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Doxycycline

別名: Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum 中文名稱：強力霉素

Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum)是一種抗生素，用于治療由細菌和原生動物引起的多種感染。Doxycycline 也是一種非特異性的 matrix metalloproteinase (MMP) 抑制劑。

Doxycycline Chemical Structure

Doxycycline Chemical Structure

CAS: 564-25-0

規(guī)格 價格 庫存 購買數(shù)量
10mM (1mL in DMSO) 1040.13 現(xiàn)貨
25mg 795.18 現(xiàn)貨
1g 3031.08 現(xiàn)貨
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Doxycycline相關(guān)產(chǎn)品

細胞實驗數(shù)據(jù)示例

細胞系 實驗類型 給藥濃度 孵育時間 活性描述 文獻信息
vascular endothelial cells Antibacterial assay 25 ug/ml 72 hrs Antibacterial activity against Rickettsia prowazekii str. Breinl infected in CD rat primary pulmonary vascular endothelial cells assessed as bacterial shape change at 25 ug/ml measured 72 hrs post infection by Hoechst 33258/phalloidin staining based fluor 28089350
Hep2 Anti-Chlamydial assay 1 ug/ml 8 hrs Anti-Chlamydial activity against Chlamydia trachomatis Serovar LGV-L2 infected in Hep2 cells assessed as reduction in size and number of chlamydial inclusion at 1 ug/ml treated at 8 hrs post-infection and 24 hrs later re-infecting fresh Hep2 cells monolay 32227948
SW1353 Function assay 50 uM Inhibition of IL-1-beta-induced MMP13 production in human SW1353 cells at 50 uM 17267227
Neuro2a Function assay 1 uM Decrease in 7-DHC levels in Dhcr7-deficient mouse Neuro2a cells at 1 uM by LC-MS/GC-MS analysis 26789657
Staphylococcus aureus 2 planktonic cells Bactericidal assay 24 hrs Bactericidal activity against methicillin-resistant Staphylococcus aureus 2 planktonic cells after 24 hrs by calgary biofilm device method, MBC=2μM. 29638121
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells after 72 hrs by flow cytometry, IC50=15μM. 19482476
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells after 72 hrs by flow cytometry, IC50=15μM. 19926173
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50=20μM. 19482476
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50=20μM. 19926173
THP1 Cytotoxicity assay 72 hrs Cytotoxicity against human THP1 cells after 72 hrs by propidium iodide staining-based flow cytometry, IC50=20μM. 19748781
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, CC50=20μM. 21741131
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, CC50=20μM. 22889559
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, CC50=20μM. 21852132
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, CC50=20μM. 24946216
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay, CC50=20μM. 25791675
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay, CC50=20μM. 25282267
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells measured after 72 hrs by MTT assay, CC50=20μM. 27155463
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay, CC50=20μM. 27654395
K-12 BW25113 Bactericidal assay 24 hrs Bactericidal activity against yafQ gene-deficient Escherichia coli K-12 BW25113 biofilm assessed as log reduction of viable cells after 24 hrs 19307375
K-12 BW25113 Bactericidal assay 24 hrs Bactericidal activity against Escherichia coli K-12 BW25113 biofilm harboring pCA24N ptac::yafQ plasmid assessed as log reduction of viable cells after 24 hrs pretreated with 5 uM of IPTG for 4 hrs 19307375
THP1 Function assay Selectivity index, ratio of IC50 for human THP1 cells to IC50 for Plasmodium falciparum, IC50=3.1μM. 19748781
A673 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells 29435139
BT-12 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells 29435139
skeletal myoblast cells Cytotoxicity assay DNDI: Cytotoxicity in Vitro, 72 hour, in rat skeletal myoblast cells, IC50=14.49μM. ChEMBL
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生物活性

產(chǎn)品描述 Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum)是一種抗生素，用于治療由細菌和原生動物引起的多種感染。Doxycycline 也是一種非特異性的 matrix metalloproteinase (MMP) 抑制劑。
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05972772 Not yet recruiting
Infectious Disease|Therapeutics
Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit|Mahidol Oxford Tropical Medicine Research Unit
 March 20 2024 Phase 2|Phase 3
NCT06007534 Recruiting
Post-exposure Prophylaxis|Sexually Transmitted Diseases|Doxycycline
Assistance Publique - H?pitaux de Paris
 October 25 2023 Not Applicable
NCT04762134 Recruiting
Bacterial Sexually Transmitted Diseases
Jonathan Troy Grennan|Canadian Institutes of Health Research (CIHR)|British Columbia Centre for Disease Control
 June 2 2023 Phase 4
NCT05853120 Recruiting
Sexually Transmitted Diseases
Emory University|Centers for Disease Control and Prevention
 May 31 2023 Phase 4
NCT05382208 Recruiting
Emphysema|HIV
Weill Medical College of Cornell University|National Heart Lung and Blood Institute (NHLBI)|University of California Los Angeles|University of Iowa|University of Michigan
 August 22 2022 Phase 2
NCT05492019 Recruiting
Parkinson Disease
Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh
 July 1 2022 Phase 2

化學信息&溶解度

分子量 444.43 分子式

C22H24N2O8
CAS號 564-25-0 SDF Download Doxycycline SDF
Smiles CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O
儲存條件(自收到貨起)

體外溶解度
批次：

DMSO : 89 mg/mL ( (200.25 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩爾濃度計算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑

 動物體內(nèi)配方計算器

實驗計算

摩爾濃度計算器

質(zhì)量 濃度 體積 分子量

動物體內(nèi)配方計算器（澄清溶液）

第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）

mg/kg g μL 只

第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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