Campathecin, (S)-(+)-Camptothecin,NSC-100880 中文名稱：喜樹堿

目錄號(hào)：S1288 Purity: 99.79%

Camptothecin (CPT)是一種特異性的DNA拓?fù)洚悩?gòu)酶I (Topo I)抑制劑，IC50為0.68 μM。Camptothecin 在癌細(xì)胞中可通過(guò)microRNA-125b介導(dǎo)的線粒體信號(hào)通路來(lái)誘導(dǎo)凋亡。Phase 2。

Camptothecin (CPT) Chemical Structure

CAS: 7689-03-4

規(guī)格	價(jià)格	庫(kù)存
10mM (1mL in DMSO)	1148.32	現(xiàn)貨
100mg	630.63	現(xiàn)貨
500mg	1409.22	現(xiàn)貨
1g	2022.93	現(xiàn)貨
更大包裝有超大折扣
400-668-6834 info@selleck.cn

產(chǎn)品質(zhì)控

批次：純度： 99.79%

99.79

Camptothecin (CPT)相關(guān)產(chǎn)品

相關(guān)產(chǎn)品	SN-38 Triptolide (+)-Bicuculline Rutin 20-Hydroxyecdysone Pinocembrin BHQ Harmine hydrochloride Psoralen Lappaconite HBr Luteoloside Lycorine hydrochloride Tetrahydropalmatine hydrochloride	點(diǎn)擊展開
相關(guān)化合物庫(kù)	FDA藥物庫(kù) 天然產(chǎn)物庫(kù) 凋亡分子化合物庫(kù) DNA損傷/ DNA修復(fù)化合物庫(kù) 細(xì)胞周期化合物庫(kù)	點(diǎn)擊展開

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系	實(shí)驗(yàn)類型	給藥濃度	孵育時(shí)間	活性描述	文獻(xiàn)信息
HL60	Apoptosis assay	1 uM	6 hrs	Induction of apoptosis in human HL60 cells assessed as nucleosomal DNA fragmentation at 1 uM after 6 hrs	17950603
HT-29	Cell cycle assay	0.1 uM	6 hrs	Cell cycle distribution in human HT-29 cells assessed as accumulation at S phase at 0.1 uM after 6 hrs by flow cytometry	19715319
HT-29	Cell cycle assay	0.1 uM	12 hrs	Cell cycle distribution in human HT-29 cells assessed as accumulation at S phase at 0.1 uM after 12 hrs by flow cytometry	19715319
HT-29	Cell cycle assay	0.1 uM	24 hrs	Cell cycle distribution in human HT-29 cells assessed as accumulation at S phase at 0.1 uM after 24 hrs by flow cytometry	19715319
HT-29	Cell cycle assay	0.1 uM	48 hrs	Cell cycle distribution in human HT-29 cells assessed as accumulation at S phase at 0.1 uM after 48 hrs by flow cytometry	19715319
HT-29	Cell cycle assay	0.1 uM	48 hrs	Cell cycle distribution in human HT-29 cells assessed as accumulation at sub-G1 phase at 0.1 uM after 48 hrs by flow cytometry	19715319
U87MG	Cytotoxicity assay	250 nM	6 days	Cytotoxicity against human U87MG cells at 250 nM after 6 days	20655220
MOLT4	Cell cycle assay	5 uM	24 hrs	Cell cycle arrest in human MOLT4 cells assessed as accumulation at sub G1 phase at 5 uM after 24 hrs using propidium iodide staining by flow cytometry	21074444
CHO	Function assay	10 uM	30 mins	Drug uptake in CHO cells at 10 uM after 30 mins by confocal microscopy	21282053
CHO	Function assay	10 uM	30 mins	Drug uptake in NK1R overexpressing CHO cells at 10 uM after 30 mins by confocal microscopy	21282053
HL60	Apoptosis assay	4 uM	9 hrs	Induction of apoptosis in human HL60 cells assessed as DNA ladder formation at 4 uM after 9 hrs by agarose gel electrophoresis	21334793
SW620	Apoptosis assay	5 uM	6 hrs	Induction of apoptosis in human SW620 cells assessed as DNA fragmentation at 5 uM after 6 hrs by gel electrophoresis	21620534
Jurkat T	Apoptosis assay	2 uM	24 hrs	Induction of apoptosis in human Jurkat T cells assessed as increase in phosphatidylserine level at 2 uM after 24 hrs by flow cytometric analysis	22200402
COLO205	Apoptosis assay	4 uM	24 hrs	Induction of apoptosis in human COLO205 cells assessed as down regulation of Bcl-2 at 4 uM after 24 hrs by ELISA	22364746
HeLa	Function assay	50 uM	6 hrs	Inhibition of Mcl-1 in doxycyclin-stimulated human HeLa cells overexpressing Bad3SA assessed as increase in caspase3/7 activity at 50 uM after 6 hrs by luminescence analysis	22386982
HL60	Apoptosis assay	5 uM	6 hrs	Induction of apoptosis in human HL60 cells assessed as DNA ladder formation at 5 uM after 6 hrs by DNA agarose gel electrophoresis	23584541
HCT116	Function assay	1 uM	1 hr	Inhibition of human recombinant topoisomerase 1 in human HCT116 cells assessed as DNA-protein cross linking at 1 uM after 1 hr	24502276
HCT116	Function assay	1 uM	1 hr	Inhibition of human recombinant topoisomerase 1 in human HCT116 cells assessed as DNA-protein cross linking at 1 uM incubated for 1 hr followed by compound washout measured after 1 hr	24502276
HCT116	Function assay	1 uM	1 hr	Inhibition of human recombinant topoisomerase 1 in human HCT116 cells assessed as reversal of topoisomerase 1-DNA cleavage complex stabilization at 1 uM incubated for 1 hr followed by compound washout measured after 24 hrs by DNA immunoblotting analysis	24502276
HCT116	Function assay	1 uM	1 hr	Inhibition of human recombinant topoisomerase 1 in human HCT116 cells assessed as reversal of topoisomerase 1-DNA cleavage complex stabilization at 1 uM incubated for 1 hr followed by compound washout measured up to 6 hrs by DNA immunoblotting analysis	24502276
HCT116	Function assay	1 uM	1 hr	Inhibition of human recombinant topoisomerase 1 in human HCT116 cells assessed as stabilization of topoisomerase 1-DNA cleavage complex at 1 uM after 1 hr by DNA immunoblotting analysis	24502276
HeLa	Apoptosis assay	0.8 to 1.6 uM	24 hrs	Induction of apoptosis in human HeLa cells assessed as inhibition of DNA synthesis at 0.8 to 1.6 uM after 24 hrs by BrdU staining-based ELISA	24980118
MDA-MB-231	Apoptosis assay	0.8 to 1.6 uM	24 hrs	Induction of apoptosis in human MDA-MB-231 cells assessed as inhibition of DNA synthesis at 0.8 to 1.6 uM after 24 hrs by BrdU staining-based ELISA	24980118
A375	Apoptosis assay	0.8 to 1.6 uM	24 hrs	Induction of apoptosis in human A375 cells assessed as inhibition of DNA synthesis at 0.8 to 1.6 uM after 24 hrs by BrdU staining-based ELISA	24980118
Caco2	Apoptosis assay	0.8 to 1.6 uM	24 hrs	Induction of apoptosis in human Caco2 cells assessed as inhibition of DNA synthesis at 0.8 to 1.6 uM after 24 hrs by BrdU staining-based ELISA	24980118
A549	Function assay	30 to 100 nM	30 mins	Inhibition of topoisomerase 1 in human A549 cells assessed as reduction in relaxation of supercoiled DNA substrate at 30 to 100 nM incubated for 30 mins by ethidium bromide staining based gel electrophoresis	25003995
PC3	Apoptosis assay	2 uM	12 hrs	Induction of apoptosis in human PC3 cells at 2 uM incubated for 12 hrs by DAPI staining based confocal laser microscopy	25176329
Sf9	Function assay	10 uM	5 mins	Inhibition of wild type recombinant human Top1 expressed in baculovirus infected insect Sf9 cells assessed as decrease in supercoiled pBS(SK+) DNA isomer relaxation at 10 uM preincubated for 5 mins followed by pBS(SK+) DNA addition by agarose gel electrop	26312433
Sf9	Function assay	10 uM	30 mins	Inhibition of wild type recombinant human Top1 expressed in baculovirus infected insect Sf9 cells assessed as decrease in supercoiled pBS(SK+) DNA isomer relaxation at 10 uM incubated simultaneously with enzyme and pBS(SK+) DNA for 30 mins by agarose gel	26312433
Sf9	Function assay	50 uM	30 mins	Inhibition of wild type recombinant human Top1 expressed in baculovirus infected insect Sf9 cells assessed as stabilization of Top1-cleavage complexes at 50 uM incubated for 30 mins by agarose gel electrophoresis	26312433
HT-29	Function assay	2 uM	1 to 2 hrs	Induction of DNA damage in human HT-29 cells assessed as gamma-H2AX foci formation at 2 uM after 1 to 2 hrs by DAPI staining based indirect immunofluorescence assay	26703795
HT-29	Function assay	2 uM	1 to 2 hrs	Induction of DNA damage in human HT-29 cells assessed as increase in gamma-H2AX protein level at 2 uM after 1 to 2 hrs by Western blot analysis	26703795
H1299	Cytotoxicity assay	up to 50 uM	24 hrs	Cytotoxicity against human H1299 cells overexpressing alphavbeta3 integrin at up to 50 uM after 24 hrs by XTT assay	26719208
A549	Function assay	10 mM	12 to 24 hrs	Drug uptake in human A549 cells at 10 mM after 12 to 24 hrs by flow cytometric method	27156772
A549	Function assay	10 mM	8 hrs	Drug uptake in human A549 cells at 10 mM after 8 hrs by flow cytometric method	27156772
HCT116	Apoptosis assay	6.7 uM	18 hrs	Induction of apoptosis in human HCT116 cells assessed as mitochondrial membrane permeability loss by measuring rhodamine 123 accumulation at 6.7 uM measured after 18 hrs by fluorescence inverted microscopic analysis	27721148
HCT116	Apoptosis assay	6.7 uM	18 hrs	Induction of apoptosis in human HCT116 cells assessed as chromatin condensation at 6.7 uM measured after 18 hrs by Hoechst 33258 staining based fluorescence inverted microscopic analysis	27721148
HCT116	Apoptosis assay	6.7 uM	18 hrs	Induction of apoptosis in human HCT116 cells assessed as appearance of half moon or crescent shape nuclei at 6.7 uM measured after 18 hrs by Hoechst 33258 staining based fluorescence inverted microscopic analysis	27721148
HCT116	Apoptosis assay	6.7 uM	18 hrs	Induction of apoptosis in human HCT116 cells assessed as nuclear fragmentation at 6.7 uM measured after 18 hrs by Hoechst 33258 staining based fluorescence inverted microscopic analysis	27721148
HCT116	Apoptosis assay	6.7 uM	18 hrs	Induction of apoptosis in human HCT116 cells assessed as formation of apoptotic bodies at 6.7 uM measured after 18 hrs by Hoechst 33258 staining based fluorescence inverted microscopic analysis	27721148
CCRF-CEM	Cell cycle assay	0.01 uM	6 hrs	Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at S phase at 0.01 uM after 6 hrs by propidium iodide staining-based flow cytometry	28233677
CCRF-CEM	Apoptosis assay	0.01 uM	72 hrs	Induction of apoptosis in human CCRF-CEM cells at 0.01 uM after 72 hrs by propidium iodide staining-based flow cytometry	28233677
Bel7402	Function assay	1 uM	1 hr	Poison activity at DNA topoisomerase 1 in human Bel7402 cells assessed as induction of DNA damage by measuring upregulated gamma-H2AX levels at 1 uM after 1 hr by Western blot analysis	28333459
Bel7402	Function assay	1 uM	1 hr	Poison activity at DNA topoisomerase 1 in human Bel7402 cells assessed as induction of DNA damage by measuring upregulated levels of CHK1 phosphorylation at Ser345 residue at 1 uM after 1 hr by Western blot analysis	28333459
Bel7402	Function assay	1 nM	1 hr	Poison activity at DNA topoisomerase 1 in human Bel7402 cells assessed as induction of DNA damage by measuring upregulated levels of CHK2 phosphorylation at Thr68 residue at 1 nM after 1 hr by Western blot analysis	28333459
CCRF-CEM	Function assay	100 to 1000 nM	2 hrs	Induction of DNA damage in human CCRF-CEM cells assessed as formation of gamma-H2AX foci at 100 to 1000 nM after 2 hrs by DAPI staining-based confocal microscopy	28418653
CCRF-CEM	Function assay	0.1 to 1 uM	2 hrs	Induction of DNA damage in human CCRF-CEM cells assessed as gamma-H2AX foci formation at 0.1 to 1 uM after 2 hrs by confocal microscopy	28657311
insect cells	Function assay	80 uM	30 mins	Inhibition of human topoisomerase-1 expressed in baculovirus infected insect cells at 80 uM using supercoiled pGEM-5Zf(+) plasmid DNA as substrate after 30 mins by agarose gel electrophoresis method	28753517
Sf9	Function assay	10 to 50 uM	30 mins	Stabilization of recombinant human topoisomerase-1-supercoiled pBS SK(+) DNA cleavage complex at 10 to 50 uM after 30 mins using topoisomerase1 expressed in baculovirus infected cells by ethidium bromide staining based agarose gel electrophoresis meth	29290109
MCF7	Function assay	10 uM	12 hrs	Stabilization of topoisomerase-1- genomic DNA cleavage complex in human MCF7 cells at 10 uM after 12 hrs by ICE assay	29290109
A549	Function assay	2 uM	2 hrs	Induction of DNA damage in human A549 cells assessed as gamma-H2AX foci formation at 2 uM after 2 hrs by DAPI staining based immunofluorescence assay	29843103
A549	Function assay	2 uM	2 hrs	Induction of DNA damage in human A549 cells assessed as increase in gamma-H2AX level at 2 uM after 2 hrs by immunoblot analysis	29843103
A549	Function assay	2 uM	2 hrs	Induction of DNA damage in human A549 cells assessed as increase in CHK1 phosphorylation level at 2 uM after 2 hrs by immunoblot analysis	29843103
HCT116	Antimigratory assay	2 uM	96 hrs	Antimigratory activity in human HCT116 cells at 2 uM after 96 hrs by wound healing assay	30340899
Sf9	Function assay	10 to 25 uM	30 mins	Poison activity at recombinant human TOP1 expressed in baculovirus infected Sf9 insect cells assessed as stabilization of enzyme-pBS(SK+) DNA cleavable complex formation at 10 to 25 uM measured after 30 mins by ethidium bromide staining based agarose gel	30897325
Sf9	Function assay	5 to 25 uM	30 mins	Poison activity at recombinant human TOP1 expressed in baculovirus infected Sf9 insect cells assessed as stabilization of enzyme-25mer duplex oligonucleotide cleavable complex formation at 5 to 25 uM measured after 30 mins by ethidium bromide staining bas	30897325
HCT116	Function assay	25 uM	1 hr	Inhibition of TOP1 in human HCT116 cells assessed as induction of cellular TOP1cc formation at 25 uM incubated for 1 hr by chemiluminescence based assay	31176097
HCT116	Function assay	1 uM	3 hrs	Inhibition of TOP1 in human HCT116 cells assessed as induction of DNA damage by measuring increase in gammaH2AX foci at 1 uM incubated for 3 hrs by DAPI staining based immunofluorescence microscopic method	31176097
MCF7	Function assay	10 uM	12 hrs	Poisoning activity at topoisomerase 1 in human MCF7 cells at 10 uM after 12 hrs by immunoband depletion assay	ChEMBL
MDA-MB-231	Cell cycle assay	1 uM	16 hrs	Cell cycle arrest in human MDA-MB-231 cells assessed as accumulation at S-phase at 1 uM incubated for 16 hrs by flow cytometry	ChEMBL
IMR-32	cytotoxicity assay	~10 μM		IC50=2.21 nM	12617894
Col2	cytotoxicity assay	~1 μM		ED50=57 nM	15043407
HUVEC	cytotoxicity assay	~1 μM		ED50=258 nM	15043407
KB	cytotoxicity assay	~1 μM		ED50=22 nM	15043407
LCNaP	cytotoxicity assay	~1 μM		ED50=28 nM	15043407
Lu1	cytotoxicity assay	~1 μM		ED50=29 nM	15043407
RPMI8402	cytotoxicity assay	~10 μM		IC50=6 nM	15482929
CPT-K5	cytotoxicity assay	~10 μM		IC50>10 μM	15482929
P388	cytotoxicity assay	~10 μM		IC50=14 nM	15482929
P388/CPT45	cytotoxicity assay	~10 μM		IC50>10 μM	15482929
KB3-1	cytotoxicity assay	~10 μM		IC50=40 nM	15482929
KBV-1 + MDR1	cytotoxicity assay	~10 μM		IC50=440 nM	15482929
KBH	cytotoxicity assay	~10 μM		IC50=440 nM	15482929
HOP-62	cytotoxicity assay	~10 μM		GI50=10 nM	15509164
HCT-116	cytotoxicity assay	~10 μM		GI50=30 nM	15509164
F-539	cytotoxicity assay	~10 μM		GI50=10 nM	15509164
UACC-62	cytotoxicity assay	~10 μM		GI50=10 nM	15509164
OVCAR-3	cytotoxicity assay	~10 μM		GI50=220 nM	15509164
SN12C	cytotoxicity assay	~10 μM		GI50=20 nM	15509164
DU-145	cytotoxicity assay	~10 μM		GI50=10 nM	15509164
MDA-MB-435	cytotoxicity assay	~10 μM		GI50=40 nM	15509164
A427	Growth inhibitory assay	~1 μM		IC50=24 nM	9876111
PC-3	Growth inhibitory assay	~1 μM		IC50=57 nM	9876111
K562adr	Growth inhibitory assay	~1 μM		IC50=57 nM	9876111
MCF7mdr	Growth inhibitory assay	~1 μM		IC50=3.1 nM	9876111
HT29	Apoptosis assay	5 uM		Induction of apoptosis in human HT29 cells at 5 uM	17512744
U937	Antiproliferative assay		72 hrs	Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay, IC50=0.015μM.	17158054
U937	Antiproliferative assay		48 hrs	Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay, IC50=0.032μM.	17158054
U937	Antiproliferative assay		24 hrs	Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay, IC50=0.68μM.	17158054
K562	Growth inhibition assay		5 days	Growth inhibition of K562 cells by XTT assay after 5 days, IC50=0.04μM.	17411092
MCF7	Growth inhibition assay		4 days	Growth inhibition of adriamycin-resistant MCF7 cells after 4 days, GI50=0.01μM.	17418582
HeLa	Growth inhibition assay		4 days	Growth inhibition of HeLa cells after 4 days, GI50=0.01μM.	17418582
MCF7	Growth inhibition assay		4 days	Growth inhibition of MCF7 cells after 4 days, GI50=0.01μM.	17418582
P388	Cytotoxicity assay		72 hrs	Cytotoxicity against mouse P388 cells after 72 hrs, IC50=0.0321μM.	17624792
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells after 48 hrs, IC50=0.004μM.	17673337
SK-OV3	Cytotoxicity assay		48 hrs	Cytotoxicity against human SK-OV3 cells after 48 hrs, IC50=0.014μM.	17673337
HCT15	Cytotoxicity assay		48 hrs	Cytotoxicity against human HCT15 cells after 48 hrs, IC50=0.083μM.	17673337
SK-MEL-2	Cytotoxicity assay		48 hrs	Cytotoxicity against human SK-MEL-2 cells after 48 hrs, IC50=0.165μM.	17673337
HL60	Cytotoxicity assay		48 hrs	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, GI50=0.0017μM.	17962028
Jurkat	Growth inhibition assay		96 hrs	Growth inhibition of human Jurkat cells after 96 hrs, IC50=0.0014μM.	18061452
K562	Cytotoxicity assay		5 days	Cytotoxicity against human K562 cells after 5 days by XTT assay, IC50=0.04μM.	18076140
A2780	Cytotoxicity assay		96 hrs	Cytotoxicity against human A2780 cells after 96 hrs by MTT assay, IC50=0.28μM.	18095653
A549	Cytotoxicity assay		96 hrs	Cytotoxicity against human A549 cells after 96 hrs by MTT assay, IC50=3.12μM.	18095653
HCT8	Cytotoxicity assay		96 hrs	Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay, IC50=3.15μM.	18095653
BGC823	Cytotoxicity assay		96 hrs	Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay, IC50=9.67μM.	18095653
Bel7402	Cytotoxicity assay		96 hrs	Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay, IC50=12.5μM.	18095653
PC3	Antiproliferative assay		48 hrs	Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay, GI50=0.09μM.	18180162
HeLa	Antiproliferative assay		48 hrs	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, GI50=0.18μM.	18180162
SKHep	Antiproliferative assay		48 hrs	Antiproliferative activity against human SKHep cells after 48 hrs by MTT assay, GI50=0.22μM.	18180162
A549	Antiproliferative assay		48 hrs	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, GI50=2.8μM.	18180162
SAS	Antiproliferative assay		48 hrs	Antiproliferative activity against human SAS cells after 48 hrs by MTT assay, GI50=6μM.	18180162
AGS	Antiproliferative assay		48 hrs	Antiproliferative activity against human AGS cells after 48 hrs by MTT assay, GI50=23.76μM.	18180162
H460	Cytotoxicity assay		72 hrs	Cytotoxicity against human H460 cells after 72 hrs, IC50=0.0062μM.	18419110
IGROV1	Cytotoxicity assay		72 hrs	Cytotoxicity against human IGROV1 cells after 72 hrs, IC50=0.012μM.	18419110
H460	Cytotoxicity assay		1 hr	Cytotoxicity against human H460 cells after 1 hr, IC50=0.33μM.	18419110
IGROV1	Cytotoxicity assay		1 hr	Cytotoxicity against human IGROV1 cells after 1 hr, IC50=1.65μM.	18419110
HT29	Cytotoxicity assay		1 hr	Cytotoxicity against human HT29 cells after 1 hr, IC50=3.16μM.	18419110
HT29	Cytotoxicity assay		1 hr	Cytotoxicity against human mitoxantrone-resistant HT29 cells after 1 hr, IC50=8.81μM.	18419110
H460	Antiproliferative assay		1 hr	Antiproliferative activity against human H460 cells after 1 hr of drug exposure measured after 72 hrs, IC50=0.18μM.	18424133
HT29	Antiproliferative assay		1 hr	Antiproliferative activity against human HT29 cells after 1 hr of drug exposure measured after 72 hrs, IC50=3.16μM.	18424133
HT29	Antiproliferative assay		1 hr	Antiproliferative activity against BCRP overexpressing mitoxantrone-resistant human HT29 cells after 1 hr of drug exposure measured after 72 hrs, IC50=8.81μM.	18424133
KB	Cytotoxicity assay		4 days	Cytotoxicity against human KB cells after 4 days by MTT assay, IC50=0.003μM.	18554906
A549	Cytotoxicity assay		4 days	Cytotoxicity against human A549 cells after 4 days by MTT assay, IC50=0.01μM.	18554906
HT29	Cytotoxicity assay		4 days	Cytotoxicity against human HT29 cells after 4 days by MTT assay, IC50=0.09μM.	18554906
HepG2	Cytotoxicity assay		4 days	Cytotoxicity against human HepG2 cells after 4 days by MTT assay, IC50=0.13μM.	18554906
BEL-7402	Cytotoxicity assay		4 days	Cytotoxicity against human BEL-7402 cells after 4 days by MTT assay, IC50=0.17μM.	18554906
MCF7	Cytotoxicity assay		4 days	Cytotoxicity against human MCF7 cells after 4 days by MTT assay, IC50=0.2μM.	18554906
A2780	Cytotoxicity assay		4 days	Cytotoxicity against human A2780 cells after 4 days by MTT assay, IC50=0.2μM.	18554906
BXPC3	Cytotoxicity assay		4 days	Cytotoxicity against human BXPC3 cells after 4 days by MTT assay, IC50=0.24μM.	18554906
NCI446	Cytotoxicity assay		4 days	Cytotoxicity against human NCI446 cells after 4 days by MTT assay, IC50=3.28μM.	18554906
RPMI8402	Cytotoxicity assay		4 days	Cytotoxicity against human RPMI8402 cells after 4 days by MTT assay, IC50=0.005μM.	18676151
P388	Cytotoxicity assay		4 days	Cytotoxicity against mouse P388 cells after 4 days by MTT assay, IC50=0.009μM.	18676151
KB3-1	Cytotoxicity assay		4 days	Cytotoxicity against human KB3-1 cells after 4 days by MTT assay, IC50=0.015μM.	18676151
KBV1	Cytotoxicity assay		4 days	Cytotoxicity against human multidrug resistant MDR1 overexpressing human KBV1 cells after 4 days by MTT assay, IC50=0.025μM.	18676151
KBH5.0	Cytotoxicity assay		4 days	Cytotoxicity against human multidrug resistant BCRP overexpressing human KBH5.0 cells after 4 days by MTT assay, IC50=0.026μM.	18676151
CCRF-CEM	Cytotoxicity assay		3 days	Cytotoxicity against p38-proficient human CCRF-CEM cells after 3 days by MTT assay, IC50=0.04μM.	19203291
A2780	Cytotoxicity assay		96 hrs	Cytotoxicity against human A2780 cells after 96 hrs by MTT assay, IC50=0.3μM.	19256478
A549	Cytotoxicity assay		96 hrs	Cytotoxicity against human A549 cells after 96 hrs by MTT assay, IC50=3.1μM.	19256478
HCT8	Cytotoxicity assay		96 hrs	Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay, IC50=3.2μM.	19256478
BGC823	Cytotoxicity assay		96 hrs	Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay, IC50=9.7μM.	19256478
Bel7402	Cytotoxicity assay		96 hrs	Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay, IC50=12.5μM.	19256478
P388	Cytotoxicity assay		4 days	Cytotoxicity against mouse P388 cells after 4 days by MTT assay, IC50=0.004μM.	19299037
RPMI8402	Cytotoxicity assay		4 days	Cytotoxicity against human RPMI8402 cells after 4 days by MTT assay, IC50=0.004μM.	19299037
P388	Cytotoxicity assay		4 days	Cytotoxicity against mouse P388 cells after 4 days by MTT method, IC50=0.004μM.	19303306
RPMI8402	Cytotoxicity assay		4 days	Cytotoxicity against human RPMI8402 cells after 4 days by MTT method, IC50=0.004μM.	19303306
A2780	Cytotoxicity assay		96 hrs	Cytotoxicity against human A2780 cells after 96 hrs by MTT assay, IC50=0.28μM.	19453174
NCI-H460	Antiproliferative assay		1 hr	Antiproliferative activity against human NCI-H460 cells after short term exposure for 1 hr measured after 72 hrs in drug-free medium, IC50=0.33μM.	19530720
HCT116	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay, IC50=0.002μM.	19655762
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay, IC50=0.003μM.	19655762
HCT15	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay, IC50=0.003μM.	19655762
HL60	Cytotoxicity assay		72 hrs	Cytotoxicity against human HL60 cells after 72 hrs by MTS assay, IC50=0.006μM.	19655762
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay, IC50=0.01μM.	19655762
KB	Cytotoxicity assay		72 hrs	Cytotoxicity against human KB cells after 72 hrs by MTS assay, IC50=0.038μM.	19655762
HepG2	Cytotoxicity assay		72 hrs	Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay, IC50=0.455μM.	19655762
SW1573	Growth inhibition assay		48 hrs	Growth inhibition of human SW1573 cells after 48 hrs by sulforhodamine B assay, GI50=0.21μM.	19664930
HBL100	Growth inhibition assay		48 hrs	Growth inhibition of human HBL100 cells after 48 hrs by sulforhodamine B assay, GI50=0.23μM.	19664930
A2780	Growth inhibition assay		48 hrs	Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay, GI50=0.46μM.	19664930
HeLa	Growth inhibition assay		48 hrs	Growth inhibition of human HeLa cells after 48 hrs by sulforhodamine B assay, GI50=1.3μM.	19664930
WiDr	Growth inhibition assay		48 hrs	Growth inhibition of human WiDr cells after 48 hrs by sulforhodamine B assay, GI50=1.7μM.	19664930
T47D	Growth inhibition assay		48 hrs	Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay, GI50=1.9μM.	19664930
HCT116	Antiproliferative assay		3 days	Antiproliferative activity against human HCT116 cells after 3 days by XTT assay, IC50=0.13μM.	19691293
SW948	Antiproliferative assay		3 days	Antiproliferative activity against human SW948 cells after 3 days by XTT assay, IC50=0.16μM.	19691293
A2780	Cytotoxicity assay		4 days	Cytotoxicity against human A2780 cells after 4 days by MTT assay, IC50=0.3μM.	19702283
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells expressing wild type p53 after 48 hrs by SRB assay, GI50=0.01μM.	19715319
AGS	Cytotoxicity assay		48 hrs	Cytotoxicity against human AGS cells expressing wild type p53 after 48 hrs by SRB assay, GI50=0.01μM.	19715319
MCF7	Cytotoxicity assay		48 hrs	Cytotoxicity against estrogen receptor-positive human MCF7 cells expressing wild type p53 after 48 hrs by SRB assay, GI50=0.01μM.	19715319
Hep3B	Cytotoxicity assay		48 hrs	Cytotoxicity against p53-deficient human Hep3B cells after 48 hrs by SRB assay, GI50=0.01μM.	19715319
AGS	Cytotoxicity assay		48 hrs	Cytotoxicity against human AGS cells expressing wild type p53 after 48 hrs by SRB assay, IC50=0.02μM.	19715319
HT-29	Cytotoxicity assay		48 hrs	Cytotoxicity against human HT-29 cells expressing p53 mutant after 48 hrs by SRB assay, GI50=0.03μM.	19715319
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells expressing wild type p53 after 48 hrs by SRB assay, IC50=0.04μM.	19715319
HeLa	Cytotoxicity assay		48 hrs	Cytotoxicity against p53-deficient human HeLa cells after 48 hrs by SRB assay, GI50=0.04μM.	19715319
Hep3B	Cytotoxicity assay		48 hrs	Cytotoxicity against p53-deficient human Hep3B cells after 48 hrs by SRB assay, IC50=0.06μM.	19715319
MDA-MB-261	Cytotoxicity assay		48 hrs	Cytotoxicity against estrogen receptor-negative human MDA-MB-261 cells expressing p53 mutant after 48 hrs by SRB assay, GI50=0.08μM.	19715319
HepG2	Cytotoxicity assay		48 hrs	Cytotoxicity against human HepG2 cells expressing wild type p53 after 48 hrs by SRB assay, GI50=0.1μM.	19715319
HepG2	Cytotoxicity assay		48 hrs	Cytotoxicity against human HepG2 cells expressing wild type p53 after 48 hrs by SRB assay, IC50=0.2μM.	19715319
HeLa	Cytotoxicity assay		48 hrs	Cytotoxicity against p53-deficient human HeLa cells after 48 hrs by SRB assay, IC50=0.2μM.	19715319
U937	Cytotoxicity assay		48 hrs	Cytotoxicity against human U937 cells expressing p53 mutant after 48 hrs by SRB assay, IC50=0.3μM.	19715319
HT-29	Cytotoxicity assay		48 hrs	Cytotoxicity against human HT-29 cells expressing p53 mutant after 48 hrs by SRB assay, IC50=0.4μM.	19715319
THP1	Cytotoxicity assay		48 hrs	Cytotoxicity against human THP1 cells expressing p53 mutant after 48 hrs by SRB assay, IC50=0.6μM.	19715319
PC3	Cytotoxicity assay		48 hrs	Cytotoxicity against p53-deficient human PC3 cells after 48 hrs by SRB assay, GI50=0.7μM.	19715319
MCF7	Cytotoxicity assay		48 hrs	Cytotoxicity against estrogen receptor-positive human MCF7 cells expressing wild type p53 after 48 hrs by SRB assay, IC50=1.1μM.	19715319
PC3	Cytotoxicity assay		48 hrs	Cytotoxicity against p53-deficient human PC3 cells after 48 hrs by SRB assay, IC50=1.4μM.	19715319
K562	Cytotoxicity assay		48 hrs	Cytotoxicity against p53-deficient human K562 cells after 48 hrs by SRB assay, IC50=1.4μM.	19715319
MDA-MB-261	Cytotoxicity assay		48 hrs	Cytotoxicity against estrogen receptor-negative human MDA-MB-261 cells expressing p53 mutant after 48 hrs by SRB assay, IC50=1.7μM.	19715319
CCRF-CEM	Cytotoxicity assay		48 hrs	Cytotoxicity against human CCRF-CEM cells after 48 hrs by cell titer-blue assay, GI50=0.000023μM.	19743858
CCRF-CEM/C2	Cytotoxicity assay		48 hrs	Cytotoxicity against human CCRF-CEM/C2 cells after 48 hrs by cell titer-blue assay, GI50=0.04321μM.	19743858
MCF7	Cytotoxicity assay		4 days	Cytotoxicity against human MCF7 cells after 4 days by ELISA reader assay, IC50=0.06μM.	19939682
K562	Cytotoxicity assay		4 days	Cytotoxicity against human K562 cells after 4 days by ELISA reader assay, IC50=0.08μM.	19939682
HeLa	Cytotoxicity assay		4 days	Cytotoxicity against human HeLa cells after 4 days by ELISA reader assay, IC50=0.63μM.	19939682
DU145	Cytotoxicity assay		4 days	Cytotoxicity against human DU145 cells after 4 days by ELISA reader assay, IC50=0.66μM.	19939682
HCT15	Cytotoxicity assay		4 days	Cytotoxicity against human HCT15 cells after 4 days by ELISA reader assay, IC50=0.76μM.	19939682
MDA-MB-231	Cytotoxicity assay		3 days	Cytotoxicity against human MDA-MB-231 cells after 3 days, IC50=1.1μM.	19954977
DU145	Cytotoxicity assay		3 days	Cytotoxicity against human DU145 cells after 3 days, IC50=1.46μM.	19954977
HeLa	Cytotoxicity assay		3 days	Cytotoxicity against human HeLa cells after 3 days, IC50=1.85μM.	19954977
HCT116	Cytotoxicity assay		3 days	Cytotoxicity against human HCT116 cells after 3 days, IC50=2.77μM.	19954977
MCF7	Cytotoxicity assay		3 days	Cytotoxicity against human MCF7 cells after 3 days, IC50=7.42μM.	19954977
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells after 48 hrs by MTT method, IC50=0.005379μM.	20063889
HL60	Cytotoxicity assay		48 hrs	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50=0.065μM.	20093033
HT-29	Cytotoxicity assay		48 hrs	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay, IC50=0.85μM.	20093033
HeLa	Cytotoxicity assay		48 hrs	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50=0.86μM.	20093033
MDA-MB-231	Cytotoxicity assay		48 hrs	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50=0.92μM.	20093033
DU145	Cytotoxicity assay		48 hrs	Cytotoxicity against human DU145 cells after 48 hrs by MTT assay, IC50=3.57μM.	20093033
THP1	Cytotoxicity assay		72 hrs	Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method, EC50=0.16μM.	20192247
KB	Cytotoxicity assay		3 days	Cytotoxicity against human KB cells after 3 days by MTT assay, IC50<0.013μM.	20392545
HCT8	Cytotoxicity assay		3 days	Cytotoxicity against human HCT8 cells after 3 days by MTT assay, IC50<0.013μM.	20392545
MCF7	Cytotoxicity assay		3 days	Cytotoxicity against human MCF7 cells after 3 days by MTT assay, IC50=0.02μM.	20392545
HL60	Cytotoxicity assay		2 days	Cytotoxicity against human HL60 cells after 2 days by automatic ELISA reader system, IC50=0.1μM.	20392646
MDA-MB-231	Cytotoxicity assay		2 days	Cytotoxicity against human MDA-MB-231 cells after 2 days by automatic ELISA reader system, IC50=0.3μM.	20392646
HeLa	Cytotoxicity assay		2 days	Cytotoxicity against human HeLa cells after 2 days by automatic ELISA reader system, IC50=0.4μM.	20392646
DU145	Cytotoxicity assay		2 days	Cytotoxicity against human DU145 cells after 2 days by automatic ELISA reader system, IC50=0.4μM.	20392646
HCT15	Cytotoxicity assay		2 days	Cytotoxicity against human HCT15 cells after 2 days by automatic ELISA reader system, IC50=0.5μM.	20392646
SKBR3	Antiproliferative assay		48 hrs	Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 48 hrs by SRB assay, GI50=0.15μM.	20438092
MCF7/BUS	Antiproliferative assay		48 hrs	Antiproliferative activity against human MCF7/BUS cells expressing estrogen receptor after 48 hrs by SRB assay, GI50=0.21μM.	20438092
MCF7	Antiproliferative assay		48 hrs	Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by SRB assay, GI50=0.28μM.	20438092
MDA-MB-231	Antiproliferative assay		48 hrs	Antiproliferative activity against estrogen receptor deficient human MDA-MB-231 cells after 48 hrs by SRB assay, GI50=1.3μM.	20438092
T47D	Antiproliferative assay		48 hrs	Antiproliferative activity against human T47D cells expressing estrogen receptor after 48 hrs by SRB assay, GI50=2μM.	20438092
K562	Cytotoxicity assay		72 hrs	Cytotoxicity against imatinib-resistant human K562 cells after 72 hrs by MTT assay, IC50=0.002μM.	20590148
DA1-3b/M2	Cytotoxicity assay		72 hrs	Cytotoxicity against imatinib and dasatinib-resistant mouse DA1-3b/M2 cells after 72 hrs by MTT assay, IC50=0.03μM.	20590148
NCI-H460	Cytotoxicity assay		72 hrs	Cytotoxicity against human NCI-H460 cells after 72 hrs by XTT assay, GI50=0.03μM.	20591678
K562	Cytotoxicity assay		72 hrs	Cytotoxicity against human K562 cells after 72 hrs by XTT assay, GI50=0.06μM.	20591678
SF268	Cytotoxicity assay		72 hrs	Cytotoxicity against human SF268 cells after 72 hrs by XTT assay, GI50=0.19μM.	20591678
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells after 72 hrs by XTT assay, GI50=0.57μM.	20591678
Detroit 551	Cytotoxicity assay		72 hrs	Cytotoxicity against human Detroit 551 cells after 72 hrs by XTT assay, GI50=0.99μM.	20591678
HeLa	Cytotoxicity assay		4 days	Cytotoxicity against human HeLa cells after 4 days by MTT assay, IC50=1.1μM.	20619511
HCT116	Cytotoxicity assay		4 days	Cytotoxicity against human HCT116 cells after 4 days by MTT assay, IC50=2.3μM.	20619511
DU145	Cytotoxicity assay		4 days	Cytotoxicity against human DU145 cells after 4 days by MTT assay, IC50=3.2μM.	20619511
MDA-MB-231	Cytotoxicity assay		4 days	Cytotoxicity against human MDA-MB-231 cells after 4 days by MTT assay, IC50=4.2μM.	20619511
MCF7	Cytotoxicity assay		4 days	Cytotoxicity against human MCF7 cells after 4 days by MTT assay, IC50=14.2μM.	20619511
U87MG	Cytotoxicity assay		6 days	Cytotoxicity against human U87MG cells after 6 days, LD50=0.02μM.	20655220
HeLa	Cytotoxicity assay		48 hrs	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, GI50=0.08μM.	20662543
PC3	Cytotoxicity assay		48 hrs	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay, GI50=0.09μM.	20662543
SKHep	Cytotoxicity assay		48 hrs	Cytotoxicity against human SKHep cells after 48 hrs by MTT assay, GI50=0.22μM.	20662543
Detroit 551	Cytotoxicity assay		48 hrs	Cytotoxicity against human Detroit 551 cells after 48 hrs by MTT assay, GI50=0.99μM.	20662543
BT-483	Cytotoxicity assay		48 hrs	Cytotoxicity against human BT-483 cells after 48 hrs by MTT assay, GI50=1.03μM.	20662543
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells after 48 hrs by MTT assay, GI50=2.8μM.	20662543
SAS	Cytotoxicity assay		48 hrs	Cytotoxicity against human SAS cells after 48 hrs by MTT assay, GI50=6μM.	20662543
HT-29	Cytotoxicity assay		3 days	Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay, ED50=0.06μM.	20939540
A549	Cytotoxicity assay		3 days	Cytotoxicity against human A549 cells after 3 days by MTT assay, IC50=0.057μM.	20942490
MDA-MB-435	Cytotoxicity assay		3 days	Cytotoxicity against human MDA-MB-435 cells after 3 days by MTT assay, IC50=0.71μM.	20942490
LoVo	Cytotoxicity assay		3 days	Cytotoxicity against human LoVo cells after 3 days by MTT assay, IC50=3.1μM.	20942490
A2780	Cytotoxicity assay		24 hrs	Cytotoxicity against human A2780 cells after 24 hrs by MTT assay, IC50=0.2μM.	20961093
A549	Cytotoxicity assay		24 hrs	Cytotoxicity against human A549 cells after 24 hrs by MTT assay, IC50=3.6μM.	20961093
HeLa	Cytotoxicity assay		72 hrs	Cytotoxicity against human HeLa cells after 72 hrs by trypan blue assay, IC50=0.0089μM.	21071230
A431	Cytotoxicity assay		72 hrs	Cytotoxicity against human A431 cells after 72 hrs by trypan blue assay, IC50=0.011μM.	21071230
HL60	Cytotoxicity assay		72 hrs	Cytotoxicity against human HL60 cells after 72 hrs by trypan blue assay, IC50=0.017μM.	21071230
DU145	Anticancer assay		48 hrs	Anticancer activity against human DU145 cells assessed as cell viability after 48 hrs by SRB assay, IC50=0.02μM.	21074444
A549	Anticancer assay		48 hrs	Anticancer activity against human A549 cells assessed as cell viability after 48 hrs by SRB assay, IC50=0.03μM.	21074444
PC3	Anticancer assay		48 hrs	Anticancer activity against human PC3 cells assessed as cell viability after 48 hrs by SRB assay, IC50=0.03μM.	21074444
HCT15	Anticancer assay		48 hrs	Anticancer activity against human HCT15 cells assessed as cell viability after 48 hrs by SRB assay, IC50=0.067μM.	21074444
IMR32	Anticancer assay		48 hrs	Anticancer activity against human IMR32 cells assessed as cell viability after 48 hrs by SRB assay, IC50=0.08μM.	21074444
Hep2	Anticancer assay		48 hrs	Anticancer activity against human Hep2 cells assessed as cell viability after 48 hrs by SRB assay, IC50=0.7μM.	21074444
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, GI50=0.01μM.	21115210
HT-29	Cytotoxicity assay		72 hrs	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, GI50=0.05μM.	21115210
PC3	Cytotoxicity assay		72 hrs	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, GI50=0.06μM.	21115210
K562	Cytotoxicity assay		72 hrs	Cytotoxicity against human K562 cells after 72 hrs by MTT assay, GI50=0.06μM.	21115210
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, TGI=0.16μM.	21115210
HT-29	Cytotoxicity assay		72 hrs	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, LC50=31.62μM.	21115210
HT-29	Cytotoxicity assay		72 hrs	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, TGI=31.62μM.	21115210
U87	Cytotoxicity assay		72 hrs	Cytotoxicity against human U87 cells after 72 hrs by MTT assay, IC50=0.5μM.	21186067
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50=0.65μM.	21186067
HeLa	Cytotoxicity assay		72 hrs	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50=1.5μM.	21186067
H69	Cytotoxicity assay		72 hrs	Cytotoxicity against human H69 cells after 72 hrs by alamar blue assay, IC50=0.001μM.	21341674
PC3	Cytotoxicity assay		72 hrs	Cytotoxicity against human PC3 cells after 72 hrs by alamar blue assay, IC50=0.012μM.	21341674
H460	Cytotoxicity assay		72 hrs	Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay, IC50=0.013μM.	21341674
MES-SA/Dx5	Cytotoxicity assay		72 hrs	Cytotoxicity against human MES-SA/Dx5 cells overexpressing MDR1 after 72 hrs by alamar blue assay, IC50=0.052μM.	21341674
MESSA	Cytotoxicity assay		72 hrs	Cytotoxicity against human MESSA cells after 72 hrs by alamar blue assay, IC50=0.057μM.	21341674
HT-29	Cytotoxicity assay		72 hrs	Cytotoxicity against human HT-29 cells after 72 hrs by alamar blue assay, IC50=0.26μM.	21341674
LoVo	Cytotoxicity assay		72 hrs	Cytotoxicity against human LoVo cells after 72 hrs by MTT assay, GI50=0.008μM.	21388138
U373	Cytotoxicity assay		72 hrs	Cytotoxicity against human U373 cells after 72 hrs by MTT assay, GI50=0.033μM.	21388138
SK-MEL	Cytotoxicity assay		72 hrs	Cytotoxicity against human SK-MEL cells after 72 hrs by MTT assay, GI50=0.047μM.	21388138
Jurkat	Cytotoxicity assay		72 hrs	Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay, GI50=0.09μM.	21388138
A549	Cytotoxicity assay		72 hrs	Cytotoxicity against human A549 cells after 72 hrs by MTT assay, GI50=0.2μM.	21388138
PC3	Cytotoxicity assay		72 hrs	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, GI50=0.48μM.	21388138
HeLa	Cytotoxicity assay		72 hrs	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, GI50=1.3μM.	21388138
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, GI50=6μM.	21388138
MDA-MB-231	Cell cycle assay		24 hrs	Cell cycle arrest in human MDA-MB-231 cells assessed as increase of cells in sub-G0 phase after 24 hrs using annexin V/propidium iodide staining by flow cytometry	21391655
HL60	Cytotoxicity assay		2 days	Cytotoxicity against human HL60 cells after 2 days, IC50=0.065μM.	21419530
DU145	Cytotoxicity assay		2 days	Cytotoxicity against human DU145 cells after 2 days, IC50=0.31μM.	21419530
MDA-MB-231	Cytotoxicity assay		2 days	Cytotoxicity against human MDA-MB-231 cells after 2 days, IC50=0.97μM.	21419530
HeLa	Cytotoxicity assay		2 days	Cytotoxicity against human HeLa cells after 2 days, IC50=1.08μM.	21419530
HCT116	Cytotoxicity assay		2 days	Cytotoxicity against human HCT116 cells after 2 days, IC50=3.97μM.	21419530
H460	Cytotoxicity assay		72 hrs	Cytotoxicity against human H460 cells after 72 hrs by MTS assay, IC50<0.04μM.	21513293
SF268	Cytotoxicity assay		72 hrs	Cytotoxicity against human SF268 cells after 72 hrs by MTS assay, IC50=0.04μM.	21513293
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay, IC50=0.07μM.	21513293
HL60	Cytotoxicity assay		2 days	Cytotoxicity against human HL60 cells after 2 days, IC50=0.1μM.	21601964
MDA-MB-231	Cytotoxicity assay		2 days	Cytotoxicity against human MDA-MB-231 cells after 2 days, INH=0.3μM.	21601964
HeLa	Cytotoxicity assay		2 days	Cytotoxicity against human HeLa cells after 2 days, IC50=0.4μM.	21601964
DU145	Cytotoxicity assay		2 days	Cytotoxicity against human DU145 cells after 2 days, IC50=0.4μM.	21601964
HCT15	Cytotoxicity assay		2 days	Cytotoxicity against human HCT15 cells after 2 days, IC50=0.5μM.	21601964
MIAPaCa2	Cytotoxicity assay		24 hrs	Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay, IC50=0.4μM.	21775156
HOP62	Cytotoxicity assay		48 hrs	Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay, GI50=0.01μM.	21823606
UACC62	Cytotoxicity assay		48 hrs	Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay, GI50=0.01μM.	21823606
SF539	Cytotoxicity assay		48 hrs	Cytotoxicity against human SF539 cells after 48 hrs by SRB assay, GI50=0.01μM.	21823606
DU145	Cytotoxicity assay		48 hrs	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay, GI50=0.01μM.	21823606
MCF7	Cytotoxicity assay		48 hrs	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay, GI50=0.013μM.	21823606
SN12C	Cytotoxicity assay		48 hrs	Cytotoxicity against human SN12C cells after 48 hrs by SRB assay, GI50=0.02μM.	21823606
HCT116	Cytotoxicity assay		48 hrs	Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay, GI50=0.03μM.	21823606
OVCAR3	Cytotoxicity assay		48 hrs	Cytotoxicity against human OVCAR3 cells after 48 hrs by SRB assay, GI50=0.22μM.	21823606
Caco2	Cytotoxicity assay		24 hrs	Cytotoxicity against human Caco2 cells assessed as cell viability after 24 hrs by MTT assay, IC50=9.55μM.	21843907
HT-29	Cytotoxicity assay		24 hrs	Cytotoxicity against human HT-29 cells assessed as cell viability after 24 hrs by MTT assay, IC50=10μM.	21843907
HT-29	Function assay		24 hrs	Induction of mitochondrial dysfunction in human HT-29 cells assessed as increase in cytosolic cytochrome c level after 24 hrs by enzyme immunometric assay	21843907
Caco2	Function assay		24 hrs	Induction of mitochondrial dysfunction in human Caco2 cells assessed as increase in cytosolic cytochrome c level after 24 hrs by enzyme immunometric assay	21843907
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50=0.091μM.	21873069
HCT15	Cytotoxicity assay		48 hrs	Cytotoxicity against human HCT15 cells after 48 hrs by MTT assay, IC50=0.166μM.	21873069
SKOV3	Cytotoxicity assay		48 hrs	Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay, IC50=2.544μM.	21873069
SK-MEL-2	Cytotoxicity assay		48 hrs	Cytotoxicity against human SK-MEL-2 cells after 48 hrs by MTT assay, IC50=7.86μM.	21873069
SMMC7721	Cytotoxicity assay		48 hrs	Cytotoxicity against human SMMC7721 cells after 48 hrs by SRB assay, IC50=0.003μM.	21973054
MCF7	Antiproliferative assay		72 hrs	Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay, IC50=0.056μM.	21978950
HeLa	Cytotoxicity assay		24 hrs	Cytotoxicity against human HeLa cells assessed as inhibition of cell viability after 24 hrs by MTT assay, IC50=8.93μM.	21983445
A2780	Cytotoxicity assay		96 hrs	Cytotoxicity against human A2780 cells after 96 hrs by MTT assay, IC50=0.26μM.	22044245
HCT8	Cytotoxicity assay		96 hrs	Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay, IC50=0.26μM.	22044245
Bel7402	Cytotoxicity assay		96 hrs	Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay, IC50=0.26μM.	22044245
BCG823	Cytotoxicity assay		96 hrs	Cytotoxicity against human BCG823 cells after 96 hrs by MTT assay, IC50=0.26μM.	22044245
A549	Cytotoxicity assay		96 hrs	Cytotoxicity against human A549 cells after 96 hrs by MTT assay, IC50=0.26μM.	22044245
CCRF-CEM	Cytotoxicity assay		96 hrs	Cytotoxicity against human CCRF-CEM cells after 96 hrs by MTT assay, CC50=0.003μM.	22047799
CCRF-SB	Cytotoxicity assay		96 hrs	Cytotoxicity against human CCRF-SB cells after 96 hrs by MTT assay, CC50=0.004μM.	22047799
WIL2-NS	Cytotoxicity assay		96 hrs	Cytotoxicity against human WIL2-NS cells after 96 hrs by MTT assay, CC50=0.005μM.	22047799
DU145	Cytotoxicity assay		96 hrs	Cytotoxicity against human DU145 cells after 96 hrs by MTT assay, CC50=0.015μM.	22047799
MCF7	Cytotoxicity assay		96 hrs	Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay, CC50=0.02μM.	22047799
HepG2	Cytotoxicity assay		96 hrs	Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay, CC50=0.02μM.	22047799
SKMES1	Cytotoxicity assay		96 hrs	Cytotoxicity against human SKMES1 cells after 96 hrs by MTT assay, CC50=0.03μM.	22047799
SK-MEL-28	Cytotoxicity assay		96 hrs	Cytotoxicity against human SK-MEL-28 cells after 96 hrs by MTT assay, CC50=0.07μM.	22047799
MRC5	Cytotoxicity assay		96 hrs	Cytotoxicity against human MRC5 cells after 96 hrs by MTT assay, CC50=0.2μM.	22047799
CRL7065	Cytotoxicity assay		96 hrs	Cytotoxicity against human CRL7065 cells after 96 hrs by MTT assay, CC50=0.3μM.	22047799
MT4	Cytotoxicity assay		96 hrs	Cytotoxicity against human MT4 cells after 96 hrs, IC50=0.004μM.	22276775
DU145	Cytotoxicity assay		96 hrs	Cytotoxicity against human DU145 cells after 96 hrs, IC50=0.015μM.	22276775
HepG2	Cytotoxicity assay		96 hrs	Cytotoxicity against human HepG2 cells after 96 hrs, IC50=0.02μM.	22276775
HCT15	Cytotoxicity assay		2 days	Cytotoxicity against human HCT15 cells after 2 days, IC50=0.26μM.	22318164
HeLa	Cytotoxicity assay		2 days	Cytotoxicity against human HeLa cells after 2 days, IC50=1.01μM.	22318164
K562	Cytotoxicity assay		2 days	Cytotoxicity against human K562 cells after 2 days, IC50=1.18μM.	22318164
DU145	Cytotoxicity assay		2 days	Cytotoxicity against human DU145 cells after 2 days, IC50=2.37μM.	22318164
MCF7	Cytotoxicity assay		2 days	Cytotoxicity against human MCF7 cells after 2 days, IC50=3.91μM.	22318164
A549	Cytotoxicity assay		2 days	Cytotoxicity against human A549 cells after 2 days by MTT assay, IC50=0.008μM.	22325897
Jurkat	Cytotoxicity assay		2 days	Cytotoxicity against human Jurkat cells after 2 days by MTT assay, IC50=0.026μM.	22325897
THP1	Cytotoxicity assay		2 days	Cytotoxicity against human THP1 cells after 2 days by MTT assay, IC50=0.071μM.	22325897
HL60	Cytotoxicity assay		2 days	Cytotoxicity against human HL60 cells after 2 days by MTT assay, IC50=0.6μM.	22325897
U937	Cytotoxicity assay		2 days	Cytotoxicity against human U937 cells after 2 days by MTT assay, IC50=1.98μM.	22325897
HepG2	Cytotoxicity assay		24 hrs	Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay, IC50=6.4μM.	22326393
FHCC-98	Cytotoxicity assay		24 hrs	Cytotoxicity against human FHCC-98 cells after 24 hrs by MTT assay, IC50=15.2μM.	22326393
QSG7701	Cytotoxicity assay		24 hrs	Cytotoxicity against human QSG7701 cells after 24 hrs by MTT assay, IC50=18.3μM.	22326393
SF539	Growth inhibition assay		48 hrs	Growth inhibition of human SF539 cells after 48 hrs by sulforhodamine B assay, GI50=0.01μM.	22329436
UACC62	Growth inhibition assay		48 hrs	Growth inhibition of human UACC62 cells after 48 hrs by sulforhodamine B assay, GI50=0.01μM.	22329436
DU145	Growth inhibition assay		48 hrs	Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay, GI50=0.01μM.	22329436
HOP62	Growth inhibition assay		48 hrs	Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay, GI50=0.01μM.	22329436
MCF7	Growth inhibition assay		48 hrs	Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay, GI50=0.013μM.	22329436
SN12C	Growth inhibition assay		48 hrs	Growth inhibition of human SN12C cells after 48 hrs by sulforhodamine B assay, GI50=0.02μM.	22329436
HCT116	Growth inhibition assay		48 hrs	Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay, GI50=0.03μM.	22329436
OVCAR3	Growth inhibition assay		48 hrs	Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay, GI50=0.22μM.	22329436
HuH7	Cytotoxicity assay		72 hrs	Cytotoxicity against human HuH7 cells after 72 hrs by SRB assay, IC50<0.1μM.	22409771
HCT116	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay, IC50<0.1μM.	22409771
Mahlavu	Cytotoxicity assay		72 hrs	Cytotoxicity against human Mahlavu cells after 72 hrs by SRB assay, IC50<0.1μM.	22409771
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay, IC50<0.1μM.	22409771
HepG2	Cytotoxicity assay		72 hrs	Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay, IC50<0.1μM.	22409771
FOCUS	Cytotoxicity assay		72 hrs	Cytotoxicity against human FOCUS cells after 72 hrs by SRB assay, IC50<0.1μM.	22409771
HEK293	Cytotoxicity assay		2 days	Cytotoxicity against human HEK293 cells after 2 days by cell counting kit-8 analysis, IC50=1.01μM.	22503656
DU145	Cytotoxicity assay		2 days	Cytotoxicity against human DU145 cells after 2 days by cell counting kit-8 analysis, IC50=1.06μM.	22503656
HCT15	Cytotoxicity assay		2 days	Cytotoxicity against human HCT15 cells after 2 days by cell counting kit-8 analysis, IC50=1.38μM.	22503656
T47D	Cytotoxicity assay		2 days	Cytotoxicity against human T47D cells after 2 days by cell counting kit-8 analysis, IC50=1.53μM.	22503656
HeLa	Cytotoxicity assay		48 hrs	Cytotoxicity against human HeLa cells after 48 hrs by MTS assay, IC50=0.4μM.	22542106
HeLa	Cytotoxicity assay		24 hrs	Cytotoxicity against human HeLa cells after 24 hrs by MTS assay, IC50=1.57μM.	22542106
KB-7d	Antiproliferative assay		72 hrs	Antiproliferative activity against human VP16-resistant KB-7d cells overexpressing MRP after 72 hrs by ethylene blue dye assay, IC50=0.0068μM.	22698783
KB	Antiproliferative assay		72 hrs	Antiproliferative activity against human KB cells after 72 hrs by ethylene blue dye assay, IC50=0.0088μM.	22698783
KBCPT100	Antiproliferative assay		72 hrs	Antiproliferative activity against human partially revertant camptothecin-resistant KBCPT100 cells after 72 hrs by ethylene blue dye assay, IC50=0.024μM.	22698783
KBCPT100	Antiproliferative assay		72 hrs	Antiproliferative activity against human camptothecin-resistant KBCPT100 cells after 72 hrs by ethylene blue dye assay, IC50=0.423μM.	22698783
NCI-H460	Cytotoxicity assay		72 hrs	Cytotoxicity against human NCI-H460 cells after 72 hrs by sulforhodamine B assay, IC50=0.005μM.	22749423
A2780	Cytotoxicity assay		72 hrs	Cytotoxicity against human A2780 cells after 72 hrs by sulforhodamine B assay, IC50=0.007μM.	22749423
GLC4	Cytotoxicity assay		72 hrs	Cytotoxicity against human GLC4 cells after 72 hrs by sulforhodamine B assay, IC50=0.01μM.	22749423
NCI-H460	Cytotoxicity assay		72 hrs	Cytotoxicity against human NCI-H460 cells incubated for 72 hrs by MTT assay, IC50=0.003μM.	22758788
HEK293	Cytotoxicity assay		72 hrs	Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay, IC50=7.94μM.	22819942
T47D	Cytotoxicity assay		72 hrs	Cytotoxicity against human T47D cells after 72 hrs by MTT assay, IC50=9.17μM.	22819942
DU145	Cytotoxicity assay		72 hrs	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay, IC50=9.29μM.	22819942
HCT15	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay, IC50=9.92μM.	22819942
NCI-H460	Cytotoxicity assay		3 days	Cytotoxicity against human NCI-H460 cells incubated for 3 days by SRB assay, IC50=0.002μM.	22863526
SF268	Cytotoxicity assay		3 days	Cytotoxicity against human SF268 cells incubated for 3 days by SRB assay, IC50=0.07μM.	22863526
MCF7	Cytotoxicity assay		3 days	Cytotoxicity against human MCF7 cells incubated for 3 days by SRB assay, IC50=0.08μM.	22863526
IMR90	Cytotoxicity assay		3 days	Cytotoxicity against human IMR90 cells incubated for 3 days by SRB assay, IC50=0.43μM.	22863526
HL60	Cytotoxicity assay		72 hrs	Cytotoxicity against human HL60 cells incubated for 72 hrs by MTT assay, GI50<0.003μM.	22867019
MDA-MB-435	Cytotoxicity assay		72 hrs	Cytotoxicity against human MDA-MB-435 cells incubated for 72 hrs by MTT assay, GI50=0.033μM.	22867019
HCT116	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTT assay, GI50=0.083μM.	22867019
A549	Cytotoxicity assay		72 hrs	Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay, GI50=0.17μM.	22867019
HepG2	Cytotoxicity assay		72 hrs	Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay, GI50=0.22μM.	22867019
PANC1	Cytotoxicity assay		72 hrs	Cytotoxicity against human PANC1 cells incubated for 72 hrs by MTT assay, GI50=6.29μM.	22867019
HepG2	Cytotoxicity assay		72 hrs	Cytotoxicity against human HepG2 cells incubated for 72 hrs by SRB assay, IC50=0.01μM.	22867707
BT20	Cytotoxicity assay		72 hrs	Cytotoxicity against human BT20 cells incubated for 72 hrs by SRB assay, IC50=0.07μM.	22867707
CAMA1	Cytotoxicity assay		72 hrs	Cytotoxicity against human CAMA1 cells incubated for 72 hrs by SRB assay, IC50=0.07μM.	22867707
HuH7	Cytotoxicity assay		72 hrs	Cytotoxicity against human HuH7 cells incubated for 72 hrs by SRB assay, IC50=0.15μM.	22867707
T47D	Cytotoxicity assay		72 hrs	Cytotoxicity against human T47D cells incubated for 72 hrs by SRB assay, IC50<1μM.	22867707
MFE296	Cytotoxicity assay		72 hrs	Cytotoxicity against human MFE296 cells incubated for 72 hrs by SRB assay, IC50<1μM.	22867707
MV	Cytotoxicity assay		72 hrs	Cytotoxicity against human MV cells incubated for 72 hrs by SRB assay, IC50<1μM.	22867707
FOCUS	Cytotoxicity assay		72 hrs	Cytotoxicity against human FOCUS cells incubated for 72 hrs by SRB assay, IC50<1μM.	22867707
HCT116	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT116 cells incubated for 72 hrs by SRB assay, IC50<1μM.	22867707
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells incubated for 72 hrs by SRB assay, IC50<1μM.	22867707
CCRF-CEM	Cytotoxicity assay		96 hrs	Cytotoxicity against human CCRF-CEM cells after 96 hrs by MTT assay, CC50=0.003μM.	22884523
MT4	Cytotoxicity assay		96 hrs	Cytotoxicity against human MT4 cells after 96 hrs by MTT assay, CC50=0.004μM.	22884523
CCRF-SB	Cytotoxicity assay		96 hrs	Cytotoxicity against human CCRF-SB cells after 96 hrs by MTT assay, CC50=0.004μM.	22884523
WIL2-NS	Cytotoxicity assay		96 hrs	Cytotoxicity against human WIL2-NS cells after 96 hrs by MTT assay, CC50=0.005μM.	22884523
HepG2	Cytotoxicity assay		96 hrs	Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay, CC50=0.04μM.	22884523
SKMES1	Cytotoxicity assay		96 hrs	Cytotoxicity against human SKMES1 cells after 96 hrs by MTT assay, CC50=0.05μM.	22884523
SK-MEL-28	Cytotoxicity assay		96 hrs	Cytotoxicity against human SK-MEL-28 cells after 96 hrs by MTT assay, CC50=0.07μM.	22884523
DU145	Cytotoxicity assay		96 hrs	Cytotoxicity against human DU145 cells after 96 hrs by MTT assay, CC50=0.08μM.	22884523
MCF7	Cytotoxicity assay		96 hrs	Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay, CC50=0.08μM.	22884523
MRC5	Cytotoxicity assay		96 hrs	Cytotoxicity against human MRC5 cells after 96 hrs by MTT assay, CC50=0.2μM.	22884523
CRL7065	Cytotoxicity assay		96 hrs	Cytotoxicity against human CRL7065 cells after 96 hrs by MTT assay, CC50=0.3μM.	22884523
MDA-MB-435	Antiproliferative assay		3 days	Antiproliferative activity against human MDA-MB-435 cells after 3 days by MTT assay, IC50=0.0436μM.	23084702
HCT116	Antiproliferative assay		3 days	Antiproliferative activity against human HCT116 cells after 3 days by MTT assay, IC50=0.11μM.	23084702
A549	Antiproliferative assay		3 days	Antiproliferative activity against human A549 cells after 3 days by MTT assay, IC50=2.61μM.	23084702
HCT116	Cytotoxicity assay		3 days	Cytotoxicity against human HCT116 cells after 3 days by SRB assay, IC50<0.01μM.	23142674
SKBR3	Cytotoxicity assay		3 days	Cytotoxicity against human SKBR3 cells after 3 days by SRB assay, IC50<0.01μM.	23142674
ZR-75-1	Cytotoxicity assay		3 days	Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay, IC50<0.01μM.	23142674
MCF12A	Cytotoxicity assay		3 days	Cytotoxicity against human MCF12A cells after 3 days by SRB assay, IC50<0.01μM.	23142674
MCF7	Cytotoxicity assay		3 days	Cytotoxicity against human MCF7 cells after 3 days by SRB assay, IC50<0.01μM.	23142674
MDA-MB-453	Cytotoxicity assay		3 days	Cytotoxicity against human MDA-MB-453 cells after 3 days by SRB assay, IC50<0.01μM.	23142674
BT20	Cytotoxicity assay		3 days	Cytotoxicity against human BT20 cells after 3 days by SRB assay, IC50<0.01μM.	23142674
T47D	Cytotoxicity assay		3 days	Cytotoxicity against human T47D cells after 3 days by SRB assay, IC50<0.01μM.	23142674
MDA-MB-231	Cytotoxicity assay		3 days	Cytotoxicity against human MDA-MB-231 cells after 3 days by SRB assay, IC50<0.01μM.	23142674
MDA-MB-157	Cytotoxicity assay		3 days	Cytotoxicity against human MDA-MB-157 cells after 3 days by SRB assay, IC50=0.02μM.	23142674
HuH7	Cytotoxicity assay		3 days	Cytotoxicity against human HuH7 cells after 3 days by SRB assay, IC50=0.06μM.	23142674
CAMA1	Cytotoxicity assay		3 days	Cytotoxicity against human CAMA1 cells after 3 days by SRB assay, IC50=0.07μM.	23142674
MDA-MB-361	Cytotoxicity assay		3 days	Cytotoxicity against human MDA-MB-361 cells after 3 days by SRB assay, IC50=0.17μM.	23142674
BT474	Cytotoxicity assay		3 days	Cytotoxicity against human BT474 cells after 3 days by SRB assay, IC50=12.75μM.	23142674
HeLa	Cytotoxicity assay		48 hrs	Cytotoxicity against human HeLa cells after 48 hrs by MTS assay, IC50=0.4μM.	23153813
HeLa	Cytotoxicity assay		24 hrs	Cytotoxicity against human HeLa cells after 24 hrs by MTS assay, IC50=1.57μM.	23153813
MCF7	Growth inhibition assay		48 hrs	Growth inhibition of human MCF7 cells after 48 hrs by MTT assay, GI50=0.002μM.	23357037
A549	Growth inhibition assay		48 hrs	Growth inhibition of human A549 cells after 48 hrs by MTT assay, GI50=0.007μM.	23357037
HeLa	Growth inhibition assay		48 hrs	Growth inhibition of human HeLa cells after 48 hrs by MTT assay, GI50=0.05μM.	23357037
HepG2	Cytotoxicity assay		72 hrs	Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay, IC50=32.3μM.	23562244
HBL100	Antiproliferative assay		48 hrs	Antiproliferative activity against human HBL100 cells after 48 hrs by SRB assay, GI50=0.23μM.	23831507
SW1573	Antiproliferative assay		48 hrs	Antiproliferative activity against human SW1573 cells after 48 hrs by SRB assay, GI50=0.25μM.	23831507
HeLa	Antiproliferative assay		48 hrs	Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay, GI50=0.6μM.	23831507
WiDr	Antiproliferative assay		48 hrs	Antiproliferative activity against human WiDr cells after 48 hrs by SRB assay, GI50=1.8μM.	23831507
T47D	Antiproliferative assay		48 hrs	Antiproliferative activity against human T47D cells after 48 hrs by SRB assay, GI50=2μM.	23831507
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, GI50=0.01μM.	23831811
HT-29	Cytotoxicity assay		72 hrs	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, GI50=0.05μM.	23831811
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, TGI=0.16μM.	23831811
HT-29	Cytotoxicity assay		72 hrs	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, TGI=0.79μM.	23831811
HT-29	Cytotoxicity assay		72 hrs	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, LC50=31.62μM.	23831811
MS	Cytotoxicity assay		72 hrs	Cytotoxicity against human MS cells after 72 hrs ny MTT assay, IC50=0.23μM.	23974020
TE-32	Cytotoxicity assay		72 hrs	Cytotoxicity against human TE-32 cells after 72 hrs ny MTT assay, IC50=4.47μM.	23974020
A549	Cytotoxicity assay		72 hrs	Cytotoxicity against human A549 cells after 72 hrs ny MTT assay, IC50=37.05μM.	23974020
T47D	Cytotoxicity assay		2 days	Cytotoxicity against human T47D cells after 2 days by CCK-8 assay, IC50=0.3μM.	24013413
DU145	Cytotoxicity assay		2 days	Cytotoxicity against human DU145 cells after 2 days by CCK-8 assay, IC50=0.39μM.	24013413
HCT15	Cytotoxicity assay		2 days	Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay, IC50=0.42μM.	24013413
HEK293	Cytotoxicity assay		2 days	Cytotoxicity against HEK293 cells after 2 days by CCK-8 assay, IC50=0.78μM.	24013413
HCT116	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT116 cells after 72 hrs by WST-8 assay, IC50=0.016μM.	24033077
COLO205	Cytotoxicity assay		48 hrs	Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay, IC50=0.05μM.	24041234
HL60	Cytotoxicity assay		48 hrs	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50=0.06μM.	24041234
MIAPaCa2	Cytotoxicity assay		48 hrs	Cytotoxicity against human MIAPaCa2 cells after 48 hrs by MTT assay, IC50=0.19μM.	24041234
HepG2	Cytotoxicity assay		48 hrs	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50=0.2μM.	24041234
PC3	Cytotoxicity assay		48 hrs	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay, IC50=1.2μM.	24041234
MDA-MB-435	Cytotoxicity assay		72 hrs	Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay, IC50<0.001μM.	24069881
HCT116	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay, IC50=0.07μM.	24069881
A549	Cytotoxicity assay		72 hrs	Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=0.65μM.	24069881
Hs683	Growth inhibition assay		72 hrs	Growth inhibition of human Hs683 cells after 72 hrs by MTT assay, IC50<0.01μM.	24180210
PC3	Growth inhibition assay		72 hrs	Growth inhibition of human PC3 cells after 72 hrs by MTT assay, IC50=0.01μM.	24180210
A549	Growth inhibition assay		72 hrs	Growth inhibition of human A549 cells after 72 hrs by MTT assay, IC50<0.01μM.	24180210
MCF7	Growth inhibition assay		72 hrs	Growth inhibition of human MCF7 cells after 72 hrs by MTT assay, IC50<0.01μM.	24180210
SK-MEL-28	Growth inhibition assay		72 hrs	Growth inhibition of human SK-MEL-28 cells after 72 hrs by MTT assay, IC50<0.01μM.	24180210
U373	Growth inhibition assay		72 hrs	Growth inhibition of human U373 cells after 72 hrs by MTT assay, IC50=0.015μM.	24180210
K562	Cytotoxicity assay		24 to 72 hrs	Cytotoxicity against human K562 cells after 24 to 72 hrs by MTT assay, IC50=0.4μM.	24303808
HeLa	Cytotoxicity assay		24 to 72 hrs	Cytotoxicity against human HeLa cells after 24 to 72 hrs by MTT assay, IC50=0.5μM.	24303808
HepG2	Cytotoxicity assay		24 to 72 hrs	Cytotoxicity against human HepG2 cells after 24 to 72 hrs by MTT assay, IC50=0.6μM.	24303808
DU145	Cytotoxicity assay		24 to 72 hrs	Cytotoxicity against human DU145 cells after 24 to 72 hrs by MTT assay, IC50=0.8μM.	24303808
K562	Cytotoxicity assay		48 hrs	Cytotoxicity against human K562 cells after 48 hrs by MTT assay, IC50=0.04μM.	24360564
HepG2	Cytotoxicity assay		48 hrs	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50=0.05μM.	24360564
HT-29	Cytotoxicity assay		48 hrs	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay, IC50=0.06μM.	24360564
CCRF-CEM	Cytotoxicity assay		24 hrs	Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 24 hrs by MTT assay, IC50=0.08μM.	24484281
CEM/ADR5000	Cytotoxicity assay		24 hrs	Cytotoxicity against human CEM/ADR5000 cells assessed as cell viability after 24 hrs by MTT assay, IC50=0.3μM.	24484281
HCT116	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay, GI50=0.01738μM.	24502276
DU145	Cytotoxicity assay		72 hrs	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay, GI50=0.0182μM.	24502276
HCT116	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT116 cells transfected with Top1-siRNA after 72 hrs by MTT assay, GI50=0.03548μM.	24502276
B16F10	Cytotoxicity assay		48 hrs	Cytotoxicity against mouse B16F10 cells after 48 hrs by MTT assay, IC50=2.78μM.	24685545
DU145	Growth inhibition assay		48 hrs	Growth inhibition of human DU145 cells after 48 hrs by SRB assay, GI50=0.01μM.	24800942
HOP62	Growth inhibition assay		48 hrs	Growth inhibition of human HOP62 cells after 48 hrs by SRB assay, GI50=0.01μM.	24800942
MCF7	Growth inhibition assay		48 hrs	Growth inhibition of human MCF7 cells after 48 hrs by SRB assay, GI50=0.01μM.	24800942
SF539	Growth inhibition assay		48 hrs	Growth inhibition of human SF539 cells after 48 hrs by SRB assay, GI50=0.01μM.	24800942
UACC62	Growth inhibition assay		48 hrs	Growth inhibition of human UACC62 cells after 48 hrs by SRB assay, GI50=0.01μM.	24800942
SN12C	Growth inhibition assay		48 hrs	Growth inhibition of human SN12C cells after 48 hrs by SRB assay, GI50=0.02μM.	24800942
HCT116	Growth inhibition assay		48 hrs	Growth inhibition of human HCT116 cells after 48 hrs by SRB assay, GI50=0.03μM.	24800942
OVCAR3	Growth inhibition assay		48 hrs	Growth inhibition of human OVCAR3 cells after 48 hrs by SRB assay, GI50=0.22μM.	24800942
MOLT4	Cytotoxicity assay		72 hrs	Cytotoxicity against human MOLT4 cells after 72 hrs by MTT assay, IC50=0.00004μM.	24900725
A2780	Cytotoxicity assay		72 hrs	Cytotoxicity against human A2780 cells after 72 hrs by MTT assay, IC50=0.013μM.	24900725
HeLa	Cytotoxicity assay		72 hrs	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50=0.024μM.	24900725
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50=0.026μM.	24900725
K562	Cytotoxicity assay		72 hrs	Cytotoxicity against human K562 cells after 72 hrs by MTT assay, IC50=0.031μM.	24900725
PC3	Cytotoxicity assay		72 hrs	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, IC50=0.078μM.	24900725
A549	Cytotoxicity assay		72 hrs	Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=0.099μM.	24900725
MDA-MB-231	Cytotoxicity assay		72 hrs	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50=0.162μM.	24900725
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay, IC50=0.0651μM.	24901491
ID8	Cytotoxicity assay		72 hrs	Cytotoxicity against mouse ID8 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay, IC50=0.474μM.	24901491
L1210	Cytotoxicity assay		72 hrs	Cytotoxicity against mouse L1210 cells overexpressing folate receptor assessed as growth inhibition after 72 hrs by MTT assay, IC50=0.51μM.	24901491
WI38	Cytotoxicity assay		72 hrs	Cytotoxicity against human WI38 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay, IC50=0.786μM.	24901491
MX1	Cytotoxicity assay		72 hrs	Cytotoxicity against human MX1 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay, IC50=1.7μM.	24901491
MCF10A	Cytotoxicity assay		2 days	Cytotoxicity against human MCF10A cells after 2 days, IC50=0.27μM.	24904965
T47D	Cytotoxicity assay		2 days	Cytotoxicity against human T47D cells after 2 days, IC50=0.28μM.	24904965
DU145	Cytotoxicity assay		2 days	Cytotoxicity against human DU145 cells after 2 days, IC50=4.01μM.	24904965
HCT15	Cytotoxicity assay		2 days	Cytotoxicity against human HCT15 cells after 2 days, IC50=10.07μM.	24904965
Jurkat	Cytotoxicity assay		24 hrs	Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay, IC50=0.11μM.	24980118
Caco2	Cytotoxicity assay		24 hrs	Cytotoxicity against human Caco2 cells after 24 hrs by MTT assay, IC50=0.131μM.	24980118
A375	Cytotoxicity assay		24 hrs	Cytotoxicity against human A375 cells after 24 hrs by MTT assay, IC50=0.187μM.	24980118
MDA-MB-231	Cytotoxicity assay		24 hrs	Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay, IC50=0.342μM.	24980118
HeLa	Cytotoxicity assay		24 hrs	Cytotoxicity against human HeLa cells after 24 hrs by MTT assay, IC50=0.42μM.	24980118
A549	Cytotoxicity assay		72 hrs	Cytotoxicity against human A549 cells after 72 hrs by SRB assay, IC50=0.016μM.	25003995
DU145	Cytotoxicity assay		72 hrs	Cytotoxicity against human DU145 cells after 72 hrs by SRB assay, IC50=0.029μM.	25003995
KB	Cytotoxicity assay		72 hrs	Cytotoxicity against human KB cells after 72 hrs by SRB assay, IC50=0.037μM.	25003995
KBVIN	Cytotoxicity assay		72 hrs	Cytotoxicity against human KBVIN cells after 72 hrs by SRB assay, IC50=0.12μM.	25003995
HEK293	Cytotoxicity assay		4 days	Cytotoxicity against HEK293 cells after 4 days by CCK-8 assay, IC50=0.28μM.	25062006
T47D	Cytotoxicity assay		4 days	Cytotoxicity against human T47D cells after 4 days by CCK-8 assay, IC50=0.75μM.	25062006
DU145	Cytotoxicity assay		4 days	Cytotoxicity against human DU145 cells after 4 days by CCK-8 assay, IC50=0.95μM.	25062006
HCT15	Cytotoxicity assay		4 days	Cytotoxicity against human HCT15 cells after 4 days by CCK-8 assay, IC50=1.98μM.	25062006
MCF7	Cytotoxicity assay		48 hrs	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay, IC50=0.0005μM.	25084144
MCF7	Cytotoxicity assay		48 hrs	Cytotoxicity against human MCF7 cells in presence of 10 mM DTT after 48 hrs by SRB assay, IC50=0.003μM.	25084144
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells after 48 hrs by SRB assay, IC50=1.3μM.	25084144
HCT116	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay, IC50=0.00015μM.	25247770
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay, IC50=0.0006μM.	25247770
HuH7	Cytotoxicity assay		72 hrs	Cytotoxicity against human HuH7 cells after 72 hrs by SRB assay, IC50=0.004μM.	25247770
SMMC7721	Cytotoxicity assay		48 hrs	Cytotoxicity against human SMMC7721 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	25453788
MCF7	Cytotoxicity assay		48 hrs	Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	25453788
MCF7	Cytotoxicity assay		2 days	Cytotoxicity against human MCF7 cells after 2 days by CCK-8 assay, IC50=0.08μM.	25481396
DU145	Cytotoxicity assay		2 days	Cytotoxicity against human DU145 cells after 2 days by CCK-8 assay, IC50=0.11μM.	25481396
HCT15	Cytotoxicity assay		2 days	Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay, IC50=0.26μM.	25481396
HeLa	Cytotoxicity assay		2 days	Cytotoxicity against human HeLa cells after 2 days by CCK-8 assay, IC50=0.4μM.	25481396
K562	Antitumor assay		48 hrs	Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay, IC50=0.13μM.	25590864
HL60	Cytotoxicity assay		48 hrs	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50=0.07μM.	25599951
K562	Cytotoxicity assay		48 hrs	Cytotoxicity against human K562 cells after 48 hrs by MTT assay, IC50=5.37μM.	25599951
HeLa	Cytotoxicity assay		48 hrs	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50=11.62μM.	25599951
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50=26.45μM.	25599951
DU145	Antiproliferative assay		72 hrs	Antiproliferative activity against human DU145 cells assessed as cell viability incubated for 72 hrs by MTT assay, IC50=0.1μM.	25799376
PC3	Antiproliferative assay		72 hrs	Antiproliferative activity against human PC3 cells assessed as cell viability incubated for 72 hrs by MTT assay, IC50=0.1μM.	25799376
T47D	Cytotoxicity assay		2 to 4 days	Cytotoxicity against human T47D cells incubated from day 2 to day 4 by CCK8 assay, IC50=0.31μM.	26022080
DU145	Cytotoxicity assay		2 to 4 days	Cytotoxicity against human DU145 cells incubated from day 2 to day 4 by CCK8 assay, IC50=0.4μM.	26022080
HeLa	Cytotoxicity assay		2 to 4 days	Cytotoxicity against human HeLa cells incubated from day 2 to day 4 by CCK8 assay, IC50=0.41μM.	26022080
HCT15	Cytotoxicity assay		2 to 4 days	Cytotoxicity against human HCT15 cells incubated from day 2 to day 4 by CCK8 assay, IC50=0.52μM.	26022080
HL60	Cytotoxicity assay		48 hrs	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50=0.015μM.	26188908
CA46	Cytotoxicity assay		48 hrs	Cytotoxicity against human CA46 cells after 48 hrs by MTT assay, IC50=0.52μM.	26188908
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50=1.6μM.	26188908
HeLa	Cytotoxicity assay		48 hrs	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50=14μM.	26188908
K562	Cytotoxicity assay		72 hrs	Cytotoxicity against human K562 cells after 72 hrs by MTT assay, IC50<0.003μM.	26226379
MV-3	Cytotoxicity assay		72 hrs	Cytotoxicity against human MV-3 cells after 72 hrs by MTT assay, IC50<0.003μM.	26226379
HCT116	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay, IC50=0.09μM.	26226379
A549	Cytotoxicity assay		72 hrs	Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=0.1μM.	26226379
Bel7404	Cytotoxicity assay		72 hrs	Cytotoxicity against human Bel7404 cells after 72 hrs by MTT assay, IC50=0.14μM.	26226379
SW579	Cytotoxicity assay		72 hrs	Cytotoxicity against human SW579 cells after 72 hrs by MTT assay, IC50=0.71μM.	26226379
SKHEP1	Cytotoxicity assay		72 hrs	Cytotoxicity against human SKHEP1 cells after 72 hrs by MTT assay, IC50=0.96μM.	26226379
MDA-MB-435	Cytotoxicity assay		72 hrs	Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay, IC50=1μM.	26226379
PC3	Cytotoxicity assay		72 hrs	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, IC50=2.5μM.	26226379
HeLa	Cytotoxicity assay		2 days	Cytotoxicity against human HeLa cells measured after 2 days by MTT assay, IC50=1.59μM.	26334499
T47D	Cytotoxicity assay		2 days	Cytotoxicity against human T47D cells measured after 2 days by MTT assay, IC50=1.62μM.	26334499
HCT15	Cytotoxicity assay		2 days	Cytotoxicity against human HCT15 cells measured after 2 days by MTT assay, IC50=6.08μM.	26334499
T47D	Cytotoxicity assay		2 days	Cytotoxicity against human T47D cells after 2 days by CCK8 assay, IC50=0.08μM.	26361737
DU145	Cytotoxicity assay		2 days	Cytotoxicity against human DU145 cells after 2 days by CCK8 assay, IC50=0.11μM.	26361737
HCT15	Cytotoxicity assay		2 days	Cytotoxicity against human HCT15 cells after 2 days by CCK8 assay, IC50=0.3μM.	26361737
MCF10A	Cytotoxicity assay		2 days	Cytotoxicity against human MCF10A cells after 2 days by CCK8 assay, IC50=0.97μM.	26361737
184B5	Antiproliferative assay		72 hrs	Antiproliferative activity against human 184B5 cells after 72 hrs by SRB assay, IC50=4.96μM.	26602827
MDA-MB-231	Antiproliferative assay		72 hrs	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay, IC50=5.77μM.	26602827
HeLa	Antiproliferative assay		72 hrs	Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay, IC50=6.13μM.	26602827
MDA-MB-468	Antiproliferative assay		72 hrs	Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by SRB assay, IC50=14.76μM.	26602827
GM07492A	Cytotoxicity assay		24 hrs	Cytotoxicity against human GM07492A cells assessed as cell growth inhibition after 24 hrs by XTT assay, IC50=3.2μM.	26649907
M059J	Cytotoxicity assay		24 hrs	Cytotoxicity against human M059J cells assessed as cell growth inhibition after 24 hrs by XTT assay, IC50=5.5μM.	26649907
MCF7	Cytotoxicity assay		24 hrs	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 24 hrs by XTT assay, IC50=6μM.	26649907
HeLa	Cytotoxicity assay		24 hrs	Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 24 hrs by XTT assay, IC50=19.8μM.	26649907
B16F10	Cytotoxicity assay		24 hrs	Cytotoxicity against mouse B16F10 cells overexpressing alphavbeta3 integrin up to 50 uM after 24 hrs by XTT assay	26719208
Mahlavu	Cytotoxicity assay		72 hrs	Cytotoxicity against human Mahlavu cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay, IC50<1μM.	26810835
Hep3B	Cytotoxicity assay		72 hrs	Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay, IC50<1μM.	26810835
HepG2	Cytotoxicity assay		72 hrs	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay, IC50<1μM.	26810835
SNU475	Cytotoxicity assay		72 hrs	Cytotoxicity against human SNU475 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay, IC50<1μM.	26810835
FOCUS	Cytotoxicity assay		72 hrs	Cytotoxicity against human FOCUS cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay, IC50<1μM.	26810835
Jurkat	Anticancer assay		48 hrs	Anticancer activity against human Jurkat cells after 48 hrs by MTT assay, IC50=0.085μM.	26890120
HeLa	Cytotoxicity assay		3 days	Cytotoxicity against human HeLa cells after 3 days by CCK8 assay, IC50=0.59μM.	26927425
HCT15	Cytotoxicity assay		3 days	Cytotoxicity against human HCT15 cells after 3 days by CCK8 assay, IC50=1.29μM.	26927425
T47D	Cytotoxicity assay		3 days	Cytotoxicity against human T47D cells after 3 days by CCK8 assay, IC50=11.17μM.	26927425
DU145	Cytotoxicity assay		48 hrs	Cytotoxicity against human DU145 cells after 48 hrs by CCK8 assay, IC50=0.02μM.	26945111
HeLa	Cytotoxicity assay		48 hrs	Cytotoxicity against human HeLa cells after 48 hrs by CCK8 assay, IC50=0.18μM.	26945111
T47D	Cytotoxicity assay		48 hrs	Cytotoxicity against human T47D cells after 48 hrs by CCK8 assay, IC50=1.84μM.	26945111
HCT15	Cytotoxicity assay		48 hrs	Cytotoxicity against human HCT15 cells after 48 hrs by CCK8 assay, IC50=2.82μM.	26945111
T47D	Antiproliferative assay		72 hrs	Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50=4.1μM.	26988802
BT474	Antiproliferative assay		72 hrs	Antiproliferative activity against human BT474 cells after 72 hrs by CCK8 assay, IC50=7μM.	26988802
HCT15	Antiproliferative assay		72 hrs	Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50=7.1μM.	26988802
A549	Cytotoxicity assay		72 hrs	Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B colorimetric assay, IC50=0.016μM.	26994847
KB	Cytotoxicity assay		72 hrs	Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B colorimetric assay, IC50=0.037μM.	26994847
KBVIN	Cytotoxicity assay		72 hrs	Cytotoxicity against human KBVIN cells after 72 hrs by sulforhodamine B colorimetric assay, IC50=0.12μM.	26994847
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by CCK8 assay, IC50=0.001μM.	27017547
SKOV3	Cytotoxicity assay		48 hrs	Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by CCK8 assay, IC50=0.0055μM.	27017547
BT20	Cytotoxicity assay		48 hrs	Cytotoxicity against human BT20 cells assessed as growth inhibition after 48 hrs by CCK8 assay, IC50=0.07μM.	27017547
MCF7	Antiproliferative assay		48 hrs	Antiproliferative activity against human MCF7 cells after 48 hrs, GI50=0.01μM.	27070999
SF539	Antiproliferative assay		48 hrs	Antiproliferative activity against human SF539 cells after 48 hrs, GI50=0.01μM.	27070999
DU145	Antiproliferative assay		48 hrs	Antiproliferative activity against human DU145 cells after 48 hrs, GI50=0.01μM.	27070999
HOP62	Antiproliferative assay		48 hrs	Antiproliferative activity against human HOP62 cells after 48 hrs, GI50=0.01μM.	27070999
UACC62	Antiproliferative assay		48 hrs	Antiproliferative activity against human UACC62 cells after 48 hrs, GI50=0.01μM.	27070999
SN12C	Antiproliferative assay		48 hrs	Antiproliferative activity against human SN12C cells after 48 hrs, GI50=0.02μM.	27070999
HCT116	Antiproliferative assay		48 hrs	Antiproliferative activity against human HCT116 cells after 48 hrs, GI50=0.03μM.	27070999
OVCAR3	Antiproliferative assay		48 hrs	Antiproliferative activity against human OVCAR3 cells after 48 hrs, GI50=0.22μM.	27070999
HCT116	Antiproliferative assay		72 hrs	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay, IC50=0.003μM.	27096049
A549	Antiproliferative assay		72 hrs	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay, IC50=0.009μM.	27096049
A375	Antiproliferative assay		72 hrs	Antiproliferative activity against human A375 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay, IC50=0.013μM.	27096049
HL60	Antiproliferative assay		72 hrs	Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay, IC50=0.035μM.	27096049
NCI-H23	Cytotoxicity assay		96 hrs	Cytotoxicity against human NCI-H23 cells assessed as cell viability after 96 hrs by MTT assay, IC50=0.07μM.	27156772
NCI-H460	Cytotoxicity assay		96 hrs	Cytotoxicity against human NCI-H460 cells assessed as cell viability after 96 hrs by MTT assay, IC50=0.19μM.	27156772
A549	Cytotoxicity assay		96 hrs	Cytotoxicity against human A549 cells assessed as cell viability after 96 hrs by MTT assay, IC50=0.35μM.	27156772
A549	Growth inhibition assay		72 hrs	Growth inhibition of human A549 cells after 72 hrs by MTT assay, IC50=0.12μM.	27344492
HepG2	Growth inhibition assay		72 hrs	Growth inhibition of human HepG2 cells after 72 hrs by MTT assay, IC50=29.81μM.	27344492
A549	Antiproliferative assay		48 hrs	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50=0.46μM.	27416553
BGC823	Antiproliferative assay		48 hrs	Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay, IC50=1.27μM.	27416553
HeLa	Antiproliferative assay		48 hrs	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50=1.41μM.	27416553
HepG2	Antiproliferative assay		48 hrs	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50=1.52μM.	27416553
NCI60	Cytotoxicity assay		48 hrs	Cytotoxicity against human NCI60 cells after 48 hrs by SRB assay, GI50=0.0398μM.	27448924
HCT15	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT15 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay, IC50=0.0014μM.	27484510
T47D	Cytotoxicity assay		72 hrs	Cytotoxicity against human T47D cells assessed as reduction in cell growth after 72 hrs by CCK8 assay, IC50=0.08μM.	27484510
HeLa	Cytotoxicity assay		72 hrs	Cytotoxicity against human HeLa cells assessed as reduction in cell growth after 72 hrs by CCK8 assay, IC50=0.13μM.	27484510
NCI-N87	Cytotoxicity assay		72 hrs	Cytotoxicity against human NCI-N87 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay, IC50=0.6μM.	27484510
H460	Growth inhibition assay		72 hrs	Growth inhibition of human H460 cells after 72 hrs by trypan blue assay, GI50=0.002μM.	27597409
MSTO-211H	Growth inhibition assay		72 hrs	Growth inhibition of human MSTO-211H cells after 72 hrs by trypan blue assay, GI50=0.0021μM.	27597409
HeLa	Growth inhibition assay		72 hrs	Growth inhibition of human HeLa cells after 72 hrs by trypan blue assay, GI50=0.0054μM.	27597409
DU145	Antiproliferative assay		72 hrs	Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay, IC50=0.11μM.	27643560
HCT15	Antiproliferative assay		72 hrs	Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50=0.31μM.	27643560
HeLa	Antiproliferative assay		72 hrs	Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay, IC50=0.4μM.	27643560
HEK293	Antiproliferative assay		72 hrs	Antiproliferative activity against HEK293 cells after 72 hrs by CCK8 assay, IC50=0.83μM.	27643560
HFL1	Antiproliferative assay		72 hrs	Antiproliferative activity against HFL1 cells after 72 hrs by CCK8 assay, IC50=1.06μM.	27643560
T47D	Antiproliferative assay		72 hrs	Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50=13.7μM.	27643560
HCT15	Antiproliferative assay		72 hrs	Antiproliferative activity against human HCT15 cells measured after 72 hrs by CCK8 assay, IC50=0.35μM.	27654394
DU145	Antiproliferative assay		72 hrs	Antiproliferative activity against human DU145 cells measured after 72 hrs by CCK8 assay, IC50=0.38μM.	27654394
T47D	Antiproliferative assay		72 hrs	Antiproliferative activity against human T47D cells measured after 72 hrs by CCK8 assay, IC50=0.59μM.	27654394
MCF7	Antiproliferative assay		72 hrs	Antiproliferative activity against human MCF7 cells measured after 72 hrs by CCK8 assay, IC50=4.54μM.	27654394
ECA109	Cytotoxicity assay		48 hrs	Cytotoxicity against human ECA109 cells assessed as decrease in cell proliferation after 48 hrs by MTT assay, IC50=9.52μM.	27667553
HeLa	Cytotoxicity assay		48 hrs	Cytotoxicity against human HeLa cells assessed as decrease in cell proliferation after 48 hrs by MTT assay, IC50=11.36μM.	27667553
HEK293	Cytotoxicity assay		72 hrs	Cytotoxicity against human HEK293 cells measured after 72 hrs by MTT assay, IC50=0.89μM.	27721148
TE32	Cytotoxicity assay		72 hrs	Cytotoxicity against human TE32 cells measured after 72 hrs by MTT assay, IC50=1.24μM.	27721148
MS	Cytotoxicity assay		72 hrs	Cytotoxicity against human MS cells measured after 72 hrs by MTT assay, IC50=1.84μM.	27721148
Hep2	Cytotoxicity assay		72 hrs	Cytotoxicity against human Hep2 cells measured after 72 hrs by MTT assay, IC50=3.04μM.	27721148
A549	Cytotoxicity assay		72 hrs	Cytotoxicity against human A549 cells measured after 72 hrs by MTT assay, IC50=5.93μM.	27721148
HCT116	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT116 cells measured after 72 hrs by MTT assay, IC50=6.7μM.	27721148
A549	Antiproliferative assay		96 hrs	Antiproliferative activity against human A549 cells after 96 hrs by MTT assay, IC50=0.006μM.	27871039
Bel7402	Antiproliferative assay		96 hrs	Antiproliferative activity against human Bel7402 cells after 96 hrs by MTT assay, IC50=0.014μM.	27871039
HCT8	Antiproliferative assay		96 hrs	Antiproliferative activity against human HCT8 cells after 96 hrs by MTT assay, IC50=0.024μM.	27871039
A2780	Antiproliferative assay		96 hrs	Antiproliferative activity against human A2780 cells after 96 hrs by MTT assay, IC50=0.029μM.	27871039
BGC823	Antiproliferative assay		96 hrs	Antiproliferative activity against human BGC823 cells after 96 hrs by MTT assay, IC50=0.057μM.	27871039
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50<0.0018μM.	28006904
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay, IC50<0.0018μM.	28006904
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay, IC50<0.0018μM.	28006904
HEK293	Cytotoxicity assay		48 hrs	Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay, IC50=0.01μM.	28027871
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50=0.24μM.	28063351
HeLa	Antiproliferative assay		72 hrs	Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay, IC50=0.09μM.	28068603
HCT15	Antiproliferative assay		72 hrs	Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50=0.6μM.	28068603
T47D	Antiproliferative assay		72 hrs	Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50=2.1μM.	28068603
CCRF-CEM	Cytotoxicity assay		72 hrs	Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by resazurin reduction assay, IC50=0.003μM.	28233677
CEM/ADR5000	Cytotoxicity assay		72 hrs	Cytotoxicity against human CEM/ADR5000 cells assessed as reduction in cell viability after 72 hrs by resazurin reduction assay, IC50=0.011μM.	28233677
A549	Cytotoxicity assay		72 hrs	Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay, IC50=0.00863μM.	28285912
KBVIN	Cytotoxicity assay		72 hrs	Cytotoxicity against human KBVIN cells after 72 hrs by sulforhodamine B assay, IC50=0.0157μM.	28285912
KB	Cytotoxicity assay		72 hrs	Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay, IC50=0.05μM.	28285912
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay, IC50=0.0875μM.	28285912
MDA-MB-231	Cytotoxicity assay		72 hrs	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay, IC50=0.307μM.	28285912
HCT116	Antiproliferative assay		72 hrs	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50=0.12μM.	28351590
ZR-7530	Antiproliferative assay		72 hrs	Antiproliferative activity against human ZR-7530 cells after 72 hrs by MTT assay, IC50=0.24μM.	28351590
A549	Antiproliferative assay		72 hrs	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50=0.26μM.	28351590
HeLa	Antiproliferative assay		72 hrs	Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay, IC50=0.06μM.	28384547
HCT15	Antiproliferative assay		72 hrs	Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50=0.26μM.	28384547
T47D	Antiproliferative assay		72 hrs	Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50=2.1μM.	28384547
MCF7	Cytotoxicity assay		3 days	Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay, IC50=0.073μM.	28409637
HOP62	Cytotoxicity assay		48 hrs	Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay, GI50<0.01μM.	28418653
SF539	Cytotoxicity assay		48 hrs	Cytotoxicity against human SF539 cells after 48 hrs by SRB assay, GI50<0.01μM.	28418653
UACC62	Cytotoxicity assay		48 hrs	Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay, GI50<0.01μM.	28418653
MCF7	Cytotoxicity assay		48 hrs	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay, GI50=0.013μM.	28418653
SN12C	Cytotoxicity assay		48 hrs	Cytotoxicity against human SN12C cells after 48 hrs by SRB assay, GI50=0.02μM.	28418653
OVCAR3	Cytotoxicity assay		48 hrs	Cytotoxicity against human OVCAR3 cells after 48 hrs by SRB assay, GI50=0.22μM.	28418653
HCT116	Cytotoxicity assay		48 hrs	Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay, IC50=0.0115μM.	28454671
MGC803	Antiproliferative assay		48 hrs	Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay, IC50=9.45μM.	28462840
HeLa	Antiproliferative assay		48 hrs	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50=10.1μM.	28462840
A549	Antiproliferative assay		48 hrs	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50=13.64μM.	28462840
MCF7	Antiproliferative assay		48 hrs	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50=28.66μM.	28462840
HL60	Antiproliferative assay		48 hrs	Antiproliferative activity against human HL60 cells measured after 48 hrs by WST1 assay, IC50=0.019μM.	28477443
HCT116	Antiproliferative assay		48 hrs	Antiproliferative activity against human HCT116 cells measured after 48 hrs by MTT assay, IC50=0.159μM.	28477443
A549	Antiproliferative assay		48 hrs	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50<1μM.	28511910
QSG7701	Antiproliferative assay		48 hrs	Antiproliferative activity against human QSG7701 cells after 48 hrs by MTT assay, IC50<1μM.	28511910
HeLa	Antiproliferative assay		48 hrs	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50=3.8μM.	28511910
HepG2	Antiproliferative assay		48 hrs	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50=4.92μM.	28511910
WI38	Cytotoxicity assay		48 hrs	Cytotoxicity against human WI38 cells after 48 hrs by WST-1 assay, IC50=0.03μM.	28557449
HeLa	Cytotoxicity assay		48 hrs	Cytotoxicity against human HeLa cells after 48 hrs by WST-1 assay, IC50=0.08μM.	28557449
HCT15	Antiproliferative assay		72 hrs	Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50=0.76μM.	28633898
T47D	Antiproliferative assay		72 hrs	Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50=2.31μM.	28633898
HeLa	Antiproliferative assay		72 hrs	Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay, IC50=2.62μM.	28633898
MIAPaCa2	Antiproliferative assay		48 hrs	Antiproliferative activity against human MIAPaCa2 cells after 48 hrs in presence of type 1 collagen coated surface by MTT assay, IC50=0.18μM.	28689976
PC3	Growth inhibition assay		24 hrs	Growth inhibition of human PC3 cells up to 25 uM cotreated with colchicine measured after 24 hrs by XTT assay	28710962
MDA-MB-231	Growth inhibition assay		24 hrs	Growth inhibition of human MDA-MB-231 cells up to 25 uM cotreated with colchicine measured after 24 hrs by XTT assay	28710962
WM266.4	Growth inhibition assay		24 hrs	Growth inhibition of human WM266.4 cells up to 25 uM cotreated with colchicine measured after 24 hrs by XTT assay	28710962
A172	Growth inhibition assay		24 hrs	Growth inhibition of human A172 cells up to 25 uM cotreated with colchicine measured after 24 hrs by XTT assay	28710962
NCI-H1299	Growth inhibition assay		24 hrs	Growth inhibition of human NCI-H1299 cells up to 25 uM cotreated with colchicine measured after 24 hrs by XTT assay	28710962
RD	Cytotoxicity assay		72 hrs	Cytotoxicity in human RD cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay, IC50=4.49μM.	28923382
A549	Cytotoxicity assay		72 hrs	Cytotoxicity in human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay, IC50=8.87μM.	28923382
HCT16	Cytotoxicity assay		72 hrs	Cytotoxicity in human HCT16 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay, IC50=12.34μM.	28923382
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity in human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay, IC50=13.62μM.	28923382
TE32	Cytotoxicity assay		72 hrs	Cytotoxicity against human TE32 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50=1.24μM.	28923388
MS	Cytotoxicity assay		72 hrs	Cytotoxicity against human MS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50=1.84μM.	28923388
HCT116	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50=1.88μM.	28923388
Hep2	Cytotoxicity assay		72 hrs	Cytotoxicity against human Hep2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50=3.04μM.	28923388
A549	Cytotoxicity assay		72 hrs	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50=5.93μM.	28923388
A549	Cytotoxicity assay		72 hrs	Cytotoxicity against human A549 cells after 72 hrs by SRB assay, IC50=0.00863μM.	28927790
KBVIN	Cytotoxicity assay		72 hrs	Cytotoxicity against human KBVIN cells after 72 hrs by SRB assay, IC50=0.0157μM.	28927790
KB	Cytotoxicity assay		72 hrs	Cytotoxicity against human KB cells after 72 hrs by SRB assay, IC50=0.05μM.	28927790
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay, IC50=0.0875μM.	28927790
MDA-MB-231	Cytotoxicity assay		72 hrs	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay, IC50=0.307μM.	28927790
HL60	Antiproliferative assay		72 hrs	Antiproliferative activity against human HL60 cells after 72 hrs by tryphan blue staining based hematocytometric method, IC50=0.92μM.	29131616
HL60	Cytotoxicity assay		48 hrs	Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay, IC50=0.02μM.	29223099
HL60	Apoptosis assay		24 hrs	Induction of apoptosis in human HL60 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay, IC50=0.07μM.	29223099
K562	Cytotoxicity assay		48 hrs	Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay, IC50=0.09μM.	29223099
MCF7	Cytotoxicity assay		48 hrs	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay, IC50=0.34μM.	29223099
PC3	Cytotoxicity assay		48 hrs	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay, IC50=0.4μM.	29223099
HepG2	Cytotoxicity assay		48 hrs	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay, IC50=0.43μM.	29223099
K562	Apoptosis assay		24 hrs	Induction of apoptosis in human K562 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay, IC50=0.711μM.	29223099
HepG2	Apoptosis assay		24 hrs	Induction of apoptosis in human HepG2 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay, IC50=4.37μM.	29223099
RPE1	Apoptosis assay		24 hrs	Induction of apoptosis in human RPE1 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay, IC50=27.2μM.	29223099
HCT15	Antiproliferative assay		72 hrs	Antiproliferative activity against human HCT15 cells incubated for 72 hrs by CCK8 assay, IC50=0.05μM.	29402741
T47D	Antiproliferative assay		72 hrs	Antiproliferative activity against human T47D cells incubated for 72 hrs by CCK8 assay, IC50=0.07μM.	29402741
HeLa	Antiproliferative assay		72 hrs	Antiproliferative activity against human HeLa cells incubated for 72 hrs by CCK8 assay, IC50=1.37μM.	29402741
HeLa	Antiproliferative assay		24 hrs	Antiproliferative activity against human HeLa cells after 24 hrs by crystal violet staining-based assay, IC50=0.94μM.	29407986
CaSki	Antiproliferative assay		24 hrs	Antiproliferative activity against human CaSki cells after 24 hrs by crystal violet staining-based assay, IC50=1.8μM.	29407986
ViBo	Antiproliferative assay		24 hrs	Antiproliferative activity against human ViBo cells after 24 hrs by crystal violet staining-based assay, IC50=1.92μM.	29407986
HEK293	Antiproliferative assay		48 hrs	Antiproliferative activity against human HEK293 cells after 48 hrs by CCK-8 assay, IC50=0.00056μM.	29501943
A549	Antiproliferative assay		48 hrs	Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay, IC50=0.001μM.	29501943
SKOV3	Antiproliferative assay		48 hrs	Antiproliferative activity against human SKOV3 cells after 48 hrs by CCK-8 assay, IC50=0.0055μM.	29501943
HCT15	Antiproliferative assay		72 hrs	Antiproliferative activity against human HCT15 cells after 72 hrs by CCK-8 assay, IC50=0.02μM.	29510948
HeLa	Antiproliferative assay		72 hrs	Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay, IC50=0.13μM.	29510948
T47D	Antiproliferative assay		72 hrs	Antiproliferative activity against human T47D cells after 72 hrs by CCK-8 assay, IC50=0.49μM.	29510948
H460	Cytotoxicity assay		72 hrs	Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=0.11μM.	29541373
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=0.16μM.	29541373
MDA-MB-231	Cytotoxicity assay		72 hrs	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=0.54μM.	29541373
CCRF-CEM	Cytotoxicity assay		72 hrs	Cytotoxicity against human CCRF-CEM cells assessed as growth inhibition after 72 hrs by MTT assay, GI50=0.002μM.	29705710
A549	Cytotoxicity assay		72 hrs	Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50=0.003μM.	29705710
HuH7	Cytotoxicity assay		72 hrs	Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50=0.006μM.	29705710
HCT116	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50=0.009μM.	29705710
DU145	Cytotoxicity assay		72 hrs	Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50=0.019μM.	29705710
HCT116	Cytotoxicity assay		72 hrs	Cytotoxicity against human HCT116 cells expressing TOP1 siRNA assessed as growth inhibition after 72 hrs by MTT assay, GI50=0.075μM.	29705710
RC0.1	Cytotoxicity assay		72 hrs	Cytotoxicity against human RC0.1 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50=7.53μM.	29705710
THP1	Cytotoxicity assay		24 hrs	Cytotoxicity against human THP1 cells after 24 hrs by LDH release assay, LD50=0.161μM.	29773506
PANC1	Cytotoxicity assay		72 hrs	Cytotoxicity against human PANC1 cells after 72 hrs by XTT assay, IC50=0.09μM.	30017114
PANC1	Cytotoxicity assay		48 hrs	Cytotoxicity against human PANC1 cells after 48 hrs by XTT assay, IC50=0.18μM.	30017114
Capan1	Cytotoxicity assay		72 hrs	Cytotoxicity against human Capan1 cells after 72 hrs by XTT assay, IC50=0.21μM.	30017114
CNE2	Cytotoxicity assay		48 hrs	Cytotoxicity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50=0.1μM.	30025344
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50=5.5μM.	30025344
HepG2	Cytotoxicity assay		48 hrs	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50=13.2μM.	30025344
K562	Antiproliferative assay		48 hrs	Antiproliferative activity against human K562 cells after 48 hrs by MTT assay, IC50=0.07μM.	30055465
HepG2	Antiproliferative assay		48 hrs	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50=0.37μM.	30055465
CNE1	Antiproliferative assay		72 hrs	Antiproliferative activity against human CNE1 cells after 72 hrs by MTT assay, IC50=0.34μM.	30125725
MCF7	Antiproliferative assay		72 hrs	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50=0.42μM.	30125725
HeLa	Antiproliferative assay		72 hrs	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay, IC50=0.66μM.	30125725
CNE2	Antiproliferative assay		72 hrs	Antiproliferative activity against human CNE2 cells after 72 hrs by MTT assay, IC50=0.98μM.	30125725
SMMC7721	Antiproliferative assay		72 hrs	Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay, IC50=1.08μM.	30125725
HepG2	Antiproliferative assay		72 hrs	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay, IC50=1.36μM.	30125725
HepG2	Antiproliferative assay		48 hrs	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50=6.08μM.	30125725
HCT15	Antiproliferative assay		72 hrs	Antiproliferative activity against human HCT15 cells after 72 hrs by EZ-CYTOX reagent based assay, IC50=0.05μM.	30262132
T47D	Antiproliferative assay		72 hrs	Antiproliferative activity against human T47D cells after 72 hrs by EZ-CYTOX reagent based assay, IC50=0.07μM.	30262132
HeLa	Antiproliferative assay		72 hrs	Antiproliferative activity against human HeLa cells after 72 hrs by EZ-CYTOX reagent based assay, IC50=1.37μM.	30262132
CCRF-CEM	Growth inhibition assay		72 hrs	Growth inhibition of human CCRF-CEM cells after 72 hrs by MTT assay, GI50=0.007μM.	30336023
HCT116	Growth inhibition assay		72 hrs	Growth inhibition of human HCT116 cells after 72 hrs by MTT assay, GI50=0.009μM.	30336023
DU145	Growth inhibition assay		72 hrs	Growth inhibition of human DU145 cells after 72 hrs by MTT assay, GI50=0.021μM.	30336023
HCT116	Growth inhibition assay		72 hrs	Growth inhibition of human HCT116 cells expressing TOP1 siRNA after 72 hrs by MTT assay, GI50=0.075μM.	30336023
HuH7	Growth inhibition assay		72 hrs	Growth inhibition of human HuH7 cells after 72 hrs by MTT assay, GI50=0.099μM.	30336023
A549	Growth inhibition assay		72 hrs	Growth inhibition of human A549 cells after 72 hrs by MTT assay, GI50=0.21μM.	30336023
RC0.1	Growth inhibition assay		72 hrs	Growth inhibition of human RC0.1 cells after 72 hrs by MTT assay, GI50=4.73μM.	30336023
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=0.04μM.	30340899
MS	Cytotoxicity assay		72 hrs	Cytotoxicity against against human MS cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=0.77μM.	30340899
A549	Cytotoxicity assay		72 hrs	Cytotoxicity against against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=1.31μM.	30340899
HEK293	Cytotoxicity assay		72 hrs	Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=1.61μM.	30340899
RD	Cytotoxicity assay		72 hrs	Cytotoxicity against against human RD cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=1.72μM.	30340899
HCT116	Cytotoxicity assay		72 hrs	Cytotoxicity against against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=1.88μM.	30340899
Hep2	Cytotoxicity assay		72 hrs	Cytotoxicity against against human Hep2 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50=3.01μM.	30340899
HL60	Cytotoxicity assay		48 hrs	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50<0.064μM.	30509782
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50=0.09μM.	30509782
SW480	Cytotoxicity assay		48 hrs	Cytotoxicity against human SW480 cells after 48 hrs by MTT assay, IC50=0.29μM.	30509782
SMMC7721	Cytotoxicity assay		48 hrs	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay, IC50=0.45μM.	30509782
MCF7	Cytotoxicity assay		48 hrs	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50=0.68μM.	30509782
HepG2	Cytotoxicity assay		72 hrs	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50=0.66μM.	30600208
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50=0.68μM.	30600208
MGC803	Antiproliferative assay		48 hrs	Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay, IC50=2.96μM.	30685528
A549	Antiproliferative assay		48 hrs	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50=4.43μM.	30685528
HepG2	Antiproliferative assay		48 hrs	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50=4.79μM.	30685528
HeLa	Antiproliferative assay		48 hrs	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50=6.51μM.	30685528
T24	Antiproliferative assay		48 hrs	Antiproliferative activity against human T24 cells after 48 hrs by MTT assay, IC50=6.8μM.	30685528
WI38	Antiproliferative assay		48 hrs	Antiproliferative activity against human WI38 cells after 48 hrs by MTT assay, IC50=8.37μM.	30685528
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells after 48 hrs by CCK8 assay, IC50=0.00032μM.	30702286
LN229	Cytotoxicity assay		48 hrs	Cytotoxicity against human LN229 cells after 48 hrs by CCK8 assay, IC50=0.00032μM.	30702286
MHCC97H	Cytotoxicity assay		48 hrs	Cytotoxicity against human MHCC97H cells after 48 hrs by CCK8 assay, IC50=0.00032μM.	30702286
LoVo	Cytotoxicity assay		48 hrs	Cytotoxicity against human LoVo cells after 48 hrs by CCK8 assay, IC50=0.00032μM.	30702286
MDA231	Cytotoxicity assay		48 hrs	Cytotoxicity against human MDA231 cells after 48 hrs by CCK8 assay, IC50=0.00032μM.	30702286
HuH7	Cytotoxicity assay		48 hrs	Cytotoxicity against human HuH7 cells after 48 hrs by CCK8 assay, IC50=0.00032μM.	30702286
MGC	Cytotoxicity assay		48 hrs	Cytotoxicity against human MGC cells after 48 hrs by CCK8 assay, IC50=0.00032μM.	30702286
HL7702	Cytotoxicity assay		48 hrs	Cytotoxicity against human HL7702 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50=2.15μM.	30875505
T24	Antiproliferative assay		48 hrs	Antiproliferative activity against human T24 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50=3.09μM.	30875505
MGC803	Antiproliferative assay		48 hrs	Antiproliferative activity against human MGC803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50=4.27μM.	30875505
NCI-H460	Antiproliferative assay		48 hrs	Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50=5.37μM.	30875505
HepG2	Antiproliferative assay		48 hrs	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50=5.69μM.	30875505
Sf9	Function assay		30 mins	Poison activity at recombinant human TOP1 expressed in baculovirus infected Sf9 insect cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium bromide staining based agarose gel electrophoresis, IC50=0.025μM.	30897325
MCF7	Function assay		30 mins	Poison activity at TOP1 in human MCF7 cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium bromide staining based agarose gel electrophoresis, IC50=2.5μM.	30897325
A549	Cytotoxicity assay		72 hrs	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay, IC50=3.32μM.	30902399
HCT116	Growth inhibition assay		72 hrs	Growth inhibition of human HCT116 cells incubated for 72 hrs by MTT assay, GI50=0.009μM.	31176097
MCF7	Growth inhibition assay		72 hrs	Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay, GI50=0.012μM.	31176097
HCT116	Growth inhibition assay		72 hrs	Growth inhibition of human HCT116 cells expressing siTOP1 incubated for 72 hrs by MTT assay, GI50=0.075μM.	31176097
A549	Growth inhibition assay		72 hrs	Growth inhibition of human A549 cells incubated for 72 hrs by MTT assay, GI50=0.099μM.	31176097
DU145	Growth inhibition assay		72 hrs	Growth inhibition of human DU145 cells incubated for 72 hrs by MTT assay, GI50=0.21μM.	31176097
DU145/RC0.1	Growth inhibition assay		72 hrs	Growth inhibition of human DU145/RC0.1 cells harboring TOP1 R364H mutant incubated for 72 hrs by MTT assay, GI50=4.73μM.	31176097
A549	Antiproliferative assay		48 hrs	Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay, IC50=0.001μM.	31229877
SKOV3	Antiproliferative assay		48 hrs	Antiproliferative activity against human SKOV3 cells incubated for 48 hrs by CCK8 assay, IC50=0.0055μM.	31229877
HCC70	Antiproliferative assay		72 hrs	Antiproliferative activity against human HCC70 cells measured after 72 hrs by Ez-cytox assay, IC50=0.044μM.	31398033
HCT15	Antiproliferative assay		72 hrs	Antiproliferative activity against human HCT15 cells measured after 72 hrs by EZ-Cytox assay, IC50=0.049μM.	31398033
DU145	Antiproliferative assay		72 hrs	Antiproliferative activity against human DU145 cells measured after 72 hrs by EZ-Cytox assay, IC50=0.05μM.	31398033
T47D	Antiproliferative assay		72 hrs	Antiproliferative activity against human T47D cells measured after 72 hrs by EZ-Cytox assay, IC50=0.25μM.	31398033
HeLa	Antiproliferative assay		72 hrs	Antiproliferative activity against human HeLa cells measured after 72 hrs by EZ-Cytox assay, IC50=0.5μM.	31398033
MDA-MB-231	Antiproliferative assay		72 hrs	Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by Ez-cytox assay, IC50=23.98μM.	31398033
MDA-MB-436	Antiproliferative assay		72 hrs	Antiproliferative activity against human MDA-MB-436 cells measured after 72 hrs by Ez-cytox assay, IC50=31.86μM.	31398033
MCF7	Antiproliferative assay		48 hrs	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay, IC50=0.03μM.	31546197
A549	Antiproliferative assay		48 hrs	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by SRB assay, IC50=0.03μM.	31546197
HCT116	Antiproliferative assay		48 hrs	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by SRB assay, IC50=0.03μM.	31546197
HT-29	Antiproliferative assay		48 hrs	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by SRB assay, IC50=0.03μM.	31546197
MV-3	Antiproliferative assay		72 hrs	Antiproliferative activity against human MV-3 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50=0.003μM.	31880942
K562	Antiproliferative assay		72 hrs	Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50<0.003μM.	31880942
HCT116	Antiproliferative assay		72 hrs	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50=0.02μM.	31880942
Bel7404	Antiproliferative assay		72 hrs	Antiproliferative activity against human Bel7404 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50=0.4μM.	31880942
SW579	Antiproliferative assay		72 hrs	Antiproliferative activity against human SW579 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50=0.7μM.	31880942
SKHEP1	Antiproliferative assay		72 hrs	Antiproliferative activity against human SKHEP1 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50=0.9μM.	31880942
PC3	Antiproliferative assay		72 hrs	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50=2.4μM.	31880942
MDA-MB-435	Antiproliferative assay		72 hrs	Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50=2.7μM.	31880942
A549	Antiproliferative assay		72 hrs	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay, IC50=2.8μM.	31880942
HCT116	Antiproliferative assay		4 days	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 4 days by [3H]-thymidine incorporation assay, IC50=0.0085μM.	ChEMBL
786-O	Antiproliferative assay		72 hrs	Antiproliferative activity against human 786-O cells incubated for 72 hrs by MTT assay, IC50=0.015μM.	ChEMBL
MDA-MB-231	Antiproliferative assay		4 days	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 4 days by [3H]-thymidine incorporation assay, IC50=0.0284μM.	ChEMBL
HeLa	Antiproliferative assay		72 hrs	Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay, IC50=0.18μM.	ChEMBL
MIAPaCa2	Antiproliferative assay		48 hrs	Antiproliferative activity against human MIAPaCa2 cells assessed as cell viability after 48 hrs by MTT assay, IC50=0.19μM.	ChEMBL
HepG2	Antiproliferative assay		48 hrs	Antiproliferative activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay, IC50=0.2μM.	ChEMBL
SKHep	Antiproliferative assay		72 hrs	Antiproliferative activity against human SKHep cells incubated for 72 hrs by MTT assay, IC50=0.22μM.	ChEMBL
HL60	Cytotoxicity assay		48 hrs	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50=0.42μM.	ChEMBL
Detroit 551	Antiproliferative assay		72 hrs	Antiproliferative activity against human Detroit 551 cells incubated for 72 hrs by MTT assay, IC50=0.99μM.	ChEMBL
PC3	Antiproliferative assay		48 hrs	Antiproliferative activity against human PC3 cells assessed as cell viability after 48 hrs by MTT assay, IC50=1.2μM.	ChEMBL
MDA-MB-231	Antiproliferative assay		72 hrs	Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay, IC50=2.11μM.	ChEMBL
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50=2.21μM.	ChEMBL
H1299	Antiproliferative assay		72 hrs	Antiproliferative activity against human H1299 cells incubated for 72 hrs by MTT assay, IC50=3.14μM.	ChEMBL
Raji	Cytotoxicity assay		48 hrs	Cytotoxicity against human Raji cells after 48 hrs by MTT assay, IC50=3.27μM.	ChEMBL
SAS	Antiproliferative assay		72 hrs	Antiproliferative activity against human SAS cells incubated for 72 hrs by MTT assay, IC50=6μM.	ChEMBL
MDA-MB-231	Cytotoxicity assay		48 hrs	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50=16.44μM.	ChEMBL
PC3	Cytotoxicity assay		48 hrs	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay, IC50=18.24μM.	ChEMBL
AGS	Antiproliferative assay		72 hrs	Antiproliferative activity against human AGS cells incubated for 72 hrs by MTT assay, IC50=23.76μM.	ChEMBL
A549	Apoptosis assay		12 to 15 hrs	Induction of apoptosis in human A549 cells assessed as formation of apoptotic bodies after 12 to 15 hrs by flow cytometric method	ChEMBL
A549	Apoptosis assay		12 to 15 hrs	Induction of apoptosis in human A549 cells assessed as cell condensation after 12 to 15 hrs by flow cytometric method	ChEMBL
HT-29	cytotoxicity assay			IC50=1.4 μM	12639541
JLC	cytotoxicity assay			IC50=5.6 nM	12620081
Lewis	cytotoxicity assay			IC50=33 nM	12620081
P388	cytotoxicity assay			IC50=13 nM	12620081
A2780	cytotoxicity assay			IC50=4 nM	11858737
HCT116	cytotoxicity assay			IC50=9 nM	11858737
LX-1	cytotoxicity assay			IC50=120 nM	11858737
SK-BR-3	cytotoxicity assay			IC50=20 nM	11334569
H128	cytotoxicity assay			IC50=18 nM	11334569
SK-OV-3	cytotoxicity assay			IC50=20 nM	11334569
MKN45	cytotoxicity assay			IC50=17 nM	11334569
A549	cytotoxicity assay			IC50=14 nM	11334569
WiDr	cytotoxicity assay			IC50=17 nM	11334569
MDA-MB-435	Growth inhibitory assay			IC50=40 nM	11020283
DU-145	Growth inhibitory assay			IC50=10 nM	11020283
SN12C	Growth inhibitory assay			IC50=20 nM	11020283
OVCAR-3	Growth inhibitory assay			IC50=220 nM	11020283
UACC-62	Growth inhibitory assay			IC50=10 nM	11020283
SF-539	Growth inhibitory assay			IC50=10 nM	11020283
HCT-116	Growth inhibitory assay			IC50=30 nM	11020283
HOP-62	Growth inhibitory assay			IC50=10 nM	11020283
T24	cytotoxicity assay			IC50=88 nM	10841808
A549	cytotoxicity assay			IC50=67 nM	10841808
HT29	cytotoxicity assay			IC50=80 nM	10841808
KBCamp	Growth inhibitory assay			IC50=1.04 μM	10411476
KB7D	Growth inhibitory assay			IC50=35 nM	10411476
KBV20C	Growth inhibitory assay			IC50=30 nM	10411476
KBMDR	Growth inhibitory assay			IC50=70 nM	10411476
KBwt	Growth inhibitory assay			IC50=40 nM	10411476
P388CPT5 R	Growth inhibitory assay			IC50=2.8 μM	10346933
P388	Growth inhibitory assay			IC50=32 nM	10346933
Caki-2	cytotoxicity assay			IC50=3.96 μM	12639541
A549	cytotoxicity assay			IC50=2.53 μM	12639541
HEC-1-B	cytotoxicity assay			IC50=8.64 μM	12639541
HL-60	cytotoxicity assay			IC50=66 nM	12639541
MT-4	cytotoxicity assay			IC50=4 nM	17254669
CCRF-CEMc	cytotoxicity assay			IC50=3 nM	17254669
WIL-2NSd	cytotoxicity assay			IC50=5 nM	17254669
CCRF-SB	cytotoxicity assay			IC50=3 nM	17254669
CRL 7065	cytotoxicity assay			IC50=400 nM	17254669
SK-MEL-28b	cytotoxicity assay			IC50=40 nM	17254669
MCF-7	cytotoxicity assay			IC50=40 nM	17254669
SKMES-1	cytotoxicity assay			IC50=10 nM	17254669
HepG2	cytotoxicity assay			IC50=30 nM	17254669
DU145	cytotoxicity assay			IC50=10 nM	17254669
SKOV3	cytotoxicity assay			IC50=51 nM	9003520
SKVLB	cytotoxicity assay			IC50=53 nM	9003520
HT29	cytotoxicity assay			IC50=87.8 nM	9003520
KB	cytotoxicity assay			IC50=8 nM	9003520
L1210	Function assay			Concentration that inhibits the proliferation of L1210 cells by 50%, IC50=0.014μM.	2537428
SK-OV-3	Cytotoxicity assay			Cytotoxicity was determined in vitro in SK-OV-3 cells (ovarian) of human tumor cell lines by using MTT assay, IC50=0.037μM.	7853331
SKVLB	Cytotoxicity assay			Cytotoxicity was determined in vitro in SKVLB cells(ovarian with upregulated MDRp-glycoprotein) of human tumor cell lines by using MTT assay, IC50=0.041μM.	7853331
HT-29	Cytotoxicity assay			Cytotoxicity was determined in vitro in HT-29 cells(colon) of human tumor cell lines by using MTT assay, IC50=0.046μM.	7853331
LOX	Cytotoxicity assay			Cytotoxicity was determined in vitro in LOX cells (melanoma) of human tumor cell lines by using MTT assay, IC50=0.048μM.	7853331
T47D	Cytotoxicity assay			Cytotoxicity was determined in vitro in T47D cells(breast) of human tumor cell lines by using MTT assay, IC50=0.207μM.	7853331
L1210	Cytotoxicity assay			Cytotoxicity was measured on cultured murine lymphoblastic leukemia cells (L1210), IC50=0.015μM.	8246238
HL-60	Function assay			Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells, IC50=0.68μM.	8410981
KB	Growth inhibition assay			Compound concentration required to reduce the exponential growth of KB cells by 50%, CC50=0.006μM.	9767632
MT-4	Growth inhibition assay			Compound concentration required to reduce the exponential growth of MT-4 cells by 50%, CC50=0.01μM.	9767632
COLO 205	Cytotoxicity assay			Cytotoxicity expressed as the concentration that inhibited incorporation of [3H]thymidine into cellular DNA of human colorectal cells (COLO 205), IC50=0.0054μM.	10479293
HepG2	Cytotoxicity assay			Cytotoxicity expressed as the concentration that inhibited incorporation of [3H]thymidine into cellular DNA of human hepatocellular cells (HepG2), IC50=0.0063μM.	10479293
H928	Cytotoxicity assay			Cytotoxicity expressed as the concentration that inhibited incorporation of [3H]-thymidine into cellular DNA of human lung carcinoma cells (H928), IC50=0.0078μM.	10479293
CaSki	Cytotoxicity assay			Cytotoxicity expressed as the concentration that inhibited incorporation of [3H]thymidine into cellular DNA of human cervical cells (CaSki), IC50=0.0085μM.	10479293
MDA-MB-435	Function assay			Inhibition against MDA-MB-435 human breast cancer cells in the absence of HSA, IC50=0.015μM.	11052802
MDA-MB-435	Function assay			Inhibition against MDA-MB-435 human breast cancer cells in the presence of 11 mg/mL HSA, IC50=0.375μM.	11052802
Jurkat	Function assay			Inhibitory activity against Jurkat human leukemia cells, IC50=0.0056μM.	11384245
P388	Function assay			Inhibitory activity against P388 murine leukemia cells, IC50=0.013μM.	11384245
Lewis lung carcinoma cells	Function assay			Inhibitory activity against Lewis lung carcinoma cells, IC50=0.033μM.	11384245
A549	Function assay			Inhibition topoisomerase 1 in human A549 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form, IC50=4μM.	11430001
HeLa	Function assay			Inhibition topoisomerase 1 in human HeLa cells assessed as conversion of supercoiled pBR322 DNA to relaxed form, IC50=9μM.	11430001
NIH/3T3	Function assay			Inhibition topoisomerase 1 in mouse NIH/3T3 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form, IC50=12μM.	11430001
COLO201	Function assay			Inhibition topoisomerase 1 in human COLO201 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form, IC50=17μM.	11430001
Vero	Function assay			Inhibition topoisomerase 1 in african green monkey Vero cells assessed as conversion of supercoiled pBR322 DNA to relaxed form, IC50=27μM.	11430001
SW626	Cytotoxicity assay			Cytotoxicity against human SW626 cells by MTT assay, IC50=0.0287μM.	11858760
Lu1	Cytotoxicity assay			Cytotoxicity against human Lu1 cells by MTT assay, IC50=0.0287μM.	11858760
KB	Cytotoxicity assay			Cytotoxicity against human KB cells by MTT assay, IC50=0.0287μM.	11858760
HOG.R5	Cytotoxicity assay			Cytotoxicity against human HOG.R5 cells by MTT assay, IC50=0.0287μM.	11858760
LNCAP	Cytotoxicity assay			Cytotoxicity against human LNCAP cells by MTT assay, IC50=0.0861μM.	11858760
HCT116	Function assay			Compound was tested in vitro for cytotoxicity against HCT116, human colon cancer cells (taxol-resistant) at a drug concentration producing 50% inhibition of colony formation, ID50=0.0028μM.	11965362
PC-3	Function assay			Compound was tested in vitro for cytotoxicity against PC-3, human prostate cancer cells (taxol-sensitive) at a drug concentration producing 50% inhibition of colony formation, ID50=0.0038μM.	11965362
MCF-7ADR	Function assay			Compound was tested in vitro for cytotoxicity against MCF-7ADR, human breast cancer cells (taxol-resistant) at a drug concentration producing 50% inhibition of colony formation, ID50=0.0039μM.	11965362
L1210	Function assay			Inhibitory concentration required against L1210 leukemia cells, IC50=0.03μM.	12182872
L1210	Cytotoxicity assay			Cytotoxicity against L1210 leukemia cells, Concentration=0.05μM.	12182872
P388	Function assay			Inhibitory activity against P388 Leukemia cells, IC50=0.007μM.	12565975
CCRF-CEM	Cytotoxicity assay			Cytotoxicity in human leukemic CCRF-CEM cells, IC50=5.3μM.	14667232
HeLa	Function assay			Concentration required to inhibit S phase and G2/M phase in HeLa cells, Concentration=0.1μM.	15026047
HeLa	Growth inhibition assay			Growth inhibitory concentration of compound was determined against HeLa cells by alamar blue assay, GI50=0.6μM.	15026047
SW620	Growth inhibition assay			Concentration required to inhibit growth of SW620 (human colon cancer) cells in the presence of 10 uM of Compound 2e, EC50=0.00015μM.	15857116
SW620	Growth inhibition assay			Concentration required to inhibit growth of SW620 (human colon cancer) cells, EC50=0.0012μM.	15857116
CNSSF-539	Growth inhibition assay			Concentration required to inhibit the growth of human CNSSF-539 cells, GI50=0.01μM.	16033260
LungHOP-62	Growth inhibition assay			Concentration required to inhibit the growth of human LungHOP-62 cells, GI50=0.01μM.	16033260
ProstateDU-145	Growth inhibition assay			Concentration required to inhibit the growth of human ProstateDU-145 cells, GI50=0.01μM.	16033260
Melanoma UACC-62	Growth inhibition assay			Concentration required to inhibit the growth of human Melanoma UACC-62 cells, GI50=0.01μM.	16033260
Renal SN12C	Growth inhibition assay			Concentration required to inhibit the growth of human Renal SN12C cells, GI50=0.02μM.	16033260
ColonHCT-11	Growth inhibition assay			Concentration required to inhibit the growth of human ColonHCT-11 cells, GI50=0.03μM.	16033260
MDA-MB-435	Growth inhibition assay			Concentration required to inhibit the growth of human Breast MDA-MB-435 cells, GI50=0.04μM.	16033260
OVCAR	Growth inhibition assay			Concentration required to inhibit the growth of human OvarianOVCAR cells, GI50=0.22μM.	16033260
T24	Growth inhibition assay			Growth inhibition of human T24 cells by neutral red assay, IC50=0.006μM.	17204425
HT29	Growth inhibition assay			Growth inhibition of human HT29 cells by neutral red assay, IC50=0.014μM.	17204425
MDA-MB-231	Growth inhibition assay			Growth inhibition of human MDA-MB-231 cells by neutral red assay, IC50=0.291μM.	17204425
SW620	Antiproliferative assay			Antiproliferative activity against human SW620 cells by soft agar assay, EC50=0.0021μM.	17287122
LNCAP	Cytotoxicity assay			Cytotoxicity against human LNCAP cells by sulforhodamine B assay, ED50=0.002μM.	17350834
1A9	Cytotoxicity assay			Cytotoxicity against human 1A9 cells by sulforhodamine B assay, ED50=0.0032μM.	17350834
MCF7	Cytotoxicity assay			Cytotoxicity against human MCF7 cells by sulforhodamine B assay, ED50=0.0032μM.	17350834
A549	Cytotoxicity assay			Cytotoxicity against human A549 cells by sulforhodamine B assay, ED50=0.0069μM.	17350834
DU145	Cytotoxicity assay			Cytotoxicity against human DU145 cells by sulforhodamine B assay, ED50=0.0109μM.	17350834
KBVIN	Cytotoxicity assay			Cytotoxicity against multi drug-resistant human KBVIN cells by sulforhodamine B assay, ED50=0.015μM.	17350834
PC3	Cytotoxicity assay			Cytotoxicity against human PC3 cells by sulforhodamine B assay, ED50=0.0167μM.	17350834
KB	Cytotoxicity assay			Cytotoxicity against human KB cells by sulforhodamine B assay, ED50=0.0209μM.	17350834
HOP62	Cytotoxicity assay			Cytotoxicity against human HOP62 cells, GI50=0.01μM.	17402722
SF268	Cytotoxicity assay			Cytotoxicity against human SF268 cells, GI50=0.01μM.	17402722
UACC62	Cytotoxicity assay			Cytotoxicity against human UACC62 cells, GI50=0.01μM.	17402722
DU145	Cytotoxicity assay			Cytotoxicity against human DU145 cells, GI50=0.01μM.	17402722
SN12C	Cytotoxicity assay			Cytotoxicity against human SN12C cells, GI50=0.02μM.	17402722
HCT116	Cytotoxicity assay			Cytotoxicity against human HCT116 cells, GI50=0.03μM.	17402722
MDA-MA-435	Cytotoxicity assay			Cytotoxicity against human MDA-MA-435 cells, GI50=0.04μM.	17402722
OVCAR-3	Cytotoxicity assay			Cytotoxicity against human OVCAR-3 cells, GI50=0.22μM.	17402722
neural precursor cells	Function assay			Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay	17417631
CEM	Growth inhibition assay			Growth inhibition of human CEM cells by Alamar blue assay, GI50=0.002μM.	17418582
MX2	Growth inhibition assay			Growth inhibition of topoisomerase 2 mutated mitoxantrone-resistant MX2 cells by Alamar blue assay, GI50=0.02μM.	17418582
HL60	Growth inhibition assay			Growth inhibition of human HL60 cells by Almar blue assay, GI50=0.03μM.	17418582
HL60	Cytotoxicity assay			Cytotoxicity against human HL60 cells by MTT assay, IC50=0.018μM.	17498951
Col2	Cytotoxicity assay			Cytotoxicity against human Col2 cells by SRB assay, IC50=0.045μM.	17498951
A549	Cytotoxicity assay			Cytotoxicity against human A549 cells by SRB assay, IC50=0.069μM.	17498951
HT1080	Cytotoxicity assay			Cytotoxicity against human HT1080 cells by SRB assay, IC50=0.08μM.	17498951
SNU638	Cytotoxicity assay			Cytotoxicity against human SNU638 cells by SRB assay, IC50=0.098μM.	17498951
HeLa	Cytotoxicity assay			Cytotoxicity against human HeLa cells by MTT method, IC50=0.5μM.	17547457
KB	Cytotoxicity assay			Cytotoxicity against human KB cells, EC50=0.0036μM.	17552563
HOP62	Cytotoxicity assay			Cytotoxicity against human HOP62 cells, GI50=0.01μM.	17676830
SF539	Cytotoxicity assay			Cytotoxicity against human SF539 cells, GI50=0.01μM.	17676830
UACC62	Cytotoxicity assay			Cytotoxicity against human UACC62 cells, GI50=0.01μM.	17676830
DU145	Cytotoxicity assay			Cytotoxicity against human DU145 cells, GI50=0.01μM.	17676830
SN12C	Cytotoxicity assay			Cytotoxicity against human SN12C cells, GI50=0.02μM.	17676830
HCT116	Cytotoxicity assay			Cytotoxicity against human HCT116 cells, GI50=0.03μM.	17676830
MDA-MB-435	Cytotoxicity assay			Cytotoxicity against human MDA-MB-435 cells, GI50=0.04μM.	17676830
OVCAR-3	Cytotoxicity assay			Cytotoxicity against human OVCAR-3 cells, GI50=0.22μM.	17676830
HOP62	Cytotoxicity assay			Cytotoxicity against human HOP62 cells, GI50=0.01μM.	17696418
SF539	Cytotoxicity assay			Cytotoxicity against human SF539 cells, GI50=0.01μM.	17696418
UACC62	Cytotoxicity assay			Cytotoxicity against human UACC62 cells, GI50=0.01μM.	17696418
DU145	Cytotoxicity assay			Cytotoxicity against human DU145 cells, GI50=0.01μM.	17696418
SN12C	Cytotoxicity assay			Cytotoxicity against human SN12C cells, GI50=0.02μM.	17696418
HCT116	Cytotoxicity assay			Cytotoxicity against human HCT116 cells, GI50=0.03μM.	17696418
MDA-MB-435	Cytotoxicity assay			Cytotoxicity against human MDA-MB-435 cells, GI50=0.04μM.	17696418
OVCAR-3	Cytotoxicity assay			Cytotoxicity against human OVCAR-3 cells, GI50=0.22μM.	17696418
OV3	Cytotoxicity assay			Cytotoxicity against human OV3 cells by SRB assay, IC50=0.024μM.	17827007
A549	Cytotoxicity assay			Cytotoxicity against human A549 cells by SRB assay, IC50=0.067μM.	17827007
SK-MEL-2	Cytotoxicity assay			Cytotoxicity against human SK-MEL-2 cells by SRB assay, IC50=0.075μM.	17827007
HCT15	Cytotoxicity assay			Cytotoxicity against human HCT15 cells by SRB assay, IC50=0.08μM.	17827007
HL60/MX2	Cytotoxicity assay			Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay, GI50=0.0015μM.	17962028
HL60	Cytotoxicity assay			Cytotoxicity against human HL60 cells, IC50=0.013μM.	18178085
HCT116	Cytotoxicity assay			Cytotoxicity against human HCT116 cells, IC50=1μM.	18178085
HeLa	Cytotoxicity assay			Cytotoxicity against human HeLa cells, IC50=1.08μM.	18178085
DU145	Cytotoxicity assay			Cytotoxicity against human DU145 cells, IC50=3.2μM.	18178085
MDA-MB-231	Cytotoxicity assay			Cytotoxicity against human MDA-MB-231 cells, IC50=4.16μM.	18178085
P388	Cytotoxicity assay			Cytotoxicity against human P388 cells, IC50=0.000004μM.	18511275
RPMI-8240	Cytotoxicity assay			Cytotoxicity against human RPMI-8240 cells, IC50=0.000004μM.	18511275
HOP62	Antiproliferative assay			Antiproliferative activity against human HOP62 cells, GI50=0.01μM.	18630891
SF539	Antiproliferative assay			Antiproliferative activity against human SF539 cells, GI50=0.01μM.	18630891
UACC62	Antiproliferative assay			Antiproliferative activity against human UACC62 cells, GI50=0.01μM.	18630891
DU145	Antiproliferative assay			Antiproliferative activity against human DU145 cells, GI50=0.01μM.	18630891
SN12C	Antiproliferative assay			Antiproliferative activity against human SN12C cells, GI50=0.02μM.	18630891
HCT116	Antiproliferative assay			Antiproliferative activity against human HCT116 cells, GI50=0.03μM.	18630891
MDA-MB-435	Antiproliferative assay			Antiproliferative activity against human MDA-MB-435 cells, GI50=0.04μM.	18630891
OVCAR-3	Antiproliferative assay			Antiproliferative activity against human OVCAR-3 cells, GI50=0.22μM.	18630891
P388	Cytotoxicity assay			Cytotoxicity against mouse P388 cells by MTT method, IC50=0.004μM.	18771930
RPMI8402	Cytotoxicity assay			Cytotoxicity against human RPMI8402 cells by MTT method, IC50=0.004μM.	18771930
KB3-1	Cytotoxicity assay			Cytotoxicity against human KB3-1 cells by MTT method, IC50=0.015μM.	18771930
KBV1	Cytotoxicity assay			Cytotoxicity against human KBV1 cells by MTT method, IC50=0.025μM.	18771930
KBH5.0	Cytotoxicity assay			Cytotoxicity against human KBH5.0 cells by MTT method, IC50=0.026μM.	18771930
RPMI8402	Cytotoxicity assay			Cytotoxicity against human RPMI8402 cells after MTT assay, IC50=0.006μM.	18829334
P388	Cytotoxicity assay			Cytotoxicity against mouse P388 cells after MTT assay, IC50=0.014μM.	18829334
HEPG2	Cytotoxicity assay			Cytotoxicity against human HEPG2 cells by MTT assay, IC50=0.3μM.	18841903
HT29	Cytotoxicity assay			Cytotoxicity against human HT29 cells by MTT assay, IC50=2μM.	18841903
MCF7	Cytotoxicity assay			Cytotoxicity against human MCF7 cells by MTT assay, IC50=10μM.	18841903
RPMI8226	Cytotoxicity assay			Cytotoxicity against human RPMI8226 cells by MTT method, IC50=0.006μM.	19012996
P388	Cytotoxicity assay			Cytotoxicity against mouse P388 cells by MTT method, IC50=0.014μM.	19012996
A549	Cytotoxicity assay			Cytotoxicity against human A549 cells by sulforhodamine B assay, IC50=0.058μM.	19345580
HeLa	Cytotoxicity assay			Cytotoxicity against human HeLa cells by sulforhodamine B assay, IC50=0.072μM.	19345580
HL60	Cytotoxicity assay			Cytotoxicity against human HL60 cells by sulforhodamine B assay, IC50=0.089μM.	19345580
A549/ATCC	Antitumor assay			Antitumor activity against human A549/ATCC cells by SRB method, IC50=0.047μM.	19541483
HT-29	Antitumor assay			Antitumor activity against human HT-29 cells by SRB method, IC50=0.12μM.	19541483
HL60	Cytotoxicity assay			Cytotoxicity against human HL60 cells by rapid colorimetric assay, IC50=0.8μM.	19585998
KB	Cytotoxicity assay			Cytotoxicity against human KB cells by SRB staining-based fluorescence cytometry, IC50=1.22μM.	19653666
HeLa	Cytotoxicity assay			Cytotoxicity against human HeLa cells by SRB staining-based fluorescence cytometry, IC50=1.22μM.	19653666
HT-29	Cytotoxicity assay			Cytotoxicity against human HT-29 cells by SRB staining-based fluorescence cytometry, IC50=1.22μM.	19653666
MCF7	Cytotoxicity assay			Cytotoxicity against human MCF7 cells by SRB staining-based fluorescence cytometry, IC50=1.22μM.	19653666
HOP62	Cytotoxicity assay			Cytotoxicity against human HOP62 cells, GI50=0.01μM.	19783447
UACC62	Cytotoxicity assay			Cytotoxicity against human UACC62 cells, GI50=0.01μM.	19783447
DU145	Cytotoxicity assay			Cytotoxicity against human DU145 cells, GI50=0.01μM.	19783447
SF539	Cytotoxicity assay			Cytotoxicity against human SF539 cells, GI50=0.01μM.	19783447
SN12C	Cytotoxicity assay			Cytotoxicity against human SN12C cells, GI50=0.02μM.	19783447
HCT116	Cytotoxicity assay			Cytotoxicity against human HCT116 cells, GI50=0.03μM.	19783447
MDA-MB-435	Cytotoxicity assay			Cytotoxicity against human MDA-MB-435 cells, GI50=0.04μM.	19783447
OVCAR-3	Cytotoxicity assay			Cytotoxicity against human OVCAR-3 cells, GI50=0.22μM.	19783447
HL60	Cytotoxicity assay			Cytotoxicity against human HL60 cells by MTT assay, IC50=0.067μM.	19836231
HeLa	Cytotoxicity assay			Cytotoxicity against human HeLa cells by MTT assay, IC50=0.58μM.	19836231
MDA-MB-231	Cytotoxicity assay			Cytotoxicity against human MDA-MB-231 cells by MTT assay, IC50=0.68μM.	19836231
DU145	Cytotoxicity assay			Cytotoxicity against human DU145 cells by MTT assay, IC50=1μM.	19836231
HT-29	Cytotoxicity assay			Cytotoxicity against human HT-29 cells by MTT assay, IC50=1.07μM.	19836231
HT-29	Cytotoxicity assay			Cytotoxicity against human HT-29 cells, ED50=0.06μM.	19839614
HepG2	Cytotoxicity assay			Cytotoxicity against human HepG2 cells by MTT assay, IC50=0.06μM.	19863101
BGC823	Cytotoxicity assay			Cytotoxicity against human BGC823 cells, IC50=0.21μM.	19916529
A2780	Cytotoxicity assay			Cytotoxicity against human A2780 cells, IC50=0.28μM.	19916529
SF539	Antiproliferative assay			Antiproliferative activity against human SF539 cells, GI50=0.01μM.	20155916
HOP62	Antiproliferative assay			Antiproliferative activity against human HOP62 cells, GI50=0.01μM.	20155916
DU145	Antiproliferative assay			Antiproliferative activity against human DU145 cells, GI50=0.01μM.	20155916
UACC62	Antiproliferative assay			Antiproliferative activity against human UACC62 cells, GI50=0.01μM.	20155916
SN12C	Antiproliferative assay			Antiproliferative activity against human SN12C cells, GI50=0.02μM.	20155916
HCT116	Antiproliferative assay			Antiproliferative activity against human HCT116 cells, GI50=0.03μM.	20155916
MDA-MB-435	Antiproliferative assay			Antiproliferative activity against human MDA-MB-435 cells, GI50=0.04μM.	20155916
OVCAR-3	Antiproliferative assay			Antiproliferative activity against human OVCAR-3 cells, GI50=0.22μM.	20155916
K562	Cytotoxicity assay			Cytotoxicity against human K562 cells in presence of 10% fetal bovine serum, IC50=0.08μM.	20188578
HeLa	Cytotoxicity assay			Cytotoxicity against human HeLa cells in presence of 10% fetal bovine serum, IC50=0.63μM.	20188578
HCT15	Cytotoxicity assay			Cytotoxicity against human HCT15 cells in presence of 10% fetal bovine serum, IC50=0.64μM.	20188578
DU145	Cytotoxicity assay			Cytotoxicity against human DU145 cells in presence of 10% fetal bovine serum, IC50=0.94μM.	20188578
K562	Cytotoxicity assay			Cytotoxicity against human imitinib-resistant K562 cells by MTT assay, IC50=0.002μM.	20329739
DA1-3b	Cytotoxicity assay			Cytotoxicity against mouse dasatinib-resistant DA1-3b cells carrying pCDNA3-p210BCR/ABL plasmid by MTT assay, IC50=0.03μM.	20329739
Raji	Cytotoxicity assay			Cytotoxicity against human Raji cells by MTT assay, IC50=1μM.	20329739
HL60	Cytotoxicity assay			Cytotoxicity against human HL60 cells by MTT assay, IC50=0.59μM.	20356735
HeLa	Cytotoxicity assay			Cytotoxicity against human HeLa cells by MTT assay, IC50=0.94μM.	20356735
SF539	Cytotoxicity assay			Cytotoxicity against human SF539 cells, GI50=0.01μM.	20630766
UACC62	Cytotoxicity assay			Cytotoxicity against human UACC62 cells, GI50=0.01μM.	20630766
HOP62	Cytotoxicity assay			Cytotoxicity against human HOP62 cells, GI50=0.01μM.	20630766
DU145	Cytotoxicity assay			Cytotoxicity against human DU145 cells, GI50=0.01μM.	20630766
MCF7	Cytotoxicity assay			Cytotoxicity against human MCF7 cells, GI50=0.01μM.	20630766
SN12C	Cytotoxicity assay			Cytotoxicity against human SN12C cells, GI50=0.02μM.	20630766
HCT116	Cytotoxicity assay			Cytotoxicity against human HCT116 cells, GI50=0.03μM.	20630766
OVCAR-3	Cytotoxicity assay			Cytotoxicity against human OVCAR-3 cells, GI50=0.22μM.	20630766
HT-29	Cytotoxicity assay			Cytotoxicity against human HT-29 cells, EC50=0.06μM.	20825206
HL60	Cytotoxicity assay			Cytotoxicity against human HL60 cells, IC50=0.018μM.	21095131
Col2	Cytotoxicity assay			Cytotoxicity against human Col2 cells, IC50=0.045μM.	21095131
A549	Cytotoxicity assay			Cytotoxicity against human A549 cells, IC50=0.069μM.	21095131
HT1080	Cytotoxicity assay			Cytotoxicity against human HT1080 cells, IC50=0.08μM.	21095131
SNU638	Cytotoxicity assay			Cytotoxicity against human SNU638 cells, IC50=0.098μM.	21095131
K562	Cytotoxicity assay			Cytotoxicity against human K562 cells by MTT assay, IC50=0.59μM.	21115246
DU145	Cytotoxicity assay			Cytotoxicity against human DU145 cells by MTT assay, IC50=0.61μM.	21115246
HCT15	Cytotoxicity assay			Cytotoxicity against human HCT15 cells by MTT assay, IC50=0.8μM.	21115246
MCF7	Cytotoxicity assay			Cytotoxicity against human MCF7 cells by MTT assay, IC50=2.43μM.	21115246
HL60	Cytotoxicity assay			Cytotoxicity against human HL60 cells by MTT assay, IC50=0.018μM.	21353568
Col2	Cytotoxicity assay			Cytotoxicity against human Col2 cells by MTT assay, IC50=0.045μM.	21353568
A549	Cytotoxicity assay			Cytotoxicity against human A549 cells by MTT assay, IC50=0.069μM.	21353568
HT1080	Cytotoxicity assay			Cytotoxicity against human HT1080 cells by MTT assay, IC50=0.08μM.	21353568
SNU638	Cytotoxicity assay			Cytotoxicity against human SNU638 cells by MTT assay, IC50=0.098μM.	21353568
MCF7	Cytotoxicity assay			Cytotoxicity against human MCF7 cells by SRB assay, IC50=0.0016μM.	21410162
NCI-H460	Anticancer assay			Anticancer activity against human NCI-H460 cells, IC50=0.03μM.	21599000
SF268	Anticancer assay			Anticancer activity against human SF268 cells, IC50=0.19μM.	21599000
MRC5	Antiproliferative assay			Antiproliferative activity against human MRC5 cells, IC50=0.89μM.	21599000
MCF7	Anticancer assay			Anticancer activity against human MCF7 cells, IC50=11.12μM.	21599000
HOP62	Antiproliferative assay			Antiproliferative activity against human HOP62 cells by SRB assay, GI50=0.01μM.	21710981
SF539	Antiproliferative assay			Antiproliferative activity against human SF539 cells by SRB assay, GI50=0.01μM.	21710981
UACC62	Antiproliferative assay			Antiproliferative activity against human UACC62 cells by SRB assay, GI50=0.01μM.	21710981
DU145	Antiproliferative assay			Antiproliferative activity against human DU145 cells by SRB assay, GI50=0.01μM.	21710981
MCF7	Antiproliferative assay			Antiproliferative activity against human MCF7 cells by SRB assay, GI50=0.01μM.	21710981
SN12C	Antiproliferative assay			Antiproliferative activity against human SN12C cells by SRB assay, GI50=0.02μM.	21710981
HCT116	Antiproliferative assay			Antiproliferative activity against human HCT116 cells by SRB assay, GI50=0.03μM.	21710981
OVCAR3	Antiproliferative assay			Antiproliferative activity against human OVCAR3 cells by SRB assay, GI50=0.22μM.	21710981
MCF7	Cytotoxicity assay			Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay, IC50=1.8μM.	22197145
MCF7	Cytotoxicity assay			Cytotoxicity against human MCF7 cells by WST-1 assay, IC50=2.6μM.	22197145
MDA-MB-231	Cytotoxicity assay			Cytotoxicity against human MDA-MB-231 cells by WST-1 assay, IC50=2.7μM.	22197145
CEM	Cytotoxicity assay			Cytotoxicity against human CEM cells, IC50=0.005μM.	22305342
MCF7	Cytotoxicity assay			Cytotoxicity against human MCF7 cells by SRB assay, IC50=0.0016μM.	22376176
A549	Cytotoxicity assay			Cytotoxicity against human A549 cells by SRB assay, IC50=0.0158μM.	23102893
DU145	Cytotoxicity assay			Cytotoxicity against human DU145 cells by SRB assay, IC50=0.0287μM.	23102893
KBVIN	Cytotoxicity assay			Cytotoxicity against human KBVIN cells by SRB assay, IC50=0.0371μM.	23102893
KB	Cytotoxicity assay			Cytotoxicity against human KB cells by SRB assay, IC50=0.121μM.	23102893
L1210	Cytotoxicity assay			Cytotoxicity against mouse L1210 cells, IC50=0.03μM.	23578545
A549	Cytotoxicity assay			Cytotoxicity against human A549 cells by WST assay, IC50=0.067μM.	23578545
T24	Cytotoxicity assay			Cytotoxicity against human chemo-resistant T24 cells by WST assay, IC50=0.088μM.	23578545
T47D	Cytotoxicity assay			Cytotoxicity against human T47D cells by MTT assay, IC50=0.07μM.	23608763
SNU638	Cytotoxicity assay			Cytotoxicity against human SNU638 cells by MTT assay, IC50=0.28μM.	23608763
CEM	Growth inhibition assay			Growth inhibition of human CEM cells, GI50=0.002μM.	23750455
CEM/C2	Growth inhibition assay			Growth inhibition of multidrug-resistant human CEM/C2 cells, GI50=1μM.	23750455
HT-29	Antiproliferative assay			Antiproliferative activity against human HT-29 cells by SRB assay, IC50=0.0007μM.	24200393
MCF7	Antiproliferative assay			Antiproliferative activity against human MCF7 cells by SRB assay, IC50=0.0033μM.	24200393
KB	Antiproliferative assay			Antiproliferative activity against human KB cells by SRB assay, IC50=0.02μM.	24200393
HeLa	Antiproliferative assay			Antiproliferative activity against human HeLa cells by SRB assay, IC50=0.13μM.	24200393
DU145	Cytotoxicity assay			Cytotoxicity against human DU145 cells by SRB assay, GI50=0.01μM.	24502276
UACC62	Cytotoxicity assay			Cytotoxicity against human UACC62 cells by SRB assay, GI50=0.01μM.	24502276
SF539	Cytotoxicity assay			Cytotoxicity against human SF539 cells by SRB assay, GI50=0.01μM.	24502276
HOP62	Cytotoxicity assay			Cytotoxicity against human HOP62 cells by SRB assay, GI50=0.01μM.	24502276
MCF7	Cytotoxicity assay			Cytotoxicity against human MCF7 cells by SRB assay, GI50=0.013μM.	24502276
SN12C	Cytotoxicity assay			Cytotoxicity against human SN12C cells by SRB assay, GI50=0.02μM.	24502276
HCT116	Cytotoxicity assay			Cytotoxicity against human HCT116 cells by SRB assay, GI50=0.03μM.	24502276
OVCAR3	Cytotoxicity assay			Cytotoxicity against human OVCAR3 cells by SRB assay, GI50=0.22μM.	24502276
MDA-MB-231	Apoptosis assay			Induction of apoptosis in human MDA-MB-231 cells assessed as p53 phosphorylation at Ser15 by Western blotting analysis	24980118
A375	Apoptosis assay			Induction of apoptosis in human A375 cells assessed as p53 phosphorylation at Ser15 by Western blotting analysis	24980118
A549	Cytotoxicity assay			Cytotoxicity against human A549 cells by MTT assay, IC50=0.001μM.	25237727
BGC823	Cytotoxicity assay			Cytotoxicity against human BGC823 cells by MTT assay, IC50=0.04μM.	25237727
A2780	Cytotoxicity assay			Cytotoxicity against human A2780 cells by MTT assay, IC50=0.9μM.	25237727
HCT8	Cytotoxicity assay			Cytotoxicity against human HCT8 cells by MTT assay, IC50=3.6μM.	25237727
Bel7402	Cytotoxicity assay			Cytotoxicity against human Bel7402 cells by MTT assay, IC50=6.3μM.	25237727
DU145	Cytotoxicity assay			Cytotoxicity against human DU145 cells measured on day 4 by CCK8 assay, IC50=0.02μM.	25936262
HeLa	Cytotoxicity assay			Cytotoxicity against human HeLa cells measured on day 4 by CCK8 assay, IC50=0.18μM.	25936262
T47D	Cytotoxicity assay			Cytotoxicity against human T47D cells measured on day 4 by CCK8 assay, IC50=1.84μM.	25936262
HCT15	Cytotoxicity assay			Cytotoxicity against human HCT15 cells measured on day 4 by CCK8 assay, IC50=2.82μM.	25936262
WI38	Cytotoxicity assay			Cytotoxicity against human WI38 cells by MTT assay, IC50=0.23μM.	26063305
MCF7	Antiproliferative assay			Antiproliferative activity against human MCF7 cells by SRB assay, IC50=0.03μM.	28274626
HeLa	Cytotoxicity assay			Cytotoxicity against human HeLa cells assessed as reduction in cell viability by MTT assay, IC50=0.12μM.	28425292
A549	Cytotoxicity assay			Cytotoxicity against human A549 cells by MTT assay, IC50=0.7μM.	28506750
NCI-H1299	Cytotoxicity assay			Cytotoxicity against human NCI-H1299 cells by MTT assay, IC50=0.8μM.	28506750
NCI-H1975	Cytotoxicity assay			Cytotoxicity against human NCI-H1975 cells by MTT assay, IC50=1.2μM.	28506750
HOP62	Antiproliferative assay			Antiproliferative activity against human HOP62 cells assessed as growth inhibition, GI50=0.01μM.	28657311
SF539	Antiproliferative assay			Antiproliferative activity against human SF539 cells assessed as growth inhibition, GI50=0.01μM.	28657311
UACC62	Antiproliferative assay			Antiproliferative activity against human UACC62 cells assessed as growth inhibition, GI50=0.01μM.	28657311
DU145	Antiproliferative assay			Antiproliferative activity against human DU145 cells assessed as growth inhibition, GI50=0.01μM.	28657311
MCF7	Antiproliferative assay			Antiproliferative activity against human MCF7 cells assessed as growth inhibition, GI50=0.013μM.	28657311
SN12C	Antiproliferative assay			Antiproliferative activity against human SN12C cells assessed as growth inhibition, GI50=0.02μM.	28657311
HCT116	Antiproliferative assay			Antiproliferative activity against human HCT116 cells assessed as growth inhibition, GI50=0.03μM.	28657311
OVCAR3	Antiproliferative assay			Antiproliferative activity against human OVCAR3 cells assessed as growth inhibition, GI50=0.22μM.	28657311
PC3	Antiproliferative assay			Antiproliferative activity against human PC3 cells by MTT assay, IC50=6.96μM.	29131616
HL60	Antiproliferative assay			Antiproliferative activity against human HL60 cells, IC50=0.0067μM.	29429833
TC32	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells	29435139
DAOY	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells	29435139
SJ-GBM2	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells	29435139
A673	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells	29435139
SK-N-MC	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells	29435139
BT-37	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells	29435139
NB-EBc1	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells	29435139
U-2 OS	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells	29435139
Saos-2	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells	29435139
SK-N-SH	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells	29435139
NB1643	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells	29435139
LAN-5	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells	29435139
BT-12	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells	29435139
Rh18	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells	29435139
OHS-50	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells	29435139
RD	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells	29435139
MG 63 (6-TG R)	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells	29435139
Rh41	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells	29435139
NB1643	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB1643 cells	29435139
A673	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells)	29435139
SK-N-MC	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells	29435139
BT-12	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells	29435139
LAN-5	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells	29435139
DAOY	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for DAOY cells	29435139
NB-EBc1	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells	29435139
SJ-GBM2	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SJ-GBM2 cells	29435139
BT-37	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells	29435139
TC32	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells	29435139
MG 63 (6-TG R)	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells	29435139
U-2 OS	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells	29435139
Rh41	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells	29435139
RD	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for RD cells	29435139
Rh18	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh18 cells	29435139
Rh30	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh30 cells	29435139
Saos-2	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells	29435139
OHS-50	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells	29435139
SK-N-SH	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells	29435139
HepG2	Antiproliferative assay			Antiproliferative activity against human HepG2 cells by MTT assay, IC50=0.5μM.	30007563
HeLa	Antiproliferative assay			Antiproliferative activity against human HeLa cells by MTT assay, IC50=1.3μM.	30007563
CCRF-CEM	Cytotoxicity assay			Cytotoxicity against human CCRF-CEM cells by MTT assay, IC50=0.002μM.	30543429
HuH7	Cytotoxicity assay			Cytotoxicity against human HuH7 cells by MTT assay, IC50=0.0023μM.	30543429
HCT116	Cytotoxicity assay			Cytotoxicity against human HCT116 cells by MTT assay, IC50=0.013μM.	30543429
DU145	Cytotoxicity assay			Cytotoxicity against human DU145 cells by MTT assay, IC50=0.016μM.	30543429
A549	Cytotoxicity assay			Cytotoxicity against human A549 cells by MTT assay, IC50=0.04μM.	30543429
HuH7	Apoptosis assay			Induction of apoptosis in human HuH7 cells assessed as increase in cytochrome C levels by Hoechst staining-based assay	30716712
Mahlavu	Apoptosis assay			Induction of apoptosis in human Mahlavu cells assessed as increase in cytochrome C levels by Hoechst staining-based assay	30716712
HL60	Function assay			Tested in vitro for growth inhibitory activity against HL60 (human promyelocytic leukemic) cells, IC50=0.005μM.	ChEMBL
DC-3F	Function assay			Tested in vitro for growth inhibitory activity against DC-3F (hamster lung) cells, IC50=0.006μM.	ChEMBL
833K	Function assay			Tested in vitro for growth inhibitory activity against 833K (human teratorcarcinoma) cells, IC50=0.01μM.	ChEMBL
HuH7	Cytotoxicity assay			Cytotoxicity against human HuH7 cells assessed as inhibition of cell proliferation by sulforhodamine B assay, IC50=0.1μM.	ChEMBL
leukemia cells	Function assay			Compound was evaluated for cytotoxic activity on L1210 murine leukemia cells, IC50=0.126μM.	ChEMBL
MV	Cytotoxicity assay			Cytotoxicity against human MV cells assessed as inhibition of cell proliferation by sulforhodamine B assay, IC50<1μM.	ChEMBL
SW480	Function assay			Inhibition of DNA topoisomerase 1 in Homo sapiens (human) SW480 cells, IC50=3.75μM.	ChEMBL
HCT116	Function assay			Inhibition of DNA topoisomerase 1 in Homo sapiens (human) HCT116 cells, IC50=4.75μM.	ChEMBL
VACO 241	Function assay			Inhibition of DNA topoisomerase 1 in Homo sapiens (human) VACO 241 cells, IC50=4.95μM.	ChEMBL
點(diǎn)擊查看更多細(xì)胞系數(shù)據(jù)

生物活性

產(chǎn)品描述

特性

Camptothecin是大量實(shí)驗(yàn)證明具有毒性的植物堿，是DNA拓?fù)洚悩?gòu)酶 I (topo I)的特定抑制劑。

靶點(diǎn)

Topo I ^[2]
(Cell-free assay)

0.68 μM

體外研究(In Vitro)
體外研究活性	Camptothecin是1966年最先從Camptotheca acuminate獨(dú)立的植物堿。^[1] 有效且特定抑制DNA拓?fù)洚悩?gòu)酶 I (topo I)，IC50 為 0.68 μM。Camptothecin 在納摩爾水平作用于多種人類腫瘤細(xì)胞系，包括 HT29, LOX, SKOV3,和 SKVLB，有一定細(xì)胞毒性，IC50為37 nM 到48 nM。^[2] 與 TNF聯(lián)用, Camptothecin作用于鼠肝細(xì)胞，誘導(dǎo)凋亡，IC50為13 μM。Camptothecin 也廢除 TNF誘導(dǎo)的NF-κB激活, 和TNF受體相關(guān)因子-2 (TRAF2)，X-連鎖凋亡蛋白抑制劑(X-IAP), 和FLICE抑制蛋白(FLIP)的表達(dá)。^[4] 5 μM Camptothecin 作用于HCT116細(xì)胞，誘導(dǎo)蛋白酶體調(diào)節(jié)的混合系白血病5 (MLL5)蛋白降解,導(dǎo)致p53在Ser392位點(diǎn)磷酸化。 ^[5] 由于Camptothecin的溶解性低，及具有一定副作用，所以已經(jīng)研發(fā)了多種Camptothecin類似物，其中兩種如Topotecan和Irinotecan, 已經(jīng)獲得FDA準(zhǔn)核，用于癌癥化學(xué)療法中。
激酶實(shí)驗(yàn)	拓?fù)洚悩?gòu)酶I裂解復(fù)雜試驗(yàn)
激酶實(shí)驗(yàn)	從小牛胸腺中分離拓?fù)洚悩?gòu)酶I。所有反應(yīng)在孔板的10 mL 反應(yīng)buffer (50 mM Tris-HCl, pH 7.5, 100 mM KCl, 0.5 mM EDTA, 和30 pg/mL BSA) 中進(jìn)行反應(yīng)。Camptothecin 溶于 DMSO，濃度為10 mg/mL，在96孔板上連續(xù)稀釋，加入末端 ³²P標(biāo)記的 pBR322 DNA 和拓?fù)洚悩?gòu)酶。反應(yīng)混合物在室溫下溫育30分鐘，然后加入2 mL十二烷基硫酸鈉（SDS）和蛋白酶 K的混合物 (終濃度分別為1.6% 和 0.14 mg/mL)終止反應(yīng)。在50^oC下加熱實(shí)驗(yàn)板30分鐘，加入10 mL含0.45 N NaOH標(biāo)準(zhǔn)停止混合物，為了獲得單鏈DNA,在TBE緩沖液中使用 1.5%瓊脂糖凝膠對(duì)樣本進(jìn)行電泳。凝膠涂抹在硝酸纖維素紙，烘干，用X-射線膠片處理。獲得IC50值。
細(xì)胞實(shí)驗(yàn)	細(xì)胞系	U87MG, A549 和 H838 細(xì)胞
	濃度	0.17 nM–10 mM
	孵育時(shí)間	48 小時(shí)
	方法	腫瘤細(xì)胞按每孔1500 到 4000個(gè)接種在96孔板上，孔中含100 μL 培養(yǎng)基，培養(yǎng)過(guò)夜，使細(xì)胞粘附。Camptothecin 處理細(xì)胞48小時(shí)，然后用新鮮培養(yǎng)基再處理48小時(shí)。加入四種不同濃度Camptothecin。用MTT處理細(xì)胞4小時(shí)，使用0.2 mL DMSO，然后用50 μL Sorensen's buffer抽提減少的染料產(chǎn)物。稍微震蕩實(shí)驗(yàn)孔板，在570 nm處讀取吸光值。使用四參數(shù)方程，根據(jù)MTT實(shí)驗(yàn)數(shù)據(jù)，繪制曲線。
實(shí)驗(yàn)圖片	檢測(cè)方法	檢測(cè)指標(biāo)	實(shí)驗(yàn)圖片	PMID
實(shí)驗(yàn)圖片	Western blot	Cyclin1 / CDK1 / CDK2 Vimentin / Fibronectin / E-cadherin TGF-β / PI3K / pPI3K / AKT / pAKT p53 / Cleaved caspase-3 / Cleaved PARP		29963130

體內(nèi)研究(In Vivo)
體內(nèi)研究活性	Camptothecin 按8 mg/kg 劑量作用于攜帶多種移植瘤的小鼠，如結(jié)腸癌，肺癌，乳腺癌，胃癌，和卵巢癌，完全抑制腫瘤生長(zhǎng)及引起腫瘤衰退。^[3] Camptothecin (50 mg/kg)和TNF (5和 7 μg/kg)聯(lián)合作用于小鼠，造成肝損傷, 而Camptothecin 單獨(dú)作用時(shí)沒有影響。^[4]
動(dòng)物實(shí)驗(yàn)	Animal Models	攜帶CASE, SW48, DOY, SPA, 和 CLO移植瘤的裸鼠
	Dosages	0–8 mg/kg
	Administration	肌肉注射或靜脈注射，每周兩次。

參考文獻(xiàn)
[1] Wall ME, et al. J Am Chem Soc, 1966, 88 (16), 3888–3890. [2] Luzzio MJ, et al. J Med Chem, 1995, 38(3), 395-401. [3] Giovanella BC, et al. Cancer Res, 1991, 51(11), 3052-3055. [4] Hentze H, et al. Hepatology, 2004, 39(5), 1311-1320. [5] Cheng F, et al. Oncogene, 2011, 30(33), 3599-3611. + 展開

參考文獻(xiàn)

[1] Wall ME, et al. J Am Chem Soc, 1966, 88 (16), 3888–3890.
[2] Luzzio MJ, et al. J Med Chem, 1995, 38(3), 395-401.
[3] Giovanella BC, et al. Cancer Res, 1991, 51(11), 3052-3055.

[4] Hentze H, et al. Hepatology, 2004, 39(5), 1311-1320.
[5] Cheng F, et al. Oncogene, 2011, 30(33), 3599-3611.

+ 展開

化學(xué)信息&溶解度

分子量	348.35	分子式	C₂₀H₁₆N₂O₄
CAS號(hào)	7689-03-4	SDF	Download Camptothecin (CPT) SDF
Smiles	CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
儲(chǔ)存條件(自收到貨起)	3年-20°C粉狀	儲(chǔ)備液保存和期限建議分裝儲(chǔ)備液，避免反復(fù)凍融！	1年-80°C溶于溶劑
儲(chǔ)存條件(自收到貨起)	3年-20°C粉狀	儲(chǔ)備液保存和期限建議分裝儲(chǔ)備液，避免反復(fù)凍融！	1個(gè)月-20°C溶于溶劑

體外溶解度
批次：

0.1M NaOH : 2.5 mg/mL (7.17 mM)

DMSO : Insoluble ( ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Water : Insoluble

DMSO : 7 mg/mL ( (20.09 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Water : Insoluble

Ethanol : Insoluble

DMSO : 6 mg/mL ( (17.22 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Water : Insoluble

Ethanol : Insoluble

DMSO : 6 mg/mL ( (17.22 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Water : Insoluble

Ethanol : Insoluble

DMSO : 4 mg/mL ( (11.48 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解度批次：現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑					動(dòng)物體內(nèi)配方計(jì)算器
	澄清溶液	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	0.2mg/ml (0.57mM)	以 1 mL 工作液為例,取50μL4mg/ml的澄清DMSO儲(chǔ)備液加到400μLPEG300中,混合均勻使其澄清;向上述體系中加入50μLTween80,混合均勻使其澄清;然后繼續(xù)加入500μLddH2O定容至1mL。工作液請(qǐng)現(xiàn)配現(xiàn)用!	動(dòng)物體內(nèi)配方計(jì)算器
澄清溶液	5% DMSO 1 95% Corn oil	0.4mg/ml (1.15mM)	以1 mL工作液為例，取50μL 8mg/ml的澄清DMSO儲(chǔ)備液加到950μL玉米油中，混合均勻。工作液請(qǐng)現(xiàn)配現(xiàn)用！
澄清溶液	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	2.0mg/ml (5.74mM)	以 1 mL 工作液為例，取50μL40mg/ml的澄清DMSO儲(chǔ)備液加到400μL PEG300中，混合均勻使其澄清；向上述體系中加入50μLTween80，混合均勻使其澄清；然后繼續(xù)加入500μL ddH2O定容至 1 mL。工作液請(qǐng)現(xiàn)配現(xiàn)用！

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量	濃度	體積	分子量
=	×	×

稀釋計(jì)算器分子量計(jì)算器

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過(guò)程中的損耗，建議多配一只動(dòng)物的藥量）

給藥劑量 mg/kg 動(dòng)物平均體重 g 每只動(dòng)物給藥體積 μL 動(dòng)物數(shù)量只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO + % + % Tween 80 + % ddH2O

%DMSO+ %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過(guò)該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH₂O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

技術(shù)支持

在訂購(gòu)、運(yùn)輸、儲(chǔ)存和使用我們的產(chǎn)品的任何階段，您遇到的任何問(wèn)題，均可以通過(guò)撥打我們的熱線電話400-668-6834，或者技術(shù)支持郵箱tech@selleck.cn，直接聯(lián)系到我們。我們會(huì)在24小時(shí)內(nèi)盡快聯(lián)系您。

操作手冊(cè)

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* 必填項(xiàng)

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

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Camptothecin (CPT)

產(chǎn)品質(zhì)控

Camptothecin (CPT)相關(guān)產(chǎn)品

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

生物活性

化學(xué)信息&溶解度

實(shí)驗(yàn)計(jì)算

技術(shù)支持