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Mitomycin C

別名: Ametycine 中文名稱：絲裂霉素 C

此產(chǎn)品請避光密封保存。

Mitomycin C (Ametycine)?是一種抗腫瘤類抗生素，通過抑制DNA合成發(fā)揮作用，用于治療各種癌癥。Mitomycin C 可誘導半胱氨酸蛋白酶依賴性和Fas/CD95非依賴性的 apoptosis。此產(chǎn)品為?；罚毙远拘?易燃/皮膚腐蝕），請在穿戴防護面罩、防護手套和防護服后使用。 已取得危險化學品經(jīng)營許可

Mitomycin C Chemical Structure

Mitomycin C Chemical Structure

CAS: 50-07-7

規(guī)格 價格 庫存 購買數(shù)量
10mM (1mL in DMSO) 794.43 現(xiàn)貨
10mg 794.43 現(xiàn)貨
50mg 2432.43 現(xiàn)貨
200mg 4889.43 現(xiàn)貨
1g 13677.3 現(xiàn)貨
更大包裝 有超大折扣

400-668-6834

info@selleck.cn
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Mitomycin C相關產(chǎn)品

細胞實驗數(shù)據(jù)示例

細胞系 實驗類型 給藥濃度 孵育時間 活性描述 文獻信息
IE Antiproliferative assay 72 hrs Antiproliferative activity against human IE cells after 72 hrs by trypan blue exclusion assay, EC50 = 1.46 μM. 19674905
SVCT-M12 Antiproliferative assay 72 hrs Antiproliferative activity against human SVCT-M12 cells after 72 hrs by trypan blue exclusion assay, EC50 = 0.96 μM. 19674905
MCF7 Antiproliferative assay 72 hrs Antiproliferative activity against human MCF7 cells after 72 hrs by trypan blue exclusion assay, EC50 = 0.96 μM. 19674905
Hs888Lu Antiproliferative assay 72 hrs Antiproliferative activity against human Hs888Lu cells after 72 hrs by trypan blue exclusion assay, EC50 = 0.56 μM. 19674905
A549 Antiproliferative assay 72 hrs Antiproliferative activity against human A549 cells after 72 hrs by trypan blue exclusion assay, EC50 = 0.43 μM. 19674905
PC3 Antiproliferative assay 72 hrs Antiproliferative activity against human PC3 cells after 72 hrs by trypan blue exclusion assay, EC50 = 0.14 μM. 19674905
SMMC7721 Cytotoxicity assay 48 hrs Cytotoxicity against human SMMC7721 cells after 48 hrs by SRB assay, IC50 = 5.4 μM. 19432411
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by SRB assay, IC50 = 3.3 μM. 19432411
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by SRB assay, IC50 = 1.5 μM. 19432411
HCT8 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT8 cells after 72 hrs by SRB assay, IC90 = 5.7 μM. 18845441
HCT8 Cytotoxicity assay 72 hrs Cytotoxicity against human HCT8 cells after 72 hrs by SRB assay, IC50 = 0.083 μM. 18845441
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by Alamar Blue assay, IC50 = 0.4 μM. 18752870
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay, IC50 = 0.2 μM. 18752870
BAC29 Cytotoxicity assay 3 days Cytotoxicity against BRCA2-proficient Chinese hamster BAC29 mutant cells after 3 days by WST1 cell viability assay, IC50 = 0.4 μM. 18505284
V-C8 Cytotoxicity assay 3 days Cytotoxicity against BRCA2-deficient Chinese hamster V-C8 mutant cells after 3 days by WST1 cell viability assay, IC50 = 0.005 μM. 18505284
HT29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT29 cells after 72 hrs by MTT assay in presence of 2 uM dicoumarol, IC50 = 2.1 μM. 18222567
HT29 Cytotoxicity assay 72 hrs Cytotoxicity against human HT29 cells after 72 hrs by MTT assay, IC50 = 0.9 μM. 18222567
MCF7 Cytotoxicity assay 24 hrs Cytotoxicity against human MCF7 cells after 24 hrs, IC50 = 5 μM. 18037301
A549 Cytotoxicity assay 24 hrs Cytotoxicity against human A549 cells after 24 hrs, IC50 = 4.5 μM. 18037301
MCF7 Cytotoxicity assay 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs, IC50 = 1.2 μM. 18037301
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs, IC50 = 0.24 μM. 18037301
MCF7 Cytotoxicity assay 3 days Cytotoxicity against human MCF7 cells after 3 days by SRB assay, IC50 = 1.5 μM. 16038545
HCT8 Cytotoxicity assay 3 days Cytotoxicity against human HCT8 cells after 3 days by SRB assay, IC50 = 0.6 μM. 16038545
KB Cytotoxicity assay 3 days Cytotoxicity against human KB cells after 3 days by SRB assay, IC50 = 0.6 μM. 16038545
A549 Cytotoxicity assay 3 days Cytotoxicity against human A549 cells after 3 days by SRB assay, IC50 = 0.3 μM. 16038545
HeLa Cytotoxicity assay 5 to 8 days Cytotoxicity against human HeLa cells assessed as inhibition of colony formation after 5 to 8 days by colony assay, IC50 = 0.068 μM. 11975488
EMT6 Function assay 1 hr Compound is measured for surviving fractions of EMT6 tumor cells treated in culture with (0.50 uM) concentration for 1 hr under aerobic condition., ED50 = 0.7 μM. 7452674
EMT6 Function assay 1 hr Compound is measured for surviving fractions of EMT6 tumor cells treated in culture with (0.50 uM) concentration for 1 hr under hypoxic condition., ED50 = 0.001 μM. 7452674
L1210 Growth inhibition assay 1 hr Inhibition of L1210 leukemia cells, after exposure to compound for period of 1 hr, ID50 = 3.1 μM. 3397995
L1210 Growth inhibition assay 8-9 hrs Inhibition of L1210 leukemia cells, after exposure to compound for period of 8-9 hr, ID50 = 0.18 μM. 3397995
AA8 Function assay 4 hrs Inhibitory activity of compound for AA8 cells to reduce cell density by 50% (exposed to compound for 4 hours), IC50 = 0.00108 μM. 2909741
P388 Antiproliferative assay 48 hrs Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay, IC50 = 3 μM. 2778449
HT-29 Antiproliferative assay 96 hrs Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay, IC50 = 0.099 μM. 2778449
Human Caki-1 Renal CellCarcinoma Cell Function assay 96 h Inhibitory concentration against Human Caki-1 Renal CellCarcinoma Cell Lines (CD70+) at 96th hour, ic50=40 nM 15743178
human colon cancer cell line HCT15 Cytotoxic?assay 72 h In vitro cytotoxic activity against human colon cancer cell line HCT15 after 72 hr of drug exposure determined by the SRB assay, IC50=70 nM 14980672
MPC5 Antiproliferative assay 72 hrs Antiproliferative activity against human MPC5 cells after 72 hrs by trypan blue exclusion assay, EC50 = 2.1 μM. 19674905
PC3 Growth inhibition assay 48 hrs Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay, IC50 = 1.5 μM. 19939522
Hep2 Growth inhibition assay 48 hrs Growth inhibition of human Hep2 cells after 48 hrs by sulforhodamine B assay, IC50 = 1.5 μM. 19939522
Daudi Growth inhibition assay 24 to 72 hrs Growth inhibition of human Daudi cells after 24 to 72 hrs by MTT assay, IC50 = 0.45 μM. 20117936
K562 Growth inhibition assay 24 to 72 hrs Growth inhibition of human K562 cells after 24 to 72 hrs by MTT assay, IC50 = 0.47 μM. 20117936
K562-Lucena 1 Growth inhibition assay 24 to 72 hrs Growth inhibition of human K562-Lucena 1 cells after 24 to 72 hrs by MTT assay, IC50 = 2.75 μM. 20117936
PBMC Growth inhibition assay 24 to 72 hrs Growth inhibition of phytohemagglutinin-activated human PBMC cells after 24 to 72 hrs by MTT assay, IC50 = 4.03 μM. 20117936
GM00637 Cytotoxicity assay 24 hrs Cytotoxicity against human GM00637 cells after 24 hrs by MTT assay, IC50 = 0.9 μM. 20122765
DU145 Cytotoxicity assay 72 hrs Cytotoxicity against human DU145 cells after 72 hrs by MTT assay, IC50 = 0.17 μM. 20605274
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 0.27 μM. 20605274
GM00637 Cytotoxicity assay 72 hrs Cytotoxicity against human GM00637 cells after 72 hrs by MTT assay, IC50 = 0.46 μM. 20605274
DU145 Cytotoxicity assay 72 hrs Cytotoxicity against human DU145 cells assessed as reduction in mean cell viability after 72 hrs by MTT assay, IC50 = 0.17 μM. 22522008
HeLa Cytotoxicity assay 72 hrs Cytotoxicity against human HeLa cells assessed as reduction in mean cell viability after 72 hrs by MTT assay, IC50 = 0.27 μM. 22522008
GM00637 Cytotoxicity assay 72 hrs Cytotoxicity against human GM00637 cells assessed as reduction in mean cell viability after 72 hrs by MTT assay, IC50 = 0.46 μM. 22522008
HL60 Cytotoxicity assay 72 hrs Cytotoxicity against human HL60 cells after 72 hrs by WST8 assay, IC50 = 0.1 μM. 22537363
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by SRB assay, IC50 = 1.8 μM. 22642381
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by SRB assay, IC50 = 3.4 μM. 22642381
SMMC7721 Cytotoxicity assay 48 hrs Cytotoxicity against human SMMC7721 cells after 48 hrs by SRB assay, IC50 = 5.6 μM. 22642381
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by alamar blue assay, IC50 = 0.4 μM. 23123017
HCT116 Antiproliferative assay 48 hrs Antiproliferative activity against human HCT116 cells after 48 hrs by sulforhodamine B assay, IC50 = 0.5 μM. 23501113
NCI-H23 Cytotoxicity assay 48 hrs Cytotoxicity against human NCI-H23 cells after 48 hrs by MTT assay, IC50 = 2 μM. 23792352
SPCA1 Cytotoxicity assay 48 hrs Cytotoxicity against human SPCA1 cells after 48 hrs by MTT assay, IC50 = 1.68 μM. 23999045
SGC7901 Cytotoxicity assay 48 hrs Cytotoxicity against human SGC7901 cells after 48 hrs by MTT assay, IC50 = 2.05 μM. 23999045
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells after 48 hrs by SRB assay, IC50 = 1.5 μM. 24056146
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by SRB assay, IC50 = 2 μM. 24056146
MDA-MB-231 Cytotoxicity assay 5 days Cytotoxicity against human MDA-MB-231 cells overexpressing DT-diaphorase after 5 days, EC50 = 0.103 μM. 24436995
MDA-MB-231 Cytotoxicity assay 5 days Cytotoxicity against wild-type human MDA-MB-231 cells after 5 days, EC50 = 1.25 μM. 24436995
HCT15 Cytotoxicity assay 48 hrs Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay, IC50 = 0.5 μM. 24910974
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by SRB method, IC50 = 3 μM. 24913558
SMMC-7221 Cytotoxicity assay 48 hrs Cytotoxicity against human SMMC-7221 cells after 48 hrs by SRB method, IC50 = 3 μM. 24913558
HL60 Cytotoxicity assay 48 hrs Cytotoxicity against human HL60 cells after 48 hrs by SRB method, IC50 = 3 μM. 24913558
PC3 Cytotoxicity assay 48 hrs Cytotoxicity against human PC3 cells after 48 hrs by SRB assay, IC50 = 1.5 μM. 25176329
HeLa Cytotoxicity assay 48 hrs Cytotoxicity against human HeLa cells after 48 hrs by SRB assay, IC50 = 2 μM. 25176329
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells after 48 hrs by SRB assay, IC50 = 0.04 μM. 25259515
THP1 Cytotoxicity assay 48 hrs Cytotoxicity against human THP1 cells after 48 hrs by SRB assay, IC50 = 0.1 μM. 25259515
MCF7 Cytotoxicity assay 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay, IC50 = 0.2 μM. 25259515
A549 Cytotoxicity assay 24 hrs Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by WST8 assay, IC50 = 0.45 μM. 25442306
SF539 Cytotoxicity assay 72 hrs Cytotoxicity against human SF539 cells after 72 hrs by MTS assay, IC50 = 0.038 μM. 26335269
M14 Cytotoxicity assay 72 hrs Cytotoxicity against human M14 cells after 72 hrs by MTS assay, IC50 = 0.47 μM. 26335269
MDA-MB-468 Cytotoxicity assay 72 hrs Cytotoxicity against human MDA-MB-468 cells after 72 hrs by MTS assay, IC50 = 0.5 μM. 26335269
SF295 Cytotoxicity assay 72 hrs Cytotoxicity against human SF295 cells after 72 hrs by MTS assay, IC50 = 0.54 μM. 26335269
NCI-H226 Cytotoxicity assay 72 hrs Cytotoxicity against human NCI-H226 cells after 72 hrs by MTS assay, IC50 = 0.58 μM. 26335269
A549 Cytotoxicity assay 48 hrs Cytotoxicity against human A549 cells assessed as decrease in cell viability at 10 to 100 uM after 48 hrs by SRB assay, EC50 = 5.2 μM. 26508550
HUT78 Antiproliferative assay 48 hrs Antiproliferative activity against human HUT78 cells after 48 hrs by resazurin reduction assay, IC50 = 0.066 μM. 26541587
Jurkat T Antiproliferative assay 48 hrs Antiproliferative activity against human Jurkat T cells in hypoxic condition after 48 hrs by resazurin reduction assay, IC50 = 0.303 μM. 26541587
HL60 Antiproliferative assay 48 hrs Antiproliferative activity against human HL60 cells after 48 hrs by resazurin reduction assay, IC50 = 0.41 μM. 26541587
Jurkat T Antiproliferative assay 48 hrs Antiproliferative activity against human Jurkat T cells after 48 hrs by resazurin reduction assay, IC50 = 0.578 μM. 26541587
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by resazurin reduction assay, IC50 = 1.87 μM. 26541587
HepG2 Antiproliferative assay 48 hrs Antiproliferative activity against human HepG2 cells after 48 hrs by resazurin reduction assay, IC50 = 2.937 μM. 26541587
T47D Antiproliferative assay 48 hrs Antiproliferative activity against human T47D cells after 48 hrs by resazurin reduction assay, IC50 = 16.97 μM. 26541587
PC3 Cytotoxicity assay 72 hrs Cytotoxicity against human PC3 cells after 72 hrs by CCK-8 assay, IC50 = 1.4 μM. 26615890
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by CCK-8 assay, IC50 = 1.7 μM. 26615890
HT-29 Antiproliferative assay 72 hrs Antiproliferative activity against human HT-29 cells expressing NQO1 after 72 hrs by MTT assay, IC50 = 7.099 μM. 28395199
NCI-H596 Antiproliferative assay 72 hrs Antiproliferative activity against NQO1 deficient human NCI-H596 cells after 72 hrs by MTT assay, IC50 = 11.969 μM. 28395199
A549 Antiproliferative assay 72 hrs Antiproliferative activity against human A549 cells expressing NQO1 after 72 hrs by MTT assay, IC50 = 15.525 μM. 28395199
LO2 Cytotoxicity assay 72 hrs Cytotoxicity against human LO2 cells after 72 hrs by MTT assay, IC50 = 25.023 μM. 28395199
CHOK1 Cytotoxicity assay 24 hrs Cytotoxicity against CHOK1 cells incubated for 24 hrs by MTT asasy, IC50 = 13.2 μM. 28615134
A549 Growth inhibition assay 72 hrs Growth inhibition of human A549 cells after 72 hrs by Cell-Titer Glo assay, GI50 = 0.08 μM. 28682609
SKOV3 Growth inhibition assay 72 hrs Growth inhibition of human SKOV3 cells after 72 hrs by Cell-Titer Glo assay, GI50 = 0.1 μM. 28682609
HCT116 Growth inhibition assay 72 hrs Growth inhibition of human HCT116 cells after 72 hrs by Cell-Titer Glo assay, GI50 = 0.2 μM. 28682609
786-O Growth inhibition assay 72 hrs Growth inhibition of human 786-O cells after 72 hrs by Cell-Titer Glo assay, GI50 = 0.21 μM. 28682609
BxPC3 Growth inhibition assay 72 hrs Growth inhibition of human BxPC3 cells after 72 hrs by Cell-Titer Glo assay, GI50 = 0.38 μM. 28682609
HEC6 Growth inhibition assay 72 hrs Growth inhibition of human HEC6 cells after 72 hrs by Cell-Titer Glo assay, GI50 = 1.4 μM. 28682609
MKN74 Growth inhibition assay 72 hrs Growth inhibition of human MKN74 cells after 72 hrs by Cell-Titer Glo assay, GI50 = 1.7 μM. 28682609
U87MG Growth inhibition assay 72 hrs Growth inhibition of human U87MG cells after 72 hrs by Cell-Titer Glo assay, GI50 = 1.8 μM. 28682609
HuH7 Growth inhibition assay 72 hrs Growth inhibition of human HuH7 cells after 72 hrs by Cell-Titer Glo assay, GI50 = 2 μM. 28682609
MCF7 Growth inhibition assay 72 hrs Growth inhibition of human MCF7 cells after 72 hrs by Cell-Titer Glo assay, GI50 = 2.5 μM. 28682609
MDA-MB-231 Antiproliferative assay 48 hrs Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 4.4 μM. 29280632
HL60 Antiproliferative assay 48 hrs Antiproliferative activity against human HL60 cells after 48 hrs by CCK8 assay, IC50 = 0.19 μM. 29475587
HeLa Antiproliferative assay 48 hrs Antiproliferative activity against human HeLa cells after 48 hrs by CCK8 assay, IC50 = 1.13 μM. 29475587
Daoy Cytotoxicity assay Cytotoxicity against human Daoy cells by MTT assay, ED50 = 0.21 μM. 19061391
WiDr Cytotoxicity assay Cytotoxicity against human WiDr cells by MTT assay, ED50 = 0.18 μM. 19061391
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by Alamar blue assay, IC50 = 0.4 μM. 18037301
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells by Alamar blue assay, IC50 = 0.2 μM. 18037301
MPC5 Cytotoxicity assay Cytotoxicity against human MPC5 cells assessed as cell viability by tryptan blue staining method, EC50 = 2.1 μM. 17950604
IE Cytotoxicity assay Cytotoxicity against human IE cells assessed as cell viability by tryptan blue staining method, EC50 = 1.46 μM. 17950604
Hc Cytotoxicity assay Cytotoxicity against human Hc cells assessed as cell viability by tryptan blue staining method, EC50 = 1.46 μM. 17950604
MCF7 Cytotoxicity assay Cytotoxicity against human MCF7 cells assessed as cell viability by tryptan blue staining method, EC50 = 0.96 μM. 17950604
Fb Cytotoxicity assay Cytotoxicity against human Fb cells assessed as cell viability by tryptan blue staining method, EC50 = 0.93 μM. 17950604
A549 Cytotoxicity assay Cytotoxicity against human A549 cells assessed as cell viability by tryptan blue staining method, EC50 = 0.43 μM. 17950604
PC3 Cytotoxicity assay Cytotoxicity against human PC3 cells assessed as cell viability by tryptan blue staining method, EC50 = 0.14 μM. 17950604
KATO III Cytotoxicity assay Cytotoxicity against human KATO III cells by MTT assay, ED50 = 49 μM. 12880314
SCL6 Cytotoxicity assay Cytotoxicity against human SCL6 cells by MTT assay, ED50 = 20.7 μM. 12880314
SCL Cytotoxicity assay Cytotoxicity against human SCL cells by MTT assay, ED50 = 20.2 μM. 12880314
NUGC4 Cytotoxicity assay Cytotoxicity against human NUGC4 cells by MTT assay, ED50 = 19.1 μM. 12880314
SCL37'6 Cytotoxicity assay Cytotoxicity against human SCL37'6 cells by MTT assay, ED50 = 19 μM. 12880314
SCL9 Cytotoxicity assay Cytotoxicity against human SCL9 cells by MTT assay, ED50 = 17.4 μM. 12880314
K562 Function assay In vitro inhibitory activity against K562 leukemia cells in the presence of pd2, IC50 = 0.0158 μM. 12699386
K562 Function assay In vitro inhibitory activity against K562 leukemia cells, IC50 = 0.001 μM. 12699386
colon cancer cell Cytotoxicity assay Cytotoxicity against human colon cancer cells, GI50 = 0.18 μM. 11473418
ovarian cancer cell Cytotoxicity assay Cytotoxicity against human ovarian cancer cells, GI50 = 0.12 μM. 11473418
stomach cancer cell Cytotoxicity assay Cytotoxicity against human stomach cancer cells, GI50 = 0.1 μM. 11473418
CNS cancer cell Cytotoxicity assay Cytotoxicity against human CNS cancer cells, GI50 = 0.064 μM. 11473418
breast cancer cell Cytotoxicity assay Cytotoxicity against human breast cancer cells, GI50 = 0.034 μM. 11473418
lung cancer cell Cytotoxicity assay Cytotoxicity against human lung cancer cells, GI50 = 0.023 μM. 11473418
MCF-7 Antiproliferative assay Antiproliferative activity of compound was evaluated on MCF-7 cells from human breast adenocarcinoma, ID50 = 42.92 μM. 11012027
Molt3 Antiproliferative assay Antiproliferative activity of compound was evaluated on Molt3 cells from human lymphoblastic leukemia, ID50 = 2.66 μM. 11012027
SupT1 Antiproliferative assay Antiproliferative activity of compound was evaluated on SupT1 cells from human non-Hodgkin lymphoma, ID50 = 0.7 μM. 11012027
aerobic cell Function assay In vitro concentration required to kill 50% of the aerobic cells, C50 = 0.8 μM. 9240349
V79-379A Function assay In vitro concentration required to kill hypoxic cells V79-379A cells, C50 = 0.4 μM. 9240349
DC-3F/AD-II Growth inhibition assay Inhibition of cell growth was studied in chinese hamster lung cells resistant to actinomycin D (DC-3F/AD-II)., IC50 = 0.11 μM. 8709111
DC-3F Growth inhibition assay Inhibition of cell growth was studied in chinese hamster lung cells (DC-3F), IC50 = 0.082 μM. 8709111
HL-60 Growth inhibition assay Inhibition of cell growth was studied in human promyelocytic leukemic (HL-60) cells., IC50 = 0.05 μM. 8709111
P388 Function assay Evaluation of inhibitory activity against multidrug resistant P388 cells (P388/ADR) cells, IC50 = 0.535 μM. 8544183
P388 Function assay Evaluation of inhibitory activity against drug sensitive P388 cells (P388/S) cells, IC50 = 0.048 μM. 8544183
HeLa S3 Function assay In vitro anticellular activity against HeLa S3 cells, IC50 = 0.59 μM. 8021919
HeLa S3 Function assay In vitro anticellular activity against HeLa S3 cells; 0.82-1.4, IC50 = 1.4 μM. 8021918
HeLa S3 Function assay In vitro anticellular activity against HeLa S3 cells; 0.59-1.1, IC50 = 1.1 μM. 8021918
V79 Function assay Inhibitory concentration required to kill 50% of the cells was evaluated under aerobic conditions from chinese hamster V79 cells., IC50 = 0.8 μM. 7966141
V79 Function assay Inhibitory concentration required to kill 50% of the cells was evaluated under anaerobic (N2) conditions from chinese hamster V79 cells., IC50 = 0.4 μM. 7966141
P388 Antitumor assay Antitumor potency on P388 leukemia cells in culture, IC50 = 0.0508 μM. 1906109
L1210 Function assay Inhibitory concentration on multidrug-resistant L1210 leukemia cells., IC50 = 1.5 μM. 1906107
L1210 Function assay Inhibitory concentration on parentral (sensitive) L1210 leukemia cells., IC50 = 0.09 μM. 1906107
HeLa Function assay In vitro anticellular activity against HeLa cells., IC50 = 0.81 μM. 1495011
WiDr colon cancer cell Growth inhibition assay In vitro inhibition of WiDr colon cancer cell line, IC50=10 nM 1920349
SW480 colon cancer cell Growth inhibition assay In vitro inhibition of SW480 colon cancer cell line, IC50=7 nM 1920349
human A2780 (ovarian) tumor cell Cytotoxic?assay The compound was evaluated for the cytotoxicity against human A2780 (ovarian) tumor cell lines, IC50=50 nM 10698444
human HT-29 (colon) tumor cell Cytotoxic?assay The compound was evaluated for the cytotoxicity against human HT-29 (colon) tumor cell lines, IC50=40 nM 10698444
human CH1 (ovarian) tumor cell Cytotoxic?assay The compound was evaluated for the cytotoxicity against human CH1 (ovarian) tumor cell lines, IC50=40 nM 10698444
A549 Cytotoxicity assay Cytotoxicity against human A549 cells by MTT assay, IC50 = 3 μM. 22545792
A549 Cytotoxicity assay Cytotoxicity against human A549 cells, IC50 = 0.5 μM. 27089214
PC3 Cytotoxicity assay Cytotoxicity against human PC3 cells, IC50 = 0.5 μM. 27089214
NTERA-S-cl-D1 Growth inhibition assay IC50 = 0.0221 nM SANGER
MOLT-4 Growth inhibition assay IC50 = 0.0325 nM SANGER
J82 Growth inhibition assay IC50 = 0.119 nM SANGER
697 Growth inhibition assay IC50 = 0.1283 nM SANGER
KYSE-510 Growth inhibition assay IC50 = 0.1486 nM SANGER
NCI-H2170 Growth inhibition assay IC50 = 0.1513 nM SANGER
BE-13 Growth inhibition assay IC50 = 0.1673 nM SANGER
LC-2-ad Growth inhibition assay IC50 = 0.2492 nM SANGER
IMR-5 Growth inhibition assay IC50 = 0.3076 nM SANGER
EW-16 Growth inhibition assay IC50 = 0.31 nM SANGER
MC-IXC Growth inhibition assay IC50 = 0.638 nM SANGER
SW872 Growth inhibition assay IC50 = 0.676 nM SANGER
NCI-H2228 Growth inhibition assay IC50 = 0.7963 nM SANGER
NALM-6 Growth inhibition assay IC50 = 1.066 nM SANGER
ES4 Growth inhibition assay IC50 = 1.555 nM SANGER
KE-37 Growth inhibition assay IC50 = 1.636 nM SANGER
IST-MEL1 Growth inhibition assay IC50 = 1.684 nM SANGER
ES8 Growth inhibition assay IC50 = 1.712 nM SANGER
MV-4-11 Growth inhibition assay IC50 = 1.732 nM SANGER
639-V Growth inhibition assay IC50 = 1.759 nM SANGER
OCI-AML2 Growth inhibition assay IC50 = 1.886 nM SANGER
SK-LU-1 Growth inhibition assay IC50 = 2.217 nM SANGER
REH Growth inhibition assay IC50 = 2.548 nM SANGER
PSN1 Growth inhibition assay IC50 = 2.554 nM SANGER
SBC-5 Growth inhibition assay IC50 = 2.589 nM SANGER
HT-3 Growth inhibition assay IC50 = 2.928 nM SANGER
SIG-M5 Growth inhibition assay IC50 = 3.524 nM SANGER
ES7 Growth inhibition assay IC50 = 3.653 nM SANGER
CHP-212 Growth inhibition assay IC50 = 4.368 nM SANGER
P12-ICHIKAWA Growth inhibition assay IC50 = 4.787 nM SANGER
HUTU-80 Growth inhibition assay IC50 = 4.83 nM SANGER
P30-OHK Growth inhibition assay IC50 = 4.842 nM SANGER
NCI-H1651 Growth inhibition assay IC50 = 4.99 nM SANGER
COR-L279 Growth inhibition assay IC50 = 5.545 nM SANGER
CMK Growth inhibition assay IC50 = 5.827 nM SANGER
MHH-CALL-2 Growth inhibition assay IC50 = 6.06 nM SANGER
BV-173 Growth inhibition assay IC50 = 6.067 nM SANGER
NCI-H209 Growth inhibition assay IC50 = 6.168 nM SANGER
NCI-H460 Growth inhibition assay IC50 = 6.452 nM SANGER
DU-145 Growth inhibition assay IC50 = 6.519 nM SANGER
769-P Growth inhibition assay IC50 = 7.112 nM SANGER
ES1 Growth inhibition assay IC50 = 7.288 nM SANGER
COLO-668 Growth inhibition assay IC50 = 7.545 nM SANGER
NKM-1 Growth inhibition assay IC50 = 7.831 nM SANGER
ES3 Growth inhibition assay IC50 = 7.882 nM SANGER
SCC-3 Growth inhibition assay IC50 = 8.519 nM SANGER
SU-DHL-1 Growth inhibition assay IC50 = 8.609 nM SANGER
ML-2 Growth inhibition assay IC50 = 8.781 nM SANGER
SF295 Growth inhibition assay IC50 = 11.48 nM SANGER
EW-7 Growth inhibition assay IC50 = 12.14 nM SANGER
H4 Growth inhibition assay IC50 = 12.44 nM SANGER
LB2241-RCC Growth inhibition assay IC50 = 13.19 nM SANGER
SR Growth inhibition assay IC50 = 13.46 nM SANGER
LB1047-RCC Growth inhibition assay IC50 = 13.6 nM SANGER
MCF7 Growth inhibition assay IC50 = 13.9 nM SANGER
ESS-1 Growth inhibition assay IC50 = 13.92 nM SANGER
NCI-H2122 Growth inhibition assay IC50 = 13.96 nM SANGER
786-0 Growth inhibition assay IC50 = 14.01 nM SANGER
COLO-205 Growth inhibition assay IC50 = 14.33 nM SANGER
HAL-01 Growth inhibition assay IC50 = 15.73 nM SANGER
MHH-ES-1 Growth inhibition assay IC50 = 16.26 nM SANGER
NUGC-3 Growth inhibition assay IC50 = 16.95 nM SANGER
RPMI-8402 Growth inhibition assay IC50 = 17.13 nM SANGER
ATN-1 Growth inhibition assay IC50 = 17.39 nM SANGER
NCI-H441 Growth inhibition assay IC50 = 17.6 nM SANGER
LB996-RCC Growth inhibition assay IC50 = 17.68 nM SANGER
CAL-148 Growth inhibition assay IC50 = 17.83 nM SANGER
CTV-1 Growth inhibition assay IC50 = 18.67 nM SANGER
HOP-62 Growth inhibition assay IC50 = 20.2 nM SANGER
CAKI-1 Growth inhibition assay IC50 = 23.32 nM SANGER
PA-1 Growth inhibition assay IC50 = 23.51 nM SANGER
HT-144 Growth inhibition assay IC50 = 23.75 nM SANGER
LOUCY Growth inhibition assay IC50 = 26.19 nM SANGER
BPH-1 Growth inhibition assay IC50 = 29.9 nM SANGER
LS-1034 Growth inhibition assay IC50 = 30.16 nM SANGER
23132-87 Growth inhibition assay IC50 = 30.53 nM SANGER
BB30-HNC Growth inhibition assay IC50 = 30.61 nM SANGER
CAL-51 Growth inhibition assay IC50 = 30.86 nM SANGER
ALL-PO Growth inhibition assay IC50 = 30.98 nM SANGER
5637 Growth inhibition assay IC50 = 31.93 nM SANGER
KYSE-150 Growth inhibition assay IC50 = 34.09 nM SANGER
RS4-11 Growth inhibition assay IC50 = 34.86 nM SANGER
A3-KAW Growth inhibition assay IC50 = 34.96 nM SANGER
NCI-H719 Growth inhibition assay IC50 = 35.12 nM SANGER
GI-1 Growth inhibition assay IC50 = 35.16 nM SANGER
HEL Growth inhibition assay IC50 = 35.8 nM SANGER
TE-8 Growth inhibition assay IC50 = 35.86 nM SANGER
HT-29 Growth inhibition assay IC50 = 36.02 nM SANGER
SW1783 Growth inhibition assay IC50 = 38.58 nM SANGER
CGTH-W-1 Growth inhibition assay IC50 = 38.74 nM SANGER
MEL-HO Growth inhibition assay IC50 = 39.4 nM SANGER
SW620 Growth inhibition assay IC50 = 39.79 nM SANGER
ME-180 Growth inhibition assay IC50 = 40.11 nM SANGER
CAL-27 Growth inhibition assay IC50 = 41.18 nM SANGER
A431 Growth inhibition assay IC50 = 43.77 nM SANGER
SW954 Growth inhibition assay IC50 = 44.91 nM SANGER
CAL-39 Growth inhibition assay IC50 = 46.49 nM SANGER
LU-134-A Growth inhibition assay IC50 = 46.72 nM SANGER
DU-4475 Growth inhibition assay IC50 = 47.47 nM SANGER
DEL Growth inhibition assay IC50 = 48.39 nM SANGER
HGC-27 Growth inhibition assay IC50 = 49.29 nM SANGER
RH-1 Growth inhibition assay IC50 = 49.57 nM SANGER
SK-MES-1 Growth inhibition assay IC50 = 51.12 nM SANGER
MEL-JUSO Growth inhibition assay IC50 = 51.25 nM SANGER
VA-ES-BJ Growth inhibition assay IC50 = 52.16 nM SANGER
EW-13 Growth inhibition assay IC50 = 52.51 nM SANGER
Ca-Ski Growth inhibition assay IC50 = 53.75 nM SANGER
LXF-289 Growth inhibition assay IC50 = 55.37 nM SANGER
IM-9 Growth inhibition assay IC50 = 56.22 nM SANGER
HCE-4 Growth inhibition assay IC50 = 57.94 nM SANGER
TYK-nu Growth inhibition assay IC50 = 58.73 nM SANGER
NCI-H748 Growth inhibition assay IC50 = 59.54 nM SANGER
ABC-1 Growth inhibition assay IC50 = 61.2 nM SANGER
CCRF-CEM Growth inhibition assay IC50 = 61.68 nM SANGER
EW-3 Growth inhibition assay IC50 = 61.95 nM SANGER
NCI-H2342 Growth inhibition assay IC50 = 62.51 nM SANGER
SK-PN-DW Growth inhibition assay IC50 = 63.76 nM SANGER
EB2 Growth inhibition assay IC50 = 65.36 nM SANGER
CAL-85-1 Growth inhibition assay IC50 = 65.88 nM SANGER
NCI-H526 Growth inhibition assay IC50 = 67.37 nM SANGER
MFH-ino Growth inhibition assay IC50 = 70.61 nM SANGER
ACHN Growth inhibition assay IC50 = 72.08 nM SANGER
MONO-MAC-6 Growth inhibition assay IC50 = 72.35 nM SANGER
CHP-126 Growth inhibition assay IC50 = 72.44 nM SANGER
SW1710 Growth inhibition assay IC50 = 72.58 nM SANGER
TE-10 Growth inhibition assay IC50 = 72.6 nM SANGER
TE-15 Growth inhibition assay IC50 = 73.7 nM SANGER
PANC-10-05 Growth inhibition assay IC50 = 73.75 nM SANGER
BHY Growth inhibition assay IC50 = 75.28 nM SANGER
HSC-3 Growth inhibition assay IC50 = 75.54 nM SANGER
COLO-800 Growth inhibition assay IC50 = 78.66 nM SANGER
NB10 Growth inhibition assay IC50 = 81.65 nM SANGER
SK-UT-1 Growth inhibition assay IC50 = 82.8 nM SANGER
HSC-2 Growth inhibition assay IC50 = 83.42 nM SANGER
GP5d Growth inhibition assay IC50 = 84 nM SANGER
A204 Growth inhibition assay IC50 = 84.19 nM SANGER
BFTC-909 Growth inhibition assay IC50 = 85.27 nM SANGER
NCI-H2087 Growth inhibition assay IC50 = 85.69 nM SANGER
G-402 Growth inhibition assay IC50 = 85.92 nM SANGER
647-V Growth inhibition assay IC50 = 87.39 nM SANGER
Daoy Growth inhibition assay IC50 = 88.01 nM SANGER
EW-1 Growth inhibition assay IC50 = 88.07 nM SANGER
BC-1 Growth inhibition assay IC50 = 88.81 nM SANGER
OAW-42 Growth inhibition assay IC50 = 89.42 nM SANGER
COLO-679 Growth inhibition assay IC50 = 90.25 nM SANGER
TE-11 Growth inhibition assay IC50 = 91.77 nM SANGER
BFTC-905 Growth inhibition assay IC50 = 92.69 nM SANGER
KP-4 Growth inhibition assay IC50 = 93.15 nM SANGER
DOHH-2 Growth inhibition assay IC50 = 93.83 nM SANGER
L-540 Growth inhibition assay IC50 = 95.14 nM SANGER
DSH1 Growth inhibition assay IC50 = 96.53 nM SANGER
M059J Growth inhibition assay IC50 = 100.6 nM SANGER
UM-UC-3 Growth inhibition assay IC50 = 101.83 nM SANGER
ES5 Growth inhibition assay IC50 = 102.42 nM SANGER
KYSE-270 Growth inhibition assay IC50 = 102.84 nM SANGER
OCUB-M Growth inhibition assay IC50 = 102.98 nM SANGER
C-4-II Growth inhibition assay IC50 = 103.51 nM SANGER
BOKU Growth inhibition assay IC50 = 103.78 nM SANGER
8-MG-BA Growth inhibition assay IC50 = 104 nM SANGER
SW982 Growth inhibition assay IC50 = 104.73 nM SANGER
AGS Growth inhibition assay IC50 = 105.8 nM SANGER
IGROV-1 Growth inhibition assay IC50 = 105.97 nM SANGER
HL-60 Growth inhibition assay IC50 = 106.06 nM SANGER
A2780 Growth inhibition assay IC50 = 106.63 nM SANGER
HOS Growth inhibition assay IC50 = 106.7 nM SANGER
HuP-T4 Growth inhibition assay IC50 = 108.1 nM SANGER
ETK-1 Growth inhibition assay IC50 = 108.24 nM SANGER
IA-LM Growth inhibition assay IC50 = 108.63 nM SANGER
MRK-nu-1 Growth inhibition assay IC50 = 110.25 nM SANGER
SUP-T1 Growth inhibition assay IC50 = 110.4 nM SANGER
A2058 Growth inhibition assay IC50 = 115.1 nM SANGER
CAPAN-1 Growth inhibition assay IC50 = 116.4 nM SANGER
NCI-H1355 Growth inhibition assay IC50 = 116.8 nM SANGER
NCI-H1618 Growth inhibition assay IC50 = 117.76 nM SANGER
QIMR-WIL Growth inhibition assay IC50 = 119.58 nM SANGER
HCC1599 Growth inhibition assay IC50 = 120.17 nM SANGER
GR-ST Growth inhibition assay IC50 = 121.34 nM SANGER
G-361 Growth inhibition assay IC50 = 123.93 nM SANGER
RKO Growth inhibition assay IC50 = 125.29 nM SANGER
NCI-H1437 Growth inhibition assay IC50 = 126.26 nM SANGER
SF539 Growth inhibition assay IC50 = 127.02 nM SANGER
ACN Growth inhibition assay IC50 = 127.91 nM SANGER
FADU Growth inhibition assay IC50 = 128.29 nM SANGER
U251 Growth inhibition assay IC50 = 128.73 nM SANGER
KALS-1 Growth inhibition assay IC50 = 129.14 nM SANGER
KM-H2 Growth inhibition assay IC50 = 130.45 nM SANGER
SJSA-1 Growth inhibition assay IC50 = 131.56 nM SANGER
TE-5 Growth inhibition assay IC50 = 132.24 nM SANGER
SNG-M Growth inhibition assay IC50 = 134.17 nM SANGER
HCC1806 Growth inhibition assay IC50 = 134.54 nM SANGER
NCI-H1734 Growth inhibition assay IC50 = 136.85 nM SANGER
LCLC-97TM1 Growth inhibition assay IC50 = 138.72 nM SANGER
NH-12 Growth inhibition assay IC50 = 139.13 nM SANGER
A375 Growth inhibition assay IC50 = 139.42 nM SANGER
NCI-SNU-5 Growth inhibition assay IC50 = 141.21 nM SANGER
SK-OV-3 Growth inhibition assay IC50 = 142.64 nM SANGER
22RV1 Growth inhibition assay IC50 = 144.07 nM SANGER
SW1573 Growth inhibition assay IC50 = 144.68 nM SANGER
BB65-RCC Growth inhibition assay IC50 = 144.71 nM SANGER
MES-SA Growth inhibition assay IC50 = 144.94 nM SANGER
K052 Growth inhibition assay IC50 = 149.34 nM SANGER
KU812 Growth inhibition assay IC50 = 149.96 nM SANGER
NOMO-1 Growth inhibition assay IC50 = 151.41 nM SANGER
Ca9-22 Growth inhibition assay IC50 = 155.57 nM SANGER
8305C Growth inhibition assay IC50 = 155.75 nM SANGER
NCI-SNU-1 Growth inhibition assay IC50 = 156.24 nM SANGER
HC-1 Growth inhibition assay IC50 = 156.51 nM SANGER
SW962 Growth inhibition assay IC50 = 157.55 nM SANGER
HCC2998 Growth inhibition assay IC50 = 160.13 nM SANGER
DMS-273 Growth inhibition assay IC50 = 160.83 nM SANGER
MC-CAR Growth inhibition assay IC50 = 160.91 nM SANGER
Caov-3 Growth inhibition assay IC50 = 161.72 nM SANGER
EoL-1-cell Growth inhibition assay IC50 = 162.39 nM SANGER
MKN45 Growth inhibition assay IC50 = 165.04 nM SANGER
TE-1 Growth inhibition assay IC50 = 165.38 nM SANGER
HMV-II Growth inhibition assay IC50 = 166.06 nM SANGER
SK-NEP-1 Growth inhibition assay IC50 = 166.53 nM SANGER
PANC-03-27 Growth inhibition assay IC50 = 167.16 nM SANGER
RPMI-7951 Growth inhibition assay IC50 = 167.55 nM SANGER
NCI-H520 Growth inhibition assay IC50 = 168.65 nM SANGER
NCI-H522 Growth inhibition assay IC50 = 169.45 nM SANGER
Detroit562 Growth inhibition assay IC50 = 170.26 nM SANGER
SF268 Growth inhibition assay IC50 = 170.86 nM SANGER
T84 Growth inhibition assay IC50 = 173.34 nM SANGER
NB69 Growth inhibition assay IC50 = 175.06 nM SANGER
OVCAR-8 Growth inhibition assay IC50 = 175.54 nM SANGER
RT-112 Growth inhibition assay IC50 = 177.98 nM SANGER
DoTc2-4510 Growth inhibition assay IC50 = 180.37 nM SANGER
J-RT3-T3-5 Growth inhibition assay IC50 = 185.8 nM SANGER
NB1 Growth inhibition assay IC50 = 186.61 nM SANGER
NEC8 Growth inhibition assay IC50 = 186.77 nM SANGER
TUR Growth inhibition assay IC50 = 189.67 nM SANGER
TE-12 Growth inhibition assay IC50 = 189.83 nM SANGER
WSU-NHL Growth inhibition assay IC50 = 192.04 nM SANGER
MHH-NB-11 Growth inhibition assay IC50 = 192.55 nM SANGER
SW48 Growth inhibition assay IC50 = 193.36 nM SANGER
C3A Growth inhibition assay IC50 = 194.31 nM SANGER
RPMI-2650 Growth inhibition assay IC50 = 195.75 nM SANGER
VMRC-RCZ Growth inhibition assay IC50 = 198.77 nM SANGER
SK-CO-1 Growth inhibition assay IC50 = 0.20181 μM SANGER
KYSE-180 Growth inhibition assay IC50 = 0.20219 μM SANGER
KGN Growth inhibition assay IC50 = 0.20713 μM SANGER
A388 Growth inhibition assay IC50 = 0.20722 μM SANGER
NCI-H2030 Growth inhibition assay IC50 = 0.21132 μM SANGER
NCI-H727 Growth inhibition assay IC50 = 0.2118 μM SANGER
BC-3 Growth inhibition assay IC50 = 0.21208 μM SANGER
CCF-STTG1 Growth inhibition assay IC50 = 0.21559 μM SANGER
NMC-G1 Growth inhibition assay IC50 = 0.21675 μM SANGER
NCI-H1299 Growth inhibition assay IC50 = 0.21841 μM SANGER
RPMI-6666 Growth inhibition assay IC50 = 0.21961 μM SANGER
D-283MED Growth inhibition assay IC50 = 0.22069 μM SANGER
AM-38 Growth inhibition assay IC50 = 0.22116 μM SANGER
LU-99A Growth inhibition assay IC50 = 0.22424 μM SANGER
KYSE-70 Growth inhibition assay IC50 = 0.22431 μM SANGER
CHL-1 Growth inhibition assay IC50 = 0.22516 μM SANGER
CESS Growth inhibition assay IC50 = 0.2254 μM SANGER
A4-Fuk Growth inhibition assay IC50 = 0.22543 μM SANGER
MG-63 Growth inhibition assay IC50 = 0.22618 μM SANGER
MKN28 Growth inhibition assay IC50 = 0.23009 μM SANGER
NCI-H1417 Growth inhibition assay IC50 = 0.2369 μM SANGER
BCPAP Growth inhibition assay IC50 = 0.2396 μM SANGER
COR-L23 Growth inhibition assay IC50 = 0.24094 μM SANGER
SIMA Growth inhibition assay IC50 = 0.24142 μM SANGER
CAL-62 Growth inhibition assay IC50 = 0.24185 μM SANGER
ARH-77 Growth inhibition assay IC50 = 0.24331 μM SANGER
COLO-680N Growth inhibition assay IC50 = 0.2441 μM SANGER
T-24 Growth inhibition assay IC50 = 0.24577 μM SANGER
PF-382 Growth inhibition assay IC50 = 0.25063 μM SANGER
NCI-H810 Growth inhibition assay IC50 = 0.25161 μM SANGER
NCI-H1882 Growth inhibition assay IC50 = 0.25709 μM SANGER
A101D Growth inhibition assay IC50 = 0.25745 μM SANGER
NCI-H2126 Growth inhibition assay IC50 = 0.2602 μM SANGER
VM-CUB-1 Growth inhibition assay IC50 = 0.26082 μM SANGER
OS-RC-2 Growth inhibition assay IC50 = 0.2637 μM SANGER
MIA-PaCa-2 Growth inhibition assay IC50 = 0.27545 μM SANGER
SW837 Growth inhibition assay IC50 = 0.27613 μM SANGER
NCI-H358 Growth inhibition assay IC50 = 0.27626 μM SANGER
NCI-H1703 Growth inhibition assay IC50 = 0.27688 μM SANGER
NCI-H1650 Growth inhibition assay IC50 = 0.28257 μM SANGER
SW626 Growth inhibition assay IC50 = 0.28622 μM SANGER
MFE-296 Growth inhibition assay IC50 = 0.28623 μM SANGER
NCI-H2009 Growth inhibition assay IC50 = 0.28857 μM SANGER
NCI-H2405 Growth inhibition assay IC50 = 0.29434 μM SANGER
BL-41 Growth inhibition assay IC50 = 0.2949 μM SANGER
SNU-C2B Growth inhibition assay IC50 = 0.29505 μM SANGER
no-10 Growth inhibition assay IC50 = 0.2996 μM SANGER
A427 Growth inhibition assay IC50 = 0.30133 μM SANGER
SNB75 Growth inhibition assay IC50 = 0.30346 μM SANGER
CTB-1 Growth inhibition assay IC50 = 0.30637 μM SANGER
BT-20 Growth inhibition assay IC50 = 0.31197 μM SANGER
GT3TKB Growth inhibition assay IC50 = 0.31823 μM SANGER
COR-L88 Growth inhibition assay IC50 = 0.31914 μM SANGER
Calu-6 Growth inhibition assay IC50 = 0.31971 μM SANGER
Calu-3 Growth inhibition assay IC50 = 0.32095 μM SANGER
IGR-1 Growth inhibition assay IC50 = 0.3216 μM SANGER
LS-411N Growth inhibition assay IC50 = 0.32176 μM SANGER
LAN-6 Growth inhibition assay IC50 = 0.32779 μM SANGER
ONS-76 Growth inhibition assay IC50 = 0.32956 μM SANGER
MZ7-mel Growth inhibition assay IC50 = 0.33256 μM SANGER
LB647-SCLC Growth inhibition assay IC50 = 0.33608 μM SANGER
OE33 Growth inhibition assay IC50 = 0.3378 μM SANGER
NCI-H1770 Growth inhibition assay IC50 = 0.34265 μM SANGER
MS-1 Growth inhibition assay IC50 = 0.34402 μM SANGER
NCI-H650 Growth inhibition assay IC50 = 0.34407 μM SANGER
MDA-MB-468 Growth inhibition assay IC50 = 0.34531 μM SANGER
A253 Growth inhibition assay IC50 = 0.34564 μM SANGER
LOXIMVI Growth inhibition assay IC50 = 0.3525 μM SANGER
BB49-HNC Growth inhibition assay IC50 = 0.35252 μM SANGER
HT-1080 Growth inhibition assay IC50 = 0.35371 μM SANGER
NB5 Growth inhibition assay IC50 = 0.3579 μM SANGER
LK-2 Growth inhibition assay IC50 = 0.35814 μM SANGER
KS-1 Growth inhibition assay IC50 = 0.36415 μM SANGER
OE19 Growth inhibition assay IC50 = 0.36496 μM SANGER
U031 Growth inhibition assay IC50 = 0.3658 μM SANGER
HCE-T Growth inhibition assay IC50 = 0.37153 μM SANGER
NCI-H1304 Growth inhibition assay IC50 = 0.37523 μM SANGER
SKG-IIIa Growth inhibition assay IC50 = 0.37738 μM SANGER
GDM-1 Growth inhibition assay IC50 = 0.37746 μM SANGER
CPC-N Growth inhibition assay IC50 = 0.38066 μM SANGER
KYSE-140 Growth inhibition assay IC50 = 0.38134 μM SANGER
SH-4 Growth inhibition assay IC50 = 0.38726 μM SANGER
IST-SL2 Growth inhibition assay IC50 = 0.38762 μM SANGER
SCC-4 Growth inhibition assay IC50 = 0.3877 μM SANGER
OMC-1 Growth inhibition assay IC50 = 0.38955 μM SANGER
Daudi Growth inhibition assay IC50 = 0.39242 μM SANGER
JVM-2 Growth inhibition assay IC50 = 0.39734 μM SANGER
NCI-H510A Growth inhibition assay IC50 = 0.40282 μM SANGER
NCI-H1838 Growth inhibition assay IC50 = 0.40419 μM SANGER
GCIY Growth inhibition assay IC50 = 0.41099 μM SANGER
NCI-H747 Growth inhibition assay IC50 = 0.41159 μM SANGER
NCI-H1694 Growth inhibition assay IC50 = 0.41528 μM SANGER
UACC-893 Growth inhibition assay IC50 = 0.41801 μM SANGER
DMS-153 Growth inhibition assay IC50 = 0.42526 μM SANGER
GAMG Growth inhibition assay IC50 = 0.42821 μM SANGER
LB373-MEL-D Growth inhibition assay IC50 = 0.42962 μM SANGER
8505C Growth inhibition assay IC50 = 0.42983 μM SANGER
DB Growth inhibition assay IC50 = 0.42995 μM SANGER
LoVo Growth inhibition assay IC50 = 0.43068 μM SANGER
MZ2-MEL Growth inhibition assay IC50 = 0.43247 μM SANGER
L-363 Growth inhibition assay IC50 = 0.43417 μM SANGER
HSC-4 Growth inhibition assay IC50 = 0.43445 μM SANGER
NCI-N87 Growth inhibition assay IC50 = 0.43812 μM SANGER
SK-LMS-1 Growth inhibition assay IC50 = 0.43929 μM SANGER
HO-1-N-1 Growth inhibition assay IC50 = 0.44064 μM SANGER
OAW-28 Growth inhibition assay IC50 = 0.44065 μM SANGER
SBC-1 Growth inhibition assay IC50 = 0.4477 μM SANGER
LNCaP-Clone-FGC Growth inhibition assay IC50 = 0.45008 μM SANGER
MZ1-PC Growth inhibition assay IC50 = 0.45011 μM SANGER
GB-1 Growth inhibition assay IC50 = 0.45218 μM SANGER
LCLC-103H Growth inhibition assay IC50 = 0.46087 μM SANGER
YT Growth inhibition assay IC50 = 0.46333 μM SANGER
HCT-15 Growth inhibition assay IC50 = 0.46462 μM SANGER
CaR-1 Growth inhibition assay IC50 = 0.46878 μM SANGER
SK-MEL-30 Growth inhibition assay IC50 = 0.47431 μM SANGER
TCCSUP Growth inhibition assay IC50 = 0.4817 μM SANGER
C-33-A Growth inhibition assay IC50 = 0.48687 μM SANGER
OVCAR-5 Growth inhibition assay IC50 = 0.48711 μM SANGER
CAL-12T Growth inhibition assay IC50 = 0.49125 μM SANGER
PC-14 Growth inhibition assay IC50 = 0.49127 μM SANGER
ST486 Growth inhibition assay IC50 = 0.49436 μM SANGER
HLE Growth inhibition assay IC50 = 0.49832 μM SANGER
TE-9 Growth inhibition assay IC50 = 0.50049 μM SANGER
AU565 Growth inhibition assay IC50 = 0.50096 μM SANGER
LU-165 Growth inhibition assay IC50 = 0.51311 μM SANGER
EW-11 Growth inhibition assay IC50 = 0.51336 μM SANGER
FTC-133 Growth inhibition assay IC50 = 0.51722 μM SANGER
NCI-H1648 Growth inhibition assay IC50 = 0.52301 μM SANGER
AN3-CA Growth inhibition assay IC50 = 0.52328 μM SANGER
KURAMOCHI Growth inhibition assay IC50 = 0.52344 μM SANGER
T98G Growth inhibition assay IC50 = 0.52375 μM SANGER
TK10 Growth inhibition assay IC50 = 0.52832 μM SANGER
LB2518-MEL Growth inhibition assay IC50 = 0.53456 μM SANGER
CAL-33 Growth inhibition assay IC50 = 0.53653 μM SANGER
A172 Growth inhibition assay IC50 = 0.53752 μM SANGER
D-263MG Growth inhibition assay IC50 = 0.54004 μM SANGER
CAMA-1 Growth inhibition assay IC50 = 0.54059 μM SANGER
MKN1 Growth inhibition assay IC50 = 0.54081 μM SANGER
NCI-H661 Growth inhibition assay IC50 = 0.54158 μM SANGER
YKG-1 Growth inhibition assay IC50 = 0.545 μM SANGER
GOTO Growth inhibition assay IC50 = 0.55371 μM SANGER
KYSE-450 Growth inhibition assay IC50 = 0.56311 μM SANGER
UMC-11 Growth inhibition assay IC50 = 0.56701 μM SANGER
DBTRG-05MG Growth inhibition assay IC50 = 0.57026 μM SANGER
KYSE-410 Growth inhibition assay IC50 = 0.58359 μM SANGER
MOLT-16 Growth inhibition assay IC50 = 0.58519 μM SANGER
HCC2218 Growth inhibition assay IC50 = 0.58882 μM SANGER
EFO-21 Growth inhibition assay IC50 = 0.59114 μM SANGER
S-117 Growth inhibition assay IC50 = 0.59244 μM SANGER
HCC1937 Growth inhibition assay IC50 = 0.59382 μM SANGER
THP-1 Growth inhibition assay IC50 = 0.5955 μM SANGER
GAK Growth inhibition assay IC50 = 0.59624 μM SANGER
SW756 Growth inhibition assay IC50 = 0.59691 μM SANGER
KG-1 Growth inhibition assay IC50 = 0.59714 μM SANGER
D-542MG Growth inhibition assay IC50 = 0.60165 μM SANGER
HCC38 Growth inhibition assay IC50 = 0.60411 μM SANGER
SAS Growth inhibition assay IC50 = 0.61465 μM SANGER
RVH-421 Growth inhibition assay IC50 = 0.62917 μM SANGER
JiyoyeP-2003 Growth inhibition assay IC50 = 0.62954 μM SANGER
G-401 Growth inhibition assay IC50 = 0.63447 μM SANGER
SW1990 Growth inhibition assay IC50 = 0.63705 μM SANGER
KP-N-YS Growth inhibition assay IC50 = 0.64012 μM SANGER
HD-MY-Z Growth inhibition assay IC50 = 0.64025 μM SANGER
LAMA-84 Growth inhibition assay IC50 = 0.64166 μM SANGER
SW13 Growth inhibition assay IC50 = 0.64249 μM SANGER
HCC1569 Growth inhibition assay IC50 = 0.64461 μM SANGER
CP66-MEL Growth inhibition assay IC50 = 0.64495 μM SANGER
SK-HEP-1 Growth inhibition assay IC50 = 0.64566 μM SANGER
NB13 Growth inhibition assay IC50 = 0.64603 μM SANGER
NY Growth inhibition assay IC50 = 0.65739 μM SANGER
EHEB Growth inhibition assay IC50 = 0.67213 μM SANGER
MEG-01 Growth inhibition assay IC50 = 0.68336 μM SANGER
HCC70 Growth inhibition assay IC50 = 0.69433 μM SANGER
OVCAR-4 Growth inhibition assay IC50 = 0.69691 μM SANGER
NCI-H1792 Growth inhibition assay IC50 = 0.69734 μM SANGER
HEC-1 Growth inhibition assay IC50 = 0.69824 μM SANGER
NCI-H187 Growth inhibition assay IC50 = 0.70799 μM SANGER
TGBC24TKB Growth inhibition assay IC50 = 0.71 μM SANGER
HuP-T3 Growth inhibition assay IC50 = 0.71055 μM SANGER
SK-MEL-3 Growth inhibition assay IC50 = 0.71112 μM SANGER
MDA-MB-415 Growth inhibition assay IC50 = 0.72395 μM SANGER
HCC2157 Growth inhibition assay IC50 = 0.72685 μM SANGER
NCI-H2081 Growth inhibition assay IC50 = 0.74057 μM SANGER
ES6 Growth inhibition assay IC50 = 0.74562 μM SANGER
KYSE-520 Growth inhibition assay IC50 = 0.77218 μM SANGER
BxPC-3 Growth inhibition assay IC50 = 0.77478 μM SANGER
NCI-H226 Growth inhibition assay IC50 = 0.77721 μM SANGER
LB771-HNC Growth inhibition assay IC50 = 0.77974 μM SANGER
CP50-MEL-B Growth inhibition assay IC50 = 0.78003 μM SANGER
HN Growth inhibition assay IC50 = 0.78254 μM SANGER
EW-24 Growth inhibition assay IC50 = 0.78297 μM SANGER
A673 Growth inhibition assay IC50 = 0.7896 μM SANGER
COLO-684 Growth inhibition assay IC50 = 0.7993 μM SANGER
DMS-53 Growth inhibition assay IC50 = 0.80856 μM SANGER
MDA-MB-361 Growth inhibition assay IC50 = 0.80898 μM SANGER
SNU-475 Growth inhibition assay IC50 = 0.81314 μM SANGER
LB831-BLC Growth inhibition assay IC50 = 0.81608 μM SANGER
RCM-1 Growth inhibition assay IC50 = 0.84728 μM SANGER
NCI-H2347 Growth inhibition assay IC50 = 0.84997 μM SANGER
NCI-H2141 Growth inhibition assay IC50 = 0.85281 μM SANGER
Becker Growth inhibition assay IC50 = 0.86232 μM SANGER
LC-1F Growth inhibition assay IC50 = 0.86233 μM SANGER
SCC-15 Growth inhibition assay IC50 = 0.86386 μM SANGER
U-266 Growth inhibition assay IC50 = 0.86618 μM SANGER
SCC-25 Growth inhibition assay IC50 = 0.87036 μM SANGER
NCI-H1155 Growth inhibition assay IC50 = 0.87336 μM SANGER
NCI-H292 Growth inhibition assay IC50 = 0.88441 μM SANGER
NCI-H2196 Growth inhibition assay IC50 = 0.886 μM SANGER
EKVX Growth inhibition assay IC50 = 0.893 μM SANGER
TE-6 Growth inhibition assay IC50 = 0.89367 μM SANGER
NCI-H1693 Growth inhibition assay IC50 = 0.89963 μM SANGER
HuCCT1 Growth inhibition assay IC50 = 0.90351 μM SANGER
NCI-H1581 Growth inhibition assay IC50 = 0.90674 μM SANGER
KARPAS-422 Growth inhibition assay IC50 = 0.90739 μM SANGER
C8166 Growth inhibition assay IC50 = 0.93232 μM SANGER
BEN Growth inhibition assay IC50 = 0.93516 μM SANGER
SCLC-21H Growth inhibition assay IC50 = 0.96303 μM SANGER
HT-1376 Growth inhibition assay IC50 = 0.96711 μM SANGER
NCI-H1963 Growth inhibition assay IC50 = 0.97437 μM SANGER
MPP-89 Growth inhibition assay IC50 = 0.99122 μM SANGER
SW1417 Growth inhibition assay IC50 = 1.00545 μM SANGER
NCCIT Growth inhibition assay IC50 = 1.01024 μM SANGER
MMAC-SF Growth inhibition assay IC50 = 1.01163 μM SANGER
LU-65 Growth inhibition assay IC50 = 1.01247 μM SANGER
NCI-H1623 Growth inhibition assay IC50 = 1.01428 μM SANGER
HCT-116 Growth inhibition assay IC50 = 1.01502 μM SANGER
CA46 Growth inhibition assay IC50 = 1.0198 μM SANGER
RERF-LC-MS Growth inhibition assay IC50 = 1.03157 μM SANGER
DJM-1 Growth inhibition assay IC50 = 1.03304 μM SANGER
EM-2 Growth inhibition assay IC50 = 1.03374 μM SANGER
HCC1395 Growth inhibition assay IC50 = 1.05754 μM SANGER
HCC1143 Growth inhibition assay IC50 = 1.0664 μM SANGER
HH Growth inhibition assay IC50 = 1.0738 μM SANGER
MDA-MB-453 Growth inhibition assay IC50 = 1.07917 μM SANGER
COLO-320-HSR Growth inhibition assay IC50 = 1.0792 μM SANGER
KM12 Growth inhibition assay IC50 = 1.08364 μM SANGER
KNS-42 Growth inhibition assay IC50 = 1.09239 μM SANGER
HPAF-II Growth inhibition assay IC50 = 1.09715 μM SANGER
OVCAR-3 Growth inhibition assay IC50 = 1.12787 μM SANGER
EFO-27 Growth inhibition assay IC50 = 1.13122 μM SANGER
L-428 Growth inhibition assay IC50 = 1.15778 μM SANGER
LS-513 Growth inhibition assay IC50 = 1.17808 μM SANGER
NB12 Growth inhibition assay IC50 = 1.20371 μM SANGER
NCI-H23 Growth inhibition assay IC50 = 1.20661 μM SANGER
TGBC1TKB Growth inhibition assay IC50 = 1.21141 μM SANGER
LU-139 Growth inhibition assay IC50 = 1.21841 μM SANGER
Raji Growth inhibition assay IC50 = 1.22094 μM SANGER
IPC-298 Growth inhibition assay IC50 = 1.22841 μM SANGER
NCI-H838 Growth inhibition assay IC50 = 1.23291 μM SANGER
RPMI-8226 Growth inhibition assay IC50 = 1.23847 μM SANGER
LC4-1 Growth inhibition assay IC50 = 1.23959 μM SANGER
MN-60 Growth inhibition assay IC50 = 1.26332 μM SANGER
U-87-MG Growth inhibition assay IC50 = 1.27372 μM SANGER
BL-70 Growth inhibition assay IC50 = 1.27667 μM SANGER
MLMA Growth inhibition assay IC50 = 1.30978 μM SANGER
RPMI-8866 Growth inhibition assay IC50 = 1.31777 μM SANGER
M14 Growth inhibition assay IC50 = 1.3376 μM SANGER
RCC10RGB Growth inhibition assay IC50 = 1.34936 μM SANGER
SK-MEL-24 Growth inhibition assay IC50 = 1.37423 μM SANGER
SHP-77 Growth inhibition assay IC50 = 1.3783 μM SANGER
EFE-184 Growth inhibition assay IC50 = 1.38125 μM SANGER
GI-ME-N Growth inhibition assay IC50 = 1.39089 μM SANGER
SF126 Growth inhibition assay IC50 = 1.40565 μM SANGER
Saos-2 Growth inhibition assay IC50 = 1.40649 μM SANGER
KARPAS-299 Growth inhibition assay IC50 = 1.41651 μM SANGER
MC116 Growth inhibition assay IC50 = 1.41664 μM SANGER
NCI-H1563 Growth inhibition assay IC50 = 1.42784 μM SANGER
COLO-824 Growth inhibition assay IC50 = 1.44461 μM SANGER
IST-SL1 Growth inhibition assay IC50 = 1.4462 μM SANGER
HDLM-2 Growth inhibition assay IC50 = 1.4601 μM SANGER
NCI-H1573 Growth inhibition assay IC50 = 1.46085 μM SANGER
NCI-H2171 Growth inhibition assay IC50 = 1.49785 μM SANGER
NOS-1 Growth inhibition assay IC50 = 1.50227 μM SANGER
COLO-792 Growth inhibition assay IC50 = 1.50264 μM SANGER
SNU-423 Growth inhibition assay IC50 = 1.52181 μM SANGER
C32 Growth inhibition assay IC50 = 1.52834 μM SANGER
KOSC-2 Growth inhibition assay IC50 = 1.53103 μM SANGER
NCI-H64 Growth inhibition assay IC50 = 1.53444 μM SANGER
HT Growth inhibition assay IC50 = 1.53659 μM SANGER
NCI-H596 Growth inhibition assay IC50 = 1.5377 μM SANGER
NCI-H720 Growth inhibition assay IC50 = 1.54425 μM SANGER
UACC-257 Growth inhibition assay IC50 = 1.56566 μM SANGER
EVSA-T Growth inhibition assay IC50 = 1.57368 μM SANGER
KNS-81-FD Growth inhibition assay IC50 = 1.59446 μM SANGER
TE-441-T Growth inhibition assay IC50 = 1.60276 μM SANGER
U-698-M Growth inhibition assay IC50 = 1.60291 μM SANGER
COR-L105 Growth inhibition assay IC50 = 1.61317 μM SANGER
KMOE-2 Growth inhibition assay IC50 = 1.62413 μM SANGER
KY821 Growth inhibition assay IC50 = 1.65078 μM SANGER
SJRH30 Growth inhibition assay IC50 = 1.6742 μM SANGER
NCI-H69 Growth inhibition assay IC50 = 1.67882 μM SANGER
RT4 Growth inhibition assay IC50 = 1.69923 μM SANGER
LS-123 Growth inhibition assay IC50 = 1.72001 μM SANGER
BHT-101 Growth inhibition assay IC50 = 1.74029 μM SANGER
K5 Growth inhibition assay IC50 = 1.78398 μM SANGER
SK-N-AS Growth inhibition assay IC50 = 1.79073 μM SANGER
NCI-H322M Growth inhibition assay IC50 = 1.80152 μM SANGER
NCI-H1793 Growth inhibition assay IC50 = 1.81482 μM SANGER
CAL-54 Growth inhibition assay IC50 = 1.84148 μM SANGER
SK-MEL-1 Growth inhibition assay IC50 = 1.88815 μM SANGER
SiHa Growth inhibition assay IC50 = 1.8934 μM SANGER
RD Growth inhibition assay IC50 = 1.89846 μM SANGER
ChaGo-K-1 Growth inhibition assay IC50 = 1.91033 μM SANGER
SNU-C1 Growth inhibition assay IC50 = 1.914 μM SANGER
NCI-H1436 Growth inhibition assay IC50 = 1.92742 μM SANGER
HOP-92 Growth inhibition assay IC50 = 1.93658 μM SANGER
HT55 Growth inhibition assay IC50 = 1.95457 μM SANGER
K-562 Growth inhibition assay IC50 = 1.97869 μM SANGER
NCI-H2052 Growth inhibition assay IC50 = 1.98812 μM SANGER
HT-1197 Growth inhibition assay IC50 = 2.02174 μM SANGER
SW1463 Growth inhibition assay IC50 = 2.08169 μM SANGER
COLO-829 Growth inhibition assay IC50 = 2.08684 μM SANGER
DMS-114 Growth inhibition assay IC50 = 2.08692 μM SANGER
EFM-19 Growth inhibition assay IC50 = 2.08896 μM SANGER
LN-405 Growth inhibition assay IC50 = 2.15428 μM SANGER
UACC-62 Growth inhibition assay IC50 = 2.15533 μM SANGER
MDA-MB-134-VI Growth inhibition assay IC50 = 2.1586 μM SANGER
MDA-MB-157 Growth inhibition assay IC50 = 2.19254 μM SANGER
COLO-741 Growth inhibition assay IC50 = 2.19928 μM SANGER
JEG-3 Growth inhibition assay IC50 = 2.23191 μM SANGER
NB6 Growth inhibition assay IC50 = 2.23352 μM SANGER
NCI-H1395 Growth inhibition assay IC50 = 2.23483 μM SANGER
KARPAS-45 Growth inhibition assay IC50 = 2.27184 μM SANGER
HCC1954 Growth inhibition assay IC50 = 2.28119 μM SANGER
A704 Growth inhibition assay IC50 = 2.38311 μM SANGER
SK-N-DZ Growth inhibition assay IC50 = 2.38958 μM SANGER
EGI-1 Growth inhibition assay IC50 = 2.39059 μM SANGER
TALL-1 Growth inhibition assay IC50 = 2.3955 μM SANGER
PANC-08-13 Growth inhibition assay IC50 = 2.39777 μM SANGER
NCI-H28 Growth inhibition assay IC50 = 2.43524 μM SANGER
DMS-79 Growth inhibition assay IC50 = 2.47163 μM SANGER
NCI-H889 Growth inhibition assay IC50 = 2.48342 μM SANGER
Ramos-2G6-4C10 Growth inhibition assay IC50 = 2.54572 μM SANGER
BT-474 Growth inhibition assay IC50 = 2.62326 μM SANGER
JVM-3 Growth inhibition assay IC50 = 2.64752 μM SANGER
NCI-H524 Growth inhibition assay IC50 = 2.7032 μM SANGER
SK-MM-2 Growth inhibition assay IC50 = 2.71695 μM SANGER
TGW Growth inhibition assay IC50 = 2.75803 μM SANGER
Capan-2 Growth inhibition assay IC50 = 2.78528 μM SANGER
NCI-H82 Growth inhibition assay IC50 = 2.80193 μM SANGER
NCI-H716 Growth inhibition assay IC50 = 2.82042 μM SANGER
MSTO-211H Growth inhibition assay IC50 = 2.82369 μM SANGER
COLO-678 Growth inhibition assay IC50 = 2.88691 μM SANGER
AsPC-1 Growth inhibition assay IC50 = 2.89855 μM SANGER
DV-90 Growth inhibition assay IC50 = 2.92143 μM SANGER
SNU-387 Growth inhibition assay IC50 = 2.93467 μM SANGER
KLE Growth inhibition assay IC50 = 2.98224 μM SANGER
U-118-MG Growth inhibition assay IC50 = 3.14284 μM SANGER
MHH-PREB-1 Growth inhibition assay IC50 = 3.14735 μM SANGER
MDA-MB-175-VII Growth inhibition assay IC50 = 3.15819 μM SANGER
EB-3 Growth inhibition assay IC50 = 3.19768 μM SANGER
HuH-7 Growth inhibition assay IC50 = 3.22286 μM SANGER
NCI-H1522 Growth inhibition assay IC50 = 3.23546 μM SANGER
MDA-MB-231 Growth inhibition assay IC50 = 3.23964 μM SANGER
NCI-H1092 Growth inhibition assay IC50 = 3.2799 μM SANGER
KU-19-19 Growth inhibition assay IC50 = 3.35835 μM SANGER
SNU-449 Growth inhibition assay IC50 = 3.36209 μM SANGER
CAS-1 Growth inhibition assay IC50 = 3.38185 μM SANGER
KP-N-YN Growth inhibition assay IC50 = 3.41535 μM SANGER
P31-FUJ Growth inhibition assay IC50 = 3.45775 μM SANGER
RMG-I Growth inhibition assay IC50 = 3.46127 μM SANGER
SN12C Growth inhibition assay IC50 = 3.46177 μM SANGER
HCC1419 Growth inhibition assay IC50 = 3.48402 μM SANGER
TT Growth inhibition assay IC50 = 3.67775 μM SANGER
SW948 Growth inhibition assay IC50 = 3.75281 μM SANGER
SCC-9 Growth inhibition assay IC50 = 3.78753 μM SANGER
KMS-12-PE Growth inhibition assay IC50 = 3.82788 μM SANGER
GMS-10 Growth inhibition assay IC50 = 3.83807 μM SANGER
EW-18 Growth inhibition assay IC50 = 3.9388 μM SANGER
SK-MEL-2 Growth inhibition assay IC50 = 3.97464 μM SANGER
PC-3 Growth inhibition assay IC50 = 4.07159 μM SANGER
IST-MES1 Growth inhibition assay IC50 = 4.14621 μM SANGER
PLC-PRF-5 Growth inhibition assay IC50 = 4.19446 μM SANGER
YAPC Growth inhibition assay IC50 = 4.36751 μM SANGER
RXF393 Growth inhibition assay IC50 = 4.38975 μM SANGER
LP-1 Growth inhibition assay IC50 = 4.55967 μM SANGER
JAR Growth inhibition assay IC50 = 4.56384 μM SANGER
GCT Growth inhibition assay IC50 = 4.6047 μM SANGER
SW1088 Growth inhibition assay IC50 = 4.66827 μM SANGER
NCI-H345 Growth inhibition assay IC50 = 4.73193 μM SANGER
Calu-1 Growth inhibition assay IC50 = 4.8072 μM SANGER
ECC4 Growth inhibition assay IC50 = 5.07036 μM SANGER
DOK Growth inhibition assay IC50 = 5.1551 μM SANGER
RL Growth inhibition assay IC50 = 5.43657 μM SANGER
NCI-H1755 Growth inhibition assay IC50 = 5.43694 μM SANGER
HTC-C3 Growth inhibition assay IC50 = 5.78944 μM SANGER
PFSK-1 Growth inhibition assay IC50 = 5.88351 μM SANGER
CAL-120 Growth inhibition assay IC50 = 5.96351 μM SANGER
Hs-578-T Growth inhibition assay IC50 = 6.20302 μM SANGER
DG-75 Growth inhibition assay IC50 = 6.2494 μM SANGER
NCI-H2227 Growth inhibition assay IC50 = 6.32364 μM SANGER
OPM-2 Growth inhibition assay IC50 = 6.34857 μM SANGER
T47D Growth inhibition assay IC50 = 6.37191 μM SANGER
HuO-3N1 Growth inhibition assay IC50 = 6.45452 μM SANGER
D-392MG Growth inhibition assay IC50 = 6.68451 μM SANGER
NCI-SNU-16 Growth inhibition assay IC50 = 6.74309 μM SANGER
CW-2 Growth inhibition assay IC50 = 7.72758 μM SANGER
no-11 Growth inhibition assay IC50 = 7.74202 μM SANGER
MFE-280 Growth inhibition assay IC50 = 8.34873 μM SANGER
KINGS-1 Growth inhibition assay IC50 = 8.61164 μM SANGER
HCC1187 Growth inhibition assay IC50 = 8.9213 μM SANGER
NCI-H2452 Growth inhibition assay IC50 = 8.93628 μM SANGER
C2BBe1 Growth inhibition assay IC50 = 9.284 μM SANGER
Mewo Growth inhibition assay IC50 = 9.55233 μM SANGER
MFM-223 Growth inhibition assay IC50 = 10.3807 μM SANGER
NCI-H446 Growth inhibition assay IC50 = 12.4227 μM SANGER
RO82-W-1 Growth inhibition assay IC50 = 13.3274 μM SANGER
EC-GI-10 Growth inhibition assay IC50 = 14.9132 μM SANGER
UACC-812 Growth inhibition assay IC50 = 16.8306 μM SANGER
SK-MEL-28 Growth inhibition assay IC50 = 18.9731 μM SANGER
DK-MG Growth inhibition assay IC50 = 21.667 μM SANGER
NCI-H1993 Growth inhibition assay IC50 = 22.984 μM SANGER
U-2-OS Growth inhibition assay IC50 = 23.6987 μM SANGER
MKN7 Growth inhibition assay IC50 = 27.8562 μM SANGER
SK-N-FI Growth inhibition assay IC50 = 39.7075 μM SANGER
CAL-72 Growth inhibition assay IC50 = 46.7339 μM SANGER
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生物活性

產(chǎn)品描述 Mitomycin C (Ametycine)?是一種抗腫瘤類抗生素，通過抑制DNA合成發(fā)揮作用，用于治療各種癌癥。Mitomycin C 可誘導半胱氨酸蛋白酶依賴性和Fas/CD95非依賴性的 apoptosis。此產(chǎn)品為?；罚毙远拘?易燃/皮膚腐蝕），請在穿戴防護面罩、防護手套和防護服后使用。
靶點
DNA synthesis [1]
體外研究(In Vitro)
體外研究活性

Mitomycin C，通過誘導DNA鏈間交聯(lián)，物理性阻斷DNA復制，重組和RNA轉(zhuǎn)錄。[1] Mitomycin C增強TRAIL-誘導的HCT116 (p53-/-)結(jié)腸癌細胞的凋亡，并通過死亡受體不依賴于JNK的上調(diào)使耐TRAIL的結(jié)腸癌細胞HT-29對細胞因子敏感。[2]在不同的人癌癥細胞系中，如OVCAR-5 (卵巢)，HT-29 (結(jié)腸)，SK-N-MC (成神經(jīng)細胞瘤)，HEP-2 (肝臟)，COLO-205 (結(jié)腸)，NIH-OVCAR-3 (卵巢)和A-549 (肺)，Mitomycin C表現(xiàn)出細胞毒性。[3]
實驗圖片 檢測方法 檢測指標 實驗圖片 PMID
Western blot PARP / Caspase 8 / Caspase 9 / Cleaved caspase-9 / Caspase 3 / Cleaved caspase-3 p-Akt / Akt / p-S6K / S6K / p-Jun / JNK Beclin 1 / p62 / ATG5 GRP78 / CHOP / Caspase-4 / Cleaved caspase-4 24901052
體內(nèi)研究(In Vivo)
體內(nèi)研究活性

作為淺表性膀胱腫瘤的臨床首選，在大鼠膀胱腫瘤模型中，Mitomycin C (400 μM)顯著預防膀胱腫瘤的生長。[4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04934540 Recruiting
Bladder Cancer
Chinese University of Hong Kong
 January 1 2020 --
NCT02199327 Completed
Conjunctival Intraepithelial Neoplasia|Corneal Intraepithelial Neoplasia
Coordinación de Investigación en Salud Mexico|Instituto Mexicano del Seguro Social|University of Guadalajara
 May 2014 Phase 4

化學信息&溶解度

分子量 334.37 分子式

C15H18N4O5
CAS號 50-07-7 SDF Download Mitomycin C SDF
Smiles CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N
儲存條件(自收到貨起) 3年 -20°C(避光) 粉狀

體外溶解度
批次：

DMSO : 67 mg/mL ( (200.37 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩爾濃度計算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑

 動物體內(nèi)配方計算器

實驗計算

摩爾濃度計算器

質(zhì)量 濃度 體積 分子量

動物體內(nèi)配方計算器（澄清溶液）

第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）

mg/kg g μL 只

第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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