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Resveratrol

別名: SRT501 中文名稱：白藜蘆醇

Resveratrol具有廣泛靶點(diǎn)，包括環(huán)氧酶（如COX, IC50=1.1 μM）、脂肪氧合酶(LOC, IC50=2.7 μM)、sirtuins和其他蛋白質(zhì)。它是一種天然的植物抗毒素，具有抗癌，抗炎，降血糖和其他有益心血管的作用。Resveratrol可誘導(dǎo)線粒體自噬、細(xì)胞自噬和自噬依賴性的凋亡。

Resveratrol Chemical Structure

Resveratrol Chemical Structure

CAS: 501-36-0

規(guī)格 價(jià)格 庫存 購買數(shù)量
10mM (1mL in DMSO) 1068.72 現(xiàn)貨
100mg 804.89 現(xiàn)貨
500mg 2551.88 現(xiàn)貨
1g 3849.3 現(xiàn)貨
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Resveratrol相關(guān)產(chǎn)品

相關(guān)信號通路圖

Autophagy Signaling Pathways

Autophagy信號通路圖

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系 實(shí)驗(yàn)類型 給藥濃度 孵育時(shí)間 活性描述 文獻(xiàn)信息
Hepa 1c1c7 Function assay 12.5 uM 24 hrs Induction of quinone reductase activity in mouse Hepa 1c1c7 cells at 12.5 uM after 24 hrs relative to control, Activity=1.24μM. 17316918
Hepa 1c1c7c1 Function assay 12.5 uM 24 hrs Induction of quinone reductase in mouse mutant Hepa 1c1c7c1 cells at 12.5 uM after 24 hrs relative to control, Activity=1.16μM. 17316918
HUVEC Function assay 100 μM 1 day Induction of mitochondrial biogenesis in H2O2-induced HUVEC at 100 umol/L pretreated for 1 day followed by compound washout and H2O2-treatment measured after 10 days by MitoTracker Red staining-based assay 23859249
MG63 Function assay 0.1 to 10 uM 24 hr Increase in proliferation of human MG63 cells at 0.1 to 10 uM after 24 hr by flow cytometry 17513867
MC3T3-E1 Function assay 0.1 to 10 uM 7 days Increase in ALP activity in mouse MC3T3-E1 cells at 0.1 to 10 uM after 7 days 17513867
primary osteoblast cells Function assay 0.1 to 10 uM 7 days Increase in ALP activity in rat primary osteoblast cells at 0.1 to 10 uM after 7 days 17513867
MC3T3-E1 Function assay 1 uM 72 hrs Increase in osteocalcin mRNA levels in mouse MC3T3-E1 cells at 1 uM after 72 hrs by RT-PCR 17513867
MG63 Function assay 1 uM 72 hrs Increase in osteocalcin mRNA levels in human MG63 cells at 1 uM after 72 hrs by RT-PCR 17513867
primary osteoblast cells Function assay 1 uM 72 hrs Increase in osteocalcin mRNA levels in rat primary osteoblast cells at 1 uM after 72 hrs by RT-PCR 17513867
MC3T3-E1 Function assay 1 uM 72 hrs Increase in osteocalcin levels in mouse MC3T3-E1 cells at 1 uM after 72 hrs by ELISA 17513867
MG63 Function assay 1 uM 72 hrs Increase in osteocalcin levels in human MG63 cells at 1 uM after 72 hrs by ELISA 17513867
primary osteoblast cells Function assay 1 uM 72 hrs Increase in osteocalcin levels in rat primary osteoblast cells at 1 uM after 72 hrs by ELISA 17513867
MC3T3-E1 Function assay 1 uM 72 hrs Increase in osteopontin mRNA levels in mouse MC3T3-E1 cells at 1 uM after 72 hrs by RT-PCR 17513867
MG63 Function assay 1 uM 72 hrs Increase in osteopontin mRNA levels in human MG63 cells at 1 uM after 72 hrs by RT-PCR 17513867
primary osteoblast cells Function assay 1 uM 72 hrs Increase in osteopontin mRNA levels in rat primary osteoblast cells at 1 uM after 72 hrs by RT-PCR 17513867
MC3T3-E1 Function assay 1 uM 72 hrs Increase in osteopontin levels in mouse MC3T3-E1 cells at 1 uM after 72 hrs by ELISA 17513867
MG63 Function assay 1 uM 72 hrs Increase in osteopontin levels in human MG63 cells at 1 uM after 72 hrs by ELISA 17513867
primary osteoblast cells Function assay 1 uM 72 hrs Increase in osteopontin levels in rat primary osteoblast cells at 1 uM after 72 hrs by ELISA 17513867
MC3T3-E1 Function assay 1 uM 4 hrs Increase in BMP2 expression in mouse MC3T3-E1 cells expressing pBMP2 mutant at 1 uM after 4 hrs by luciferase method relative to control 17513867
MC3T3-E1 Function assay 1 uM 4 hrs Increase in BMP2 expression in mouse MC3T3-E1 cells expressing pBMP2delta1 mutant at 1 uM after 4 hrs by luciferase method relative to control 17513867
MDA-MB-231 Function assay 10 mg/kg 2 days Decrease in Akt activation in human MDA-MB-231 cells expressing FOXO3a-specific small interfering RNA xenografted in nude mice at 10 mg/kg for 2 days 17513867
MDA-MB-231 Function assay 10 mg/kg 2 days Induction of FOXO3a nuclear accumulation in human MDA-MB-231 cells FOXO3a-specific small interfering RNA xenografted in nude mice at 10 mg/kg for 2 days 17513867
MC3T3-E1 Function assay 1 uM 48 hrs Inhibition of induction of ALP activity in mouse MC3T3-E1 cells at 1 uM after 48 hrs in presence of BMP2-specific neutralizing antibody 17513867
primary osteoblast cells Function assay 1 uM 48 hrs Inhibition of induction of ALP activity in rat primary osteoblast cells at 1 uM after 48 hrs in presence of BMP2-specific neutralizing antibody 17513867
MC3T3-E1 Function assay 1 uM 48 hrs Inhibition of induction of ALP activity in mouse MC3T3-E1 cells at 1 uM after 48 hrs in presence of noggin 17513867
primary osteoblast cells Function assay 1 uM 48 hrs Inhibition of induction of ALP activity in rat primary osteoblast cells at 1 uM after 48 hrs in presence of noggin 17513867
primary osteoblast cells Antiapoptotic activity assay 1 uM 48 hrs Inhibition of antiapoptotic activity in rat primary osteoblast cells at 1 uM after 48 hrs in presence of BMP2-specific neutralizing antibody 17513867
primary osteoblast cells Antiapoptotic activity assay 1 uM 48 hrs Inhibition of antiapoptotic activity in rat primary osteoblast cells at 1 uM after 48 hrs in presence of noggin 17513867
MC3T3-E1 Function assay 0.1 to 10 uM 24 hr Increase in proliferation of mouse MC3T3-E1 cells assessed as fraction of cells in S phase at 0.1 to 10 uM after 24 hr by flow cytometry 17513867
primary osteoblast cells Function assay 0.1 to 10 uM 24 hr Increase in proliferation of rat primary osteoblast cells at 0.1 to 10 uM after 24 hr by flow cytometry 17513867
MG63 Function assay 0.1 to 10 uM 7 days Increase in ALP activity in human MG63 cells at 0.1 to 10 uM after 7 days 17513867
MC3T3-E1 Antiapoptotic activity assay 1 uM 48 hrs Inhibition of antiapoptotic activity in mouse MC3T3-E1 cells at 1 uM after 48 hrs in presence of BMP2-specific neutralizing antibody 17513867
MC3T3-E1 Antiapoptotic activity assay 1 uM 48 hrs Inhibition of antiapoptotic activity in mouse MC3T3-E1 cells at 1 uM after 48 hrs in presence of noggin 17513867
HEK293 Function assay 100 uM 1 hr Inhibition of heat killed Escherichia coli K12-induced nuclear translocation of p65 element of NF-kappaB in HEK293 cells expressing TLR2 at 100 uM pretreated for 1 hr before 6 hrs heat killed bacterial stimulation by immunostaining method 17938187
HEK293 Function assay 100 uM 1 hr Inhibition of heat killed Staphylococcus aureus 209P-induced nuclear translocation of p65 element of NF-kappaB in HEK293 cells expressing TLR2 at 100 uM pretreated for 1 hr before 6 hrs heat killed bacterial stimulation by immunostaining method 17938187
RAW264.7 Function assay 1 to 100 uM 6 hrs Inhibition of heat killed Escherichia coli K12-induced TNF alpha production in mouse RAW264.7 cells at 1 to 100 uM after 6 hrs by ELISA 17938187
THP1 Function assay 1 to 100 uM 6 hrs Inhibition of heat killed Escherichia coli K12-induced TNF alpha production in human THP1 cells at 1 to 100 uM after 6 hrs by ELISA 17938187
RAW264.7 Function assay 1 to 100 uM 6 hrs Inhibition of heat killed Staphylococcus aureus 209P-induced TNF alpha production in mouse RAW264.7 cells at 1 to 100 uM after 6 hrs by ELISA 17938187
THP1 Function assay 1 to 100 uM 6 hrs Inhibition of heat killed Staphylococcus aureus 209P-induced TNF alpha production in human THP1 cells at 1 to 100 uM after 6 hrs by ELISA 17938187
THP1 Function assay 100 uM 1 hr Inhibition of FSL1-induced upregulation of MSR1 mRNA expression in in human THP1 cells at 100 uM after 1 hr by RT-PCR 17938187
THP1 Function assay 100 uM 1 hr Inhibition of FSL1-induced upregulation of CD36 mRNA expression in in human THP1 cells at 100 uM after 1 hr by RT-PCR 17938187
THP1 Function assay 100 uM 1 hr Inhibition of FSL1-induced upregulation of DC-SIGN mRNA expression in in human THP1 cells at 100 uM after 1 hr by RT-PCR 17938187
THP1 Function assay 100 uM 1 hr Inhibition of FSL1-induced upregulation of dectin-1 mRNA expression in in human THP1 cells at 100 uM after 1 hr by RT-PCR 17938187
HL60 Function assay 150 uM 48 hrs Induction of DNA fragmentation in human HL60 cells at 150 uM after 48 hrs by ethidium bromide based gel electrophoresis 19271734
C2C12 Function assay 50 uM 16 hrs Increase in mitochondrial function in mouse C2C12 cells assessed as enhancement of mitochondrial density at 50 uM after 16 hrs by green FM dye straining-based fluorescence assay 19663498
H460 Cell cycle assay 20 uM 24 hrs Cell cycle arrest in human H460 cells assessed as accumulation at G2/M phase at 20 uM after 24 hrs by propidium iodide staining-based flow cytometry 20409723
RAW264.7 Function assay 34 uM 15 mins Inhibition of LPS-induced iNOS expression in mouse RAW264.7 cells at 34 uM treated 15 mins before LPS challenge measured after 18 hrs by Western blotting 20527891
CCD-18Co Antiinflammatory assay 1 uM 18 hrs Antiinflammatory activity in human CCD-18Co cells assessed inhibition of IL1beta-induced PGE2 production at 1 uM after 18 hrs 20866032
CCD-18Co Antiinflammatory assay 2.5 to 25 uM 18 hrs Antiinflammatory activity in human CCD-18Co cells assessed as inhibition of IL1beta-induced PGE2 production at 2.5 to 25 uM after 18 hrs 20866032
SW480 Cytotoxicity assay 10 uM 2 days Cytotoxicity against human SW480 cells at 10 uM for 2 days by vi-cell cell viability analysis 21291235
HCT116 Cytotoxicity assay 10 uM 2 days Cytotoxicity against human HCT116 cells at 10 uM for 2 days by vi-cell cell viability analysis 21291235
HCT116 Cytotoxicity assay 10 uM 4 days Cytotoxicity against human HCT116 cells at 10 uM for 4 days by vi-cell cell viability analysis 21291235
LS 174T Cytotoxicity assay 10 uM 4 days Cytotoxicity against human LS 174T cells at 10 uM for 4 days by vi-cell cell viability analysis 21291235
LS 174T Cytotoxicity assay 10 uM 2 days Cytotoxicity against human LS 174T cells at 10 uM for 2 days by vi-cell cell viability analysis 21291235
LS174T Function assay 100 uM 36 hrs Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in Ki67 mRNA level at 100 uM after 36 hrs by RT-PCR analysis 21291235
LS174T Function assay 100 uM 36 hrs Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in c-Myc mRNA level at 100 uM after 36 hrs by RT-PCR analysis 21291235
LS174T Function assay 100 uM 36 hrs Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in CD44 mRNA level at 100 uM after 36 hrs by RT-PCR analysis 21291235
LS174T Function assay 100 uM 36 hrs Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in Lgr5 mRNA level at 100 uM after 36 hrs by RT-PCR analysis 21291235
LS174T Function assay 100 uM 36 hrs Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in survivin mRNA level at 100 uM after 36 hrs by RT-PCR analysis 21291235
HEK293T Function assay 100 uM 12 hrs Inhibition of LiCl-induced Wnt/beta-casein in human HEK293T cells transfected with TOP Flash assessed as decrease in luciferase expression at 100 uM after 12 hrs by dual luciferase reporter assay 21291235
SW480 Cytotoxicity assay 10 uM 4 days Cytotoxicity against human SW480 cells at 10 uM for 4 days by vi-cell cell viability analysis 21291235
HEK293T Function assay 100 uM 12 hrs Inhibition of Wnt/beta-casein in human HEK293T cells transfected with TOP Flash assessed as decrease in luciferase expression at 100 uM after 12 hrs by dual luciferase reporter assay 21291235
32Dcl3 Function assay 10 uM 1 hr Radioprotective activity against 0 to 7 Gy gamma radiation-induced death in mouse 32Dcl3 cells at 10 uM treated 1 hr prior to irradiation after 7 days by microscopy 21826253
RAW264.7 Antiinflammatory assay 50 uM 1.5 hrs Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha production at 50 uM after 1.5 hrs by ELISA 22088309
B16F10 Antimelanogenic assay 200 uM 72 hrs Antimelanogenic activity in mouse assessed as cellular melanin content B16F10 cells at 200 uM after 72 hrs spectrophotometric analysis 22189272
SH-SY5Y Neuroprotective assay 10 uM 24 hrs Neuroprotective activity in human SH-SY5Y cells assessed as inhibition H2O2-induced reduction of cell viability at 10 uM after 24 hrs by phase-contrast micrograph analysis 24269515
HeLa Function assay 10 to 100 uM 24 hrs Induction of SV40 promoter-mediated luciferase gene expression in human HeLa cells at 10 to 100 uM after 24 hrs by RT-PCR analysis 25147604
RAW264.7 Anti-inflammatory assay 10 mM 10 mins Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL6 production at 10 mM pre-incubated for 10 mins before LPS stimulation for 24 hrs by ELISA method 26048788
RAW264.7 Anti-inflammatory assay 10 mM 10 mins Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production at 10 mM pre-incubated for 10 mins before LPS stimulation for 24 hrs by ELISA method 26048788
HaCaT Function assay 1 uM 1 hr Activation of SIRT1 in human HaCaT cells assessed as H4K16 deacetylation at 1 uM after 1 hr by Western blotting method 26689352
U373-MAGI Antiviral assay 50 uM 2 hrs Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as 5-Aza-C EC50 at 50 uM preincubated for 2 hrs followed by 5-Aza-C addition for 2 hrs and subsequent viral infection measu, EC50=10μM. 27117260
U373-MAGI Antiviral assay 50 uM 4 hrs Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in viral infectivity at 50 uM incubated for 4 hrs prior to viral infection measured at 72 hrs post infection by flow cytometric analysis 27117260
U373-MAGI Function assay 200 uM 6 hrs Reduction in dGTP level in human U373-MAGI cells at 200 uM after 6 hrs by LC-MS/MS analysis 27117260
U373-MAGI Function assay 200 uM 6 hrs Reduction in dTTP level in human U373-MAGI cells at 200 uM after 6 hrs by LC-MS/MS analysis 27117260
U373-MAGI Antiviral assay 25 to 100 uM 2 hrs Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in viral infectivity at 25 to 100 uM preincubated for 2 hrs followed by 5-Aza-C addition for 2 hrs and subsequ 27117260
U373-MAGI Function assay 200 uM 6 hrs Reduction in dCTP level in human U373-MAGI cells at 200 uM after 6 hrs by LC-MS/MS analysis 27117260
U373-MAGI Function assay 50 uM 2 hrs Reduction in dCTP level in human U373-MAGI cells at 50 uM preincubated for 2 hrs followed by 5-aza-C addition measured after 4 hrs by LC-MS/MS analysis 27117260
U373-MAGI Function assay 200 uM 6 hrs Reduction in dATP level in human U373-MAGI cells at 200 uM after 6 hrs by LC-MS/MS analysis 27117260
U373-MAGI Function assay 200 uM 2 hrs Reduction in dRGU-TP level in human U373-MAGI cells at 200 uM preincubated for 2 hrs followed by 5-aza-C addition measured after 4 hrs by LC-MS/MS analysis 27117260
U373-MAGI Function assay 50 uM 2 hrs Increase in 5-aza-dCTP/dCTP ratio in human U373-MAGI cells at 50 uM preincubated for 2 hrs followed by 5-aza-dC addition measured after 4 hrs by LC-MS/MS analysis relative to 5-aza-dC 27117260
U373-MAGI Function assay 200 uM 2 hrs Reduction in dCTP level in human U373-MAGI cells at 200 uM preincubated for 2 hrs followed by 5-aza-C addition measured after 4 hrs by LC-MS/MS analysis relative to 5-aza-C 27117260
U373-MAGI Antiviral assay 50 uM 2 to 72 hrs Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in U5-gag level at 50 uM after 2 to 72 hrs by qPCR method 27117260
U373-MAGI Antiviral assay 50 uM 6 hrs Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in gag level at 50 uM measured at 6 hrs post infection by qPCR method 27117260
U373-MAGI Function assay 200 uM 2 hrs Increase in 5-aza-dCTP/dCTP ratio in human U373-MAGI cells at 200 uM preincubated for 2 hrs followed by 5-aza-dC addition measured after 4 hrs by LC-MS/MS analysis relative to 5-aza-dC 27117260
U373-MAGI Function assay 200 uM 2 hrs Reduction in 5-aza-dCTP level in human U373-MAGI cells at 200 uM preincubated for 2 hrs followed by 5-aza-C addition measured after 4 hrs by LC-MS/MS analysis 27117260
U373-MAGI Antiviral assay 50 uM 2 to 8 hrs Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in viral infectivity at 50 uM preincubated for 2 to 8 hrs followed by 5-Aza-C addition for 2 hrs and subsequen 27117260
U373-MAGI Antiviral assay 25 uM 2 hrs Potentiation of 5-Aza-dC-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in viral infectivity at 25 uM preincubated for 2 hrs followed by 5-Aza-dC addition for 2 hrs and subsequent v 27117260
U373-MAGI Function assay 50 uM 2 hrs Increase in 5-aza-dCTP/dCTP ratio in human U373-MAGI cells at 50 uM preincubated for 2 hrs followed by 5-aza-C addition measured after 4 hrs by LC-MS/MS analysis relative to 5-aza-C 27117260
U373-MAGI Function assay 50 uM 2 hrs Reduction in dCTP level in human U373-MAGI cells at 50 uM preincubated for 2 hrs followed by 5-aza-dC addition measured after 4 hrs by LC-MS/MS analysis relative to 5-aza-dC 27117260
U373-MAGI Function assay 200 uM 2 hrs Reduction in dCTP level in human U373-MAGI cells at 200 uM preincubated for 2 hrs followed by 5-aza-dC addition measured after 4 hrs by LC-MS/MS analysis relative to 5-aza-dC 27117260
U373-MAGI Antiviral assay 50 uM 2 to 72 hrs Potentiation of 5-Aza-dC-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in U5-gag level at 50 uM after 2 to 72 hrs by qPCR method 27117260
U373-MAGI Antiviral assay 50 uM 2 to 72 hrs Potentiation of 5-Aza-C-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in gag level at 50 uM after 2 to 72 hrs by qPCR method 27117260
U373-MAGI Antiviral assay 50 uM 2 to 72 hrs Potentiation of 5-Aza-dC-induced antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in gag level at 50 uM after 2 to 72 hrs by qPCR method 27117260
U373-MAGI Antiviral assay 50 uM 6 hrs Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in U5-gag level at 50 uM measured at 6 hrs post infection by qPCR method 27117260
HCT116 Cytotoxicity assay 100 uM 48 hrs Cytotoxicity against human HCT116 cells assessed as cell growth inhibition at 100 uM after 48 hrs by MTT assay 27887843
Bel7402 Cytotoxicity assay 100 uM 48 hrs Cytotoxicity against human Bel7402 cells assessed as cell growth inhibition at 100 uM after 48 hrs by MTT assay 27887843
A375 Function assay 25 uM 24 hrs Inhibition of alpha-MSH-induced TRP-1 expression in human A375 cells at 25 uM after 24 hrs by Western blot method 29150333
A375 Function assay 25 uM 24 hrs Inhibition of alpha-MSH-induced TRP-2 expression in human A375 cells at 25 uM after 24 hrs by Western blot method 29150333
A375 Function assay 25 uM 4 hrs Inhibition of alpha-MSH-induced reactive oxygen species generation in human A375 cells at 25 uM after 4 hrs by DCFDA staining-based fluorescence assay 29150333
3T3L1 Function assay 1 to 10 uM 6 days Inhibition of triglyceride accumulation in mouse 3T3L1 cells at 1 to 10 uM after 6 days by ORO staining-based microscopic method 29172079
RAW264.7 Function assay 10 uM 24 hrs Inhibition of LPS-induced TNF-alpha production in rat RAW264.7 cells at 10 uM after 24 hrs by ELISA 29407944
RAW264.7 Function assay 10 uM 24 hrs Inhibition of LPS-induced IL-6 production in rat RAW264.7 cells at 10 uM after 24 hrs by ELISA 29407944
BV2 Antineuroinflammatory assay 10 to 30 uM 24 hrs Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production at 10 to 30 uM after 24 hrs by Griess assay 30096650
T cells Antiproliferative assay 50 uM 1 hr Antiproliferative activity against Con-A-induced T cells isolated from splenocytes of C57/BL6 mouse at 50 uM incubated with Con-A for 1 hr followed by compound addition measured after 72 hrs by MTT assay 30193941
B cells Antiproliferative assay 50 uM 1 hr Antiproliferative activity against LPS-induced B cells isolated from splenocytes of C57/BL6 mouse at 50 uM incubated with LPS for 1 hr followed by compound addition measured after 72 hrs by MTT assay 30193941
RAW264.7 Immunomodulatory assay 50 uM 1 hr Immunomodulatory activity in LPS-stimulated mouse RAW264.7 cells assessed as decrease in CD80 expression at 50 uM incubated with LPS for 1 hr followed by compound addition measured after 24 hrs by flow cytometry 30193941
RAW264.7 Immunomodulatory assay 50 uM 1 hr Immunomodulatory activity in LPS-stimulated mouse RAW264.7 cells assessed as decrease in CD86 expression at 50 uM incubated with LPS for 1 hr followed by compound addition measured after 24 hrs by flow cytometry 30193941
HBZY-1 Function assay 6 uM 24 hrs Activation of Nrf2 in rat HBZY-1 cells assessed as increase in NQO-1 mRNA expression at 6 uM after 24 hrs by RT-PCR analysis 30408749
HBZY-1 Function assay 6 uM 24 hrs Activation of Nrf2 in rat HBZY-1 cells assessed as increase in HO-1 mRNA expression at 6 uM after 24 hrs by RT-PCR analysis 30408749
HBZY-1 Function assay 6 uM 24 hrs Activation of Nrf2 in rat HBZY-1 cells assessed as increase in GCLM mRNA expression at 6 uM after 24 hrs by RT-PCR analysis 30408749
HBZY-1 Function assay 6 uM 24 hrs Activation of Nrf2 in rat HBZY-1 cells assessed as increase in GCLC mRNA expression at 6 uM after 24 hrs by RT-PCR analysis 30408749
BV2 Antineuroinflammatory assay 30 mins 24 hrs Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 30 mins followed by LPS-stimulation for 24 hrs by Griess assay, IC50=11.1μM. 30771601
MCF7 Antioxidant assay 100 uM 24 hrs Antioxidant activity in human MCF7 cells assessed as decrease in reactive oxygen species generation at 100 uM incubated for 24 hrs by CellROX green/Hoechst 33342 staining based assay 30921758
RAW264.7 Antiinflammatory assay 10 uM 1 hr Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 10 uM pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay 31077997
H9c2 Antioxidant assay 80 nM to 2 uM 18 hrs Antioxidant activity in rat H9c2 cells assessed as reduction in hypoxia-induced NO release at 80 nM to 2 uM preincubated for 18 hrs followed by incubated in hypoxia for 48 hrs by griess assay 31351395
H9c2 Antioxidant assay 2 uM 18 hrs Antioxidant activity in rat H9c2 cells assessed as increase in hypoxia-induced reduction of MnSOD expression at 2 uM preincubated for 18 hrs followed by incubated in hypoxia for 48 hrs by Western blot analysis 31351395
HuH7 Apoptosis assay 100 uM 48 hrs Induction of apoptosis in human HuH7 cells transfected with ShSGK1 assessed as late apoptosis at 100 uM incubated for 48 hrs by annexin V and 7-AAD staining based assay 31539779
HUH7 Function assay 100 uM 6 hrs Inhibition of insulin-induced SGK1 in human HUH7 cells at 100 uM using peptide as substrate incubated for 6 hrs by scintillation counter method 31539779
HuH7 Function assay 100 uM 6 hrs Inhibition of SGK1 in human HuH7 cells assessed as reduction in insulin-induced MDM2 phosphorylation on Ser166 at 100 uM incubated for 6 hrs by Western blot analysis 31539779
HuH7 Antiproliferative assay 100 uM 48 hrs Antiproliferative activity against human HuH7 cells assessed as reduction in cell viability at 100 uM incubated for 48 hrs by trypan blue dye based assay 31539779
HuH7 Apoptosis assay 100 uM 48 hrs Induction of apoptosis in human HuH7 cells assessed as increase in early apoptotic cells at 100 uM incubated for 48 hrs by annexin V and 7-AAD staining based assay 31539779
HuH7 Apoptosis assay 100 uM 48 hrs Induction of apoptosis in human HuH7 cells assessed as increase in late apoptotic cells at 100 uM incubated for 48 hrs by annexin V and 7-AAD staining based assay 31539779
HuH7 Apoptosis assay 100 uM 48 hrs Induction of apoptosis in human HuH7 cells assessed as increase in necrotic cells at 100 uM incubated for 48 hrs by annexin V and 7-AAD staining based assay 31539779
HuH7 Antiproliferative assay 100 uM 48 hrs Antiproliferative activity against human HuH7 cells transfected with ShSGK1 assessed as reduction in cell viability at 100 uM incubated for 48 hrs by trypan blue dye based assay 31539779
HuH7 Antiproliferative assay 100 uM 48 hrs Antiproliferative activity against human HuH7 cells overexpressing EGFP assessed as reduction in cell viability at 100 uM incubated for 48 hrs by trypan blue dye based assay 31539779
HuH7 Apoptosis assay 100 uM 48 hrs Induction of apoptosis in human HuH7 cells transfected with ShSGK1 assessed as early apoptosis at 100 uM incubated for 48 hrs by annexin V and 7-AAD staining based assay 31539779
HuH7 Apoptosis assay 100 uM 48 hrs Induction of apoptosis in human HuH7 cells overexpressing EGFP at 100 uM incubated for 48 hrs by annexin V and 7-AAD staining based assay 31539779
MC3T3-E1 Function assay 1 uM Reversal of increase in ER.DNA complex in mouse MC3T3-E1 cells transfected with dominant-negative mutant Src expression vector at 1 uM by RT-PCR 17513867
MC3T3-E1 Function assay 1 uM Reversal of increase in Src kinase phosphorylation in mouse MC3T3-E1 cells at 1 uM in presence of PP2 17513867
MC3T3-E1 Function assay 1 uM Reversal of increase in Src kinase phosphorylation in mouse MC3T3-E1 cells transfected with dominant-negative mutant Src expression vector at 1 uM 17513867
MC3T3-E1 Function assay 1 uM Increase in Src kinase phosphorylation in mouse MC3T3-E1 cells at 1 uM 17513867
T47D Antiproliferative assay 1 uM Antiproliferative activity against human T47D cells at 1 uM by flow cytometry 17513867
primary osteoblast cells Function assay 1 uM Reversal of increase in ER.DNA complex in rat primary osteoblast cells transfected with dominant-negative mutant Src expression vector at 1 uM by RT-PCR 17513867
MC3T3-E1 Function assay 1 uM Reversal of increase in pBMP2 expression in mouse MC3T3-E1 cells at 1 uM by luciferase method in presence of PP2 17513867
MC3T3-E1 Function assay 1 uM Induction of ER association with BMP2 promoter in mouse MC3T3-E1 cells at 1 uM by ChiP assay 17513867
MC3T3-E1 Function assay 1 uM Reversal of induction in nuclear translocation of ERalpha in mouse MC3T3-E1 cells transfected with dominant-negative mutant Src expression vector at 1 uM 17513867
MCF7 Antiproliferative assay 1 uM Antiproliferative activity against human MCF7 cells at 1 uM by flow cytometry 17513867
MC3T3-E1 Function assay 1 uM Reversal of increase in pBMP2 expression in mouse MC3T3-E1 cells transfected with dominant-negative mutant Src expression vector at 1 uM by luciferase method 17513867
MCF7 Function assay 1 uM Reduction in anchorage-independent colony formation of human MCF7 cells at 1 uM by soft agar colony forming assay 17513867
T47D Function assay 1 uM Reduction in anchorage-independent colony formation of human T47D cells at 1 uM by soft agar colony forming assay 17513867
primary osteoblast cells Function assay 1 uM Increase in BMP2 mRNA levels in rat primary osteoblast cells at 1 uM by RT-PCR method 17513867
primary osteoblast cells Function assay 1 uM Reversal of increase in ER.DNA complex in rat primary osteoblast cells at 1 uM by RT-PCR in presence of PP2 17513867
MC3T3-E1 Function assay 1 uM Reversal of induction of BMP2 expression in mouse MC3T3-E1 cells at 1 uM by Western blot in presence of ICI-182780 17513867
MC3T3-E1 Function assay 1 uM Reversal of induction of BMP2 expression in mouse MC3T3-E1 cells at 1 uM by Western blot in presence of short interfering ERalpha-RNA 17513867
MC3T3-E1 Function assay 1 uM Reversal of induction in nuclear translocation of ERalpha in mouse MC3T3-E1 cells at 1 uM in presence of PP2 17513867
MC3T3-E1 Function assay 1 uM Reversal of induction in BMP2 expression in mouse MC3T3-E1 cells transfected with dominant-negative mutant Src expression vector at 1 uM by Western blot 17513867
MC3T3-E1 Function assay 1 uM Reversal of induction in BMP2 expression in mouse MC3T3-E1 cells at 1 uM by Western blot in presence of PP2 17513867
MC3T3-E1 Function assay 1 uM Reversal of increase in ER.DNA complex in mouse MC3T3-E1 cells at 1 uM by RT-PCR in presence of PP2 17513867
primary osteoblast cells Function assay 1 uM Reversal of increase in pBMP2 expression in rat primary osteoblast cells transfected with dominant-negative mutant Src expression vector at 1 uM by luciferase method 17513867
primary osteoblast cells Function assay 1 uM Reversal of increase in pBMP2 expression in rat primary osteoblast cells at 1 uM by luciferase method in presence of PP2 17513867
MC3T3-E1 Function assay 1 uM Reversal of increase in BMP2 expression in mouse MC3T3-E1 cells expressing small interfering RNA for FOXA1 protein at 1 uM by Western blot 17513867
MC3T3-E1 Function assay 1 uM Reversal of increase in pBMP2 expression in mouse MC3T3-E1 cells expressing small interfering RNA for FOXA1 protein at 1 uM by luciferase method 17513867
MC3T3-E1 Function assay 1 uM Reversal of increase in ER.DNA complex in mouse MC3T3-E1 cells expressing small interfering RNA for FOXA1 protein at 1 uM by RT-PCR 17513867
MDA-MB-231 Antiproliferative assay 1 uM Antiproliferative activity against human MDA-MB-231 cells at 1 uM by flow cytometry 17513867
MDA-MB-231 Function assay 1 uM Reduction in anchorage-independent colony formation of human MDA-MB-231 cells at 1 uM by soft agar colony forming assay 17513867
HEK293 Function assay 100 uM Inhibition of DC-SIGN expression in HEK293 cells expressing DC-SIGN at 100 uM by Western blot analysis 17938187
U2OS Function assay 100 uM Activation of SIRT1 in human U2OS cells assessed as decrease in p53 deacetylation level at 100 uM 18046409
PBL Function assay 12.5 uM Inhibition of hydrogen peroxide-induced DNA damage in human PBL cells at 12.5 uM by Comet assay 19271734
LS174T Function assay 100 uM Inhibition of Wnt/beta-casein in human LS174T cells assessed as increase in p21WAF1/CIP1 protein level at 100 uM by Western blotting 21291235
LS174T Function assay 100 uM Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in cyclin B1 protein level at 100 uM by Western blotting 21291235
LS174T Function assay 100 uM Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in c-Myc protein level at 100 uM by Western blotting 21291235
LS174T Function assay 100 uM Inhibition of Wnt/beta-casein in human LS174T cells assessed as reduction in Cyclin D1 protein level at 100 uM by Western blotting 21291235
LS 174T Function assay 100 uM Inhibition of Wnt/beta-casein in human LS 174T cells assessed as reduction in TCF4 protein level at 100 uM by Western blotting 21291235
LS 174T Function assay 100 uM Inhibition of Wnt/beta-casein in human LS 174T cells assessed as reduction in pygopus2 protein level at 100 uM by Western blotting 21291235
MCF7 Function assay >100 uM Activation of SIRT1 in human MCF7 cells assessed as reduction in doxorubicin-induced acetyl-p53 level at >100 uM after 6 hrs by Western blotting analysis 23316803
HBZY-1 Function assay 6 uM Activation of Nrf2 in rat HBZY-1 cells assessed as increase in NQO-1 level at 6 uM by Western blot analysis 30408749
HBZY-1 Function assay 6 uM Activation of Nrf2 in rat HBZY-1 cells assessed as increase in HO-1 level at 6 uM by Western blot analysis 30408749
HBZY-1 Function assay 6 uM Activation of Nrf2 in rat HBZY-1 cells assessed as increase in GCLM level at 6 uM by Western blot analysis 30408749
HBZY-1 Function assay 6 uM Activation of Nrf2 in rat HBZY-1 cells assessed as increase in GCLC level at 6 uM by Western blot analysis 30408749
HBZY-1 Function assay 6 uM Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Keap1/Nrf2 signaling by measuring increase in NQO-1 mRNA expression at 6 uM by RT-PCR analysis 31301564
HBZY-1 Function assay 6 uM Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Keap1/Nrf2 signaling by measuring increase in HO-1 mRNA expression at 6 uM by RT-PCR analysis 31301564
HBZY-1 Function assay 6 uM Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Keap1/Nrf2 signaling by measuring increase in GCLM mRNA expression at 6 uM by RT-PCR analysis 31301564
HBZY-1 Function assay 6 uM Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Keap1/Nrf2 signaling by measuring increase in GCLC mRNA expression at 6 uM by RT-PCR analysis 31301564
MCF7 Function assay 6 hrs Inhibition of phorbol ester-induced ornithine decarboxylase in human MCF7 cells after 6 hrs, IC50=19μM. 10075742
Hepa1clc7 Cytotoxicity assay 72 hrs Cytotoxicity against mouse Hepa1clc7 cells after 72 hrs, IC50=11μM. 10075742
MC3T3-E1 Function assay 24 hrs Inhibition of TNF-alpha-induced apoptosis in mouse MC3T3-E1 cells after 24 hrs by flow cytometry 17513867
primary osteoblast cells Function assay 24 hrs Inhibition of etoposide-induced apoptosis in rat primary osteoblast cells after 24 hrs by flow cytometry 17513867
primary osteoblast cells Function assay 24 hrs Inhibition of TNF-alpha-induced apoptosis in rat primary osteoblast cells after 24 hrs by flow cytometry 17513867
MC3T3-E1 Function assay 24 hrs Inhibition of etoposide-induced apoptosis in mouse MC3T3-E1 cells after 24 hrs by flow cytometry 17513867
THP1 Function assay 1 hr Inhibition of FSL-1-induced increase in phagocytosis of FITC-conjugated Escherichia coli K12 in human THP1 cells assessed as reduction in number of cells phagocytosing bacteria per cell after 1 hr by CLSM 17938187
THP1 Function assay 1 hr Inhibition of FSL-1-induced increase in phagocytosis of FITC-conjugated Escherichia coli K12 in human THP1 cells assessed as reduction in number of phagocytosing bacteria to total number of cells after 1 hr by CLSM 17938187
HEK293 Function assay 1 hr Inhibition of heat killed Escherichia coli K12-induced NF-kappaB activation in HEK293 cells expressing TLR2 pretreated for 1 hr before 6 hrs heat killed bacterial stimulation by luciferase reporter gene assay 17938187
HEK293 Function assay 1 hr Inhibition of heat killed Staphylococcus aureus 209P-induced NF-kappaB activation in HEK293 cells expressing TLR2 pretreated for 1 hr before 6 hrs heat killed bacterial stimulation by luciferase reporter gene assay 17938187
293 Function assay 24 hrs Inhibition of TNFalpha induced NF-kappaB activation in human 293 cells after 24 hrs by luciferase reporter gene assay, IC50=16.1μM. 18487053
cortical microglial Function assay 48 hrs Inhibition of LPS-stimulated NO release in rat cortical microglial cells assessed as nitrite accumulation after 48 hrs, IC50=11.5μM. 18588343
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50=36.3μM. 19251420
DLKP Antiproliferative assay 5 days Antiproliferative activity against MRP1-expressing human DLKP cells after 5 days by acid phosphatase assay, IC50=10μM. 19481462
DLKP-A Antiproliferative assay 5 days Antiproliferative activity against P-gp expressing human DLKP-A cells after 5 days by acid phosphatase assay, IC50=15μM. 19481462
HT144 Antiproliferative assay 5 days Antiproliferative activity against human HT144 cells after 5 days by acid phosphatase assay, IC50=40μM. 19481462
3T3L1 Antiadipogenic assay 7 days Antiadipogenic activity against mouse 3T3L1 cells assessed as inhibition of differentiation after 7 days by oil-red O staining, IC50=31.4μM. 19757853
SW480 Antiproliferative assay 48 hrs Antiproliferative activity against human SW480 cells assessed as cell viability using propidium iodide staining after 48 hrs, IC50=20μM. 20395019
H460 Antiproliferative assay 72 hrs Antiproliferative activity against human H460 cells after 72 hrs, IC50=12.9μM. 20409723
HEK293 Function assay 48 hrs Inhibition of TNF-alpha-induced NF-kappaB activity expressed in HEK293 cells after 48 hrs by luciferase reporter gene assay, IC50=0.173μM. 20527891
RAW 264.7 Function assay 20 hrs Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells pretreated 30 mins before LPS challenge measured after 20 hrs by Griess reaction method relative to control, IC50=15μM. 20527891
Caco-2 Cytotoxicity assay 3 days Cytotoxicity against human Caco-2 cells after 3 days by [3H]thymidine incorporation assay, IC50=24.35μM. 20627379
HT-29 Cytotoxicity assay 3 days Cytotoxicity against human HT-29 cells after 3 days by [3H]thymidine incorporation assay, IC50=45.3μM. 20627379
MDA-MB-231 Antitumor assay 6 days Antitumor activity against human MDA-MB-231 cells after 6 days by SRB assay, IC50=20.5μM. 20728369
Caco2 Function assay 6 hrs Metabolic stability in human Caco2 cells after 6 hrs by LC-MS-MS analysis 20866032
HT22 Neuroprotective assay 24 hrs Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxytosis after 24 hrs by MTT assay, EC50=4.667μM. 21129978
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells assessed as cell viability after 48 hrs by SRB assay, IC50=0.0000225μM. 21851083
SK-N-SH Antiproliferative assay 48 hrs Antiproliferative activity against human SK-N-SH cells assessed as cell viability after 48 hrs by SRB assay, IC50=0.0000403μM. 21851083
A549 Antiproliferative assay 48 hrs Antiproliferative activity against human A549 cells assessed as cell viability after 48 hrs by SRB assay, IC50=0.0000447μM. 21851083
MCF7 Antiproliferative assay 48 hrs Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs by SRB assay, IC50=0.0000791μM. 21851083
RAW264.7 Antiinflammatory assay 30 mins Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 30 mins before LPS challenge measured after 24 hrs by Griess method, IC50=30.71μM. 22115839
RAW264.7 Function assay 18 hrs Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells after 18 hrs, IC50=23.2μM. 22386564
RAW264.7 Antiinflammatory assay 30 mins Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 30 mins measured 24 hrs post LPS challenge by Griess method, IC50=30.71μM. 22386564
NIH/3T3 Cytotoxicity assay 96 hrs Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay, IC50=24.22μM. 22749392
Hepa-1c1c7 Function assay 48 hrs Induction of quinone reductase-1 activity in mouse Hepa-1c1c7 cells after 48 hrs by MTT assay, CD=21μM. 23142320
RAW 264.7 Function assay 30 mins Inhibition of LPS-induced iNOS activity in mouse RAW 264.7 cells assessed as inhibition of NO production pretreated with compound for 30 mins before LPS challenge after 24 hrs by Griess reagent method, IC50=23.2μM. 23142320
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells assessed as growth inhibition measured after 48 hrs by XTT assay, IC50=31.8μM. 23547843
SK-MEL Cytotoxicity assay 48 hrs Cytotoxicity against human SK-MEL cells assessed as growth inhibition measured after 48 hrs by XTT assay, IC50=47.3μM. 23547843
Huh7.5.1 Cytotoxicity assay 72 hrs Cytotoxicity against human Huh7.5.1 cells after 72 hrs, IC50=10.6μM. 23673225
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human estrogen receptor positive MCF7 cells after 72 hrs by MTT assay, IC50=28.07μM. 23860590
SKBR3 Cytotoxicity assay 72 hrs Cytotoxicity against human estrogen receptor negative SKBR3 cells after 72 hrs by MTT assay, IC50=41.42μM. 23860590
ScN2a-cl3 Function assay 5 days Inhibition of RML prion protein infected in mouse dividing ScN2a-cl3 cells expressing full length mouse PrP assessed as reduction of PrPsc level after 5 days by Western blotting analysis, EC50=0.58μM. 24183589
ScN2a-cl3 Function assay 5 days Inhibition of RML prion protein infected in mouse dividing ScN2a-cl3 cells expressing full length mouse PrP assessed as reduction of PrPsc level after 5 days by ELISA, EC50=3.06μM. 24183589
HEK293 Function assay 6 hrs Inhibition of TNF-alpha-induced NF-kappaB activity in HEK293 cells after 6 hrs by luciferase reporter gene assay, IC50=2.5μM. 24992702
Hepa-1c1c7 Function assay 48 hrs Induction of quinone reductase 1 in mouse Hepa-1c1c7 cells after 48 hrs by MTT assay, CD=21μM. 24992702
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay, IC50=47.9μM. 25817772
U373-MAGI Antiviral assay 2 to 8 hrs Antiviral activity against VSV-G pseudotyped HIV-1 NL4-3 infected in human U373-MAGI cells assessed as reduction in viral infectivity preincubated for 2 to 8 hrs followed by viral infection measured at 72 hrs post infection by flow cytometric analysis 27117260
DH5aplha Function assay 2 mins Inhibition of recombinant human CYP1A1 expressed in Escherichia coli DH5aplha cells assessed as O-deethylation of ethoxyresorufin in presence of NADPH measured after 2 mins by spectrofluorometric method, IC50=34μM. 27265259
MDAH 2774 Cytotoxicity assay 72 hrs Cytotoxicity against human MDAH 2774 cells after 72 hrs by MTT assay, CD50=14.6μM. 27515319
T24 Cytotoxicity assay 72 hrs Cytotoxicity against human T24 cells after 72 hrs by MTT assay, CD50=22.7μM. 27515319
MDAH 2774 Cytotoxicity assay 48 hrs Cytotoxicity against human MDAH 2774 cells after 48 hrs by MTT assay, CD50=23μM. 27515319
DU145 Cytotoxicity assay 72 hrs Cytotoxicity against human DU145 cells after 72 hrs by MTT assay, CD50=27.9μM. 27515319
MHRF Cytotoxicity assay 72 hrs Cytotoxicity against human MHRF cells after 72 hrs by MTT assay, CD50=32μM. 27515319
MDAH 2774 Cytotoxicity assay 24 hrs Cytotoxicity against human MDAH 2774 cells after 24 hrs by MTT assay, CD50=36.9μM. 27515319
HepG2 Function assay 5 hrs Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assay, EC50=5.4μM. 28126440
HEK293 Growth inhibition assay 2 days Growth inhibition of HEK293 cells after 2 days by MTT assay, IC50=17μM. 28408224
MCF7 Growth inhibition assay 2 days Growth inhibition of human MCF7 cells after 2 days by MTT assay, IC50=34μM. 28408224
Ramos Growth inhibition assay 2 days Growth inhibition of human Ramos cells after 2 days by MTT assay, IC50=37μM. 28408224
ALL5 Cytotoxicity assay 120 hrs Cytotoxicity against human ALL5 cells after 120 hrs by MTT method, IC50=10.5μM. 28499732
LN229 Cytotoxicity assay 48 hrs Cytotoxicity against human LN229 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50=11μM. 28654265
NCI-H460 Cytotoxicity assay 48 hrs Cytotoxicity against human NCI-H460 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50=12μM. 28654265
MML1 Cytotoxicity assay 48 hrs Cytotoxicity against human MML1 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50=12μM. 28654265
BxPC3 Cytotoxicity assay 48 hrs Cytotoxicity against human BxPC3 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50=14μM. 28654265
SK-MEL-2 Cytotoxicity assay 48 hrs Cytotoxicity against human SK-MEL-2 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50=14μM. 28654265
MDA-MB-231 Cytotoxicity assay 48 hrs Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50=15μM. 28654265
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50=16μM. 28654265
U87 Cytotoxicity assay 48 hrs Cytotoxicity against human U87 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50=20μM. 28654265
T47D Cytotoxicity assay 48 hrs Cytotoxicity against human T47D cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50=25μM. 28654265
HT-29 Cytotoxicity assay 48 hrs Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50=27μM. 28654265
COLO201 Cytotoxicity assay 48 hrs Cytotoxicity against human COLO201 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50=37μM. 28654265
PANC1 Cytotoxicity assay 48 hrs Cytotoxicity against human PANC1 cells assessed as decrease in cell viability after 48 hrs by MTT assay, IC50=39μM. 28654265
BV2 Antineuroinflammatory assay 24 hrs Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay, IC50=18.66μM. 28911817
HEK293T Cytotoxicity assay 24 hrs Cytotoxicity against HEK293T cells after 24 hrs by MTT assay, CC50=22.75μM. 29172079
BV2 Antineuroinflammatory assay 24 hrs Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced IL-1beta production after 24 hrs by ELISA, IC50=8.7μM. 29499485
BV2 Antineuroinflammatory assay 24 hrs Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA, IC50=9.5μM. 29499485
BV2 Antineuroinflammatory assay 30 mins Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins followed by LPS stimulation and measured after 24 hrs by Griess assay, IC50=11.1μM. 29499485
J774 Antiinflammatory assay 24 hrs Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced IL6 expression after 24 hrs by ELISA, IC50=6.8μM. 29726680
J774 Antiinflammatory assay 24 hrs Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced nitric oxide production after 24 hrs by Griess assay, IC50=12.15μM. 29726680
J774 Antiinflammatory assay 24 hrs Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA, IC50=13.6μM. 29726680
RAW 264.7 Function assay 24 hrs Inhibition of NFkappaB in mouse RAW 264.7 cells assessed as reduction in LPS induced NO production after 24 hrs in presence of OBHS by Griess assay, IC50=11μM. 30053783
RAW 264.7 Function assay 24 hrs Inhibition of NFkappaB in mouse RAW 264.7 cells assessed as reduction in LPS induced NO production after 24 hrs by Griess assay, IC50=13.1μM. 30053783
MCF7 Antiproliferative assay 72 hrs Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50=22.9μM. 30053783
MCF7 Antiproliferative assay 72 hrs Antiproliferative activity against human MCF7 cells after 72 hrs in presence of OBHS by MTT assay, IC50=25.4μM. 30053783
RAW264.7 Antiinflammatory assay 1 hr Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS/IFNgamma-induced NO production by measuring NO levels incubated with LPS/IFNgamma for 1 hr followed by compound addition measured after 48 hrs by Griess assay (Rvb = 55 +/- 2., Activity=44.5μM. 30193941
RAW264.7 Antiinflammatory assay 2 hrs Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS/IFNgamma-induced NO production by measuring NO level preincubated for 2 hrs and followed by LPS/IFNgamma addition and measured after 24 hrs by Griess assay, IC50=44.1μM. 31350127
PMNL Function assay 15 mins Inhibition of 5-LOX in human PMNL cells assessed as A23187-stimulated LTB4 production preincubated for 15 mins followed by A23187 addition and measured after 10 mins by HPLC analysis, IC50=4.9μM. 31351395
TOV112D Cytotoxicity assay 96 hrs Cytotoxicity against human TOV112D cells transfected with empty vector assessed as reduction in cell viability incubated for 96 hrs by MTT assay, IC50=10.67μM. 31514018
TOV112D Cytotoxicity assay 96 hrs Cytotoxicity against human TOV112D cells expressing NQO2 assessed as reduction in cell viability incubated for 96 hrs by MTT assay, IC50=11μM. 31514018
SKOV3 Cytotoxicity assay 96 hrs Cytotoxicity against human SKOV3 cells transfected with non-targeted vector assessed as reduction in cell viability incubated for 96 hrs in presence of doxycycline by MTT assay, IC50=29μM. 31514018
SKOV3 Cytotoxicity assay 96 hrs Cytotoxicity against human SKOV3 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay, IC50=36.3μM. 31514018
SKOV3 Cytotoxicity assay 96 hrs Cytotoxicity against human SKOV3 cells transfected with shRNA assessed as reduction in cell viability incubated for 96 hrs in presence of doxycycline by MTT assay, IC50=39.67μM. 31514018
RAW 264.7 Function assay Inhibition of LPS and TNF-alpha-activated NO production in murine RAW 264.7 cells, IC50=23.5μM. 17253844
BV2 Function assay Suppression of LPS-stimulated COX2 mRNA expression in mouse BV2 cells at 20 uM 17125270
HEK293T Function assay Inhibition of TNF-alpha-induced NF-kappaB activation in HEK293T cells, IC50=20μM. 17125270
HL60 Antiproliferative assay Antiproliferative activity against human HL60 cells, IC50=5μM. 16580204
U937 Cytotoxicity assay Cytotoxicity against human U937 cells after 48 hrs by WST1 test, IC50=17μM. 16252924
MDA-MB-231 Antiproliferative assay Inhibitory concentration required for antiproliferative activity against human MDA-MB-231 cells, IC50=20.5μM. 16250636
MCF7 Function assay Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by alamar blue assay, Activity=1.6μM. 15787436
T47D Function assay Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by alamar blue assay, Activity=0.03μM. 15787436
RAW264.7 Function assay inhibitory concentration against PGE-2 production in LPS-stimulated RAW264.7 cells, IC50=20.8μM. 15501064
RAW264.7 Function assay Inhibitory effect on PGE-2 production in LPS-stimulated RAW264.7 cells, IC50=4μM. 15080988
RAW264.7 Function assay Inhibitory activity against nitric oxide production in lipopolysaccharide-activated mouse macrophage RAW264.7 cells, IC50=15.9μM. 14552759
HL60 Function assay In vitro inhibitory concentration against proliferation of HL60 cells, IC50=5μM. 12877593
CHO Function assay Blockade of human Glut3 expressed in CHO cells assessed as inhibition of [14C]dehydroascorbic acid uptake by scintillation spectrometry 11277764
CHO Function assay Blockade of human Glut3 expressed in CHO cells assessed as inhibition of 2-[1,2-3H(N)]deoxy-D-glucose uptake by scintillation spectrometry 11277764
CHO Function assay Blockade of rat Glut1 expressed in CHO cells assessed as inhibition of [14C]dehydroascorbic acid uptake by scintillation spectrometry 11277764
CHO Function assay Blockade of rat Glut1 expressed in CHO cells assessed as inhibition of 2-[1,2-3H(N)]deoxy-D-glucose uptake by scintillation spectrometry 11277764
HL60 Function assay Inhibition of [14C]dehydroascorbic acid uptake in human HL60 cells by scintillation spectrometry in presence of sodium-free buffer 11277764
U937 Function assay Inhibition of [14C]dehydroascorbic acid uptake in human U937 cells by scintillation spectrometry in presence of sodium-free buffer 11277764
HL60 Function assay Inhibition of 2-[1,2-3H(N)]deoxy-D-glucose uptake in human HL60 cells by scintillation spectrometry in presence of sodium-free buffer 11277764
U937 Function assay Inhibition of 2-[1,2-3H(N)]deoxy-D-glucose uptake in human U937 cells by scintillation spectrometry in presence of sodium-free buffer 11277764
U937 Function assay Inhibition of [14C]dehydroascorbic acid uptake in human U937 cells by Michaelis-Menten plot, Ki=35μM. 11277764
human K562 cell line Proliferation assay Antiproliferative activity against human K562 cell line expressing Bcr-Abl, IC50=28 μM 16686543
human HL60 cell line Proliferation assay Antiproliferative activity against human HL60 cell line, IC50=5 μM 16686543
MDA-MB-231 Function assay Reversal of induction of FOXO3a activity in human MDA-MB-231 cells transfected with FOXO3a-specific small interfering RNA 17513867
MDA-MB-231 Function assay Induction of FOXO3a activity in human MDA-MB-231 cells 17513867
MC3T3-E1 Function assay Reversal of increase in DNA-binding activity of ERalpha in nuclear extracts of mouse MC3T3-E1 cells by electrophoretic mobility shift assays in presence of short interfering ER alpha-RNA 17513867
MC3T3-E1 Function assay Reversal of increase in DNA-binding activity of ERalpha in nuclear extracts of mouse MC3T3-E1 cells by electrophoretic mobility shift assays in presence of ICI-182780 17513867
MC3T3-E1 Function assay Increase in DNA-binding activity of ERalpha in nuclear extracts of mouse MC3T3-E1 cells by electrophoretic mobility shift assays 17513867
MC3T3-E1 Function assay Reversal of increase in DNA-binding activity of ERalpha in nuclear extracts of mouse MC3T3-E1 cells transfected with dominant-negative mutant Src expression vector by electrophoretic mobility shift assays 17513867
MC3T3-E1 Function assay Reversal of increase in DNA-binding activity of ERalpha in nuclear extracts of mouse MC3T3-E1 cells by electrophoretic mobility shift assays in presence of PP2 17513867
MDA-MB-231 Function assay Reversal of inhibition in anchorage-independent colony formation of human MDA-MB-231 cells transfected with FOXO3a-specific small interfering RNA by soft agar colony forming assay 17513867
MDA-MB-231 Function assay Inhibition of IGF-induced FOXO3a phosphorylation at Thr32 residue in human MDA-MB-231 cells by Western blot 17513867
MDA-MB-231 Function assay Inhibition of IGF-induced Akt phosphorylation in human MDA-MB-231 cells by Western blot 17513867
MDA-MB-231 Function assay Reversal of induction of Akt inactivation in human MDA-MB-231 cells transfected with constitutively activated Akt mutant 17513867
MDA-MB-231 Function assay Reversal of induction of FOXO3a nuclear accumulation in human MDA-MB-231 cells transfected with constitutively activated Akt mutant 17513867
MDA-MB-231 Function assay Reversal of induction of FOXO3a activity in human MDA-MB-231 cells transfected with constitutively activated Akt mutant 17513867
MDA-MB-231 Function assay Enhancement of Akt inactivation in human MDA-MB-231 cells transfected with dominant negative Akt mutant 17513867
MDA-MB-231 Function assay Enhancement of FOXO3a nuclear accumulation in human MDA-MB-231 cells transfected with dominant negative Akt mutant 17513867
MDA-MB-231 Function assay Enhancement of FOXO3a activity in human MDA-MB-231 cells transfected with dominant negative Akt mutant 17513867
RAW264.7 Function assay Inhibition of phagocytosis of FITC-conjugated Escherichia coli K12 in mouse RAW264.7 cells assessed as reduction in ratio of number of bacterial cells to phagocytes using trypan blue staining by flow cytometry 17938187
RAW264.7 Function assay Inhibition of phagocytosis of FITC-conjugated Staphylococcus aureus 209P in mouse RAW264.7 cells assessed as reduction in ratio of number of bacterial cells to phagocytes using trypan blue staining by flow cytometry 17938187
THP1 Function assay Inhibition of phagocytosis of FITC-conjugated Escherichia coli K12 in human THP1 cells assessed as reduction in ratio of number of bacterial cells to phagocytes using trypan blue staining by flow cytometry 17938187
THP1 Function assay Inhibition of phagocytosis of FITC-conjugated Staphylococcus aureus 209P in human THP1 cells assessed as reduction in ratio of number of bacterial cells to phagocytes using trypan blue staining by flow cytometry 17938187
Hepa 1c1c7 Function assay Inhibition of quinone reductase 1 in mouse Hepa 1c1c7 cells assessed as drug level required to double enzyme activity by MTT assay, CD=21μM. 20527891
HEK293 Function assay Inhibition of TNFalpha-activated NF-kappaB expressed in HEK293 cells by luciferase reporter gene assay, IC50=0.98μM. 22115839
Hepa-1c1c7 Function assay Induction of QR1 activity in mouse Hepa-1c1c7 cells using MTT as substrate by spectrophotometry, CD=21μM. 22115839
HEK293 Function assay Inhibition of TNF-alpha activated NF-kappaB expressed in HEK293 cells by luciferase reporter gene assay, IC50=0.98μM. 22386564
Hepa-1c1c7 Function assay Induction of QR1 in mouse Hepa-1c1c7 cells assessed as concentration required to double QR1 induction by MTT assay, CD=21μM. 22386564
HEK293 Function assay Inhibition of TNFalpha-induced NF-kappaB activity expressed in HEK293 cells by luciferase reporter gene assay, IC50=0.98μM. 23142320
HeLa Function assay Inhibition of smad3/4 signaling pathway in human HeLa cells assessed as measured as lowest concentration required 50 to 60 % inhibition of TGF-beta induced luciferase treated 30 mins before induction, MED=33μM. 23547843
HeLa Function assay Inhibition of Hedgehog signaling pathway in human HeLa cells assessed as measured as lowest concentration required 50 to 60 % inhibition of PMA induced luciferase treated 30 mins before induction, MED=40μM. 23547843
HeLa Function assay Inhibition of Hedgehog signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase treated 30 mins before induction, IC50=40μM. 23547843
HeLa Function assay Inhibition of Notch signaling pathway in human HeLa cells assessed as measured as lowest concentration required 50 to 60 % inhibition of PMA induced luciferase treated 30 mins before induction, MED=40μM. 23547843
HeLa Function assay Inhibition of Notch signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase treated 30 mins before induction, IC50=40μM. 23547843
HL60 Cytotoxicity assay Cytotoxicity against human HL60 cells, ED50=22μM. 23582778
COLO205 Antiproliferative assay Antiproliferative activity against human COLO205 cells by MTT assay, IC50=23.5μM. 25455486
MGC803 Antiproliferative assay Antiproliferative activity against human MGC803 cells by MTT assay, IC50=42μM. 25455486
MDA468 Antiproliferative assay Antiproliferative activity against human MDA468 cells by MTT assay, IC50=45.2μM. 25455486
HEK293 Function assay Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase of intracellular calcium level, IC50=0.75μM. 26750258
HEK293 Function assay Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level in absence of AITC, IC50=1.4μM. 26750258
HEK293 Function assay Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level in presence of AITC, IC50=2.74μM. 26750258
HEK293 Function assay Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level, IC50=19.9μM. 26750258
HEK293 Function assay Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced current response by whole cell patch clamp method, IC50=0.75μM. 28576617
A549 Growth inhibition assay Growth inhibition of human A549 cells, IC50=30μM. 28814374
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells 29435139
BT-37 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells 29435139
HBZY-1 Function assay Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Nrf2 nuclear translocation by measuring increase in ratio of nuclear to cytosolic Nrf2 level by Western blot analysis 31301564
HBZY-1 Function assay Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Keap1/Nrf2 signaling by measuring increase in NQO-1 protein expression by Western blot analysis 31301564
HBZY-1 Function assay Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Keap1/Nrf2 signaling by measuring increase in HO-1 protein expression by Western blot analysis 31301564
HBZY-1 Function assay Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Keap1/Nrf2 signaling by measuring increase in GCLM protein expression by Western blot analysis 31301564
HBZY-1 Function assay Binding affinity to Keap1 in rat HBZY-1 cells assessed as induction of Keap1/Nrf2 signaling by measuring increase in GCLC protein expression by Western blot analysis 31301564
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生物活性

產(chǎn)品描述 Resveratrol具有廣泛靶點(diǎn)，包括環(huán)氧酶（如COX, IC50=1.1 μM）、脂肪氧合酶(LOC, IC50=2.7 μM)、sirtuins和其他蛋白質(zhì)。它是一種天然的植物抗毒素，具有抗癌，抗炎，降血糖和其他有益心血管的作用。Resveratrol可誘導(dǎo)線粒體自噬、細(xì)胞自噬和自噬依賴性的凋亡。
靶點(diǎn)
SIRT1 [2]
(Cell-free assay)		 SIRT2 [2]
(Cell-free assay)		 Quinone reductase 2 [9]
(Cell-free assay)		 IKK β [1]
(Cell-free assay)		 COX1 [9]
(Cell-free assay)		 點(diǎn)擊更多
88 nM 1 μM 1.1 μM
體外研究(In Vitro)
體外研究活性 Resveratro 抑制環(huán)氧合酶和脂氧化酶，PKCs和p56lck， ERK1，JNK1，p38，IKK β，Src，STAT3，核苷酸還原酶，DNA聚合酶α和 δ，PKD，PKC α，醌還原酶2，以及芳香化酶的活性，IC50值為0.035-60 μM。Resveratrol也是腺苷酸環(huán)化酶和AMPK的活化劑，IC50值分別為0.8 μM和50 μM。Resveratrol作為抑制劑或活化劑，能夠減少細(xì)胞炎癥相關(guān)的表現(xiàn)，抑制癌癥細(xì)胞的生長并誘導(dǎo)細(xì)胞凋亡，逆轉(zhuǎn)內(nèi)皮素-1受激的細(xì)胞應(yīng)答，抑制佛波醇酯誘導(dǎo)的COX-2表達(dá)，抑制細(xì)胞中DNA合成，抵抗甲萘醌誘導(dǎo)的細(xì)胞死亡，并且改善細(xì)胞線粒體功能和葡萄糖/脂質(zhì)代謝。[1]Resveratrol也是抗衰老酶的活化劑。Resveratrol降低作用于乙酰化底物和NAD+的SIRT1的Michaelis常數(shù)，通過促進(jìn)SIRT1依賴性的p53脫乙酰作用增加細(xì)胞存活。在酵母中，Resveratrol通過刺激Sir2模擬熱量限制，增加DNA穩(wěn)定性并延長壽命。[2] Resveratrol通過其抗氧化活性，能夠有效保護(hù)離體的大鼠心臟免受心臟缺血/再灌注損傷，改善發(fā)展壓和主動(dòng)脈血流的恢復(fù)，降低丙二醛的濃度并減少梗死面積。[3]
細(xì)胞實(shí)驗(yàn) 細(xì)胞系 人類乳腺癌細(xì)胞MCF-7
濃度 30-300 μM
孵育時(shí)間 2天
方法

細(xì)胞接種于平底96孔微量滴定板（4000細(xì)胞/ 6.4毫米直徑的孔）。在12-24小時(shí)后，細(xì)胞用DMSO(0.1–0.3%)處理或者增加Resveratrol的劑量。治療48小時(shí)后，細(xì)胞用10μL 的MTT試劑在37℃下處理4小時(shí)，然后用100 μL增溶溶液在37 ℃下處理過夜。甲臜產(chǎn)生的數(shù)量利用分光光度微量滴定板讀數(shù)器在570nm波長下測量。
實(shí)驗(yàn)圖片 檢測方法 檢測指標(biāo) 實(shí)驗(yàn)圖片 PMID
Western blot Nanog / Oct-4 / Sox-2 p-EGFR / EGFR / p-HER2 / HER2 / p-ERK / ERK / PTEN 21304978
Growth inhibition assay Cell viability 23272133
體內(nèi)研究(In Vivo)
體內(nèi)研究活性 Resveratrol改善高熱量飲食小鼠的健康和生存。Resveratrol (22.4 毫克/千克/天)使高熱量飲食中年小鼠的生理機(jī)能轉(zhuǎn)變?yōu)榕c標(biāo)準(zhǔn)飲食小鼠相符，并且顯著增加他們的存活率。Resveratrol產(chǎn)生與延長壽命相關(guān)的改變，包括增加胰島素敏感性，降低胰島素樣生長因子-1(IGF-I)的水平，增加AMP活化的蛋白激酶(AMPK) 過氧化物酶體增殖物激活的受體-γ共激活因子1α(PGC-1α)的活性，增加線粒體數(shù)量，并改善運(yùn)動(dòng)機(jī)能。在153顯著改變的通路中，Resveratrol能夠抵抗144的高熱量飲食作用。[3] 在各種嚙齒動(dòng)物癌癥模型中，Resveratrol被證明能夠抑制腫瘤的發(fā)生和生長。Resveratrol在低至200微克/千克劑量下已經(jīng)在結(jié)腸癌變的大鼠模型中表現(xiàn)出了功效。在40毫克/千克的較高劑量下，Resveratrol使患有皮下成神經(jīng)細(xì)胞瘤的小鼠的存活率從0％增加到70％。Resveratrol在48微克/千克劑量下每天給藥，抑制小鼠角膜微囊袋法中血管形成。[3] Resveratrol對心臟疾病表現(xiàn)出有益作用。Resveratrol阻斷高脂飲食誘發(fā)的血小板聚集的增加。Resveratrol增加內(nèi)皮細(xì)胞和誘導(dǎo)型一氧化氮合酶的表達(dá)。在易卒型自發(fā)性高血壓大鼠體內(nèi)，Resveratrol顯著降低氧化應(yīng)激的標(biāo)志物，如血清中的糖化白蛋白和尿液中的8-羥基鳥嘌呤核苷。Resveratrol加入到飲用水中15天(1 毫克/千克)足以改善離體心臟的功能和冠狀動(dòng)脈血流量的恢復(fù)。[3] Resveratrol在體內(nèi)顯示抗炎活性。Resveratrol顯著降低急慢性化學(xué)誘發(fā)的水腫，脂多糖誘發(fā)的氣道炎癥和骨關(guān)節(jié)炎，并且有助于防止同種異體移植排斥。在大鼠體內(nèi)，Resveratrol靜脈注射給藥降低局部缺血/再灌注誘發(fā)的炎癥，減少次黃嘌呤/黃嘌呤氧化酶（HX/ XO）或血小板活化因子產(chǎn)生的氧化劑，但不影響白三烯B4。[3] Resveratrol顯示出對中風(fēng)和腦損傷的有益作用。Resveratrol在100納克/千克和1 微克/千克的極低劑量下靜脈注射給藥，顯著減少大鼠大腦中動(dòng)脈閉塞后缺血體積和腦組織含水量。[5]
動(dòng)物實(shí)驗(yàn) Animal Models 人類卵巢異種移植物PA-1
Dosages 100毫克/千克
Administration 每天腹腔注射連續(xù)四周
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05684848 Recruiting
Wheezing|Recurrent Respiratory Tract Infections
Noos S.r.l.
 November 1 2022 Not Applicable
NCT03743636 Completed
Peripheral Artery Disease
Northwestern University|American Heart Association
 October 1 2018 Phase 3

化學(xué)信息&溶解度

分子量 228.24 分子式

C14H12O3
CAS號 501-36-0 SDF Download Resveratrol SDF
Smiles C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O
儲(chǔ)存條件(自收到貨起)

體外溶解度
批次：

DMSO : 46 mg/mL ( (201.54 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請使用新開封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑

 動(dòng)物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量 濃度 體積 分子量

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過程中的損耗，建議多配一只動(dòng)物的藥量）

mg/kg g μL 只

第二步：請輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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